Association between a serotonin transporter gene variant and hopelessness among men in the heart and soul study

Journal of General Internal Medicine

Volumn 25, Issue 10, 2010, Pages 1030-1037

  Kangelaris, Kirsten Neudoerffer ^a,b   Vittinghoff, Eric ^a   Otte, Christian ^d   Na, Beeya ^a   Auerbach, Andrew D ^b   Whooley, Mary A ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

5 HTTLPR; cross sectional; depression; Everson hopelessness scale; hopelessness

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; SEROTONIN TRANSPORTER;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DEPRESSION; DNA POLYMORPHISM; FEMALE; GENETIC VARIABILITY; GENOTYPE; HOPELESSNESS; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PROMOTER REGION; RACE DIFFERENCE; SEX RATIO; SOCIAL SUPPORT;

AGED; ALLELES; COHORT STUDIES; CORONARY DISEASE; CROSS-SECTIONAL STUDIES; DEPRESSION; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX CHARACTERISTICS;

EID: 77957189726     PISSN: 08848734     EISSN: 15251497     Source Type: Journal    
DOI: 10.1007/s11606-010-1403-0     Document Type: Article

References (48)

1. R Anda D Williamson D Jones, et al. 1993 Depressed affect, hopelessness, and the risk of ischemic heart disease in a cohort of U.S. adults Epidemiology 4 4 285 94 1:STN:280:DyaK3szltVSmtw%3D%3D 10.1097/00001648-199307000-00003 8347738 (Pubitemid 23199705)
2. SA Everson DE Goldberg GA Kaplan, et al. 1996 Hopelessness and risk of mortality and incidence of myocardial infarction and cancer Psychosom Med 58 2 113 21 1:STN:280:DyaK2s%2Fgt1ahtA%3D%3D 8849626
3. SA Everson GA Kaplan DE Goldberg JT Salonen 2000 Hypertension incidence is predicted by high levels of hopelessness in Finnish men Hypertension 35 2 561 7 1:STN:280:DC%2BD3c7ksFymsw%3D%3D 10679498
4. SA Everson GA Kaplan DE Goldberg R Salonen JT Salonen 1997 Hopelessness and 4-year progression of carotid atherosclerosis. 1495 Arterioscler Thromb Vasc Biol 17 8 1490 5 1:STN:280:DyaK2svkslWktg%3D%3D 9301625 (Pubitemid 27091523)
5. FT Melges J Bowlby 1969 Types of hopelessness in psychopathological process Arch Gen Psychiatry 20 6 690 9 1:STN:280:DyaF1M7psVGnsw%3D%3D 4890814
6. SM Greene 1989 The relationship between depression and hopelessness. Implications for current theories of depression Br J Psychiatry 154 650 9 1:STN:280:DyaK3c%2FovFOrtg%3D%3D 10.1192/bjp.154.5.650 2597858
7. CJ Nekanda-Trepka S Bishop IM Blackburn 1983 Hopelessness and depression Br J Clin Psychol 22 Pt 1 49 60 6831077 (Pubitemid 13117925)
8. MO Whipple TT Lewis K Sutton-Tyrrell, et al. 2009 Hopelessness, depressive symptoms, and carotid atherosclerosis in women: the Study of Women's Health Across the Nation (SWAN) heart study Stroke 40 10 3166 72 10.1161/STROKEAHA.109.554519 19713542
9. A Heils A Teufel S Petri, et al. 1996 Allelic variation of human serotonin transporter gene expression J Neurochem 66 6 2621 4 1:CAS:528:DyaK28XjtFCrsrk%3D 10.1046/j.1471-4159.1996.66062621.x 8632190 (Pubitemid 26159101)
10. BD Greenberg TJ Tolliver SJ Huang Q Li D Bengel DL Murphy 1999 Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets Am J Med Genet 88 1 83 7 1:STN:280:DyaK1M7lvValsg%3D%3D 10.1002/(SICI)1096-8628(19990205)88:1<83::AID-AJMG15>3.0.CO;2-0 10050973 (Pubitemid 29075327)
11. JM McCaffery M Bleil MF Pogue-Geile RE Ferrell SB Manuck 2003 Allelic variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cardiovascular reactivity in young adult male and female twins of European-American descent Psychosom Med 65 5 721 8 10.1097/01.PSY.0000088585. 67365.1D 14508012 (Pubitemid 37163375)
12. R Uher P McGuffin 2008 The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis Mol Psychiatry 13 2 131 46 1:CAS:528: DC%2BD1cXnt1GntQ%3D%3D 10.1038/sj.mp.4002067 17700575
13. E Smeraldi R Zanardi F Benedetti D Di Bella J Perez M Catalano 1998 Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine Mol Psychiatry 3 6 508 11 1:CAS:528:DC%2BD3cXls12nsLY%3D 10.1038/sj.mp.4000425 9857976 (Pubitemid 28515526)
14. X Gonda G Juhasz A Laszik Z Rihmer G Bagdy 2005 Subthreshold depression is linked to the functional polymorphism of the 5HT transporter gene J Affect Disord 87 2-3 291 7 1:CAS:528:DC%2BD2MXmvVGjs70%3D 10.1016/j.jad.2005.05.007 16002148 (Pubitemid 41039951)
15. X Gonda KN Fountoulakis G Juhasz, et al. 2009 Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population Eur Arch Psychiatry Clin Neurosci 259 2 106 13 10.1007/s00406-008-0842-7 18806915
16. KP Lesch D Bengel A Heils, et al. 1996 Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 5292 1527 31 1:CAS:528:DyaK28Xnt1ansL8%3D 10.1126/science.274.5292. 1527 8929413 (Pubitemid 26403928)
17. A Caspi K Sugden TE Moffitt, et al. 2003 Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Science 301 5631 386 9 1:CAS:528:DC%2BD3sXls1ygsrw%3D 10.1126/science.1083968 12869766 (Pubitemid 36877077)
18. TC Eley K Sugden A Corsico, et al. 2004 Gene-environment interaction analysis of serotonin system markers with adolescent depression Mol Psychiatry 9 10 908 15 1:CAS:528:DC%2BD2cXnvVKmsLg%3D 10.1038/sj.mp.4001546 15241435 (Pubitemid 39381955)
19. B Hoefgen TG Schulze S Ohlraun, et al. 2005 The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder Biol Psychiatry 57 3 247 51 1:CAS:528:DC%2BD2MXhtV2nt7s%3D 10.1016/j.biopsych.2004.11.027 15691525 (Pubitemid 40187368)
20. N Jacobs G Kenis F Peeters C Derom R Vlietinck J van Os 2006 Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression Arch Gen Psychiatry 63 9 989 96 1:CAS:528:DC%2BD28XhtVamtr7P 10.1001/archpsyc.63.9. 989 16953001 (Pubitemid 44330457)
21. KS Kendler JW Kuhn J Vittum CA Prescott B Riley 2005 The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication Arch Gen Psychiatry 62 5 529 35 1:CAS:528:DC%2BD2MXkslKksbk%3D 10.1001/archpsyc.62.5.529 15867106 (Pubitemid 40628882)
22. C Otte J McCaffery S Ali MA Whooley 2007 Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study Am J Psychiatry 164 9 1379 84 10.1176/appi.ajp.2007.06101617 17728423 (Pubitemid 47461138)
23. K Wilhelm PB Mitchell H Niven, et al. 2006 Life events, first depression onset and the serotonin transporter gene Br J Psychiatry 188 210 5 10.1192/bjp.bp.105.009522 16507960 (Pubitemid 43341646)
24. N Risch R Herrell T Lehner, et al. 2009 Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis JAMA 301 23 2462 71 1:CAS:528:DC%2BD1MXnsFWgurc%3D 10.1001/jama.2009.878 19531786
25. P Huezo-Diaz R Uher R Smith, et al. 2009 Moderation of antidepressant response by the serotonin transporter gene Br J Psychiatry 195 1 30 8 10.1192/bjp.bp.108.062521 19567893
26. PR Joyce RT Mulder SE Luty, et al. 2003 Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptyline Int J Neuropsychopharmacol 6 4 339 46 1:CAS:528:DC%2BD3sXpsFOnu74%3D 10.1017/S1461145703003663 14604448 (Pubitemid 38146251)
27. RL Sjoberg KW Nilsson N Nordquist, et al. 2006 Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene Int J Neuropsychopharmacol 9 4 443 9 10.1017/S1461145705005936 16212676 (Pubitemid 43979704)
28. E Walderhaug A Magnusson A Neumeister, et al. 2007 Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people Biol Psychiatry 62 6 593 9 1:CAS:528:DC%2BD2sXhtVSjs73N 10.1016/j.biopsych.2007.02.012 17544379 (Pubitemid 47314384)
29. B Ruo JS Rumsfeld MA Hlatky H Liu WS Browner MA Whooley 2003 Depressive symptoms and health-related quality of life: the Heart and Soul Study JAMA 290 2 215 21 10.1001/jama.290.2.215 12851276 (Pubitemid 37430060)
30. P Xie HR Kranzler J Poling, et al. 2009 Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations Arch Gen Psychiatry 66 11 1201 9 10.1001/archgenpsychiatry.2009.153 19884608
31. K Kroenke RL Spitzer JB Williams 2001 The PHQ-9: validity of a brief depression severity measure J Gen Intern Med 16 9 606 13 1:STN:280: DC%2BD3MrhtVWnsQ%3D%3D 10.1046/j.1525-1497.2001.016009606.x 11556941 (Pubitemid 32823891)
32. RL Spitzer K Kroenke JB Williams 1999 Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary care evaluation of mental disorders. Patient health questionnaire JAMA 282 18 1737 44 1:STN:280:DC%2BD3c%2Fjtlaqtg%3D%3D 10.1001/jama.282.18.1737 10568646 (Pubitemid 29533604)
33. D McManus SS Pipkin MA Whooley 2005 Screening for depression in patients with coronary heart disease (data from the Heart and Soul Study) Am J Cardiol 96 8 1076 81 10.1016/j.amjcard.2005.06.037 16214441 (Pubitemid 41416598)
34. MA Whooley P de Jonge E Vittinghoff, et al. 2008 Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease JAMA 300 20 2379 88 1:CAS:528:DC%2BD1cXhsVCgtbrF 10.1001/jama.2008.711 19033588
35. LN Robins JE Helzer J Croughan KS Ratcliff 1981 National Institute of mental health diagnostic interview Schedule. Its history, characteristics, and validity Arch Gen Psychiatry 38 4 381 9 1:STN:280:DyaL3M7lvFeguw%3D%3D 6260053 (Pubitemid 11156022)
36. S Wacholder N Rothman N Caporaso 2000 Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias J Natl Cancer Inst 92 14 1151 8 1:STN:280:DC%2BD3cvlvFeguw%3D%3D 10.1093/jnci/92.14.1151 10904088
37. AT Hattersley MI McCarthy 2005 What makes a good genetic association study? Lancet 366 9493 1315 23 10.1016/S0140-6736(05)67531-9 16214603 (Pubitemid 41416588)
38. TG Schulze FJ McMahon 2002 Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines Am J Med Genet 114 1 1 11 10.1002/ajmg.10042 11840498 (Pubitemid 34027572)
39. NA Gillespie JB Whitfield B Williams AC Heath NG Martin 2005 The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression Psychol Med 35 1 101 11 10.1017/S0033291704002727 15842033 (Pubitemid 40201920)
40. HJ Grabe M Lange B Wolff, et al. 2005 Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden Mol Psychiatry 10 2 220 4 1:CAS:528:DC%2BD2MXnt1Slsg%3D%3D 10.1038/sj.mp.4001555 15263905 (Pubitemid 40188517)
41. J Gelernter H Kranzler JF Cubells 1997 Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects Hum Genet 101 2 243 6 1:STN:280:DyaK1c%2Fms1KrsQ%3D%3D 10.1007/s004390050624 9402979 (Pubitemid 28014742)
42. T Konishi JL Smith KM Lin YJ Wan 2003 Influence of genetic admixture on polymorphisms of alcohol-metabolizing enzymes: analyses of mutations on the CYP2E1, ADH2, ADH3 and ALDH2 genes in a Mexican-American population living in the Los Angeles area Alcohol Alcohol 38 1 93 4 1:CAS:528:DC%2BD3sXitl2ls7o%3D 12554615 (Pubitemid 36204372)
43. T Nakamura T Muramatsu Y Ono, et al. 1997 Serotonin transporter gene regulatory region polymorphism and anxiety-related traits in the Japanese Am J Med Genet 74 5 544 5 1:STN:280:DyaK1c%2FgtVamtA%3D%3D 10.1002/(SICI)1096- 8628(19970919)74:5<544::AID-AJMG18>3.0.CO;2-C 9342209 (Pubitemid 27424224)
44. LA Weiss M Abney EH Cook Jr C Ober 2005 Sex-specific genetic architecture of whole blood serotonin levels Am J Hum Genet 76 1 33 41 1:CAS:528: DC%2BD2MXhtVyntA%3D%3D 10.1086/426697 15526234 (Pubitemid 40023763)
45. NZ Lu AJ Eshleman A Janowsky CL Bethea 2003 Ovarian steroid regulation of serotonin reuptake transporter (SERT) binding, distribution, and function in female macaques Mol Psychiatry 8 3 353 60 1:CAS:528:DC%2BD3sXitlyqsLo%3D 10.1038/sj.mp.4001243 12660809 (Pubitemid 36712930)
46. JK McQueen H Wilson G Fink 1997 Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain Brain Res Mol Brain Res 45 1 13 23 1:CAS:528:DyaK2sXhtlygur8%3D 10.1016/S0169-328X(96)00233-1 9105666 (Pubitemid 27182220)
47. AT Beck A Weissman D Lester L Trexler 1974 The measurement of pessimism: the hopelessness scale J Consult Clin Psychol 42 6 861 5 1:STN:280: DyaE2M%2FmtVOgtA%3D%3D 10.1037/h0037562 4436473
48. D Nakatani H Sato Y Sakata, et al. 2005 Influence of serotonin transporter gene polymorphism on depressive symptoms and new cardiac events after acute myocardial infarction Am Heart J 150 4 652 8 1:CAS:528: DC%2BD2MXhtVymsL7E 10.1016/j.ahj.2005.03.062 16209960 (Pubitemid 41396493)