-
1
-
-
34247863736
-
Metabolic syndrome increases all-cause and vascular mortality: The Hong Kong Cardiovascular Risk Factor Study
-
Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee
-
Thomas GN, Schooling CM, McGhee SM, et al.; Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee. Metabolic syndrome increases all-cause and vascular mortality: the Hong Kong Cardiovascular Risk Factor Study. Clin Endocrinol (Oxf) 2007;66:666-671.
-
(2007)
Clin Endocrinol (Oxf)
, vol.66
, pp. 666-671
-
-
Thomas, G.N.1
Schooling, C.M.2
McGhee, S.M.3
-
2
-
-
33644878402
-
Metabolic syndrome: Risk factor distribution and 18-year mortality in the multiple risk factor intervention trial
-
Multiple Risk Factor Intervention Trial Research Group
-
Eberly LE, Prineas R, Cohen JD, et al.; Multiple Risk Factor Intervention Trial Research Group. Metabolic syndrome: risk factor distribution and 18-year mortality in the multiple risk factor intervention trial. Diabetes Care 2006;29:123-130.
-
(2006)
Diabetes Care
, vol.29
, pp. 123-130
-
-
Eberly, L.E.1
Prineas, R.2
Cohen, J.D.3
-
3
-
-
17644412023
-
Inflammation, atherosclerosis, and coronary artery disease
-
Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005;352:1685-1695.
-
(2005)
N Engl J Med
, vol.352
, pp. 1685-1695
-
-
Hansson, G.K.1
-
4
-
-
33644755633
-
Interleukin-6 and diabetes: The good the bad or the indifferent?
-
Kristiansen OP, Mandrup-Poulsen T. Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes 2005;54 Suppl 2:S114-S124.
-
(2005)
Diabetes
, vol.54
, Issue.SUPPL. 2
-
-
Kristiansen, O.P.1
Mandrup-Poulsen, T.2
-
5
-
-
0033984744
-
Inflammation obesity stress and coronary heart disease: Is interleukin-6 the link?
-
Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 2000;148:209-214.
-
(2000)
Atherosclerosis
, vol.148
, pp. 209-214
-
-
Yudkin, J.S.1
Kumari, M.2
Humphries, S.E.3
Mohamed-Ali, V.4
-
6
-
-
0025190892
-
Interleukin-6 and the acute phase response
-
Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J 1990;265:621-636.
-
(1990)
Biochem J
, vol.265
, pp. 621-636
-
-
Heinrich, P.C.1
Castell, J.V.2
Andus, T.3
-
8
-
-
55949119252
-
Muscle as an endocrine organ: Focus on muscle-derived interleukin-6
-
Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 2008;88:1379-1406.
-
(2008)
Physiol Rev
, vol.88
, pp. 1379-1406
-
-
Pedersen, B.K.1
Febbraio, M.A.2
-
9
-
-
0032518415
-
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
-
Xing Z, Gauldie J, Cox G, et al. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 1998;101:311-320.
-
(1998)
J Clin Invest
, vol.101
, pp. 311-320
-
-
Xing, Z.1
Gauldie, J.2
Cox, G.3
-
10
-
-
34848822828
-
Plasma levels of fibrinogen and C-reactive protein are related to interleukin-6 gene -572C>G polymorphism in subjects with and without hypertension
-
Wong LY, Leung RY, Ong KL, Cheung BM. Plasma levels of fibrinogen and C-reactive protein are related to interleukin-6 gene -572C>G polymorphism in subjects with and without hypertension. J Hum Hypertens 2007;21: 875-882.
-
(2007)
J Hum Hypertens
, vol.21
, pp. 875-882
-
-
Wong, L.Y.1
Leung, R.Y.2
Ong, K.L.3
Cheung, B.M.4
-
11
-
-
4644262151
-
No association of interleukin-6 gene polymorphism (-174 G/C) with myocardial infarction or traditional cardiovascular risk factors
-
Lieb W, Pavlik R, Erdmann J, et al. No association of interleukin-6 gene polymorphism (-174 G/C) with myocardial infarction or traditional cardiovascular risk factors. Int J Cardiol 2004;97:205-212.
-
(2004)
Int J Cardiol
, vol.97
, pp. 205-212
-
-
Lieb, W.1
Pavlik, R.2
Erdmann, J.3
-
12
-
-
33644556827
-
Interleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients
-
Testa R, Olivieri F, Bonfigli AR, et al. Interleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients. Diabetes Res Clin Pract 2006;71:299-305.
-
(2006)
Diabetes Res Clin Pract
, vol.71
, pp. 299-305
-
-
Testa, R.1
Olivieri, F.2
Bonfigli, A.R.3
-
13
-
-
38949151073
-
Association between inflammatory markers and the interleukin-6 -174 G/C polymorphism is abolished in peripheral arterial occlusive disease
-
Potaczek DP, Undas A, Nowakowski T, Szczeklik A. Association between inflammatory markers and the interleukin-6 -174 G/C polymorphism is abolished in peripheral arterial occlusive disease. Int Angiol 2007;26: 318-323.
-
(2007)
Int Angiol
, vol.26
, pp. 318-323
-
-
Potaczek, D.P.1
Undas, A.2
Nowakowski, T.3
Szczeklik, A.4
-
14
-
-
32544459783
-
Analysis of G(-174)C IL-6 polymorphism and plasma concentrations of inflammatory markers in patients with type 2 diabetes and peripheral arterial disease
-
Libra M, Signorelli SS, Bevelacqua Y, et al. Analysis of G(-174)C IL-6 polymorphism and plasma concentrations of inflammatory markers in patients with type 2 diabetes and peripheral arterial disease. J Clin Pathol 2006;59:211-215.
-
(2006)
J Clin Pathol
, vol.59
, pp. 211-215
-
-
Libra, M.1
Signorelli, S.S.2
Bevelacqua, Y.3
-
15
-
-
38949097096
-
Interleukin-6-572C>G polymorphismassociation with inflammatory variables in Korean men with coronary artery disease
-
Jang Y, Kim OY, Hyun YJ, et al. Interleukin-6-572C>G polymorphismassociation with inflammatory variables in Korean men with coronary artery disease. Transl Res 2008;151:154-161.
-
(2008)
Transl Res
, vol.151
, pp. 154-161
-
-
Jang, Y.1
Kim, O.Y.2
Hyun, Y.J.3
-
16
-
-
61349133510
-
Joint analysis of individual participants data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index
-
Huth C, Illig T, Herder C, et al. Joint analysis of individual participants data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index. Ann Med 2009;41:128-138.
-
(2009)
Ann Med
, vol.41
, pp. 128-138
-
-
Huth, C.1
Illig, T.2
Herder, C.3
-
17
-
-
34147171031
-
Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels
-
Health, Aging and Body Composition (Health ABC) Study
-
Reich D, Patterson N, Ramesh V, et al.; Health, Aging and Body Composition (Health ABC) Study. Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. Am J Hum Genet 2007;80:716-726.
-
(2007)
Am J Hum Genet
, vol.80
, pp. 716-726
-
-
Reich, D.1
Patterson, N.2
Ramesh, V.3
-
18
-
-
35548974357
-
A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects
-
Rafiq S, Frayling TM, Murray A, et al. A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes Immun 2007;8:552-559.
-
(2007)
Genes Immun
, vol.8
, pp. 552-559
-
-
Rafiq, S.1
Frayling, T.M.2
Murray, A.3
-
19
-
-
36849038962
-
Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S.
-
Qi L, Rifai N, Hu FB. Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. Women. Diabetes 2007;56:3075-3081.
-
(2007)
Women. Diabetes
, vol.56
, pp. 3075-3081
-
-
Qi, L.1
Rifai, N.2
Hu, F.B.3
-
20
-
-
23844449000
-
The -174 IL-6 GG genotype is associated with a reduced risk of type 2 diabetes mellitus in a family sample from the National Heart, Lung and Blood Institutes Framingham Heart Study
-
Herbert A, Liu C, Karamohamed S, et al. The -174 IL-6 GG genotype is associated with a reduced risk of type 2 diabetes mellitus in a family sample from the National Heart, Lung and Blood Institutes Framingham Heart Study. Diabetologia 2005;48:1492-1495.
-
(2005)
Diabetologia
, vol.48
, pp. 1492-1495
-
-
Herbert, A.1
Liu, C.2
Karamohamed, S.3
-
21
-
-
33745247167
-
Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome
-
Esteve E, Villuendas G, Mallolas J, et al. Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome. Clin Endocrinol (Oxf) 2006;65:88-91.
-
(2006)
Clin Endocrinol (Oxf)
, vol.65
, pp. 88-91
-
-
Esteve, E.1
Villuendas, G.2
Mallolas, J.3
-
22
-
-
20244369579
-
Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes
-
Hamid YH, Rose CS, Urhammer SA, et al. Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes. Diabetologia 2005;48:251-260.
-
(2005)
Diabetologia
, vol.48
, pp. 251-260
-
-
Hamid, Y.H.1
Rose, C.S.2
Urhammer, S.A.3
-
23
-
-
9444245832
-
Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites
-
Hamid YH, Urhammer SA, Jensen DP, et al. Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites. Diabetes 2004;53:3342-3345.
-
(2004)
Diabetes
, vol.53
, pp. 3342-3345
-
-
Hamid, Y.H.1
Urhammer, S.A.2
Jensen, D.P.3
-
24
-
-
33750877102
-
IL6 gene promoter polymorphisms and type 2 diabetes: Joint analysis of individual participants data from 21 studies
-
Huth C, Heid IM, Vollmert C, et al. IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants data from 21 studies. Diabetes 2006;55:2915-2921.
-
(2006)
Diabetes
, vol.55
, pp. 2915-2921
-
-
Huth, C.1
Heid, I.M.2
Vollmert, C.3
-
25
-
-
75149121880
-
An overview of the Guangzhou biobank cohort study-cardiovascular disease subcohort (GBCS-CVD): A platform for multidisciplinary collaboration
-
Jiang CQ, Lam TH, Lin JM et al. An overview of the Guangzhou biobank cohort study-cardiovascular disease subcohort (GBCS-CVD): a platform for multidisciplinary collaboration. J Hum Hypertens 2010;24:139150.
-
(2010)
J Hum Hypertens
, vol.24
, pp. 139-150
-
-
Jiang, C.Q.1
Lam, T.H.2
Lin, J.M.3
-
26
-
-
14044259453
-
Molecular screening and association analyses of the interleukin 6 receptor gene variants with type 2 diabetes, diabetic nephropathy, and insulin sensitivity
-
Wang H, Zhang Z, Chu W, et al. Molecular screening and association analyses of the interleukin 6 receptor gene variants with type 2 diabetes, diabetic nephropathy, and insulin sensitivity. J Clin Endocrinol Metab 2005;90:1123-1129.
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 1123-1129
-
-
Wang, H.1
Zhang, Z.2
Chu, W.3
-
27
-
-
0142185104
-
Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians
-
Wolford JK, Colligan PB, Gruber JD, Bogardus C. Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians. Mol Genet Metab 2003;80:338-343.
-
(2003)
Mol Genet Metab
, vol.80
, pp. 338-343
-
-
Wolford, J.K.1
Colligan, P.B.2
Gruber, J.D.3
Bogardus, C.4
-
28
-
-
27444443876
-
Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
-
American Heart Association; National Heart, Lung, and Blood Institute
-
Grundy SM, Cleeman JI, Daniels SR et al.; American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112:27352752.
-
(2005)
Circulation
, vol.112
, pp. 2735-2752
-
-
Grundy, S.M.1
Cleeman, J.I.2
Daniels, S.R.3
-
29
-
-
77951897950
-
The asia-pacific perspective: Redefining obesity and its treatment
-
World Health Organization Western Pacific Region Australia, Accessed 2 Nov 2005
-
World Health Organization Western Pacific Region. The Asia-Pacific perspective: redefining obesity and its treatment. Health Communications, Australia (2000). Accessed 2 Nov 2005.
-
(2000)
Health Communications
-
-
-
30
-
-
0030670944
-
Some comments on frequently used multiple endpoint adjustment methods in clinical trials
-
Sankoh AJ, Huque MF, Dubey SD. Some comments on frequently used multiple endpoint adjustment methods in clinical trials. Stat Med 1997;16:2529-2542.
-
(1997)
Stat Med
, vol.16
, pp. 2529-2542
-
-
Sankoh, A.J.1
Huque, M.F.2
Dubey, S.D.3
-
31
-
-
33744779065
-
Genetic variation in IL6 gene and type 2 diabetes: Tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis
-
Qi L, van Dam RM, Meigs JB, et al. Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis. Hum Mol Genet 2006;15: 1914-1920.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 1914-1920
-
-
Qi, L.1
Van Dam, R.M.2
Meigs, J.B.3
-
32
-
-
11144353628
-
Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes
-
Möhlig M, Boeing H, Spranger J, et al. Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes. J Clin Endocrinol Metab 2004;89:1885-1890.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 1885-1890
-
-
Möhlig, M.1
Boeing, H.2
Spranger, J.3
-
33
-
-
0038353486
-
Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: The Finnish Diabetes Prevention Study
-
Finnish Diabetes Prevention Study
-
Kubaszek A, Pihlajamäki J, Komarovski V, et al.; Finnish Diabetes Prevention Study. Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. Diabetes 2003;52:1872-1876.
-
(2003)
Diabetes
, vol.52
, pp. 1872-1876
-
-
Kubaszek, A.1
Pihlajamäki, J.2
Komarovski, V.3
-
34
-
-
1442321080
-
Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism
-
Escobar-Morreale HF, Calvo RM, Villuendas G, Sancho J, San Millán JL. Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism. Obes Res 2003;11: 987-996.
-
(2003)
Obes Res
, vol.11
, pp. 987-996
-
-
Escobar-Morreale, H.F.1
Calvo, R.M.2
Villuendas, G.3
Sancho, J.4
San Millán, J.L.5
-
35
-
-
21344460247
-
An immune origin of type 2 diabetes?
-
Kolb H, Mandrup-Poulsen T. An immune origin of type 2 diabetes? Diabetologia 2005;48:1038-1050.
-
(2005)
Diabetologia
, vol.48
, pp. 1038-1050
-
-
Kolb, H.1
Mandrup-Poulsen, T.2
-
37
-
-
31544472312
-
Age-related anthropometric remodelling resulting in increased and redistributed adiposity is associated with increases in the prevalence of cardiovascular risk factors in Chinese subjects
-
Thomas GN, Tomlinson B, Hong AW, Hui SS. Age-related anthropometric remodelling resulting in increased and redistributed adiposity is associated with increases in the prevalence of cardiovascular risk factors in Chinese subjects. Diabetes Metab Res Rev 2006;22:72-78.
-
(2006)
Diabetes Metab Res Rev
, vol.22
, pp. 72-78
-
-
Thomas, G.N.1
Tomlinson, B.2
Hong, A.W.3
Hui, S.S.4
-
38
-
-
0030735542
-
Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo
-
Mohamed-Ali V, Goodrick S, Rawesh A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 1997;82:4196-4200.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 4196-4200
-
-
Mohamed-Ali, V.1
Goodrick, S.2
Rawesh, A.3
-
39
-
-
0031762908
-
Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid
-
Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 1998;83:847-850.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 847-850
-
-
Fried, S.K.1
Bunkin, D.A.2
Greenberg, A.S.3
-
40
-
-
0035211501
-
Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells
-
Dovio A, Masera RG, Sartori ML, Racca S, Angeli A. Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells. Calcif Tissue Int 2001;69:293-298.
-
(2001)
Calcif Tissue Int
, vol.69
, pp. 293-298
-
-
Dovio, A.1
Masera, R.G.2
Sartori, M.L.3
Racca, S.4
Angeli, A.5
-
41
-
-
0029820720
-
Cytokine modulation by glucocorticoids: Mechanisms and actions in cellular studies
-
discussion 91
-
Brattsand R, Linden M. Cytokine modulation by glucocorticoids: mechanisms and actions in cellular studies. Aliment Pharmacol Ther 1996;10 Suppl 2:81-90; discussion 91.
-
(1996)
Aliment Pharmacol Ther
, vol.10
, Issue.SUPPL. 2
, pp. 81-90
-
-
Brattsand, R.1
Linden, M.2
-
42
-
-
0036899812
-
Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial
-
Choy EH, Isenberg DA, Garrood T, et al. Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum 2002;46: 3143-3150.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 3143-3150
-
-
Choy, E.H.1
Isenberg, D.A.2
Garrood, T.3
|