메뉴 건너뛰기




Volumn 18, Issue 5, 2010, Pages 223-232

Licofelone attenuates MPTP-induced neuronal toxicity: Behavioral, biochemical and cellular evidence

Author keywords

1 Methyl 4 phenyl 1,2,3,6 tetrahydropyridine (MPTP); Cyclooxygenase (COX); Licofelone (LCF); Lipooxygenase (LOX); Neuroinflammation; Parkinson's disease (PD)

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CASPASE 3; LICOFELONE; LIPID; MALONALDEHYDE; NITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; THIOL; TRANSCRIPTION FACTOR RELA;

EID: 77957018445     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-010-0052-6     Document Type: Article
Times cited : (11)

References (53)
  • 1
    • 0025893945 scopus 로고
    • Parkinson's disease: Pathophysiology
    • 1674304
    • Y Agid 1991 Parkinson's disease: pathophysiology Lancet 337 1321 1324 1674304
    • (1991) Lancet , vol.337 , pp. 1321-1324
    • Agid, Y.1
  • 2
    • 41749093649 scopus 로고    scopus 로고
    • The novel cyclooxygenase-2 inhibitor GW637185x protects against l-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine toxicity
    • 18382281
    • JA Aguirre G Leo R Cueto B Andbjer A Naylor AD Medhurst, et al. 2008 The novel cyclooxygenase-2 inhibitor GW637185x protects against l-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine toxicity Neuroreport 19 657 660 18382281
    • (2008) Neuroreport , vol.19 , pp. 657-660
    • Aguirre, J.A.1    Leo, G.2    Cueto, R.3    Andbjer, B.4    Naylor, A.5    Medhurst, A.D.6
  • 3
    • 0015596284 scopus 로고
    • Biological defense mechanism. The production by leukocytes of superoxide, a potential bacterial agent
    • 4346473
    • BM Babior RS Kipner JT Cerutte 1973 Biological defense mechanism. The production by leukocytes of superoxide, a potential bacterial agent J Clin Invest 52 741 744 4346473
    • (1973) J Clin Invest , vol.52 , pp. 741-744
    • Babior, B.M.1    Kipner, R.S.2    Cerutte, J.T.3
  • 4
    • 36249003354 scopus 로고    scopus 로고
    • Neuroinflammation in the pathophysiology of Parkinson's disease: Evidence from animal models to human in vivo studies with [11C]-PK11195 PET
    • 17592621
    • AL Bartels KL Leenders 2007 Neuroinflammation in the pathophysiology of Parkinson's disease: evidence from animal models to human in vivo studies with [11C]-PK11195 PET Mov Disord 22 1852 1856 17592621
    • (2007) Mov Disord , vol.22 , pp. 1852-1856
    • Bartels, A.L.1    Leenders, K.L.2
  • 5
    • 0032842038 scopus 로고    scopus 로고
    • Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: Implications for Parkinson's disease
    • 10461904
    • SB Berman TG Hastings 1999 Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease J Neurochem 73 1127 1137 10461904
    • (1999) J Neurochem , vol.73 , pp. 1127-1137
    • Berman, S.B.1    Hastings, T.G.2
  • 6
    • 2342496237 scopus 로고    scopus 로고
    • The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: Results from randomized, controlled trial
    • 15089890
    • P Bias A Buchner B Klesser S Laufer 2004 The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from randomized, controlled trial Am J Gastroenterol 99 611 618 15089890
    • (2004) Am J Gastroenterol , vol.99 , pp. 611-618
    • Bias, P.1    Buchner, A.2    Klesser, B.3    Laufer, S.4
  • 8
    • 0025191219 scopus 로고
    • Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme
    • 1689048
    • DS Bredt SH Snyder 1990 Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme Proc Natl Acad Sci USA 87 682 685 1689048
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 682-685
    • Bredt, D.S.1    Snyder, S.H.2
  • 9
    • 33745991786 scopus 로고    scopus 로고
    • Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced parkinsonism in mice
    • 16716528
    • M Chalimoniuk N Lukacova J Marsala J Langfort 2006 Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice Neuroscience 141 1033 1046 16716528
    • (2006) Neuroscience , vol.141 , pp. 1033-1046
    • Chalimoniuk, M.1    Lukacova, N.2    Marsala, J.3    Langfort, J.4
  • 10
    • 34247269064 scopus 로고    scopus 로고
    • 1-Methyl-4-phenylpyridinium-induced alterations of glutathione status in immortalized rat dopaminergic neurons
    • 17395226
    • DA Drechsel LP Liang M Patel 2007 1-Methyl-4-phenylpyridinium-induced alterations of glutathione status in immortalized rat dopaminergic neurons Toxicol Appl Pharmacol 220 341 348 17395226
    • (2007) Toxicol Appl Pharmacol , vol.220 , pp. 341-348
    • Drechsel, D.A.1    Liang, L.P.2    Patel, M.3
  • 11
    • 3042934967 scopus 로고
    • Tissue sulfhydryl groups
    • 13650640
    • GL Ellman 1959 Tissue sulfhydryl groups Arch Biochem Biophys 82 70 77 13650640
    • (1959) Arch Biochem Biophys , vol.82 , pp. 70-77
    • Ellman, G.L.1
  • 12
    • 41549133855 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: A retrospective cohort study
    • 18343119
    • M Etminan BC Carleton A Samii 2008 Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: a retrospective cohort study J Clin Neurosci 15 576 577 18343119
    • (2008) J Clin Neurosci , vol.15 , pp. 576-577
    • Etminan, M.1    Carleton, B.C.2    Samii, A.3
  • 13
    • 0037031609 scopus 로고    scopus 로고
    • Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra
    • 12183047
    • ZH Feng TG Wang DD Li P Fung BC Wilson B Liu, et al. 2002 Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra Neurosci Lett 329 354 358 12183047
    • (2002) Neurosci Lett , vol.329 , pp. 354-358
    • Feng, Z.H.1    Wang, T.G.2    Li, D.D.3    Fung, P.4    Wilson, B.C.5    Liu, B.6
  • 14
    • 0035584272 scopus 로고    scopus 로고
    • Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy
    • 11728379
    • S Fiorucci R Meli M Bucci G Cirino 2001 Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy Biochem Pharmacol 62 1433 1438 11728379
    • (2001) Biochem Pharmacol , vol.62 , pp. 1433-1438
    • Fiorucci, S.1    Meli, R.2    Bucci, M.3    Cirino, G.4
  • 15
    • 29744466425 scopus 로고
    • Determination of serum proteins by means of the biuret reaction
    • 18110453
    • AG Gornall CJ Bardawill MM David 1949 Determination of serum proteins by means of the biuret reaction J Biol Chem 177 751 766 18110453
    • (1949) J Biol Chem , vol.177 , pp. 751-766
    • Gornall, A.G.1    Bardawill, C.J.2    David, M.M.3
  • 16
    • 72049098787 scopus 로고    scopus 로고
    • Protective effect of cyclooxygenase (COX)-inhibitors against drug-induced catatonia and MPTP-induced striatal lesions in rats
    • 19666045
    • A Gupta A Dhir A Kumar SK Kulkarni 2009 Protective effect of cyclooxygenase (COX)-inhibitors against drug-induced catatonia and MPTP-induced striatal lesions in rats Pharmacol Biochem Behav 94 219 226 19666045
    • (2009) Pharmacol Biochem Behav , vol.94 , pp. 219-226
    • Gupta, A.1    Dhir, A.2    Kumar, A.3    Kulkarni, S.K.4
  • 17
    • 77954286433 scopus 로고    scopus 로고
    • Effect of preferential cyclooxygenase-2 (COX-2)-inhibitor against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced striatal lesions in rats: Behavioral, biochemical and histological evidences
    • A Gupta A Dhir A Kumar SK Kulkarni 2010 Effect of preferential cyclooxygenase-2 (COX-2)-inhibitor against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced striatal lesions in rats: behavioral, biochemical and histological evidences Indian J Exp Biol 48 577 585
    • (2010) Indian J Exp Biol , vol.48 , pp. 577-585
    • Gupta, A.1    Dhir, A.2    Kumar, A.3    Kulkarni, S.K.4
  • 18
    • 0026754574 scopus 로고
    • Reactive oxygen species and the central nervous system
    • 1402908
    • B Halliwell 1992 Reactive oxygen species and the central nervous system J Neurochem 59 1609 1623 1402908
    • (1992) J Neurochem , vol.59 , pp. 1609-1623
    • Halliwell, B.1
  • 19
    • 0028812293 scopus 로고
    • Enzymatic oxidation of dopamine: The role of prostaglandin H synthase
    • 7830086
    • TG Hastings 1995 Enzymatic oxidation of dopamine: the role of prostaglandin H synthase J Neurochem 64 919 924 7830086
    • (1995) J Neurochem , vol.64 , pp. 919-924
    • Hastings, T.G.1
  • 21
    • 33847005101 scopus 로고    scopus 로고
    • Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system
    • 17254027
    • RL Hunter N Dragicevic K Seifert DY Choi M Liu HC Kim, et al. 2007 Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system J Neurochem 100 1375 1386 17254027
    • (2007) J Neurochem , vol.100 , pp. 1375-1386
    • Hunter, R.L.1    Dragicevic, N.2    Seifert, K.3    Choi, D.Y.4    Liu, M.5    Kim, H.C.6
  • 22
    • 69049108579 scopus 로고    scopus 로고
    • Effect of caffeic acid and rofecoxib and their combination against intrastriatal quinolinic acid induced oxidative damage, mitochondrial and histological alterations in rats
    • Kalonia H, Kumar P, Kumar A, Nehru B (2009) Effect of caffeic acid and rofecoxib and their combination against intrastriatal quinolinic acid induced oxidative damage, mitochondrial and histological alterations in rats. Inflammopharmacol 17:211-219
    • (2009) Inflammopharmacol , vol.17 , pp. 211-219
    • Kalonia, H.1    Kumar, P.2    Kumar, A.3    Nehru, B.4
  • 23
    • 33748447845 scopus 로고    scopus 로고
    • Microglia, major player in the brain inflammation: Their roles in the pathogenesis of Parkinson's disease
    • 16953112
    • YS Kim TH Joh 2006 Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease Exp Mol Med 38 333 347 16953112
    • (2006) Exp Mol Med , vol.38 , pp. 333-347
    • Kim, Y.S.1    Joh, T.H.2
  • 24
    • 77956999492 scopus 로고
    • Preparations and properties of soluble NADH dehydrogenases from cardiac muscle
    • TE King RL Howard 1967 Preparations and properties of soluble NADH dehydrogenases from cardiac muscle Methods Enzymol 10 275 284
    • (1967) Methods Enzymol , vol.10 , pp. 275-284
    • King, T.E.1    Howard, R.L.2
  • 25
    • 0034520395 scopus 로고    scopus 로고
    • Inflammatory regulators in Parkinson's disease: INOS, lipocortin-1, and cyclooxygenases-1 and -2
    • 11124893
    • C Knott G Stern GP Wilkin 2000 Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2 Mol Cell Neurosci 16 724 739 11124893
    • (2000) Mol Cell Neurosci , vol.16 , pp. 724-739
    • Knott, C.1    Stern, G.2    Wilkin, G.P.3
  • 26
    • 33847657523 scopus 로고    scopus 로고
    • Licofelone-a novel analgesic and anti-inflammatory agent
    • 17305568
    • SK Kulkarni VP Singh 2007 Licofelone-a novel analgesic and anti-inflammatory agent Curr Top Med Chem 7 251 263 17305568
    • (2007) Curr Top Med Chem , vol.7 , pp. 251-263
    • Kulkarni, S.K.1    Singh, V.P.2
  • 27
    • 0028322243 scopus 로고
    • Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase
    • 8024637
    • S Laufer S Tries J Augustin G Dannhardt 1994 Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase Arzneimittelforschung 44 629 636 8024637
    • (1994) Arzneimittelforschung , vol.44 , pp. 629-636
    • Laufer, S.1    Tries, S.2    Augustin, J.3    Dannhardt, G.4
  • 28
    • 0025164256 scopus 로고
    • Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases
    • 2166915
    • RA Lewis KF Austen RJ Soberman 1990 Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases N Engl J Med 323 645 655 2166915
    • (1990) N Engl J Med , vol.323 , pp. 645-655
    • Lewis, R.A.1    Austen, K.F.2    Soberman, R.J.3
  • 29
    • 52949144196 scopus 로고    scopus 로고
    • Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity
    • 18760329
    • Z Li DY Choi EJ Shin RL Hunter CH Jin MB Wie, et al. 2008 Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity Neurosci Lett 445 1 6 18760329
    • (2008) Neurosci Lett , vol.445 , pp. 1-6
    • Li, Z.1    Choi, D.Y.2    Shin, E.J.3    Hunter, R.L.4    Jin, C.H.5    Wie, M.B.6
  • 30
    • 0038147318 scopus 로고    scopus 로고
    • Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs
    • 12759283
    • J Martel-Pelletier D Lajeunesse P Reboul JP Pelletier 2003 Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs Ann Rheum Dis 62 501 509 12759283
    • (2003) Ann Rheum Dis , vol.62 , pp. 501-509
    • Martel-Pelletier, J.1    Lajeunesse, D.2    Reboul, P.3    Pelletier, J.P.4
  • 31
  • 32
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth survival: Application to proliferation and cytotoxicity assays
    • 6606682
    • T Mosmann 1983 Rapid colorimetric assay for cellular growth survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 55 63 6606682
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 33
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • 36810
    • H Ohkawa N Ohishi K Yagi 1979 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem 95 351 358 36810
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 34
    • 0029984860 scopus 로고    scopus 로고
    • Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity
    • 8643444
    • S Przedborski V Jackson-Lewis R Yokoyama T Shibata VL Dawson TM Dawson 1996 Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity Proc Natl Acad Sci USA 93 4565 4571 8643444
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4565-4571
    • Przedborski, S.1    Jackson-Lewis, V.2    Yokoyama, R.3    Shibata, T.4    Dawson, V.L.5    Dawson, T.M.6
  • 35
    • 4043167628 scopus 로고    scopus 로고
    • Cyclooxygenases mRNA and protein expression in striata in the experimental mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine administration to mouse
    • 15306248
    • A Przybyłkowski I Kurkowska-Jastrzebska I Joniec A Ciesielska A Członkowska 2004 Cyclooxygenases mRNA and protein expression in striata in the experimental mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to mouse Brain Res 1019 144 151 15306248
    • (2004) Brain Res , vol.1019 , pp. 144-151
    • Przybyłkowski, A.1    Kurkowska-Jastrzebska, I.2    Joniec, I.3    Ciesielska, A.4    Członkowska, A.5
  • 36
    • 0034696884 scopus 로고    scopus 로고
    • Melatonin reversal of lipopolysaccharide-induced thermal and behavioral hyperalgesia in mice
    • 10781668
    • V Raghavendra JN Agrewala SK Kulkarni 2000 Melatonin reversal of lipopolysaccharide-induced thermal and behavioral hyperalgesia in mice Eur J Pharmacol 395 15 21 10781668
    • (2000) Eur J Pharmacol , vol.395 , pp. 15-21
    • Raghavendra, V.1    Agrewala, J.N.2    Kulkarni, S.K.3
  • 37
    • 34547598278 scopus 로고    scopus 로고
    • Anti-inflammatory drugs in the 21st century
    • 17612044
    • KD Rainsford 2007 Anti-inflammatory drugs in the 21st century Subcell Biochem 42 3 27 17612044
    • (2007) Subcell Biochem , vol.42 , pp. 3-27
    • Rainsford, K.D.1
  • 38
    • 0036339106 scopus 로고    scopus 로고
    • Role of adenosine in drug-induced catatonia
    • 12597016
    • A Singh SK Kulkarni 2002 Role of adenosine in drug-induced catatonia Indian J Exp Biol 40 882 888 12597016
    • (2002) Indian J Exp Biol , vol.40 , pp. 882-888
    • Singh, A.1    Kulkarni, S.K.2
  • 39
    • 14944349089 scopus 로고    scopus 로고
    • Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation
    • 15816411
    • VP Singh CS Patil SK Kulkarni 2005 Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation Indian J Exp Biol 43 247 253 15816411
    • (2005) Indian J Exp Biol , vol.43 , pp. 247-253
    • Singh, V.P.1    Patil, C.S.2    Kulkarni, S.K.3
  • 40
    • 33645018843 scopus 로고    scopus 로고
    • Anti-inflammatory effect of licofelone against various inflammatory challenges
    • 16448396
    • VP Singh CS Patil SK Kulkarni 2006 Anti-inflammatory effect of licofelone against various inflammatory challenges Fundam Clin Pharmacol 20 65 71 16448396
    • (2006) Fundam Clin Pharmacol , vol.20 , pp. 65-71
    • Singh, V.P.1    Patil, C.S.2    Kulkarni, S.K.3
  • 41
    • 0022398587 scopus 로고
    • Hydroxyl radical attack on dopamine
    • 2999117
    • A Slivka G Cohen 1985 Hydroxyl radical attack on dopamine J Biol Chem 260 15466 15472 2999117
    • (1985) J Biol Chem , vol.260 , pp. 15466-15472
    • Slivka, A.1    Cohen, G.2
  • 43
    • 0345724066 scopus 로고
    • Dopamine turnover and glutathione oxidation: Implications for Parkinson disease
    • 2919185
    • MB Spina G Cohen 1989 Dopamine turnover and glutathione oxidation: implications for Parkinson disease Proc Natl Acad Sci USA 86 1398 1400 2919185
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 1398-1400
    • Spina, M.B.1    Cohen, G.2
  • 44
    • 33645123006 scopus 로고    scopus 로고
    • Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: Role of tumor necrosis factor-alpha
    • 16405514
    • K Sriram DB Miller P O'Callaghan 2006 Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha J Neurochem 96 706 718 16405514
    • (2006) J Neurochem , vol.96 , pp. 706-718
    • Sriram, K.1    Miller, D.B.2    O'Callaghan, P.3
  • 46
    • 58149380755 scopus 로고    scopus 로고
    • Targeted overexpression of human alphasynuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease
    • 19018246
    • S Theodore S Cao PJ McLean DG Standaert 2008 Targeted overexpression of human alphasynuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease J Neuropathol Exp Neurol 67 1149 1158 19018246
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 1149-1158
    • Theodore, S.1    Cao, S.2    McLean, P.J.3    Standaert, D.G.4
  • 47
    • 0027504297 scopus 로고
    • Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds
    • 8376979
    • KF Tipton TP Singer 1993 Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds J Neurochem 61 1191 1206 8376979
    • (1993) J Neurochem , vol.61 , pp. 1191-1206
    • Tipton, K.F.1    Singer, T.P.2
  • 48
    • 0034940687 scopus 로고    scopus 로고
    • The pharmacological profile of ML 3000: A new pyrrolizine derivative inhibiting the enzymes cyclooxygenase and 5-lipoxygenase
    • S Tries S Laufer 2001 The pharmacological profile of ML 3000: a new pyrrolizine derivative inhibiting the enzymes cyclooxygenase and 5-lipoxygenase Inflammopharmacology 9 113 124
    • (2001) Inflammopharmacology , vol.9 , pp. 113-124
    • Tries, S.1    Laufer, S.2
  • 49
    • 0036219338 scopus 로고    scopus 로고
    • The mechanism of action of the new anti-inflammatory compound ML3000: Inhibition of 5-LOX and COX-1/2
    • 12005204
    • S Tries W Neupert S Laufer 2002 The mechanism of action of the new anti-inflammatory compound ML3000: inhibition of 5-LOX and COX-1/2 Inflamm Res 51 135 143 12005204
    • (2002) Inflamm Res , vol.51 , pp. 135-143
    • Tries, S.1    Neupert, W.2    Laufer, S.3
  • 50
    • 0038205745 scopus 로고    scopus 로고
    • Targeting programmed cell death in neurodegenerative diseases
    • DOI 10.1038/nrn1100
    • M Vila S Przedborski 2003 Targeting programmed cell death in neurodegenerative diseases Nat Rev Neurosci 4 365 375 12728264 (Pubitemid 37280175)
    • (2003) Nature Reviews Neuroscience , vol.4 , Issue.5 , pp. 365-375
    • Vila, M.1    Przedborski, S.2
  • 51
    • 53149087460 scopus 로고    scopus 로고
    • Mitochondrial alterations in Parkinson's disease: New clues
    • 18680555
    • M Vila D Ramonet C Perier 2008 Mitochondrial alterations in Parkinson's disease: new clues J Neurochem 107 317 328 18680555
    • (2008) J Neurochem , vol.107 , pp. 317-328
    • Vila, M.1    Ramonet, D.2    Perier, C.3
  • 52
    • 35948985533 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs may protect against Parkinson disease
    • 17984451
    • AD Wahner JM Bronstein YM Bordelon B Ritz 2007 Nonsteroidal anti-inflammatory drugs may protect against Parkinson disease Neurology 69 1836 1842 17984451
    • (2007) Neurology , vol.69 , pp. 1836-1842
    • Wahner, A.D.1    Bronstein, J.M.2    Bordelon, Y.M.3    Ritz, B.4
  • 53
    • 55649106830 scopus 로고    scopus 로고
    • Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson's disease
    • 18941931
    • H Yokoyama H Kuroiwa R Yano T Araki 2008 Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson's disease Neurol Sci 29 293 301 18941931
    • (2008) Neurol Sci , vol.29 , pp. 293-301
    • Yokoyama, H.1    Kuroiwa, H.2    Yano, R.3    Araki, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.