Asymmetric synthesis of 3,5-dihydroxy-6(E)-heptenoate-containing HMG-CoA reductase inhibitors

Tetrahedron

Volumn 53, Issue 31, 1997, Pages 10659-10670

  Tempkin, Orin ^a   Abel, Stephan ^a   Chen, Chung Pin ^a   Underwood, Russell ^a   Prasad, Kapa ^a   Chen, Kau Ming ^a   Repic, Oljan ^a   Blacklock, Thomas J ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; MASS SPECTROMETRY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY; TEMPERATURE;

EID: 0030743263     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(97)00686-8     Document Type: Article

References (10)

1. Kathawala, F.G. Med. Res. Reviews, 1991, 11, 121.
2. Prasad, K.; Chen, K.-M.; Repic, O.; Hardtmann, G.E. Tetrahedron: Asymmetry, 1990, 1, 307.
3. Lee, G.T.; Linder, J.; Chen, K.-M.; Prasad, K.; Repic, O.; Hardtmann, G.E. Synlett, 1990, 508.
4. Chen, K.-M.; Hardtmann, G.E.; Prasad, K.; Repic, O.; Shapiro, M.J. Tetrahedron Letters, 1987, 28, 155.
5. Evans, D.A.; Chapman, K.T.; Carreira, E.M. J. Am. Chem. Soc., 1988, 110, 3560.
6. Braun, M.; Devant, R. Tetrahedron Letters, 1984, 25, 5031.
7. Prasad, K.; Chen, K.-M.; Repic, O.; Hardtmann, G.E. Tetrahedron: Asymmetry, 1990, 1, 703.
8. Lynch, J.E.; Volante, R.P.; Wattley, R.V.; Shinkai, I. Tetrahedron Letters, 1987, 28, 1385.
9. Baader, E.; Bartmann, W.; Beck, G.; Below, P.; Bergmann, A.; Jendralla, H.; Kesseler, K.; Wess, G. Tetrahedron Letters, 1989, 30, 5115.
10. The optically pure triphenylglycol which is the by-product in this reaction was recovered as the acetyl derivative by treating the mother liquors with acetyl chloride and reused