Regulation of placental nutrient transport and implications for fetal growth

Nutrition Research Reviews

Volumn 15, Issue 2, 2002, Pages 211-230

  Bell, Alan W ^a   Ehrhardt, Richard A ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Amino acids; Fetal growth; Glucose; Placental transport; Regulatory factors

Indexed keywords

AMINO ACID; AMINO ACID TRANSPORTER; FATTY ACID; FRUCTOSE; GLUCOSE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 3; GROWTH FACTOR; HORMONE; INSULIN; LACTIC ACID; LEPTIN; SOMATOMEDIN;

ACTIVE TRANSPORT; AEROBIC METABOLISM; AMINO ACID METABOLISM; CELL FRACTIONATION; CELL FUNCTION; FATTY ACID METABOLISM; FETOMATERNAL TRANSFUSION; FETOPLACENTAL UNIT; FETUS CIRCULATION; FETUS GROWTH; GESTATION PERIOD; GESTATIONAL AGE; GLUCOSE METABOLISM; HUMAN; MACRONUTRIENT; MATERNAL NUTRITION; NONHUMAN; NUTRIENT CONCENTRATION; NUTRIENT SUPPLY; NUTRIENT UPTAKE; NUTRITIONAL REQUIREMENT; NUTRITIONAL SUPPORT; PLACENTA CIRCULATION; PLACENTA INSUFFICIENCY; PLACENTAL TRANSFER; REGULATORY MECHANISM; REVIEW; SHEEP; THIRD TRIMESTER PREGNANCY; TRANSPORT KINETICS; UMBILICAL CORD BLOOD FLOW;

OVIS ARIES;

EID: 0036896631     PISSN: 09544224     EISSN: None     Source Type: Journal    
DOI: 10.1079/nrr200239     Document Type: Review

References (144)

1. Aldoretta PW & Hay WW Jr (1999) Effect of glucose supply on uteroplacental glucose metabolism. American Journal of Physiology 277, R947-R958.
2. Alexander G (1964) Studies on the placenta of the sheep (Ovis aries L.): Effect of reduction in the number of caruncles. Journal of Reproduction and Fertility 7, 307-322.
3. Alexander G & Williams D (1971) Heat stress and development of the conceptus in domestic sheep. Journal of Agricultural Science, Cambridge 76, 53-72.
4. Anderson AH, Fennessey PV, Meschia G, Wilkening RB & Battaglia FC (1997) Placental transport of threonine and its utilization in the normal and growth-restricted fetus. American Journal of Physiology 272, E892-E900.
5. Anthony RV, Pratt SL, Liang R & Holland MD (1995) Placental-fetal hormonal interactions: Impact on fetal growth. Journal of Animal Science 73, 1861-1871.
6. Ayuk PT, Sibley C, Donnai P, D'Souza S & Glazier J (2000) Development and polarization of cationic amino acid transporters and regulators in the human placenta. American Journal of Physiology 278, C1162-C1171.
7. Baker J, Liu J-P, Robertson EJ & Efstratiadis A (1993) Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75, 73-82.
8. Barker DJP (1994) Mothers, Babies and Disease in Later Life. London: BMJ Publishing Group.
9. Barros LF, Yudilevich DL, Jarvis SM, Beaumont M & Baldwin SA (1995) Quantitation and immunolocalization of glucose transporters in the human placenta. Placenta 16, 623-633.
10. Bassett JM (1986) Nutrition of the conceptus: Aspects of its regulation. Proceedings of the Nutrition Society 45, 1-10.
11. Battaglia FC & Meschia G (1988) Fetal nutrition. Annual Review of Nutrition 8, 43-61.
12. Battaglia FC & Regnault TRH (2001) Placental transport and metabolism of amino acids. Placenta 22, 145-161.
13. Bell AW (1987) Consequences of severe heat stress for fetal development. In Heat Stress: Physical Exertion and Environment, pp. 313-333 [JRS Hales and DAB Richards, editors]. Amsterdam: Elsevier.
14. Bell AW (1993) Pregnancy and fetal metabolism. In Quantitative Aspects of Ruminant Digestion and Metabolism, pp. 405-431 [JM Forbes and J France, editors]. Oxford: CAB International.
15. Bell AW & Ehrhardt RA (1998) Placental regulation of nutrient partitioning during pregnancy. In Nutrition and Reproduction, pp. 229-254 [W Hansel, GA Bray and DH Ryan, editors]. Baton Rouge: Louisiana State University Press.
16. Bell AW, Hay WW Jr & Ehrhardt RA (1999) Placental transport of nutrients and its implications for fetal growth. Journal of Reproduction and Fertility 54, Suppl., 401-410.
17. Bell AW, Kennaugh IM, Battaglia FC & Meschia G (1989) Uptake of amino acids and ammonia at mid-gestation by the fetal lamb. Quarterly Journal of Experimental Physiology 74, 635-643.
18. Bell AW, Wilkening RB & Meschia G (1987) Some aspects of placental function in chronically heat-stressed ewes. Journal of Developmental Physiology 9, 17-29.
19. Britton HG, Huggett AStG & Nixon DA (1967) Carbohydrate metabolism in the sheep placenta. Biochimica et Biophysica Acta 136, 426-440.
20. Brunette MG, Lajeunesse D, Leclerc M & Lafond J (1990) Effect of insulin on D-glucose transport by human placental brush border membranes. Molecular and Cellular Endocrinology 69, 59-68.
21. Campbell DM, Hall MH, Barker DJ, Cross J, Shiell AW & Godfrey KM (1996a) Diet in pregnancy and the offspring's blood pressure 40 years later. British Journal of Obstetrics and Gynaecology 103, 273-280.
22. pm) from the sheep placenta. Biochimica et Biophysica Acta 1214, 187-192.
23. Campbell FM, Gordon MJ & Dutta-Roy AK (1996b) Preferential uptake of long chain polyunsaturated fatty acids by isolated human placental membranes. Molecular and Cellular Biochemistry 155, 77-83.
24. Campbell FM, Taffesse S, Gordon MJ & Dutta-Roy AK (1995) Plasma membrane fatty acid-binding protein from human placenta: Identification and characterisation. Biochemistry and Biophysics Research Communications 209, 1011-1017.
25. 2 consumption after long-term hypoglycemia in pregnant sheep. American Journal of Physiology 269, E299-E308.
26. Challier JC, Hauguel S & Desmaizieres V (1986) Effect of insulin on glucose uptake and metabolism in the human placenta. Journal of Clinical Endocrinology and Metabolism 62, 803-807.
27. Char VC & Creasy RK (1976) Acetate as a metabolic substrate in the fetal lamb. American Journal of Physiology 230, 357-361.
28. Chung M, Teng C, Timmerman M, Meschia G & Battaglia FC (1998) Production and utilization of amino acids by ovine placenta in vivo. American Journal of Physiology 274, E13-E22.
29. Clegg RA (1981) Placental lipoprotein lipase activity in the rabbit, rat and sheep. Comparative Biochemistry and Physiology 69B, 585-591.
30. Comline RS & Silver M (1976) Some aspects of foetal and utero-placental metabolism in cows with indwelling umbilical and uterine vascular catheters. Journal of Physiology 260, 571-586.
31. Currie MJ, Bassett NS & Gluckman PD (1997) Ovine glucose transporter-1 and -3: cDNA partial sequences and developmental gene expression in the placenta. Placenta 18, 393-401.
32. Das UG, He J, Ehrhardt RA, Hay WW Jr & Devaskar SU (2000) Time-dependent physiological regulation of the ovine placental GLUT-3 glucose transporter protein. American Journal of Physiology 279, R2252-R2261.
33. Das UG, Sadiq HF, Soares MJ, Hay WW Jr & Devaskar SU (1998) Time-dependent physiological regulation of rodent and ovine placental glucose transporter (GLUT-1) protein. American Journal of Physiology 274, R339-R347.
34. DeChiara TM, Robertson EJ & Efstratiadis A (1991) Parental imprinting of the mouse insulin-like growth factor II gene. Cell 64, 849-859.
35. DiGiacomo JE & Hay WW Jr (1990) Placental-fetal glucose exchange and placental glucose consumption in pregnant sheep. American Journal of Physiology 258, E360-E367.
36. Dodic M, May N, Wintour EM & Coghlan JP (1998) An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep. Clinical Science 94, 149-155.
37. Dutta-Roy AK (2000) Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. American Journal of Clinical Nutrition 71, Suppl., 315S-322S.
38. Edwards EM, Rattenbury IM, Varnam GC, Dhand UK, Jeacock MK & Shepherd DAL (1977) Enzyme activities in the sheep placenta during the last three months of pregnancy. Biochimica et Biophysica Acta 497, 133-143.
39. Ehrhardt RA & Bell AW (1995) Growth and metabolism of the ovine placenta during mid-gestation. Placenta 16, 727-741.
40. Ehrhardt RA & Bell AW (1997) Developmental increases in glucose transporter concentration in the sheep placenta. American Journal of Physiology 273, R1132-R1141.
41. Ehrhardt RA, Bell AW & Boisclair YR (1999) Analysis of leptin and leptin receptor mRNA expression in the sheep placenta. Journal of Animal Science 77, Suppl. 1, 159.
42. Ehrhardt RA, Bell AW & Boisclair YR (2002) Spatial and developmental regulation of leptin in fetal sheep. American Journal of Physiology 282, R1628-R1635.
43. Ehrhardt RA, Boston RC, Slepetis RM & Bell AW (1996a) Development of a compartmental model to measure maternal to fetal clearance of 3-O methyl glucose in sheep. Journal of Animal Science 74, Suppl. 1, 152.
44. Ehrhardt RA, Boston RC, Slepetis RM & Bell AW (1996b) Moderate maternal undernutrition elevates placental glucose transport capacity in sheep. Journal of Animal Science 74, Suppl. 1, 152.
45. Ehrhardt RA, Slepetis RM & Bell AW (1998) Moderate undernutrition alters glucose transporter levels in maternal insulin-responsive tissues and in the placenta. Journal of Animal Science 76, Suppl. 1, 130.
46. Ehrhardt RA, Slepetis RM, Bell AW & Boisclair YR (2001) Maternal leptin is elevated during pregnancy in sheep. Domestic Animal Endocrinology 21, 85-96.
47. 14C] palmitic acid in pigs. Journal of Developmental Physiology 2, 347-356.
48. Elphick MC & Hull D (1977) The transfer of free fatty acids across the rabbit placenta. Journal of Physiology 264, 751-766.
49. Elphick MC, Hull D & Broughton Pipkin F (1979) The transfer of fatty acids across the sheep placenta. Journal of Developmental Physiology 1, 31-45.
50. Faichney GJ & White GA (1987) Effects of maternal nutritional status on fetal and placental growth and on fetal urea synthesis in sheep. Australian Journal of Biological Sciences 40, 365-377.
51. Fletcher JM & Bassett JM (1986) Effects of streptozotocin injection into fetal rabbits on their subsequent growth in utero. Biology of the Neonate 49, 51-59.
52. Fowden AL, Hughes P & Comline RS (1989) The effects of insulin on the growth rate of the sheep fetus during late gestation. Quarterly Journal of Experimental Physiology 74, 703-714.
53. Garrick DJ, Pollak EJ, Quaas RL & Van Vleck LD (1989) Variance heterogeneity in direct and maternal weight traits by sex and percent purebred for Simmental-sired calves. Journal of Animal Science 67, 2515-2528.
54. Geddie G, Moores R, Meschia G, Fennessey P, Wilkening R & Battaglia FC (1996) Comparison of leucine, serine and glycine transport across the ovine placenta. Placenta 17, 619-627.
55. Godfrey K, Robinson S, Barker DJP, Osmond C & Cox V (1996) Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. British Medical Journal 312, 410-414.
56. Goodwin RFW (1952) Fetal fructose in various mammals. Nature 170, 750.
57. Greenwood PL, Slepetis RM & Bell AW (2000) Influences on fetal and placental weights during mid to late gestation in prolific ewes well nourished throughout pregnancy. Reproduction, Fertility and Development 12, 149-156.
58. Harding JE, Liu L, Evans PC & Gluckman PD (1994) Insulin-like growth factor 1 alters feto-placental protein and carbohydrate metabolism in fetal sheep. Endocrinology 134, 1509-1514.
59. Harris RBS (2000) Leptin - Much more than a satiety signal. Annual Review of Nutrition 20, 45-75.
60. Hauguel S, Desmaizieres V & Challier JC (1986) Placental glucose uptake, transfer and utilization as functions of maternal glucose concentration. Pediatric Research 20, 269-273.
61. Hauguel S, Leturque A, Gilbert M, Kandé J & Girard J (1988) Glucose utilization by the placenta and fetal tissues in fed and fasted pregnant rabbits. Pediatric Research 23, 480-483.
62. Hauguel-de Mouzon S, Challier J, Kacemi A, Caüzac M, Malek A & Girard J (1997) The GLUT3 glucose transporter isoform is differentially expressed within human placental cell types. Journal of Clinical Endocrinology and Metabolism 82, 2689-2694.
63. Hauguel-de Mouzon S, Leturque A, Alsat E, Loizeau M, Evain-Brion D & Girard J (1994) Developmental expression of Glut1 glucose transporter and c-fos genes in human placental cells. Placenta 15, 35-46.
64. Hay WW Jr (1995) Regulation of placental metabolism by glucose supply. Reproduction, Fertility and Development 7, 365-375.
65. Hay WW Jr (1998) Fetal requirements and placental transfer of nitrogenous compounds. In Fetal and Neonatal Physiology, 2nd Ed., pp. 619-634 [RA Polin and WW Fox, editors]. Philadelphia: Saunders.
66. Hay WW Jr & Meznarich HK (1988) Effect of maternal glucose concentration on uteroplacental glucose consumption and transfer in pregnant sheep. Proceedings of the Society for Experimental Biology and Medicine 190, 63-69.
67. Hay WW Jr, Molina RD, DiGiacamo JE & Meschia G (1990) Model of placental glucose consumption and transfer. American Journal of Physiology 258, R569-R577.
68. Hay WW Jr, Sparks JW, Gilbert M, Battaglia FC & Meschia G (1984) Effect of insulin on glucose uptake by the maternal hindlimb and uterus, and by the fetus in conscious pregnant sheep. Journal of Endocrinology 100, 119-124.
69. Hay WW Jr, Sparks JW, Wilkening RB, Battaglia FC & Meschia G (1983) Partition of maternal glucose production between conceptus and maternal tissues in sheep. American Journal of Physiology 245, E347-E350.
70. Heasman L, Clarke L, Firth K, Stephenson T & Symonds ME (1998) Influence of restricted maternal nutrition in early to mid gestation on placental and fetal development at term in sheep. Pediatric Research 44, 546-551.
71. Holzman IR, Lemons JA, Meschia G & Battaglia FC (1977) Ammonia production by the pregnant uterus. Proceedings of the Society for Experimental Biology and Medicine 156, 27-30.
72. Hummel L, Schirrmeister W & Zimmerman T (1975) Transfer of maternal plasma free fatty acids into the rat fetus. Acta Biologica et Medica Germanica 34, 603-605.
73. Illsley NP (2000) Glucose transporters in the human placenta. Placenta 21, 14-22.
74. Jansson T, Cowley EA & Illsley NP (1995) Cellular localization of glucose transporter messenger RNA in human placenta. Reproduction, Fertility and Development 7, 1425-1430.
75. Jansson T, Wennergren M & Illsley NP (1993) Glucose transporter expression and distribution in the human placenta throughout gestation and in intrauterine growth retardation. Journal of Clinical Endocrinology and Metabolism 77, 1554-1562.
76. Jodarski GD, Shanahan MF & Rankin JHG (1985) Fetal insulin and placental 3-O-methyl glucose clearance in nearterm sheep. Journal of Developmental Physiology 7, 251-258.
77. Jozwik M, Teng C, Battaglia FC & Meschia G (1999) Fetal supply of amino acids and amino nitrogen after maternal infusion of amino acids in pregnant sheep. American Journal of Obstetrics and Gynecology 180, 447-453.
78. Jozwik M, Teng C, Timmerman M, Chung M, Meschia G & Battaglia FC (1998) Uptake and transport by the ovine placenta of neutral nonmetabolizable amino acids with different transport system affinities. Placenta 19, 531-538.
79. Kamath SG, Furesz TC, Way BA & Smith CH (1999) Identification of three cationic amino acid transporters in placental trophoblast: Cloning, expression, and characterization of hCAT-1. Journal of Membrane Biology 171, 55-62.
80. Kastendieck E, Künzel W & Kurz CS (1979) Placental clearance of lactate and bicarbonate in sheep. Gynecologic and Obstetric Investigation 10, 9-22.
81. Kastendieck E & Moll W (1977) Placental clearance of lactate and bicarbonate in the guinea pig. Pflügers Archiv 370, 165-171.
82. Kniss DA, Shubert PJ, Zimmerman PD, Landon MB & Gabbe SG (1994) Insulinlike growth factors: Their regulation of glucose and amino acid transport in placental trophoblasts isolated from first-trimester chorionic villi. Journal of Reproductive Medicine 39, 249-256.
83. Krishnamurti CR & Schaefer AL (1984) Effect of acute maternal starvation on tyrosine metabolism and protein synthesis in fetal sheep. Growth 48, 391-403.
84. Langley SC, Browne RF & Jackson AA (1994) Altered glucose tolerance in rats exposed to maternal low protein diets in utero. Comparative Biochemistry and Physiology 109A, 223-229.
85. Langley SC & Jackson AA (1994) Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diet. Clinical Science 86, 217-222.
86. Langley-Evans SC (2001) Fetal programming of cardiovascular function through exposure to maternal undernutrition. Proceedings of the Nutrition Society 60, 505-513.
87. Langley-Evans SC, Gardner DS & Jackson AA (1996a) Maternal protein restriction influences the programming of the rat hypothalamic-pituitary-adrenal axis. Journal of Nutrition 126, 1578-1585.
88. Langley-Evans SC, Phillips GJ, Benediktsson R, Gardner DS, Edwards CRW, Jackson AA & Seckl JR (1996b) Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension. Placenta 17, 169-172.
89. Leat WMF & Harrison FA (1980) Transfer of long-chain fatty acids to the fetal and neonatal lamb. Journal of Developmental Physiology 2, 257-274.
90. Lemons JA & Schreiner RL (1983) Amino acid metabolism in the ovine fetus. American Journal of Physiology 244, E459-E466.
91. Leturque A, Hauguel S, Kandé J & Girard J (1987) Glucose utilization by the placenta of anaesthetized rats: Effects of insulin, glucose and ketone bodies. Pediatric Research 22, 483-487.
92. Leury BJ, Bird AR, Chandler KD & Bell AW (1990a) Glucose partitioning in the pregnant ewe: Effects of undernutrition and exercise. British Journal of Nutrition 64, 449-462.
93. Leury BJ, Bird AR, Chandler KD & Bell AW (1990b) Effects of maternal undernutrition and exercise on glucose kinetics in fetal sheep. British Journal of Nutrition 64, 463-472.
94. Liechty EA, Boyle DW, Moorehead H, Lee W-H, Bowsher RR & Denne SC (1996) Effects of circulating IGF-1 on glucose and amino acid kinetics in the ovine fetus. American Journal of Physiology 271, E177-E185.
95. Liechty EA, Kelley J & Lemons JA (1991) Effect of fasting on uteroplacental amino acid metabolism in the pregnant sheep. Biology of the Neonate 60, 207-214.
96. Lindsay RS, Lindsay RM, Edwards CRW & Seckl JR (1996) Inhibition of 11β-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in offspring. Hypertension 27, 1200-1204.
97. Liu L, Harding JE, Evans PC & Gluckman PD (1994) Maternal insulin-like growth factor-1 infusion alters feto-placental carbohydrate and protein metabolism in pregnant sheep. Endocrinology 135, 895-900.
98. Loy GL, Quick AN Jr, Hay WW Jr, Meschia G, Battaglia FC & Fennessey PV (1990) Fetoplacental deamination and decarboxylation of leucine. American Journal of Physiology 259, E492-E497.
99. McCrabb GJ, Egan AR & Hosking BJ (1992) Maternal undernutrition during mid-pregnancy in sheep: Variable effects on placental growth. Journal of Agricultural Science, Cambridge 118, 127-132.
100. McNeill DM, Slepetis R, Ehrhardt RA, Smith DM & Bell AW (1997) Protein requirements of sheep in late pregnancy: Partitioning of nitrogen between gravid uterus and maternal tissues. Journal of Animal Science 75, 809-816.
101. Marconi AM, Paolini CL, Stramare L, Cetin I, Fennessey PV, Pardi G & Battaglia FC (1999) Steady state maternal-fetal leucine enrichments in normal and intrauterine growth-restricted pregnancies. Pediatric Research 46, 114-119.
102. Mellor DJ (1983) Nutritional and placental determinants of foetal growth rate in sheep and consequences for the newborn lamb. British Veterinary Journal 139, 307-324.
103. Meznarich HK, Hay WW Jr, Sparks JW, Meschia G & Battaglia FC (1987) Fructose disposal and oxidation rates in the ovine fetus. Quarterly Journal of Experimental Physiology 72, 617-625.
104. Molina RD, Meschia G, Battaglia FC & Hay WW Jr (1991) Gestational maturation of placental glucose transfer capacity in sheep. American Journal of Physiology 261, R697-R704.
105. Moores RR Jr, Vaughn PR, Battaglia FC, Fennessey PV, Wilkening RB & Meschia G (1994) Glutamate metabolism in the fetus and placenta of late-gestation sheep. American Journal of Physiology 267, R89-R96.
106. Morriss FH, Boyd RD, Makowski EL, Meschia G & Battaglia FC (1974) Umbilical V-A differences of acetoacetate and β-hydroxybutyrate in fed and starved ewes. Proceedings of the Society for Experimental Biology and Medicine 145, 879-883.
107. Mueckler M (1994) Facilitative glucose transporters. European Journal of Biochemistry 219, 713-725.
108. Noble RC (1979) Lipid metabolism in the neonatal ruminant. Progress in Lipid Research 18, 179-216.
109. Noble RC, Shand JH & Christie WW (1985) Synthesis of C20 and C22 polyunsaturated fatty acids by the placenta of the sheep. Biology of the Neonate 47, 333-338.
110. Novak DA, Beveridge MJ, Malandro M & Seo J (1996) Ontogeny of amino acid transport system A in rat placenta. Placenta 17, 643-651.
111. Nyrienda MJ, Lindsay RS, Kenyon CJ, Burchell A & Seckl JR (1998) Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. Journal of Clinical Investigation 101, 2174-2181.
112. Owens JA, Falconer J & Robinson JS (1987a) Effect of restriction of placental growth on fetal and utero-placental metabolism. Journal of Developmental Physiology 9, 225-238.
113. Owens JA, Falconer J & Robinson JS (1987b) Restriction of placental size in sheep enhances efficiency of placental transfer of antipyrine, 3-O-methyl-D-glucose but not urea. Journal of Developmental Physiology 9, 457-464.
114. Owens JA, Owens PC & Robinson JS (1989) Experimental growth retardation: Metabolic and endocrine consequences. In Research in Perinatal Medicine VIII. Advances in Fetal Physiology, pp. 263-286 [PD Gluckman, BM Johnston and PW Nathanielsz, editors]. Ithaca: Perinatology Press.
115. Paolini CL, Meschia G, Fennessey PV, Pike AW, Teng C, Battaglia FC & Wilkening RB (2001) An in vivo study of ovine placental transport of essential amino acids. American Journal of Physiology 280, E31-E39.
116. Phillips DIW, Barker DJP, Hales CN, Hirst S & Osmond C (1994) Thinness at birth and insulin resistance in adult life. Diabetologia 37, 150-154.
117. Rankin JHG, Jodarski G & Shanahan MR (1986) Maternal insulin and placental 3-O-methyl glucose transport. Journal of Developmental Physiology 8, 247-253.
118. Robinson J, Chidzanja S, Kind K, Lok F, Owens P & Owens J (1995) Placental control of fetal growth. Reproduction, Fertility and Development 7, 333-344.
119. Ross JC, Fennessey PV, Wilkening RB, Battaglia FC & Meschia G (1996) Placental transport and fetal utilization of leucine in a model of fetal growth retardation. American Journal of Physiology 270, E491-E503.
120. Sakata M, Kurachi H, Imai T, Tadokoro C, Yamaguchi M, Yoshimoto Y, Oka Y & Miyake A (1995) Increase in human placental glucose transporter-1 during pregnancy. European Journal of Endocrinology 132, 206-212.
121. Shin B-C, Fujikura K, Suzuki T, Tanaka S & Takata K (1997) Glucose transporter GLUT3 in the rat placental barrier: A possible machinery for the transplacental transfer of glucose. Endocrinology 138, 3997-4004.
122. Simmons MA, Battaglia FC & Meschia G (1979) Placental transfer of glucose. Journal of Developmental Physiology 1, 227-243.
123. Simmons MA, Jones MD Jr, Battaglia FC & Meschia G (1978) Insulin effect on fetal glucose utilization. Pediatric Research 12, 90-92.
124. Smeaton TC, Owens JA, Kind KL & Robinson JS (1989) The placenta releases branched-chain amino acids into the umbilical and uterine circulations in the pregnant sheep. Journal of Developmental Physiology 12, 95-99.
125. Stegeman JHG (1974) Placental development in the sheep and its relation to fetal development. Bijdragen tot de Dierkunde 44, 1-72.
126. Stevens D, Alexander G & Bell AW (1990) Effect of prolonged glucose infusion into fetal sheep on body growth, fat deposition and gestation length. Journal of Developmental Physiology 13, 277-281.
127. Tadokoro C, Yoshimoto Y, Sakata M, Fujimiya M, Kurachi H, Adachi E, Maeda T & Miyake A (1996) Localization of human placental glucose transporter 1 during pregnancy. An immunohistochemical study. Histology and Histopathology 11, 673-681.
128. Thomas CR & Lowy C (1983) Placental transfer of free fatty acids: Factors affecting transfer across the guinea-pig placenta. Journal of Developmental Physiology 5, 323-332.
129. Thomas L; Wallace JM, Aitken RP, Mercer JG & Trayhum P (2001) Circulating leptin during ovine pregnancy in relation to maternal nutrition, body composition and pregnancy outcome. Journal of Endocrinology 169, 465-476.
130. Thureen P, Trembler KA, Meschia G, Makowski EL & Wilkening RB (1992) Placental glucose transport in heatinduced fetal growth retardation. American Journal of Physiology 263, R578-R585.
131. Thureen, PJ, Padbury JF & Hay WW Jr (2001) The effect of maternal hypoaminoacidaemia on placental uptake and transport of amino acids in pregnant sheep. Placenta 22, 162-170.
132. Timmerman M, Chung M, Wilkening RB, Fennessey PV, Battaglia FC & Meschia G (1998) Relationship of fetal alanine uptake and placental alanine metabolism to maternal alanine concentration. American Journal of Physiology 275, E942-E950.
133. Vatnick I, Ignotz G, McBride BW & Bell AW (1991) Effect of heat stress on ovine placental growth in early pregnancy. Journal of Developmental Physiology 16, 163-166.
134. Vaughn PR, Lobo C, Battaglia FC, Fennessey PV, Wilkening RB & Meschia G (1995) Glutamine-glutamate exchange between placenta and fetal liver. American Journal of Physiology 268, E705-E711.
135. Wallace JM, Bourke DA, Aitken RP, Palmer RM, Da Silva P & Cruickshank MA (2000) Relationship between nutritionally-mediated placental growth restriction and fetal growth, body composition and endocrine status during late gestation in adolescent sheep. Placenta 21, 100-108.
136. Whorwood CB, Firth KM, Budge H & Symonds ME (2001) Maternal undernutrition during early to midgestation programs tissue-specific alterations in the expression of the glucocorticoid receptor, 11β-hydroxysteroid dehydrogenase isoforms, and type 1 angiotensin II receptor in neonatal sheep. Endocrinology 142, 2854-2864.
137. Widdas WF (1952) Inability of diffusion to account for placental glucose transfer in the sheep and consideration of the kinetics of a possible carrier transfer. Journal of Physiology 118, 23-39.
138. Wilkening RB, Battaglia FC & Meschia G (1985) The relationship of umbilical glucose uptake to uterine blood flow. Journal of Developmental Physiology 7, 313-319.
139. Wilkening RB, Molina RD, Battaglia FC & Meschia G (1987) Effect of insulin on glucose/oxygen and lactate/oxygen quotients across the hindlimb of fetal lambs. Biology of the Neonate 51, 18-23.
140. Xing AY, Challier JC, Leperq L, Caüzac M, Charron MJ, Girard J & Hauguel-de Mouzon S (1998) Unexpected expression of glucose transporter 4 in villous stromal cells of human placenta. Journal of Clinical Endocrinology and Metabolism 83, 4097-4101.
141. Young M & McFadyen IR (1973) Placental tranfer and fetal uptake of amino acids in the pregnant ewe. Journal of Perinatal Medicine 1, 174-182.
142. Young M, Stem MDR, Home J & Noakes DE (1982) Protein synthetic rate in the sheep placenta in vivo: The influence of insulin. Placenta 3, 159-164.
143. Zhou J & Bondy CA (1993) Placental glucose transporter gene expression and metabolism in the rat. Journal of Clinical Investigation 91, 845-852.
144. Zumkeller W (2000) The role of growth hormone and insulin-like growth factors for placental growth and development. Placenta 21, 451-467.