Chapter 1 Regulation of metabolism and growth during prenatal life

Biology of Growing Animals

Volumn 3, Issue C, 2005, Pages 3-34

  Bell, A W ^a   Greenwood, P L ^b   Ehrhardt, R A ^a  

^a Cornell University ^*  (United States)

^b UNIVERSITY OF NEW ENGLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77957153166     PISSN: 18771823     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1877-1823(09)70008-6     Document Type: Article

References (215)

1. Ahima R.S., and Flier J.S. Leptin. Annu. Rev. Physiol. 62 (2000) 413-437
2. Aldoretta P.W., Carver T.D., and Hay Jr. W.W. Maturation of glucose-stimulated insulin secretion in fetal sheep. Biol. Neonate 73 (1998) 375-396
3. Aldoretta P.W., and Hay Jr. W.W. Effect of glucose supply on ovine uteroplacental glucose metabolism. Amer. J. Physiol. 277 (1999) R947-R958
4. Alexander D.P., Assan R., Britton H.G., Fenton E., and Redstone D. Glucagon release in the sheep fetus I. Effect of hypo- and hyperglycemia and arginine. Biol. Neonate 30 (1976) 1-10
5. Alexander D.P., Britton H.G., Cohen N.M., Nixon D.A., and Parker R.A. Insulin concentrations in the foetal plasma and foetal fluids of the sheep. J. Endocrinol. 40 (1968) 389-390
6. Alexander G. Studies on the placenta of the sheep (Ovis aries L.): effect of reduction in the number of caruncles. J. Reprod. Fertil. 7 (1964) 307-322
7. Alexander G., and Williams D. Heat stress and development of the conceptus in domestic sheep. J. Agr. Sci. 76 (1971) 53-72
8. Anderson A.H., Fennessey P.V., Meschia G., Wilkening R.B., and Battaglia F.C. Placental transport of threonine and its utilization in the normal and growth-restricted fetus. Amer. J. Physiol. 272 (1997) E892-E900
9. Anderson M.S., Flowers-Ziegler J., Das U.G., Hay Jr. W.W., and Devaskar S.U. Glucose transporter protein responses to selective hyperglycemia or hyperinsulinemia in fetal sheep. Amer. J. Physiol. 281 (2001) R1545-R1552
10. Anderson M.S., He J., Flowers-Ziegler J., Devaskar S.U., and Hay Jr. W.W. Effects of selective hyperglycemia and hyperinsulinemia on glucose transporters in fetal ovine skeletal muscle. Amer. J. Physiol. 281 (2001) R1256-R1263
11. Anthony R.V., Pratt S.L., Liang R., and Holland M.D. Placental-fetal hormonal interactions: impact on fetal growth. J. Anim. Sci. 73 (1995) 1861-1871
12. Barbera A., Wilkening R.B., Teng C., Battaglia F.C., and Meschia G. Metabolic alterations in the fetal hepatic and umbilical circulations during glucocorticoid-induced parturition in sheep. Pediat. Res. 41 (1997) 242-248
13. Barker D.J.P. Mothers, Babies and Health in Later Life. 2nd Edition (1998), Churchill Livingstone, Edinburgh
14. Barnes R.J., Comline R.S., and Silver M. Effect of cortisol on liver glycogen concentrations in hypophysectomized, adrenalectomized and normal foetal lambs during late or prolonged gestation. J. Physiol. 275 (1978) 567-579
15. Bassett J.M., and Hanson C. Catecholamines inhibit growth in fetal sheep in the absence of hypoxemia. Amer. J. Physiol. 274 (1998) R1536-R1545
16. Bassett J.M., and Hanson C. Prevention of hypoinsulinemia modifies catecholamine effects in fetal sheep. Amer. J. Physiol. 278 (2000) R1171-R1181
17. Bassett J.M., Thorburn G.D., and Wallace A.L.C. The plasma growth hormone concentration of the foetal lamb. J. Endocrinol. 48 (1970) 251-263
18. Bassett N.S., Oliver M.H., Breier B.H., and Gluckman P.D. The effect of maternal starvation on plasma insulin-like growth factor I concentrations in the late gestation ovine fetus. Pediat. Res. 27 (1990) 401-404
19. Battaglia F.C., and Meschia G. Fetal nutrition. Annu. Rev. Nutr. 8 (1988) 43-61
20. Battaglia F.C., and Regnault T.R.H. Placental transport and metabolism of amino acids. Placenta 22 (2001) 145-161
21. Bauer M.K., Harding J.E., Breier B.H., and Gluckman P.D. Exogenous GH infusion to late-gestational fetal sheep does not alter fetal growth and metabolism. J. Endocrinol. 166 (2000) 591-597
22. Bell A.W. Pregnancy and fetal metabolism. In: Forbes J.M., and France J. (Eds). Quantitative Aspects of Ruminant Digestion and Metabolism (1993), CAB International, Oxford 406-431
23. Bell A.W., Battaglia F.C., and Meschia G. Relation between metabolic rate and body size in the ovine fetus. J. Nutr. 117 (1987) 1181-1186
24. Bell A.W., and Ehrhardt R.A. Regulation of placental nutrient transport and implications for fetal growth. Nutr. Res. Rev. 15 (2002) 211-230
25. Bell A.W., Hay Jr. W.W., and Ehrhardt R.A. Placental transport of nutrients and its implications for fetal growth. J. Reprod. Fertil. Suppl. 54 (1999) 401-410
26. Bell A.W., Kennaugh J.M., Battaglia F.C., Makowski E.L., and Meschia G. Metabolic and circulatory studies of fetal lamb at midgestation. Amer. J. Physiol. 250 (1986) E538-E544
27. Bell A.W., Kennaugh J.M., Battaglia F.C., and Meschia G. Uptake of amino acids and ammonia at mid-gestation by the fetal lamb. Quart. J. Exp. Physiol. 74 (1989) 635-643
28. Bell A.W., Slepetis R., and Ehrhardt R.A. Growth and accretion of energy and protein in the gravid uterus during late pregnancy in Holstein cows. J. Dairy Sci. 78 (1995) 1954-1961
29. Bell A.W., Wilkening R.B., and Meschia G. Some aspects of placental function in chronically heatstressed ewes. J. Dev. Physiol. 9 (1987) 17-29
30. Boisclair Y.R., Rhoads R.P., Ueki I., Wang J., and Ooi G.T. The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten component of the circulating IGF system. J. Endocrinol. 170 (2001) 63-70
31. pm) from the sheep placenta. Biochim. Biophys. Acta 1214 (1994) 187-192
32. Campbell F.M., Taffesse S., Gordon M.J., and Dutta-Roy A.K. Plasma membrane fatty acid-binding protein from human placenta: identification and characterisation. Biochem. Biophys. Res. Comm. 209 (1995) 1011-1017
33. Carter B.S., Moores Jr. R.R., Teng C., Meschia G., and Battaglia F.C. Main routes of plasma lactate carbon disposal in the midgestation fetal lamb. Biol. Neonate 67 (1995) 295-300
34. Carver T.D., Quick A.A., Teng C., Pike A.W., Fennessey P.V., and Hay Jr. W.W. Leucine metabolism in chronically hypoglycemic hypoinsulinemic growth-restricted fetal sheep. Amer. J. Physiol. 272 (1997) E107-E117
35. Char V.C., and Creasy R.K. Acetate as a metabolic substrate in the fetal lamb. Amer. J. Physiol. 230 (1976) 357-361
36. Chung M., Teng C., Timmerman M., Meschia G., and Battaglia F.C. Production and utilization of amino acids by ovine placenta in vivo. Amer. J. Physiol. 274 (1998) E13-E22
37. Clegg R.A. Placental lipoprotein lipase activity in the rabbit, rat and sheep. Comp. Biochem. Physiol. 69B (1981) 585-591
38. Cohen W.R., Piasecki G.J., and Jackson B.T. Plasma catecholamines during hypoxemia in fetal lamb. Amer. J. Physiol. 243 (1982) R520-R525
39. Comline R.S., and Silver M. Some aspects of foetal and utero-placental metabolism in cows with indwelling umbilical and uterine vascular catheters. J. Physiol. 260 (1976) 571-586
40. Constancia M., Hemberger M., Hughes J., Dean W., Ferguson-Smith A., Fundeles R., Stewart F., Kelsey G., Fowden A., Sibley C., and Reik W. Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature 417 (2002) 945-948
41. Creasy R.K., Barrett C.T., de Swiet M., Kahanpää K.V., and Rudolph A.M. Experimental intrauterine growth retardation in the sheep. Amer. J. Obstet. Gynecol. 112 (1972) 566-573
42. Currie M.J., Bassett N.S., and Gluckman P.D. Ovine glucose transporter-1 and -3: cDNA partial sequences and developmental gene expression in the placenta. Placenta 18 (1997) 393-401
43. D'Agostino J., Field J.B., and Frazier M.L. Ontogeny of immunoreactive insulin in the fetal bovine pancreas. Endocrinology 116 (1985) 1108-1116
44. Das U.G., He J., Ehrhardt R.A., Hay Jr. W.W., and Devaskar S.U. Time-dependent physiological regulation of ovine placental GLUT-3 glucose transporter protein. Amer. J. Physiol. 279 (2000) R2252-R2261
45. Das U.G., Sadiq H.F., Soares M.J., Hay Jr. W.W., and Devaskar S.U. Time-dependent physiological regulation of rodent and ovine placental glucose transporter (GLUT-1) protein. Amer. J. Physiol. 274 (1998) R339-R347
46. DeChiara T.M., Robertson E.J., and Efstratiadis A. Parental imprinting of the mouse insulin-like growth factor II gene. Cell 64 (1991) 849-859
47. Delhanty P.J., and Han V.K. The expression of insulin-like growth factor (IGF)-binding protein-2 and IGF-II genes in the tissues of the developing ovine fetus. Endocrinology 132 (1993) 41-52
48. Devaskar S.U., Anthony R., and Hay Jr. W. Ontogeny and insulin regulation of fetal ovine white adipose tissue leptin expression. Amer. J. Physiol. 282 (2002) R431-R438
49. de Zegher F., Styne D.M., Daaboul J., Bettendorf M., Kaplan S.L., and Grumbach M.M. Hormone ontogeny in the ovine fetus and neonatal lamb. XX. Effect of age, breeding season, and twinning on the growth hormone (GH) response to GH-releasing factor: evidence for a homeostatic role of fetal GH. Endocrinology 124 (1989) 124-128
50. Dickson M.C., Saunders J.C., and Gilmour R.S. The ovine insulin-like growth factor-I gene: characterization, expression and identification of a putative promoter. J. Mol. Endocrinol. 6 (1991) 17-31
51. DiGiacomo J.E., and Hay Jr. W.W. Placental-fetal glucose exchange and placental glucose consumption in pregnant sheep. Amer. J. Physiol. 258 (1990) E360-E367
52. DiGiacomo J.E., and Hay Jr. W.W. Fetal glucose metabolism and oxygen consumption during sustained hypoglycemia. Metabolism 39 (1990) 193-202
53. Dodic M., May C.N., Wintour E.M., and Coghlan J.P. An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep. Clin. Sci. 94 (1998) 149-155
54. Dodic M., Peers A., Coghlan J.P., May C.N., Lumbers E., Yu Z.-Y., and Wintour E.M. Altered cardiovascular haemodynamics and baroreceptor-heart rate reflex in adult sheep after prenatal exposure to dexamethasone. Clin. Sci. 97 (1999) 103-109
55. Dodic M., Peers A., Moritz K., Hantzis V., and Wintour E.M. No evidence for HPA reset in adult sheep with high blood pressure due to short prenatal exposure to dexamethasone. Amer. J. Physiol. 282 (2002) R343-R350
56. Ehrhardt R.A., and Bell A.W. Growth and metabolism of the ovine placenta during mid-gestation. Placenta 16 (1995) 727-741
57. Ehrhardt R.A., and Bell A.W. Developmental increases in glucose transporter concentration in the sheep placenta. Amer. J. Physiol. 273 (1997) R1132-R1141
58. Ehrhardt R.A., Bell A.W., and Boisclair Y.R. Analysis of leptin and leptin receptor mRNA expression in the sheep placenta. J. Anim. Sci. 77 Suppl. 1 (1999) 159
59. Ehrhardt R.A., Bell A.W., and Boisclair Y.R. Spatial and developmental regulation of leptin in fetal sheep. Amer. J. Physiol. 282 (2002) R1628-R1635
60. Ehrhardt R.A., Boston R.C., Slepetis R.M., and Bell A.W. Moderate maternal undernutrition elevates placental glucose transport capacity in sheep. J. Anim. Sci. 74 Suppl. 1 (1996) 152
61. Ehrhardt R.A., Greenwood P.L., Bell A.W., and Boisclair Y.R. Plasma leptin is regulated predominantly by nutrition in preruminant lambs. J. Nutr. 133 (2003) 4196-4201
62. Ehrhardt R.A., Slepetis R.M., and Bell A.W. Moderate maternal undernutrition alters glucose transporter levels in maternal insulin-responsive tissues and in the placenta. J. Anim. Sci. 76 Suppl. 1 (1998) 130
63. Etherton T.D., and Bauman D.E. Biology of somatotropin in growth and lactation of domestic animals. Physiol. Rev. 78 (1998) 745-761
64. Faichney G.J., and White G.A. Effects of maternal nutritional status on fetal and placental growth and on fetal urea synthesis in sheep. Aust. J. Biol. Sci. 40 (1987) 365-377
65. Ferrell C.L. Maternal and fetal influences on uterine and conceptus development in the cow: II. Blood flow and nutrient flux. J. Anim. Sci. 69 (1991) 1954-1965
66. Ferrell C.L., Garrett W.N., and Hinman N. Growth, development and composition of the udder and gravid uterus of beef heifers during pregnancy. J. Anim. Sci. 42 (1976) 1477-1489
67. Florini J.R., Ewton D.Z., and Coolican S.A. Growth hormone and insulin-like growth factor system in myogenesis. Endocr. Rev. 17 (1996) 481-517
68. Forhead A.J., Li J., Saunders J.C., Dauncey M.J., Gilmour R.S., and Fowden A.L. Control of ovine hepatic growth hormone receptor and insulin-like growth factor I by thyroid hormones in utero. Amer. J. Physiol. 278 (2000) E1166-E1174
69. Forhead A.J., Thomas L., Crabtree J., Hoggard N., Gardner D.S., Giussani D.A., and Fowden A.L. Plasma leptin concentration in fetal sheep during late gestation: ontogeny and effect of glucocorticoids. Endocrinology 143 (2002) 1166-1173
70. Fowden A.L. Comparative aspects of fetal carbohydrate metabolism. Equine Vet. J. 24 (1997) 19-25
71. Fowden A.L., Apatu R.S.K., and Silver M. The glucogenic capacity of the fetal pig: developmental regulation by cortisol. Exp. Physiol. 80 (1995) 457-467
72. Fowden A.L., Forhead A.J., Silver M., and Macdonald A.A. Glucose, lactate and oxygen metabolism in the fetal pig during late gestation. Exp. Physiol. 82 (1997) 171-182
73. Fowden A.L., Forhead, White K.L., and Taylor P.M. Equine uteroplacental metabolism at mid- and late gestation. Exp. Physiol. 85 (2000) 539-545
74. Fowden A.L., and Hay Jr. W.W. The effects of pancreatectomy on the rates of glucose utilization, oxidation and production in the sheep fetus. Quart. J. Exp. Physiol. 73 (1988) 973-984
75. Fowden A.L., Li J., and Forhead A.L. Glucocorticoids and the preparation for life after birth: are there long-term consequences of the life insurance?. Proc. Nutr. Soc. 57 (1998) 113-122
76. Fowden A.L., Mapstone J., and Forhead A.J. Regulation of glucogenesis by thyroid hormones in fetal sheep during late gestation. J. Endocrinol. 170 (2001) 461-469
77. Fowden A.L., and Silver M. The effect of thyroid hormones on oxygen and glucose metabolism in the sheep fetus during late gestation. J. Physiol. 482 (1995) 203-213
78. Fowden A.L., Taylor P.M., White K.L., and Forhead A.J. Ontogenic and nutritionally induced changes in fetal metabolism in the horse. J. Physiol. 528 (2000) 209-219
79. Freemark M., and Handwerger S. Ovine placental lactogen stimulates glycogen synthesis in fetal rat hepatocytes. Amer. J. Physiol. 246 (1984) E21-E24
80. Freemark M., and Handwerger S. The glycogenic effects of placental lactogen and growth hormone in ovine fetal liver are mediated through binding to specific fetal ovine placental lactogen receptors. Endocrinology 118 (1986) 613-618
81. Gatford K.L., Clarke I.J., De Blasio M.J., McMillen I.C., Robinson J.S., and Owens J.A. Perinatal growth and plasma GH profiles in adolescent and adult sheep. J. Endocrinol. 173 (2002) 151-159
82. Gatford K.L., Wintour E.M., De Blasio M.J., Owens J.A., and Dodic M. Differential timing for programming of glucose homeostasis, sensitivity to insulin and blood pressure by in utero exposure to dexamethasone in sheep. Clin. Sci. 98 (2000) 553-560
83. Gertler A., and Djiane J. Mechanism of ruminant placental lactogen action: molecular and in vivo studies. Mol. Genet. Metab. 75 (2002) 189-201
84. Gluckman P.D., Butler J.H., Comline R., and Fowden A. The effects of pancreatectomy on the plasma concentrations of insulin-like growth factors 1 and 2 in the sheep fetus. J. Dev. Physiol. 9 (1987) 79-88
85. Gluckman P.D., Mueller P.L., Kaplan S.L., Rudolph A.M., and Grumbach M.M. Hormone ontogeny in the ovine fetus. I. Circulating growth hormone in mid and late gestation. Endocrinology 104 (1979) 162-168
86. Goalstone M.L., Leitner J.W., Wall K., Dolgonos L., Rothen K.I., Accili D., and Draznin B. Effect of insulin on farnesyltransferase: specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor-1, epidermal growth factor, and platelet-derived growth factor. J. Biol. Chem. 273 (1998) 23892-23896
87. Grajwer L.A., Sperling M.A., Sack J., and Fisher D.A. Possible mechanisms and significance of the neonatal surge in glucagon secretion: studies in newborn lambs. Pediat. Res. 11 (1977) 833-836
88. Greenwood P.L., and Bell A.W. Consequences of intrauterine growth retardation for postnatal growth, metabolism and pathophysiology. Reproduction Suppl. 61 (2003) 195-206
89. Greenwood P.L., Hunt A.S., Hermanson J.W., and Bell A.W. Effects of birth weight and postnatal nutrition on neonatal sheep: I. Body growth and composition, and some aspects of energetic efficiency. J. Anim. Sci. 76 (1998) 2354-2367
90. Greenwood P.L., Hunt A.S., Slepetis R.M., Finnerty K.D., Alston C., Beermann D.H., and Bell A.W. Effects of birth weight and postnatal nutrition on neonatal sheep: III. Regulation of energy metabolism. J. Anim. Sci. 80 (2002) 2850-2861
91. Greenwood P.L., Slepetis R.M., and Bell A.W. Influences on fetal and placental weights during mid to late gestation in prolific ewes well nourished throughout pregnancy. Reprod. Fertil. Dev. 12 (2000) 149-156
92. Greenwood P.L., Slepetis R.M., Hermanson J.W., and Bell A.W. Intrauterine growth retardation is associated with reduced cell cycle activity, but not myofibre number, in ovine fetal muscle. Reprod. Fertil. Dev. 11 (1999) 281-291
93. Hales C.N., Desai M., Ozanne S.E., and Crowther N.J. Fishing in the stream of diabetes: from measuring insulin to the control of fetal organogenesis. Biochem. Soc. Trans. 24 (1996) 341-350
94. Han V.K., Lund P.K., Lee D.C., and D'Ercole A.J. Expression of somatomedin/insulin-like growth factor messenger ribonucleic acids in the human fetus: identification, characterization, and tissue distribution. J. Clin. Endocrinol. Metab. 66 (1988) 422-429
95. Harding J.E., Jones C.T., and Robinson J.S. Studies on experimental growth retardation in sheep: the effects of a small placenta in restricting transport to and growth of the fetus. J. Dev. Physiol. 7 (1985) 427-442
96. Harding J.E., Liu L., Evans P.C., and Gluckman P.D. Insulin-like growth factor I alters feto-placental protein and carbohydrate metabolism in fetal sheep. Endocrinology 134 (1994) 1509-1514
97. Harwell C.M., Padbury J.F., Anand R.S., Martinez A.M., Ipp E., Thio L., and Burnell E.E. Fetal catecholamine responses to maternal hypoglycemia. Amer. J. Physiol. 259 (1990) R1126-R1130
98. Hawkins P., Steyn C., McGarrigle H.H.G., Calder N.A., Saito T., Stratford L.L., Noakes D.E., and Hanson M.A. Cardiovascular and hypothalamic-pituitary-adrenal axis development in late gestation fetal sheep and young lambs following modest maternal nutrient restriction in early gestation. Reprod. Fertil. Dev. 12 (2000) 443-456
99. Hay Jr. W.W. Regulation of placental metabolism by glucose supply. Reprod. Fertil. Dev. 7 (1995) 365-375
100. Hay W.W. Fetal requirements, placental transfer of nitrogenous compounds. In: Polin R.A., and Fox W.W. (Eds). Fetal, Neonatal Physiology. 2nd Edition (1998), Saunders, Philadelphia 619-634
101. Hay Jr. W.W., and Meznarich H.K. The effect of hyperinsulinaemia on glucose utilization and oxidation and on oxygen consumption in the fetal lamb. Quart. J. Exp. Physiol. 71 (1986) 689-698
102. Hay Jr. W.W., and Meznarich H.K. Effect of maternal glucose concentration on uteroplacental glucose consumption and transfer in pregnant sheep. Proc. Soc. Exp. Biol. Med. 190 (1988) 63-69
103. Hay Jr. W.W., Meznarich H.K., DiGiacomo J.E., Hirst K., and Zerbe G. Effects of insulin and glucose concentrations on glucose utilization in fetal sheep. Pediat. Res. 23 (1988) 381-387
104. Hay Jr. W.W., Molina R.D., DiGiacomo J.E., and Meschia G. Model of placental glucose consumption and glucose transfer. Amer. J. Physiol. 258 (1990) R569-R577
105. Hay Jr. W.W., Myers S.A., Sparks J.W., Wilkening R.B., Meschia G., and Battaglia F.C. Glucose and lactate oxidation rates in the fetal lamb. Proc. Soc. Exp. Biol. Med. 173 (1983) 553-563
106. Hay Jr. W.W., Sparks J.W., Wilkening R.B., Battaglia F.C., and Meschia G. Fetal glucose uptake and utilization as functions of maternal glucose concentration. Amer. J. Physiol. 246 (1984) E237-EE242
107. Hodgson J.C., Mellor D.J., and Field A.C. Foetal and maternal rates of urea production and disposal in well-nourished and undernourished sheep. Brit. J. Nutr. 48 (1982) 49-58
108. Holzman I.R., Lemons J.A., Meschia G., and Battaglia F.C. Ammonia production by the pregnant uterus. Proc. Soc. Exp. Biol. Med. 156 (1977) 27-30
109. Hooper S.B., Bocking A.D., White S.E., Fraher L.J., McDonald T.J., and Han V.K. Catecholamines stimulate the synthesis and release of insulin-like growth factor binding protein-1 (IGFBP-1) by fetal sheep liver in vivo. Endocrinology 134 (1994) 1104-1112
110. Hopkins P.S., and Thorburn G.D. The effects of fetal thyroidectomy on the development of the ovine fetus. J. Endocrinol. 54 (1972) 55-66
111. Horn J., Stern M.D.R., Young M., and Noakes D.E. Influence of insulin and substrate concentration on protein synthetic rate in fetal tissues. Res. Vet. Sci. 35 (1983) 35-41
112. Huxley R., Neil A., and Collins R. Unravelling the fetal origins hypothesis: is there really an inverse association between birthweight and subsequent blood pressure?. Lancet 360 (2002) 659-665
113. Illsley N.P. Glucose transporters in the human placenta. Placenta 21 (2000) 14-22
114. Jodarski G.D., Shanahan M.F., and Rankin J.H.G. Fetal insulin and placental 3-O-methyl glucose clearance in near-term sheep. J. Dev. Physiol. 7 (1985) 251-258
115. Jones C.T., Ritchie J.W., and Walker D. The effects of hypoxia on glucose turnover in the fetal sheep. J. Dev. Physiol. 5 (1983) 223-235
116. Jones J.I., and Clemmons D.R. Insulin-like growth factors and their binding proteins: biological actions. Endocr. Rev. 16 (1995) 3-34
117. Jozwik M., Teng C., Battaglia F.C., and Meschia G. Fetal supply of amino acids and amino nitrogen after maternal infusion of amino acids in pregnant sheep. Amer. J. Obstet. Gynecol. 180 (1999) 447-453
118. Jozwik M., Teng C., Timmerman M., Chung M., Meschia G., and Battaglia F.C. Uptake and transport by the ovine placenta of neutral nonmetabolizable amino acids with different transport system affinities. Placenta 19 (1998) 531-538
119. Kennaugh J.M., Bell A.W., Teng C., Meschia G., and Battaglia F.C. Ontogenetic changes in the rates of protein synthesis and leucine oxidation during fetal life. Pediat. Res. 22 (1987) 688-692
120. Klempt M., Bingham B., Breier B.H., Baumbach W.R., and Gluckman P.D. Tissue distribution and ontogeny of growth hormone receptor messenger ribonucleic acid and ligand binding to hepatic tissue in the midgestation sheep fetus. Endocrinology 132 (1993) 1071-1077
121. Krishnamurti C.R., and Schaefer A.L. Effect of acute maternal starvation on tyrosine metabolism and protein synthesis in fetal sheep. Growth 48 (1984) 391-403
122. Langley S.C., Browne R.F., and Jackson A.A. Altered glucose tolerance in rats exposed to maternal low protein diets in utero. Comp. Biochem. Physiol. 109A (1994) 223-229
123. Langley S.C., and Jackson A.A. Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diet. Clin. Sci. 86 (1994) 217-222
124. Langley-Evans S.C. Fetal programming of cardiovascular function through exposure to maternal undernutrition. Proc. Nutr. Soc. 60 (2001) 505-513
125. Lee C.Y., Bazer F.W., Etherton T.D., and Simmen F.H. Ontogeny of insulin-like growth factors (IGF-I and IGF-II) and IGF-binding proteins in porcine serum during fetal and postnatal development. Endocrinology 128 (1991) 2336-2344
126. Lee C.Y., Chung C.S., and Simmen F.A. Ontogeny of the porcine insulin-like growth factor system. Mol. Cell. Endocrinol. 93 (1993) 71-80
127. Leibovich H., Gertler A., Bazer F.W., and Gootwine E. Active immunization of ewes against ovine placental lactogen increases birth weight of lambs and milk production with no adverse effect on conception rate. Anim. Reprod. Sci. 64 (2000) 33-47
128. Lemons J.A., and Schreiner R.L. Amino acid metabolismin the ovine fetus. Amer. J. Physiol. 244 (1983) E459-E466
129. Leury B.J., Bird A.R., Chandler K.D., and Bell A.W. Effects of maternal undernutrition and exercise on glucose kinetics in fetal sheep. Brit. J. Nutr. 64 (1990) 463-472
130. Leury B.J., Bird A.R., Chandler K.D., and Bell A.W. Glucose partitioning in the pregnant ewe: effects of undernutrition and exercise. Brit. J. Nutr. 64 (1990) 449-462
131. Li J., Forhead A.J., Dauncey M.J., Gilmour R.S., and Fowden A.L. Control of growth hormone receptor and insulin-like growth factor-I expression by cortisol in ovine fetal skeletal muscle. J. Physiol. 541 (2002) 581-589
132. Li J., Owens J.A., Owens P.C., Saunders J.C., Fowden A.L., and Gilmour R.S. The ontogeny of hepatic growth hormone receptor and insulin-like growth factor I gene expression in the sheep fetus during late gestation: developmental regulation by cortisol. Endocrinology 137 (1996) 1650-1657
133. Li J., Saunders J.C., Gilmour R.S., Silver M., and Fowden A.L. Insulin-like growth factor-II messenger ribonucleic acid expression in fetal tissues of the sheep during late gestation: effects of cortisol. Endocrinology 132 (1993) 2083-2089
134. Liechty E.A., Boyle D.W., Moorehead H., Lee W.-H., Bowsher R.R., and Denne S.C. Effects of circulating IGF-I on glucose and amino acid kinetics in the ovine fetus. Amer. J. Physiol. 271 (1996) E177-E185
135. Liechty E.A., Boyle D.W., Moorehead H., Liu Y.M., and Denne S.C. Increased fetal glucose concentration decreases ovine fetal leucine oxidation independent of insulin. Amer. J. Physiol. 265 (1993) E617-E623
136. Liechty E.A., Denne S., Lemons J.A., and Klein C.L. Effects of glucose infusion on leucine transamination and oxidation in the ovine fetus. Pediat. Res. 30 (1991) 423-429
137. Liechty E.A., Kelley J., and Lemons J.A. Effect of fasting on uteroplacental amino acid metabolism in the pregnant sheep. Biol. Neonate 60 (1991) 207-214
138. Liu J.-L., Baker J., Perkins A.S., Roberson E.J., and Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor-I and type 1 receptor. Cell 75 (1993) 59-72
139. Lopez M.F., Dikkes P., Zurakowski D., Villa-Komaroff L., and Majzoub J.A. Regulation of hepatic glycogen in the insulin-like growth factor II-deficient mouse. Endocrinology 140 (1999) 1442-1448
140. Lorijn R.H.W., Nelson J.C., and Longo L.D. Induced fetal hyperthyroidism: cardiac output and oxygen consumption. Amer. J. Physiol. 235 (1980) H302-H307
141. Loy G.L., Quick Jr. A.N., Hay Jr. W.W., Meschia G., Battaglia F.W., and Fennessey P.V. Fetoplacental deamination and decarboxylation of leucine. Amer. J. Physiol. 259 (1990) E492-E497
142. McMillen I.C., Adams M.B., Ross J.T., Coulter C.L., Simonetta G., Owens J.A., Robinson J.S., and Edwards L.J. Fetal growth restriction: adaptations and consequences. Reproduction 122 (2001) 195-204
143. McNeill D.M., Slepetis R., Ehrhardt R.A., Smith D.M., and Bell A.W. Protein requirements of sheep in late pregnancy: partitioning of nitrogen between gravid uterus and maternal tissues. J. Anim. Sci. 75 (1997) 809-816
144. Mellor D.J., Matheson I.C., and Small J. Some changes in the composition of maternal and fetal plasma from chronically catheterised sheep during short periods of reduced feed intake in late pregnancy. Res. Vet. Sci. 23 (1977) 119-121
145. Meschia G., Battaglia F.C., Hay Jr. W.W., and Sparks J.W. Utilization of substrates by the ovine placenta in vivo. Fed. Proc. 39 (1980) 245-249
146. Mesiano S., Young I.R., Hey A.W., Browne C.A., and Thorburn G.D. Hypophysectomy of the fetal lamb leads to a fall in the plasma concentration of insulin-like growth factor I (IGF-I), but not IGF-II. Endocrinology 124 (1989) 1485-1491
147. Meznarich H.K., Hay Jr. W.W., Sparks J.W., Meschia G., and Battaglia F.C. Fructose disposal and oxidation rates in the ovine fetus. Quart. J. Exp. Physiol. 72 (1987) 617-625
148. Milley J.R. Effects of insulin on ovine fetal leucine kinetics and protein metabolism. J. Clin. Invest. 93 (1994) 1616-1624
149. Milley J.R. Fetal substrate uptake during increased ovine fetal cortisol concentration. Amer. J. Physiol. 271 (1996) E186-E191
150. Molina R.D., Meschia G., Battaglia F.C., and Hay Jr. W.W. Gestational maturation of placental glucose transfer capacity in sheep. Amer. J. Physiol. 261 (1991) R697-R704
151. Moores Jr. R.R., Vaughn P.R., Battaglia F.C., Fennessey P.V., Wilkening R.B., and Meschia G. Glutamate metabolism in fetus and placenta of late-gestation sheep. Amer. J. Physiol. 267 (1994) R89-R96
152. Mounzih K., Qiu J., Ewart-Toland A., and Chehab F.F. Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance state. Endocrinology 139 (1998) 5259-5262
153. Mühlhüusler B.S., Roberts C.T., McFarlane J.R., Kauter K.G., and McMillen I.C. Fetal leptin is a signal of fat mass independent of maternal nutrition in ewes fed at or above maintenance energy requirements. Biol. Reprod. 67 (2002) 493-499
154. Noble R.C., Shand J.H., and Christie W.W. Synthesis of C20 and C22 polyunsaturated fatty acids by the placenta of the sheep. Biol. Neonate 47 (1985) 333-338
155. Noden D.M., and deLahunta A. The Embryology of Domestic Animals: Developmental Mechanisms, Malformations (1985), Williams & Wilkins, Baltimore
156. Osborn B.H., Fowlkes J., Han V.K.M., and Freemark M. Nutritional regulation of insulin-like growth factor-binding protein gene expression in the ovine fetus and pregnant ewe. Endocrinology 131 (1992) 1743-1750
157. Osgerby J.C., Wathes D.C., Howard D., and Gadd T.S. The effect of maternal undernutrition on ovine fetal growth. J. Endocrinol. 173 (2002) 131-141
158. Owens J.A., Falconer J., and Robinson J.S. Effect of restriction of placental growth on umbilical and uterine blood flows. Amer. J. Physiol. 250 (1986) R427-R434
159. Owens J.A., Falconer J., and Robinson J.S. Effect of restriction of placental growth on fetal and utero-placental metabolism. J. Dev. Physiol. 9 (1987) 225-238
160. Owens J.A., Falconer J., and Robinson J.S. Restriction of placental size in sheep enhances efficiency of placental transfer of antipyrine, 3-O-methyl-D-glucose but not urea. J. Dev. Physiol. 9 (1987) 457-464
161. Owens J.A., Kind K.L., Carbone F., Robinson J.S., and Owens P.C. Circulating insulin-like growth factors-I and -II and substrates in fetal sheep following restriction of placental growth. J. Endocrinol. 140 (1994) 5-13
162. Paolini C.L., Meschia G., Fennessey P.V., Pike A.W., Teng C., Battaglia F.C., and Wilkening R.B. An in vivo study of ovine placental transport of essential amino acids. Amer. J. Physiol. 280 (2001) E31-E39
163. Parkes M.J., and Bassett J.M. Antagonism by growth hormone of insulin action in fetal sheep. J. Endocrinol. 105 (1985) 379-382
164. Philipps A.F., Dubin J.W., Matty P.J., and Raye J.R. Influence of exogenous glucagon on fetal glucose metabolism and ketone production. Pediat. Res. 17 (1983) 51-56
165. Phillips I.D., Simonetta G., Owens J.A., Robinson J.S., Clarke I.J., and McMillen I.C. Placental restriction alters the functional development of the pituitary-adrenal axis in the sheep fetus during late gestation. Pediat. Res. 40 (1996) 861-866
166. Polk D.H., Wu S.Y., Wright C., Reviczky A.L., and Fisher D.A. Ontogeny of thyroid hormone effect on tissue 5′-monoiodinase activity in fetal sheep. Amer. J. Physiol. 254 (1988) E337-E341
167. Rankin J.H.G., Jodarski G., and Shanahan M.R. Maternal insulin and placental 3-O-methyl glucose transport. J. Dev. Physiol. 8 (1986) 247-253
168. Rehfeldt C., Kuhn G., Nürnberg G., Kanitz E., Schneiders F., Beyer M., Nürnberg K., and Ender K. Effects of exogenous somatotropin during early gestation on maternal performance, fetal growth, and composition traits in sheep. J. Anim. Sci. 79 (2001) 1789-1799
169. Reynolds L.P., Ferrell C.L., Robertson D.A., and Ford S.P. Metabolism of the gravid uterus, foetus and utero-placenta at several stages of gestation in cows. J. Agr. Sci. 106 (1986) 437-444
170. Rhind S.M., Robinson J.J., and McDonald I. Relationships among uterine and placental factors in prolific ewes and their relevance to variations in foetal weight. Anim. Prod. 30 (1980) 115-124
171. Rhoads R.P., Greenwood P.L., Bell A.W., and Boisclair Y.R. Organization and regulation of the gene encoding the sheep acid-labile subunit of the 150-kilodalton insulin-like growth factor-binding protein complex. Endocrinology 141 (2000) 1425-1433
172. Rhoads R.P., Greenwood P.L., Bell A.W., and Boisclair Y.R. Nutritional regulation of the genes encoding the acid-labile subunit and other components of the circulating insulin-like growth factor system in the sheep. J. Anim. Sci. 78 (2000) 2681-2689
173. Robinson J.S., Chidzanja S., Kind K., Lok F., Owens P., and Owens J. Placental control of fetal growth. Reprod. Fertil. Dev. 7 (1995) 333-344
174. Robinson J.S., Hart I.C., Kingston E.J., Jones C.T., and Thorburn G.D. Studies on the growth of the fetal sheep: the effects of reduction of placental size on hormone concentration in fetal plasma. J. Dev. Physiol. 2 (1980) 239-248
175. Ross J.C., Fennessey P.V., Wilkening R.B., Battaglia F.C., and Meschia G. Placental transport and fetal utilization of leucine in a model of fetal growth retardation. Amer. J. Physiol. 270 (1996) E491-E503
176. Rudolph C.D., Roman C., and Rudolph A.M. Effect of cortisol on hepatic gluconeogenesis in the fetal sheep. J. Dev. Physiol. 11 (1989) 219-223
177. Schoknecht P.A., Currie W.B., and Bell A.W. Kinetics of placental lactogen in mid- and late-gestation ovine fetuses. J. Endocrinol. 188 (1992) 95-100
178. Schoknecht P.A., McGuire M.A., Cohick W.S., Currie W.B., and Bell A.W. Effect of chronic infusion of placental lactogen on ovine fetal growth in late gestation. Domest. Anim. Endocrinol. 13 (1996) 519-528
179. Schreiner R.L., Nolen P.A., Bonderman P.W., Moorehead H.C., Gresham E.L., Lemons J.A., and Escobedo M.B. Fetal and maternal hormonal response to starvation in the ewe. Pediat. Res. 14 (1980) 103-108
180. Shen W.-H., Yang X., Boyle D.W., Lee W.H., and Liechty E.A. Effects of intravenous insulin-like growth factor-I and insulin administration on insulin-like growth factor binding proteins in the ovine fetus. J. Endocrinol. 171 (2001) 143-151
181. Silver M., Fowden A.L., Taylor P.M., Knox J., and Hill C.M. Blood amino acids in the pregnant mare and fetus: the effects of maternal fasting and intrafetal insulin. Exp. Physiol. 79 (1994) 423-433
182. Simmons M.A., Battaglia F.C., and Meschia G. Placental transfer of glucose. J. Dev. Physiol. 1 (1979) 227-243
183. Slotkin T.A., and Seidler F.J. Adrenomedullary catecholamine release in the fetus and newborn: secretory mechanisms and their role in stress and survival. J. Dev. Physiol. 10 (1988) 1-16
184. Smeaton T.C., Owens J.A., Kind K.L., and Robinson J.S. The placenta releases branched-chain amino acids into the umbilical and uterine circulations in the pregnant sheep. J. Dev. Physiol. 12 (1989) 95-99
185. Sparks J.W., Hay Jr. W.W., Bonds D., Meschia G., and Battaglia F.C. Simultaneous measurements of lactate turnover rate and umbilical lactate uptake in the fetal lamb. J. Clin. Invest. 70 (1982) 179-192
186. Stegeman J.H.G. Placental development in the sheep and its relation to fetal development. Bjd. Dierk. 44 (1974) 1-72
187. Stephens E., Thureen P.J., Goalstone M.L., Serson M., Leitner J.W., Hay Jr. W.W., and Draznin B. Fetal hyperinsulinemia increases farnesylation of p21 Ras in fetal tissues. Amer. J. Physiol. 281 (2001) E217-E223
188. Sterle J.A., Cantley T.C., Lamberson W.R., Lucey M.C., Gerrard D.E., Matteri R.L., and Day B.N. Effects of recombinant porcine somatotropin on placental size, fetal growth, and IGF-I and IGF-II concentrations in pigs. J. Anim. Sci. 73 (1995) 2980-2985
189. Stevens D., and Alexander G. Lipid deposition after hypophysectomy and growth hormone treatment in the sheep fetus. J. Dev. Physiol. 8 (1986) 139-145
190. Stevens D., Alexander G., and Bell A.W. Effect of prolonged glucose infusion into fetal sheep on body growth, fat deposition and gestation length. J. Dev. Physiol. 13 (1990) 277-281
191. Teasdale F. Numerical density of nuclei in the sheep placenta. Anat. Rec. 185 (1976) 187-196
192. Thomas L., Wallace J.M., Aitken R.P., Mercer J.G., and Trayhurn P. Circulating leptin during ovine pregnancy in relation to maternal nutrition, body composition and pregnancy outcome. J. Endocrinol. 169 (2001) 465-476
193. Thureen P.J., Merson S., and Hay Jr. W.W. Regulation of uterine and umbilical amino acid uptakes by maternal amino acid concentrations. Amer. J. Physiol. 279 (2000) R849-R859
194. Thureen P.J., Padbury J.F., and Hay Jr. W.W. The effect of maternal hypoaminoacidaemia on placental uptake and transport of amino acids in pregnant sheep. Placenta 22 (2001) 162-170
195. Thureen P., Trembler K.A., Meschia G., Makowski E.L., and Wilkening R.B. Placental glucose transport in heat-induced fetal growth retardation. Amer. J. Physiol. 263 (1992) R578-R585
196. Timmerman M., Chung M., Wilkening R.B., Fennessey P.V., Battaglia F.C., and Meschia G. Relationship of fetal alanine uptake and placental alanine metabolism to maternal plasma alanine concentration. Amer. J. Physiol. 275 (1998) E942-E950
197. Timmerman M., Teng C., Wilkening R.B., Fennessey P., Battaglia F.C., and Meschia G. Effect of dexamethasone on fetal hepatic glutamine-glutamate exchange. Amer. J. Physiol. 278 (2000) E839-E845
198. Townsend S.F., Rudolph C.D., and Rudolph A.M. Cortisol induces perinatal hepatic gluconeogenesis in the lamb. J. Dev. Physiol. 16 (1991) 71-79
199. Van Veen L.C.P., Teng C., Hay Jr. W.W., Meschia G., and Battaglia F.C. Leucine disposal and oxidation rates in the fetal lamb. Metabolism 36 (1987) 48-53
200. Van Vliet G., Styne D.M., Kaplan S.L., and Grumbach M.M. Hormone ontogeny in the ovine fetus. XVI. Plasma immunoreactive somatomedin C/insulin-like growth factor I in the fetal and neonatal lamb and in the pregnant ewe. Endocrinology 113 (1983) 1716-1720
201. Vatnick I., and Bell A.W. Ontogeny of fetal hepatic and placental growth and metabolism in sheep. Amer. J. Physiol. 263 (1992) R619-R623
202. Vaughn P.R., Lobo C., Battaglia F.C., Fennessey P.V., Wilkening R.B., and Meschia G. Glutamineglutamate exchange between placenta and fetal liver. Amer. J. Physiol. 268 (1995) E705-E711
203. Vernon R.G., Robertson J.P., Clegg R.A., and Flint D.J. Aspects of adipose-tissue metabolism in foetal lambs. Biochem. J. 196 (1981) 819-824
204. Wallace J.M., Bourke D.A., Aitken R.P., Leitch N., and Hay Jr. W.W. Blood flows and nutrient uptakes in growth-restricted pregnancies induced by overnourishing adolescent sheep. Amer. J. Physiol. 282 (2002) R1027-R1036
205. Wallace J.M., Bourke D.A., Aitken R.P., Palmer R.M., Da Silva P., and Cruickshank M.A. Relationship between nutritionally-mediated placental growth restriction and fetal growth, body composition and endocrine status during late gestation in adolescent sheep. Placenta 21 (2000) 100-108
206. Ward J.W., Wooding F.B.P., and Fowden A.L. The effects of cortisol on the binucleate cell population in the ovine placenta during late gestation. Placenta 23 (2002) 451-458
207. Whorwood C.B., Firth K.M., Budge H., and Symonds M.E. Maternal undernutrition during early to midgestation programs tissue-specific alterations in the expression of the glucocorticoid receptor, 11β-hydroxysteroid dehydrogenase isoforms, and type 1 angiotensin II receptor in neonatal sheep. Endocrinology 142 (2001) 2854-2864
208. Widdas W.F. Inability of diffusion to account for placental glucose transfer in the sheep and consideration of the kinetics of a possible carrier transfer. J. Physiol. 118 (1952) 23-39
209. Wilkening R.B., Molina R.D., Battaglia F.C., and Meschia G. Effect of insulin on glucose/oxygen and lactate/oxygen quotients across the hindlimb of fetal lambs. Biol. Neonate 51 (1987) 18-23
210. Wooding F.B.P., Morgan G., Fowden A.L., and Allen W.R. Separate sites and mechanisms for placental transport of calcium, iron and glucose in the equine placenta. Placenta 21 (2000) 635-645
211. Young M., and McFadyen I.R. Placental transfer and fetal uptake of amino acids in the pregnant ewe. J. Perinatal Med. 1 (1973) 174-182
212. Yuen B.S.J., McMillen I.C., Symonds M.E., and Owens P.C. Abundance of leptin mRNA in fetal adipose tissue is related to fetal body weight. J. Endocrinol. 163 (1999) R11-R14
213. Yuen B.S.J., Owens P.C., McFarlane J.R., Symonds M.E., Edwards L.J., Kauter K.G., and McMillen I.C. Circulating leptin concentrations are positively related to leptin messenger RNA expression in adipose tissue of fetal sheep in the pregnant ewe fed at or below maintenance energy requirements during late gestation. Biol. Reprod. 67 (2002) 911-916
214. Yuen, B.S.J., Owens, P.C., Mühlhäusler, B.S., Roberts, C.T., Symonds, M.E., Keisler, D.H., McFarlane, J.R., Kauter, K.G., Evens, Y., McMillen, I.C., 2003. Leptin alters the structural and functional characteristics of adipose tissue before birth. FASEB J. Express article 10.1096/fj.02-0756fje. Published online, April 22, 2003.
215. Zhou J., and Bondy C.A. Placental glucose transporter gene expression and metabolism in the rat. J. Clin. Invest. 91 (1993) 845-852