Interleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients

Diabetes Research and Clinical Practice

Volumn 71, Issue 3, 2006, Pages 299-305

  Testa, R ^a   Olivieri, F ^a   Bonfigli, A R ^a   Sirolla, C ^a   Boemi, M ^a   Marchegiani, F ^a   Marra, M ^a   Cenerelli, S ^a   Antonicelli, R ^a   Dolci, A ^b   Paolisso, G ^c   Franceschi, C ^a,d  

^a INRCA   (Italy)

^b IRCCS MULTIMEDICA   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

174 G > C interleukin 6 polymorphism; HOMA; Insulin resistance; Interleukin 6; Type 2 diabetes

Indexed keywords

INTERLEUKIN 6;

ADULT; AGED; ARTICLE; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; GENDER; GENETIC POLYMORPHISM; GENOTYPE; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN BLOOD LEVEL; SENSITIVITY ANALYSIS;

AGED; BLOOD GLUCOSE; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FASTING; FEMALE; GENOTYPE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; INTERLEUKIN-6; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; REFERENCE VALUES;

EID: 33644556827     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2005.07.007     Document Type: Article

References (15)

1. J.M. Fernandez-Real, and W. Ricart Insulin resistance and chronic cardiovascular inflammatory syndrome Endocr. Rev. 24 2003 278 301
2. A Festa, R. D'Agostino Jr., L. Howard, L. Mykkanen, R.P. Tracy, and S.M. Haffner Chronic subclinical inflammation as part of the insulin resistance syndrome: the insulin resistance atherosclerosis study (IRAS) Circulation 102 2000 42 47
3. J.C. Pickup, M.B. Mattock, G.D. Chusney, and D. Burt NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X Diabetologia 40 1997 1286 1292
4. J.W. Stephens, S.J. Hurel, J.A. Cooper, J. Acharya, G.J. Miller, and S.E. Humphries A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus Mol. Genet. Metab. 82 2 2004 180 186
5. D. Fishman, G. Faulds, R. Jeffery, V. Mohamed-Ali, J.S. Yudkin, and S. Humphries The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis J. Clin. Invest. 102 1998 1369 1376
6. M. Bonafe, F. Olivieri, L. Cavallone, S. Giovagnetti, F. Marchegiani, and M. Cardelli A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity Eur. J. Immunol. 31 2001 2357 2361
7. F. Olivieri, M. Bonafe, S. Giovagnetti, R. Stecconi, M. Cardelli, and L. Cavallone In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging Mech. Ageing Dev. 124 2003 549 553
8. B. Vozarova, J.M. Fernandez-Real, W.C. Knowler, L. Gallart, R.L. Hanson, and J.D. Gruber The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians Hum. Genet. 112 2003 409 413
9. A. Kubaszek, J. Pihlajamaki, V. Komarovski, V. Lindi, J. Lindstrom, and J. Eriksson Finnish Diabetes Prevention Study. Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study Diabetes 52 2003 1872 1876
10. J.M. Fernandez-Real, M. Broch, J. Vendrell, C. Gutierrez, R. Casamitjana, and M. Pugeat Interleukin-6 gene polymorphism and insulin sensitivity Diabetes 49 2000 517 520
11. A. Kubaszek, J. Pihlajamaki, K. Punnonen, P. Karhapaa, I. Vauhkonen, and M. Laakso The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity Diabetes 52 2003 558 561
12. Report of the expert committee on the diagnosis and classification of diabetes mellitus, Diab. Care 20 (1997) 1183-1197.
13. O. Olomolaiye, N.A. Wood, and J.L. Bidwell A novel Nla III polymorphism in the human IL-6 promoter Eur. J. Immunogenet. 25 1998 267
14. K. Kain, A.J. Catto, and P.J. Grant Clustering of thrombotic factors with insulin resistance in south Asian patients with ischaemic stroke Thromb. Haemost. 88 2002 950 953
15. A.L. Carey, C.R. Bruce, M. Sacchetti, M.J. Anderson, D.B. Olsen, and B. Saltin Interleukin-6 and tumor necrosis factor-α are not increased in patients with type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness Diabetologia 47 2004 1029 1037