Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors

Tetrahedron

Volumn 63, Issue 34, 2007, Pages 8124-8134

  Pfefferkorn, Jeffrey A ^a   Bowles, Daniel M ^a   Kissel, William ^a   Boyles, David C ^a   Choi, Chulho ^a   Larsen, Scott D ^a   Song, Yuntao ^a   Sun, Kuai Lin ^a   Miller, Steven R ^a   Trivedi, Bharat K ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 FLUOROPHENYL) 1 PHENYLETHANONE; 3 CHLORO 2 (4 FLUOROPHENYL) 3 PHENYLACRYLALDEHYDE; 3 DIMETHYLAMINO 1 (4 FLUOROPHENYL) 2 PHENYLPROPENONE; 3,4 BIS(4 FLUOROPHENYL) 5 (HYDROXYMETHYL) 1 ISOPROPYL N PHENYL 1H PYRROLE 2 CARBOXAMIDE; 3,4 BIS(4 FLUOROPHENYL) 5 FORMYL 1 ISOPROPYL N PHENYL 1H PYRROLE 2 CARBOXAMIDE; 4 (4 FLUOROPHENYL) 1 ISOPROPYL 3 PHENYL 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 4 (4 FLUOROPHENYL) 5 FORMYL 1 ISOPROPYL 3 PHENYL 1H PYRROLE 2 CARBOXYLIC ACID; 4 (4 FLUOROPHENYL) 5 FORMYL 1 ISOPROPYL 3 PHENYL 1H PYRROLE 2 CARBOXYLIC ACID 4 METHOXYBENZYLAMIDE; 4 (4 FLUOROPHENYL) 5 FORMYL 1 ISOPROPYL 3 PHENYL 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; 4 (4 FLUOROPHENYL) 5 HYDROXYMETHYL 1 ISOPROPYL 3 PHENYL 1H PYRROLE 2 CARBOXYLIC ACID 4 METHOXYBENZYLAMIDE; 7 [3 (4 FLUOROPHENYL) 1 ISOPROPYL 5 (4 METHOXYBENZYLCARBAMOYL) 4 PHENYL 1H PYRROL 2 YL] 3,5 DIHYDROXYHEPTANOIC ACID SODIUM SALT; 7 [3 (4 FLUOROPHENYL) 1 ISOPROPYL 5 (4 METHOXYBENZYLCARBAMOYL) 4 PHENYL 1H PYRROL 2 YL] 3,5 DIHYDROXYHEPTANOIC ACID TERTBUTYL ESTER; [3 (4 FLUOROPHENYL) 1 ISOPROPYL 5 (4 METHOXYBENZYLCARBAMOYL) 4 PHENYL 1H PYRROL 2 YLMETHYL]TRIPHENYLPHOSPHONIUM BROMIDE; [3 (4 FLUOROPHENYL) 1 ISOPROPYL 5 (PHENYLCARBAMOYL) 4 (4 FLUOROPHENYL) 1H PYRROL 2 YLMETHYL]TRIPHENYLPHOSPHONIUM BROMIDE; DIETHYL [5 (BENZYLCARBAMOYL) 3 (4 FLUOROPHENYL) 1 ISOPROPYL 4 PHENYL 1H PYRROL 2 YL]METHYLPHOSPHONATE; HEXANOIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPROPYLAMINO ACETIC ACID ETHYL ESTER; N BENZYL 2 (ISOPROPYLAMINO)ACETAMIDE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMISTRY; DRUG SYNTHESIS; HORNER WADSWORTH EMMONS REACTION; HYPERCHOLESTEROLEMIA; OLEFINATION; PRIORITY JOURNAL; WITTIG REACTION;

EID: 34447098447     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2007.06.005     Document Type: Article

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