Novel dihydropyrimidines as a potential new class of antitubercular agents

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 20, 2010, Pages 6100-6102

  Trivedi, Amit R ^a   Bhuva, Vimal R ^a   Dholariya, Bipin H ^a   Dodiya, Dipti K ^a   Kataria, Vipul B ^a   Shah, Viresh H ^a  

^a SAURASHTRA UNIVERSITY   (India)

Author keywords

Antimycobacterial activity; Antitubercular activity; DHFR (dihydrofolate reductase); Dihydropyrimidines; Mycobacterium tuberculosis H37Rv

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; ETHYL 4 [ 3 ( 4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 6 METHYL 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID; ETHYL 4 [ 3 ( 4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 6 METHYL 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID; ISONIAZID; PYRIMIDINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BIGINELLI REACTION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTITUBERCULAR AGENTS; CERCOPITHECUS AETHIOPS; HUMANS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PYRIMIDINES; TUBERCULOSIS; VERO CELLS;

MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS H37RV;

EID: 77956936909     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.046     Document Type: Article

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