Facile cleavage of silyl protecting groups with catalytic amounts of FeCl3

Synlett

Volumn , Issue 8, 2006, Pages 1260-1262

  Yang, Yong Qing ^a   Cui, Jia Rong ^a   Zhu, Lin Gui ^a   Sun, Ya Ping ^a   Wu, Yikang ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Cleavage; Deprotection; Hydrolysis; Iron ion; Removal

Indexed keywords

FERRIC CHLORIDE; FERRIC ION; SILANE DERIVATIVE; TERT BUTYLDIMETHYLSILYL; TERT BUTYLDIPHENYLSILYL; TRIETHYLSILYL; TRIISOPROPYLSILYL; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DESILYLATION; ROOM TEMPERATURE;

EID: 33744461045     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-926256     Document Type: Article

References (19)

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19. 3 was stirred at the ambient temperature (ca. 23 °C). The progress of the reaction was monitored with TLC. When the cleavage of the silyl protecting groups was complete, the reaction mixture was filtered through a short pad of silica gel to remove the inorganic salt (eluting with EtOAc). The filtrate and effluent were combined and concentrated on a rotary evaporator and the residue was purified by column chromatography on silica gel to give the product.