-
1
-
-
40049093132
-
Is the obesity epidemic exaggerated? No
-
10.1136/bmj.39458.495127.AD 10.1136/bmj.39458.495127.AD
-
RW Jeffery NE Sherwood 2008 Is the obesity epidemic exaggerated? No Br Med J 336 244 246 10.1136/bmj.39458.495127.AD 10.1136/bmj.39458.495127.AD
-
(2008)
Br Med J
, vol.336
, pp. 244-246
-
-
Jeffery, R.W.1
Sherwood, N.E.2
-
2
-
-
0034611791
-
Obesity as a medical problem
-
1:CAS:528:DC%2BD3cXis1Grtb8%3D 10766250
-
PG Kopelman 2000 Obesity as a medical problem Nature 404 635 643 1:CAS:528:DC%2BD3cXis1Grtb8%3D 10766250
-
(2000)
Nature
, vol.404
, pp. 635-643
-
-
Kopelman, P.G.1
-
3
-
-
0035936764
-
Obesity and the regulation of energy balance
-
DOI 10.1016/S0092-8674(01)00240-9
-
BM Spiegelman JS Flier 2001 Obesity and the regulation of energy balance Cell 104 531 543 10.1016/S0092-8674(01)00240-9 1:CAS:528:DC%2BD3MXis1Kks78%3D 10.1016/S0092-8674(01)00240-9 11239410 (Pubitemid 32201948)
-
(2001)
Cell
, vol.104
, Issue.4
, pp. 531-543
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
4
-
-
33751542980
-
Identification of differentially expressed genes in omental adipose tissues of obese patients by suppression subtractive hybridization
-
DOI 10.1016/j.bbrc.2006.11.049, PII S0006291X06025058
-
J Qiu YH Ni HX Gong L Fei XQ Pan M Guo RH Chen XR Guo 2007 Identification of differentially expressed genes in omental adipose tissues of obese patients by suppression subtractive hybridization Biochem Biophys Res Commun 352 469 478 10.1016/j.bbrc.2006.11.049 1:CAS:528:DC%2BD28XhtlShsr3M 10.1016/j.bbrc.2006.11. 049 17129576 (Pubitemid 44838510)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.352
, Issue.2
, pp. 469-478
-
-
Qiu, J.1
Ni, Y.-h.2
Gong, H.-x.3
Fei, L.4
Pan, X.-q.5
Guo, M.6
Chen, R.-h.7
Guo, X.-r.8
-
5
-
-
33747366434
-
Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation
-
DOI 10.1016/j.gene.2006.05.008, PII S0378111906003167
-
B Wang M Zhang YH Ni F Liu HQ Fan L Fei XQ Pan M Guo RH Chen XR Guo 2006 Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation Gene 379 132 140 10.1016/j.gene.2006.05.008 1:CAS:528: DC%2BD28Xos12ktbs%3D 10.1016/j.gene.2006.05.008 16815647 (Pubitemid 44247334)
-
(2006)
Gene
, vol.379
, Issue.1-2
, pp. 132-140
-
-
Wang, B.1
Zhang, M.2
Ni, Y.-h.3
Liu, F.4
Fan, H.-q.5
Fei, L.6
Pan, X.-q.7
Guo, M.8
Chen, R.-h.9
Guo, X.-r.10
-
6
-
-
64849098867
-
Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt
-
10.1038/aps.2008.9 10.1038/aps.2008.9 19079291
-
CM Zhang XH Chen B Wang F Liu X Chi ML Tong YH Ni RH Chen XR Guo 2009 Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt Acta Pharmacol Sin 30 120 124 10.1038/aps.2008.9 10.1038/aps.2008.9 19079291
-
(2009)
Acta Pharmacol Sin
, vol.30
, pp. 120-124
-
-
Zhang, C.M.1
Chen, X.H.2
Wang, B.3
Liu, F.4
Chi, X.5
Tong, M.L.6
Ni, Y.H.7
Chen, R.H.8
Guo, X.R.9
-
7
-
-
33847632605
-
Identification of the ligands of protein interaction domains through a functional approach
-
DOI 10.1074/mcp.M600289-MCP200
-
G Caratù D Allegra M Bimonte GG Schiattarella C D'Ambrosio A Scaloni M Napolitano T Russo N Zambrano 2007 Identification of the ligands of protein interaction domains through a functional approach Mol Cell Proteomics 6 333 345 10.1074/mcp.M600289-MCP200 17124247 (Pubitemid 46359520)
-
(2007)
Molecular and Cellular Proteomics
, vol.6
, Issue.2
, pp. 333-345
-
-
Caratu, G.1
Allegra, D.2
Bimonte, M.3
Schiattarella, G.G.4
D'Ambrosio, C.5
Scaloni, A.6
Napolitano, M.7
Russo, T.8
Zambrano, N.9
-
8
-
-
42949088997
-
The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance
-
DOI 10.1016/j.physbeh.2007.10.010, PII S0031938407004027
-
GH Goossens 2008 The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance Physiol Behav 94 206 218 10.1016/j.physbeh.2007.10.010 1:CAS:528:DC%2BD1cXlslyjsrk%3D 10.1016/j.physbeh.2007.10.010 18037457 (Pubitemid 351615418)
-
(2008)
Physiology and Behavior
, vol.94
, Issue.2
, pp. 206-218
-
-
Goossens, G.H.1
-
9
-
-
0031014830
-
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
-
10.2337/diabetes.46.1.3 1:CAS:528:DyaK2sXks1aj 10.2337/diabetes.46.1.3 8971073
-
G Boden 1997 Role of fatty acids in the pathogenesis of insulin resistance and NIDDM Diabetes 46 3 10 10.2337/diabetes.46.1.3 1:CAS:528:DyaK2sXks1aj 10.2337/diabetes.46.1.3 8971073
-
(1997)
Diabetes
, vol.46
, pp. 3-10
-
-
Boden, G.1
-
10
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
10.1126/science.7678183 1:CAS:528:DyaK3sXnvFaitw%3D%3D 10.1126/science.7678183 7678183
-
GS Hotamisligil NS Shargill BM Spiegelman 1993 Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Science 259 87 91 10.1126/science.7678183 1:CAS:528:DyaK3sXnvFaitw%3D%3D 10.1126/science.7678183 7678183
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
11
-
-
0035403205
-
Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
-
10.1038/oby.2001.54 1:CAS:528:DC%2BD3MXlslSmtbs%3D 10.1038/oby.2001.54 11445664
-
B Vozarova C Weyer K Hanson PA Tataranni C Bogardus RE Pratley 2001 Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion Obes Res 9 414 417 10.1038/oby.2001.54 1:CAS:528:DC%2BD3MXlslSmtbs%3D 10.1038/oby.2001.54 11445664
-
(2001)
Obes Res
, vol.9
, pp. 414-417
-
-
Vozarova, B.1
Weyer, C.2
Hanson, K.3
Tataranni, P.A.4
Bogardus, C.5
Pratley, R.E.6
-
12
-
-
0028845877
-
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
-
10.1038/nm1195-1155 1:CAS:528:DyaK2MXptFahs7s%3D 10.1038/nm1195-1155 7584987
-
M Maffei J Halaas E Ravussin RE Pratley GH Lee Y Zhang H Fei S Kim R Lallone S Ranganathan 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects Nat Med 1 1155 1161 10.1038/nm1195-1155 1:CAS:528:DyaK2MXptFahs7s%3D 10.1038/nm1195-1155 7584987
-
(1995)
Nat Med
, vol.1
, pp. 1155-1161
-
-
Maffei, M.1
Halaas, J.2
Ravussin, E.3
Pratley, R.E.4
Lee, G.H.5
Zhang, Y.6
Fei, H.7
Kim, S.8
Lallone, R.9
Ranganathan, S.10
-
13
-
-
0035905758
-
The hormone resistin links obesity to diabetes
-
DOI 10.1038/35053000
-
CM Steppan ST Bailey S Bhat EJ Brown RR Banerjee CM Wright HR Patel RS Ahima MA Lazar 2001 The hormone resistin links obesity to diabetes Nature 409 307 312 10.1038/35053000 1:CAS:528:DC%2BD3MXms12nsA%3D%3D 10.1038/35053000 11201732 (Pubitemid 32151228)
-
(2001)
Nature
, vol.409
, Issue.6818
, pp. 307-312
-
-
Steppan, C.M.1
Bailey, S.T.2
Bhat, S.3
Brown, E.J.4
Banerjee, R.R.5
Wright, C.M.6
Patel, H.R.7
Ahima, R.S.8
Lazar, M.A.9
-
14
-
-
0018869666
-
Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes
-
1:CAS:528:DyaL3cXksVamtr8%3D 7372608
-
AK Student RY Hsu MD Lane 1980 Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes J Biol Chem 255 4745 4750 1:CAS:528:DyaL3cXksVamtr8%3D 7372608
-
(1980)
J Biol Chem
, vol.255
, pp. 4745-4750
-
-
Student, A.K.1
Hsu, R.Y.2
Lane, M.D.3
-
15
-
-
0033779714
-
Free fatty acids and pathogenesis of type 2 diabetes mellitus
-
10.1016/S1043-2760(00)00323-4 1:CAS:528:DC%2BD3cXotVSrsbs%3D 10.1016/S1043-2760(00)00323-4 11042464
-
RN Bergman M Ader 2000 Free fatty acids and pathogenesis of type 2 diabetes mellitus Trends Endocrinol Metab 11 351 356 10.1016/S1043-2760(00) 00323-4 1:CAS:528:DC%2BD3cXotVSrsbs%3D 10.1016/S1043-2760(00)00323-4 11042464
-
(2000)
Trends Endocrinol Metab
, vol.11
, pp. 351-356
-
-
Bergman, R.N.1
Ader, M.2
-
16
-
-
0032954778
-
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
-
10.1172/JCI5001 1:CAS:528:DyaK1MXltFequw%3D%3D 10.1172/JCI5001 9916137
-
A Dresner D Laurent M Marcucci ME Griffin S Dufour GW Cline LA Slezak DK Andersen RS Hundal DL Rothman KF Petersen GI Shulman 1999 Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity J Clin Invest 103 253 259 10.1172/JCI5001 1:CAS:528: DyaK1MXltFequw%3D%3D 10.1172/JCI5001 9916137
-
(1999)
J Clin Invest
, vol.103
, pp. 253-259
-
-
Dresner, A.1
Laurent, D.2
Marcucci, M.3
Griffin, M.E.4
Dufour, S.5
Cline, G.W.6
Slezak, L.A.7
Andersen, D.K.8
Hundal, R.S.9
Rothman, D.L.10
Petersen, K.F.11
Shulman, G.I.12
-
17
-
-
3442895916
-
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes
-
DOI 10.1210/me.2003-0383
-
Z Gao X Zhang A Zuberi D Hwang MJ Quon M Lefevre J Ye 2004 Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes Mol Endocrinol 18 2024 2034 10.1210/me.2003-0383 1:CAS:528:DC%2BD2cXmtlKqsrs%3D 10.1210/me.2003-0383 15143153 (Pubitemid 39006506)
-
(2004)
Molecular Endocrinology
, vol.18
, Issue.8
, pp. 2024-2034
-
-
Gao, Z.1
Zhang, X.2
Zuberi, A.3
Hwang, D.4
Quon, M.J.5
Lefevre, M.6
Ye, J.7
-
18
-
-
0033867178
-
Potential role of TNF-α in the pathogenesis of insulin resistance and type 2 diabetes
-
DOI 10.1016/S1043-2760(00)00272-1, PII S1043276000002721
-
DE Moller 2000 Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes Trends Endocrinol Metab 11 212 217 10.1016/S1043-2760(00)00272-1 1:CAS:528:DC%2BD3cXks12rtbo%3D 10.1016/S1043-2760(00)00272-1 10878750 (Pubitemid 30603166)
-
(2000)
Trends in Endocrinology and Metabolism
, vol.11
, Issue.6
, pp. 212-217
-
-
Moller, D.E.1
-
19
-
-
0031022434
-
Tumor necrosis factor-α-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction
-
DOI 10.1074/jbc.272.2.971
-
JM Stephens J Lee PF Pilch 1997 Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction J Biol Chem 272 971 976 10.1074/jbc.272.2.971 1:CAS:528:DyaK2sXmtFGjuw%3D%3D 10.1074/jbc.272.2.971 8995390 (Pubitemid 27034588)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.2
, pp. 971-976
-
-
Stephens, J.M.1
Lee, J.2
Pilch, P.F.3
-
20
-
-
0035836770
-
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
-
DOI 10.1073/pnas.051042298
-
ON Ozes H Akca LD Mayo JA Gustin T Maehama JE Dixon DB Donner 2001 A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1 Proc Natl Acad Sci USA 98 4640 4645 10.1073/pnas.051042298 1:CAS:528:DC%2BD3MXjtVansr8%3D 10.1073/pnas.051042298 11287630 (Pubitemid 32295029)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.8
, pp. 4640-4645
-
-
Ozes, O.N.1
Akca, H.2
Mayo, L.D.3
Gustin, J.A.4
Maehama, T.5
Dixon, J.E.6
Donner, D.B.7
-
21
-
-
0036098188
-
Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro
-
DOI 10.1210/jc.87.5.2084
-
JP Bastard M Maachi JT Van Nhieu C Jardel E Bruckert A Grimaldi JJ Robert J Capeau B Hainque 2002 Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro J Clin Endocrinol Metab 87 2084 2089 10.1210/jc.87.5.2084 1:CAS:528: DC%2BD38XjsFGhtLo%3D 10.1210/jc.87.5.2084 11994345 (Pubitemid 34521492)
-
(2002)
Journal of Clinical Endocrinology and Metabolism
, vol.87
, Issue.5
, pp. 2084-2089
-
-
Bastard, J.-P.1
Maachi, M.2
Van Nhieu, J.T.3
Jardel, C.4
Bruckert, E.5
Grimaldi, A.6
Robert, J.-J.7
Capeau, J.8
Hainque, B.9
-
22
-
-
0242580711
-
Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant Subjects
-
DOI 10.1074/jbc.M301977200
-
V Rotter I Nagaev U Smith 2003 Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects J Biol Chem 278 45777 45784 10.1074/jbc.M301977200 1:CAS:528:DC%2BD3sXosl2itrs%3D 10.1074/jbc.M301977200 12952969 (Pubitemid 37432722)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.46
, pp. 45777-45784
-
-
Rotter, V.1
Nagaev, I.2
Smith, U.3
-
24
-
-
0038745434
-
Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans
-
DOI 10.1113/jphysiol.2002.032938
-
A Steensberg CP Fischer M Sacchetti C Keller T Osada P Schjerling G van Hall MA Febbraio BK Pedersen 2003 Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans J Physiol 548 631 638 10.1113/jphysiol.2002.032938 1:CAS:528:DC%2BD3sXktlCisrw%3D 10.1113/jphysiol.2002.032938 12640021 (Pubitemid 36527483)
-
(2003)
Journal of Physiology
, vol.548
, Issue.2
, pp. 631-638
-
-
Steensberg, A.1
Fischer, C.P.2
Sacchetti, M.3
Keller, C.4
Osada, T.5
Schjerling, P.6
Van Hall, G.7
Febbraio, M.A.8
Pedersen, B.K.9
-
25
-
-
34249682779
-
Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle
-
DOI 10.2337/db06-1733
-
S Glund A Deshmukh YC Long T Moller HA Koistinen K Caidahl JR Zierath A Krook 2007 Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle Diabetes 56 1630 1637 10.2337/db06-1733 1:CAS:528: DC%2BD2sXmtlKhs78%3D 10.2337/db06-1733 17363741 (Pubitemid 46842596)
-
(2007)
Diabetes
, vol.56
, Issue.6
, pp. 1630-1637
-
-
Glund, S.1
Deshmukh, A.2
Yun, C.L.3
Moller, T.4
Koistinen, H.A.5
Caidahl, K.6
Zierath, J.R.7
Krook, A.8
-
26
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
DOI 10.1038/27376
-
JM Friedman JL Halaas 1998 Leptin and the regulation of body weight in mammals Nature 395 763 770 10.1038/27376 1:CAS:528:DyaK1cXmvFOmsL0%3D 10.1038/27376 9796811 (Pubitemid 28485436)
-
(1998)
Nature
, vol.395
, Issue.6704
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
27
-
-
0031044566
-
Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin
-
10.1677/jme.0.0180077 1:CAS:528:DyaK2sXivFWkt7o%3D 10.1677/jme.0.0180077 9061609
-
SM Luoh F Di Marco N Levin M Armanini MH Xie C Nelson GL Bennett M Williams SA Spencer A Gurney FJ de Sauvage 1997 Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin J Mol Endocrinol 18 77 85 10.1677/jme.0.0180077 1:CAS:528:DyaK2sXivFWkt7o%3D 10.1677/jme.0.0180077 9061609
-
(1997)
J Mol Endocrinol
, vol.18
, pp. 77-85
-
-
Luoh, S.M.1
Di Marco, F.2
Levin, N.3
Armanini, M.4
Xie, M.H.5
Nelson, C.6
Bennett, G.L.7
Williams, M.8
Spencer, S.A.9
Gurney, A.10
De Sauvage, F.J.11
-
28
-
-
0035905758
-
The hormone resistin links obesity to diabetes
-
DOI 10.1038/35053000
-
CM Steppan ST Bailey S Bhat EJ Brown RR Banerjee CM Wright HR Patel RS Ahima MA Lazar 2001 The hormone resistin links obesity to diabetes Nature 409 307 312 10.1038/35053000 1:CAS:528:DC%2BD3MXms12nsA%3D%3D 10.1038/35053000 11201732 (Pubitemid 32151228)
-
(2001)
Nature
, vol.409
, Issue.6818
, pp. 307-312
-
-
Steppan, C.M.1
Bailey, S.T.2
Bhat, S.3
Brown, E.J.4
Banerjee, R.R.5
Wright, C.M.6
Patel, H.R.7
Ahima, R.S.8
Lazar, M.A.9
-
29
-
-
0035930998
-
Suppressed gene expression of adipocyte resistin in an insulin-resistant rat model probably by elevated free fatty acids
-
DOI 10.1006/bbrc.2001.6132
-
CC Juan LC Au VS Fang SF Kang YH Ko SF Kuo YP Hsu CF Kwok LT Ho 2001 Suppressed gene expression of adipocyte resistin in an insulin-resist ant rat model probably by elevated free fatty acids Biochem Biophys Res Commun 289 1328 1333 10.1006/bbrc.2001.6132 1:CAS:528:DC%2BD3MXptVWitrg%3D 10.1006/bbrc.2001. 6132 11741341 (Pubitemid 34076338)
-
(2001)
Biochemical and Biophysical Research Communications
, vol.289
, Issue.5
, pp. 1328-1333
-
-
Juan, C.-C.1
Au, L.-C.2
Fang, V.S.3
Kang, S.-F.4
Ko, Y.-H.5
Kuo, S.-F.6
Hsu, Y.-P.7
Kwok, C.-F.8
Ho, L.-T.9
-
30
-
-
0035976808
-
Decreased resistin expression in mice with different sensitivities to a high-fat diet
-
DOI 10.1006/bbrc.2001.6015
-
S Le Lay J Boucher A Rey I Castan-Laurell S Krief P Ferre P Valet I Dugail 2001 Decreased resistin expression in mice with different sensitivities to a high-fat diet Biochem Biophys Res Commun 289 564 567 10.1006/bbrc.2001.6015 10.1006/bbrc.2001.6015 11716511 (Pubitemid 33141092)
-
(2001)
Biochemical and Biophysical Research Communications
, vol.289
, Issue.2
, pp. 564-567
-
-
Lay, S.L.1
Boucher, J.2
Rey, A.3
Castan-Laurell, I.4
Krief, S.5
Ferre, P.6
Valet, P.7
Dugail, I.8
|