Pyridoxal phosphate inhibits dynamic subunit interchange among serine hydroxymethyltransferase tetramers

Journal of Biological Chemistry

Volumn 278, Issue 12, 2003, Pages 10142-10149

  Zanetti, Krista A ^b   Stover, Patrick J ^a  

^a Department of Obstetrics Gynecology   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; CONCENTRATION (PROCESS); DIMERS; PHOSPHATES;

TETRAMERS;

ENZYME INHIBITION;

DIMER; GLYCINE; GLYCINE HYDROXYMETHYLTRANSFERASE; METHYLENETETRAHYDROFOLIC ACID; MONOMER; OLIGOMER; PYRIDOXAL 5 PHOSPHATE; RECOMBINANT PROTEIN; SERINE; TETRAHYDROFOLIC ACID; TETRAMER; FOLIC ACID; PROTEIN SUBUNIT;

AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; ARTICLE; ENZYME ACTIVE SITE; ENZYME ENGINEERING; ENZYME MECHANISM; ENZYME SUBUNIT; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN STABILITY; BINDING SITE; CATALYSIS; CHEMISTRY; DIMERIZATION; ENZYME STABILITY; METABOLISM;

BINDING SITES; CATALYSIS; DIMERIZATION; ENZYME STABILITY; FOLIC ACID; GLYCINE HYDROXYMETHYLTRANSFERASE; PROTEIN SUBUNITS; PYRIDOXAL PHOSPHATE; RECOMBINANT PROTEINS;

EID: 0038532318     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211569200     Document Type: Article

References (25)

1. Herbig, K., Chiang, E. P., Lee, L. R., Hills, J., Shane, B., and Stover, P. J. (2002) J. Biol. Chem. 277, 38381-38389
2. Schirch, V., and Strong, W. B. (1989) Arch. Biochem. Biophys. 269, 371-380
3. Egan, M. G., Sirlin, S., Rumberger, B. G., Garrow, T. A., Shane, B., and Sirotnak, F. M. (1995) J. Biol. Chem. 270, 5462-5468
4. Stover, P. J., Chen, L. H., Suh, J. R., Stover, D. M., Keyomarsi, K., and Shane, B. (1997) J. Biol. Chem. 272, 1842-1848
5. Girgis, S., Nasrallah, I. M., Suh, J. R., Oppenheim, E., Zanetti, K. A., Mastri, M. G., and Stover, P. J. (1998) Gene (Amst.) 210, 315-324
6. Shane, B. (1995) in Folate in Health and Disease (Bailey, L. B., ed) pp. 1-22, Marcel Dekker, Inc., New York
7. Appling, D. R. (1991) FASEB J. 5, 2645-2651
8. Renwick, S. B., Snell, K., and Baumann, U. (1998) Structure 6, 1105-1116
9. Szebenyi, D. M., Liu, X., Kriksunov, I. A., Stover, P. J., and Thiel, D. J. (2000) Biochemistry 39, 13313-13323
10. Scarsdale, J. N., Kazanina, G., Radaev, S., Schirch, V., and Wright, H. T. (1999) Biochemistry 38, 8347-8358
11. Scarsdale, J. N., Radaev, S., Kazanina, G., Schirch, V., and Wright, H. T. (2000) J. Mol. Biol. 296, 155-168
12. Trivedi, V., Gupta, A., Jala, V. R., Saravanan, P., Rao, G. S., Rao, N. A., Savithri, H. S., and Subramanya, H. S. (2002) J. Biol. Chem. 277, 17161-17169
13. Jagath, J. R., Sharma, B., Rao, N. A., and Savithri, H. S. (1997) J. Biol. Chem. 272, 24355-24362
14. Krishna Rao, J. V., Jagath, J. R., Sharma, B., Appaji Rao, N., and Savithri, H. S. (1999) Biochem. J. 343, 257-263
15. Kruschwitz, H., Ren, S., Di Salvo, M., and Schirch, V. (1995) Protein Expression Purif. 6, 411-416
16. Bensadoun, A., and Weinstein, D. (1976) Anal. Biochem. 70, 241-250
17. Schirch, L., and Gross, T. (1968) J. Biol. Chem. 243, 5651-5655
18. Strong, W. B., Cook, R., and Schirch, V. (1989) Biochemistry 28, 106-114
19. Stover, P., and Schirch, V. (1991) J. Biol. Chem. 266, 1543-1550
20. Schirch, D., Delle Fratte, S., Iurescia, S., Angelaccio, S., Contestabile, R., Bossa, F., and Schirch, V. (1993) J. Biol. Chem. 268, 23132-23138
21. Contestabile, R., Angelaccio, S., Bossa, F., Wright, H. T., Scarsdale, N., Kazanina, G., and Schirch, V. (2000) Biochemistry 39, 7492-7500
22. Heil, S. G., Van der Put, N. M., Waas, E. T., den Heijer, M., Trijbels, F. J., and Blom, H. J. (2001) Mol. Genet. Metab. 73, 164-172
23. Skibola, C. F., Smith, M. T., Hubbard, A., Shane, B., Roberts, A. C., Law, G. R., Rollinson, S., Roman, E., Cartwright, R. A., and Morgan, G. J. (2002) Blood 99, 3786-3791
24. Martinez, M., Cuskelly, G. J., Williamson, J., Toth, J. P., and Gregory, J. F., 3rd. (2000) J. Nutr. 130, 1115-1123
25. Huang, T., Wang, C., Maras, B., Barra, D., and Schirch, V. (1998) Biochemistry 37, 13536-13542