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Volumn 75, Issue 7, 2010, Pages

Modeling the fluid dynamics in a human stomach to gain insight of food digestion

Author keywords

Computational fluid dynamics (CFD); Gastric flow; Gastric motility; Stomach model; Viscosity

Indexed keywords

ARTICLE; AUDIOVISUAL EQUIPMENT; BIOLOGY; DIGESTION; GASTROINTESTINAL MOTILITY; HISTOLOGY; HUMAN; HYDRODYNAMICS; METHODOLOGY; PHYSIOLOGY; STOMACH;

EID: 77957111764     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2010.01748.x     Document Type: Article
Times cited : (238)

References (58)
  • 1
    • 62649158833 scopus 로고    scopus 로고
    • Anonymous, Lebanon, N.H., ANSYS Inc
    • Fluent 6.3 documentation 2007, Anonymous, Lebanon, N.H., ANSYS Inc
    • (2007) Fluent 6.3 documentation
  • 2
    • 0026737859 scopus 로고
    • Evaluation of the correlation between in vivo and in vitro release of phenylpropanolamine HCl from controlled-release tablets
    • Aoki S, Uesugi K, Ozawa H, Kayano M. Evaluation of the correlation between in vivo and in vitro release of phenylpropanolamine HCl from controlled-release tablets. Int J Pharm 1992, 85:65-73.
    • (1992) Int J Pharm , vol.85 , pp. 65-73
    • Aoki, S.1    Uesugi, K.2    Ozawa, H.3    Kayano, M.4
  • 3
    • 0027258785 scopus 로고
    • Determination of the mechanical impact force in the in vitro dissolution test and evaluation of the correlation between in vivo and in vitro release
    • Aoki S, Ando H, Tatsuishi K, Uesugi K, Ozawa H. Determination of the mechanical impact force in the in vitro dissolution test and evaluation of the correlation between in vivo and in vitro release. Int J Pharm 1993, 95:67-75.
    • (1993) Int J Pharm , vol.95 , pp. 67-75
    • Aoki, S.1    Ando, H.2    Tatsuishi, K.3    Uesugi, K.4    Ozawa, H.5
  • 4
    • 0020000220 scopus 로고
    • Effects of meal temperature and volume on the emptying of liquid from human stomach
    • Bateman DN. Effects of meal temperature and volume on the emptying of liquid from human stomach. J Physiol 1982, 331:461-7.
    • (1982) J Physiol , vol.331 , pp. 461-467
    • Bateman, D.N.1
  • 5
    • 0033005214 scopus 로고    scopus 로고
    • Fat delays emptying but increases forward and backward antral flow as assessed by flow-sensitive magnetic resonance imaging
    • Boulby P, Moore R, Gowland P, Spiller RC. Fat delays emptying but increases forward and backward antral flow as assessed by flow-sensitive magnetic resonance imaging. Neurogastroenterol Motil 1999, 11(1):27-36.
    • (1999) Neurogastroenterol Motil , vol.11 , Issue.1 , pp. 27-36
    • Boulby, P.1    Moore, R.2    Gowland, P.3    Spiller, R.C.4
  • 6
    • 0344011986 scopus 로고    scopus 로고
    • Prediction of viscosity of glucose and calcium chloride solutions
    • Buia AV, Nguyen MH. Prediction of viscosity of glucose and calcium chloride solutions. J Food Engr 2004, 62(4):345-9.
    • (2004) J Food Engr , vol.62 , Issue.4 , pp. 345-349
    • Buia, A.V.1    Nguyen, M.H.2
  • 7
    • 33746517597 scopus 로고    scopus 로고
    • Integrated upper gastrointestinal response to food intake
    • Camilleri M. Integrated upper gastrointestinal response to food intake. Gastroenterology 2006, 131:640-58.
    • (2006) Gastroenterology , vol.131 , pp. 640-658
    • Camilleri, M.1
  • 8
    • 0002202163 scopus 로고
    • Gastric motor physiology and motor disorders
    • Feldmann M, Scharschmidt BF, Sleisenger MH. editors, 6th ed, Philadelphia, Pa., WB Saunders Co
    • Camilleri M, Prather CM. Gastric motor physiology and motor disorders. Gastrointestinal and liver disease: pathophysiology/diagnosis/management 1993, 572-86. Feldmann M, Scharschmidt BFSleisenger MH. editors, 6th ed, Philadelphia, Pa., WB Saunders Co, p
    • (1993) Gastrointestinal and liver disease: pathophysiology/diagnosis/management , pp. 572-586
    • Camilleri, M.1    Prather, C.M.2
  • 9
    • 84986038285 scopus 로고    scopus 로고
    • Foods that help prevent disease: consumer attitudes and public policy implications
    • Childs NM, Poryzees GH. Foods that help prevent disease: consumer attitudes and public policy implications. Br Food J 1998, 100(9):419-26.
    • (1998) Br Food J , vol.100 , Issue.9 , pp. 419-426
    • Childs, N.M.1    Poryzees, G.H.2
  • 11
    • 0025734920 scopus 로고
    • Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects
    • Coupe AJ, Davis SS, Wilding IR. Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects. Pharm Res 1991, 8:360-4.
    • (1991) Pharm Res , vol.8 , pp. 360-364
    • Coupe, A.J.1    Davis, S.S.2    Wilding, I.R.3
  • 13
    • 11144268879 scopus 로고    scopus 로고
    • Effect of wall roughness on laminar flow of Bingham plastic fluids through microtubes
    • Engin T, Dogruer U, Evrensel C, Heavin S, Gordaninejadand F. Effect of wall roughness on laminar flow of Bingham plastic fluids through microtubes. Trans ASME 2004, 126:880-3.
    • (2004) Trans ASME , vol.126 , pp. 880-883
    • Engin, T.1    Dogruer, U.2    Evrensel, C.3    Heavin, S.4    Gordaninejadand, F.5
  • 14
    • 0033041935 scopus 로고    scopus 로고
    • Scintigraphic validation of a magnetic resonance imaging method to study gastric emptying of a solid meal in humans
    • Feinle C, Kunz P, Boesiger P, Fried M, Schwizer W. Scintigraphic validation of a magnetic resonance imaging method to study gastric emptying of a solid meal in humans. Gut 1999, 44:106-11.
    • (1999) Gut , vol.44 , pp. 106-111
    • Feinle, C.1    Kunz, P.2    Boesiger, P.3    Fried, M.4    Schwizer, W.5
  • 15
    • 77957166928 scopus 로고    scopus 로고
    • PIV analysis of the flow field within a closed system that simulates the peristaltic movement of the stomach wall
    • IFT Annual Meeting. Anaheim, California. Nr 09-A-2619-IFT
    • Ferrua MJ, Marra F, Singh RP. PIV analysis of the flow field within a closed system that simulates the peristaltic movement of the stomach wall. 2009, IFT Annual Meeting. Anaheim, California. Nr 09-A-2619-IFT
    • (2009)
    • Ferrua, M.J.1    Marra, F.2    Singh, R.P.3
  • 16
    • 84992997644 scopus 로고    scopus 로고
    • Opportunities and constraints in the functional food market
    • Gray J, Armstrong G, Farley H. Opportunities and constraints in the functional food market. Nutr Food Sci 2003, 33(5):213-8.
    • (2003) Nutr Food Sci , vol.33 , Issue.5 , pp. 213-218
    • Gray, J.1    Armstrong, G.2    Farley, H.3
  • 18
    • 0026505245 scopus 로고
    • Antroduodenal motility and movements of luminal contents studied by duplex sonography
    • Hausken T, Ødegaard S, Matre K, Berstad A. Antroduodenal motility and movements of luminal contents studied by duplex sonography. Gastroenterology 1992, 102:1583-90.
    • (1992) Gastroenterology , vol.102 , pp. 1583-1590
    • Hausken, T.1    Ødegaard, S.2    Matre, K.3    Berstad, A.4
  • 19
    • 0036122922 scopus 로고    scopus 로고
    • Low antroduodenal pressure gradients are responsible for gastric emptying of a low-caloric liquid meal in humans
    • Hausken T, Mundt M, Samsom M. Low antroduodenal pressure gradients are responsible for gastric emptying of a low-caloric liquid meal in humans. Neurogastroenterol Mot 2002, 14:97-105.
    • (2002) Neurogastroenterol Mot , vol.14 , pp. 97-105
    • Hausken, T.1    Mundt, M.2    Samsom, M.3
  • 21
    • 0028576883 scopus 로고
    • Role and integration of mechanisms controlling gastric emptying
    • Horowitz M, Dent J, Fraser R, Sun W, Hebbard G. Role and integration of mechanisms controlling gastric emptying. Dig Dis Sci 1994, 39(12):7S-13S.
    • (1994) Dig Dis Sci , vol.39 , Issue.12
    • Horowitz, M.1    Dent, J.2    Fraser, R.3    Sun, W.4    Hebbard, G.5
  • 23
    • 77957140948 scopus 로고
    • Infantile hypertrophic pyloric stenosis
    • Berlin Heidelberg, Springer-Verlag, ISBN 3-540-55814-4
    • Keet AD. Infantile hypertrophic pyloric stenosis. The pyloric sphincteric cylinder in health and disease 1993, 107. Berlin Heidelberg, Springer-Verlag, ISBN 3-540-55814-4, p
    • (1993) The pyloric sphincteric cylinder in health and disease , pp. 107
    • Keet, A.D.1
  • 24
    • 0021686406 scopus 로고
    • Mechanical factors regulating gastric emptying of viscous nutrients meals in dogs
    • Keinke O, Schemann M, Ehrlein HJ. Mechanical factors regulating gastric emptying of viscous nutrients meals in dogs. Q J Exp Physiol 1984, 69:781-95.
    • (1984) Q J Exp Physiol , vol.69 , pp. 781-795
    • Keinke, O.1    Schemann, M.2    Ehrlein, H.J.3
  • 25
    • 0021711423 scopus 로고
    • Relationships of human antroduodenal motility and transpyloric fluid movement: non-invasive observations with real-time ultrasound
    • King PM, Adam RD, Pryde A, McDicken WN, Heading RC. Relationships of human antroduodenal motility and transpyloric fluid movement: non-invasive observations with real-time ultrasound. Gut 1984, 25:1384-91.
    • (1984) Gut , vol.25 , pp. 1384-1391
    • King, P.M.1    Adam, R.D.2    Pryde, A.3    McDicken, W.N.4    Heading, R.C.5
  • 26
    • 0023189631 scopus 로고
    • Transpyloric fluid movement and antroduodenal motility in patients with gastro-oesophageal reflux
    • King PM, Pryde A, Heading RC. Transpyloric fluid movement and antroduodenal motility in patients with gastro-oesophageal reflux. Gut 1987, 28:545-8.
    • (1987) Gut , vol.28 , pp. 545-548
    • King, P.M.1    Pryde, A.2    Heading, R.C.3
  • 27
    • 44949255007 scopus 로고    scopus 로고
    • Disintegration of solid foods in human stomach
    • Kong F, Singh RP. Disintegration of solid foods in human stomach. J Food Sci 2008a, 73(5):R67-78.
    • (2008) J Food Sci , vol.73 , Issue.5
    • Kong, F.1    Singh, R.P.2
  • 28
    • 44949220285 scopus 로고    scopus 로고
    • A model stomach system to investigate disintegration kinetics of solid foods during gastric digestion
    • Kong F, Singh RP. A model stomach system to investigate disintegration kinetics of solid foods during gastric digestion. J Food Sci 2008b, 73(5):E202-10.
    • (2008) J Food Sci , vol.73 , Issue.5
    • Kong, F.1    Singh, R.P.2
  • 30
    • 3042758903 scopus 로고    scopus 로고
    • Analysis of surface geometry of the human stomach using real-time 3-D ultrasonography in vivo
    • Liao D, Gregersen H, Hausken T, Gilja OH, Mundt M, Kassab G. Analysis of surface geometry of the human stomach using real-time 3-D ultrasonography in vivo. Neurogastroenterol Motil 2004, 16(3):315-24.
    • (2004) Neurogastroenterol Motil , vol.16 , Issue.3 , pp. 315-324
    • Liao, D.1    Gregersen, H.2    Hausken, T.3    Gilja, O.H.4    Mundt, M.5    Kassab, G.6
  • 31
    • 16244420758 scopus 로고    scopus 로고
    • A dynamic model that simulates the human upper gastrointestinal tract for the study of probiotics
    • Mainville I, Arcand Y, Farnworth ER. A dynamic model that simulates the human upper gastrointestinal tract for the study of probiotics. Int J Food Microbiol 2005, 99:287-96.
    • (2005) Int J Food Microbiol , vol.99 , pp. 287-296
    • Mainville, I.1    Arcand, Y.2    Farnworth, E.R.3
  • 32
    • 0034977024 scopus 로고    scopus 로고
    • Effect of meal viscosity and nutrients on satiety, intragastric dilution and emptying assessed by MRI
    • Marciani L, Gowland PA, Spiller RC. Effect of meal viscosity and nutrients on satiety, intragastric dilution and emptying assessed by MRI. Am J Physiol Gastrointest Liver Physiol 2001a, 280:G1227-33.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.280
    • Marciani, L.1    Gowland, P.A.2    Spiller, R.C.3
  • 33
    • 0034762767 scopus 로고    scopus 로고
    • Antral motility measurements by magnetic resonance imaging
    • Marciani L, Young P, Wright J. Antral motility measurements by magnetic resonance imaging. Neurogastroenterol Motil 2001b, 13(5):511-8.
    • (2001) Neurogastroenterol Motil , vol.13 , Issue.5 , pp. 511-518
    • Marciani, L.1    Young, P.2    Wright, J.3
  • 35
    • 0001386891 scopus 로고
    • The physiology of gastric storage and emptying
    • Johnson L. editor, 3rd ed, New York, Raven Press
    • Mayer EA. The physiology of gastric storage and emptying. Physiology of the gastrointestinal tract 1994, 929-76. Johnson L. editor, 3rd ed, New York, Raven Press, p
    • (1994) Physiology of the gastrointestinal tract , pp. 929-976
    • Mayer, E.A.1
  • 37
    • 84909981817 scopus 로고    scopus 로고
    • A service of the U.S. National Library of Medicine and the National Institutes of Health
    • MedlinePlus, Available from, Accessed Jul 2010
    • A service of the U.S. National Library of Medicine and the National Institutes of Health. http://www.nlm.nih.gov/medlineplus/ency/imagepages/19223.htm, MedlinePlus, Available from, Accessed Jul 2010
  • 38
    • 0001151974 scopus 로고
    • A multicompartmental dynamic computer-controlled model simulating the stomach and the small intestine
    • Minekus M, Marteau P, Havenaar R, Huis In't Veld JHJ. A multicompartmental dynamic computer-controlled model simulating the stomach and the small intestine. Altern Lab Anim 1995, 23:254-8.
    • (1995) Altern Lab Anim , vol.23 , pp. 254-258
    • Minekus, M.1    Marteau, P.2    Havenaar, R.3    Huis In't Veld, J.H.J.4
  • 40
    • 0027251567 scopus 로고
    • Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem
    • Molly K, Vandewoestyjne M, Verstraete W. Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem. Appl Microbiol Biotechnol 1993, 39:254-8.
    • (1993) Appl Microbiol Biotechnol , vol.39 , pp. 254-258
    • Molly, K.1    Vandewoestyjne, M.2    Verstraete, W.3
  • 41
    • 33646348120 scopus 로고    scopus 로고
    • Product/process integration in food manufacture: engineering sustained health
    • Norton I, Fryer P, Moore S. Product/process integration in food manufacture: engineering sustained health. AIChE J 2006, 52(5):1632-40.
    • (2006) AIChE J , vol.52 , Issue.5 , pp. 1632-1640
    • Norton, I.1    Fryer, P.2    Moore, S.3
  • 44
    • 33947605765 scopus 로고    scopus 로고
    • A stomach road or ''Magenstrasse'' for gastric emptying
    • Pal A, Brasseur JG, Abrahamsson B. A stomach road or ''Magenstrasse'' for gastric emptying. J Biomech 2007, 40:1202-10.
    • (2007) J Biomech , vol.40 , pp. 1202-1210
    • Pal, A.1    Brasseur, J.G.2    Abrahamsson, B.3
  • 45
    • 0032447579 scopus 로고    scopus 로고
    • Antropyloric contractile patterns and transpyloric flow after meal ingestion in humans
    • Pallotta N, Cicala M, Frandina C, Corazziari E. Antropyloric contractile patterns and transpyloric flow after meal ingestion in humans. Am J Gastroenterol 1998, 93:2513-22.
    • (1998) Am J Gastroenterol , vol.93 , pp. 2513-2522
    • Pallotta, N.1    Cicala, M.2    Frandina, C.3    Corazziari, E.4
  • 46
    • 33847784843 scopus 로고    scopus 로고
    • Food microstructure affects the bioavailability of several nutrients
    • Parada J, Aguilera JM. Food microstructure affects the bioavailability of several nutrients. J Food Sci 2007, 72(2):R21-32.
    • (2007) J Food Sci , vol.72 , Issue.2
    • Parada, J.1    Aguilera, J.M.2
  • 48
    • 0019504479 scopus 로고
    • Viscosity and electrolyte concentrations in gastric juice from cystic fibrosis children compared to healthy children
    • Schmidt KD, Abiodun P, Tolckmitt W. Viscosity and electrolyte concentrations in gastric juice from cystic fibrosis children compared to healthy children. Eur J Pediatr 1981, 136:193-7.
    • (1981) Eur J Pediatr , vol.136 , pp. 193-197
    • Schmidt, K.D.1    Abiodun, P.2    Tolckmitt, W.3
  • 49
    • 33645073926 scopus 로고    scopus 로고
    • Imaging and modeling of digestion in the stomach and the duodenum
    • Schulze K. Imaging and modeling of digestion in the stomach and the duodenum. Neurogastroenterol Motil 2006, 18(3):172-83.
    • (2006) Neurogastroenterol Motil , vol.18 , Issue.3 , pp. 172-183
    • Schulze, K.1
  • 52
    • 77957161692 scopus 로고    scopus 로고
    • Fluid flow and disintegration of food in human stomach
    • Ph.D. diss.]. University of California, Davis, CA: Biological Systems Engineering
    • Singh SK. Fluid flow and disintegration of food in human stomach. 2007, Ph.D. diss.]. University of California, Davis, CA: Biological Systems Engineering
    • (2007)
    • Singh, S.K.1
  • 54
    • 77957160953 scopus 로고    scopus 로고
    • Electrogastrography
    • Wnek GE, Bowlin GL. editors, 2nd ed, New York, Informa Healthcare USA, Inc
    • Stern RM, Koch KL. Electrogastrography. Encyclopedia of biomaterials and biomedical engineering 2008, Vol. 2:947. Wnek GE, Bowlin GL. editors, 2nd ed, New York, Informa Healthcare USA, Inc, p
    • (2008) Encyclopedia of biomaterials and biomedical engineering , vol.2 , pp. 947
    • Stern, R.M.1    Koch, K.L.2
  • 55
    • 0023678154 scopus 로고
    • Effect of test meal temperature on the gastric emptying of liquids
    • Troncon LE, Iazigi N. Effect of test meal temperature on the gastric emptying of liquids. Braz J Med Biol Res 1988, 21(1):57-60.
    • (1988) Braz J Med Biol Res , vol.21 , Issue.1 , pp. 57-60
    • Troncon, L.E.1    Iazigi, N.2
  • 56
    • 34547145283 scopus 로고    scopus 로고
    • Development and applicability of an in vitro digestion model in assessing the bioaccessibility of contaminants from food
    • RIVM report 320102002, Available from, Accessed Mar 2010
    • Versantvoort CH, Van de Kamp E, Rompelberg CJM. Development and applicability of an in vitro digestion model in assessing the bioaccessibility of contaminants from food. 2004, http://rivm.openrepository.com/rivm/handle/10029/8885, RIVM report 320102002, Available from, Accessed Mar 2010
    • (2004)
    • Versantvoort, C.H.1    Van de Kamp, E.2    Rompelberg, C.J.M.3
  • 57
    • 69149106437 scopus 로고    scopus 로고
    • In vitro digestion methods for assessing the effect of food structure on allergen breakdown
    • Wickham M, Faulks R, Mills C. In vitro digestion methods for assessing the effect of food structure on allergen breakdown. Mol Nutr Food Res 2009, 53:952-8.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 952-958
    • Wickham, M.1    Faulks, R.2    Mills, C.3
  • 58
    • 33750910000 scopus 로고    scopus 로고
    • GIT physicochemical modeling-a critical review
    • Art. 4. Available from, Accessed Jul 2010
    • Yoo JY, Chen XD. GIT physicochemical modeling-a critical review. Int J Food Engr 2006, 2(4). http://www.bepress.com/ijfe/vol2/iss4/art4, Art. 4. Available from, Accessed Jul 2010
    • (2006) Int J Food Engr , vol.2 , Issue.4
    • Yoo, J.Y.1    Chen, X.D.2


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