Antimycobacterial activity of 1-deaza-7,8-dihydropteridine derivatives against Mycobacterium tuberculosis and Mycobacterium avium complex in vitro

Journal of Antimicrobial Chemotherapy

Volumn 47, Issue 4, 2001, Pages 451-454

  Suling, W J ^a   Maddry, J A ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIHYDROPYRIDO[3,4 B]PYRAZINE DERIVATIVE; 6 PHENYL 2,4 DIAMINO 1 DEAZA 7,8 DIHYDROPTERIDINE; ALKYL GROUP; ANTIINFECTIVE AGENT; ANTIMYCOBACTERIAL AGENT; ANTINEOPLASTIC AGENT; CARBONYL DERIVATIVE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; DIMETHYL SULFOXIDE; EDETIC ACID; ETHAMBUTOL; FOLIC ACID ANTAGONIST; NEW DRUG; NITROGEN; PHENYL GROUP; PTERIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TUBULIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIUM ISOLATION; COLORIMETRY; CONTROLLED STUDY; DILUTION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; IN VITRO STUDY; MYCOBACTERIUM INTRACELLULARE AVIUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRAIN DIFFERENCE; STRUCTURE ANALYSIS;

EID: 0035048959     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/47.4.451     Document Type: Article

References (10)

1. Mycobacterium avium infection and AIDS: A therapeutic dilemma in rapid evolution
2. The neglected global tuberculosis problem: A report of the 1992 World Congress on Tuberculosis
3. 1,2-Dihydropyrido[3,4-b]pyrazines: Structure-activity relationships
4. 1-Deaza-7,8-dihydropteridines, a new class of mitotic inhibitors with anticancer activity
5. Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilino) methyl]-pyrido[3,4-b]pyrazin-7-yl carbamate (NSC 181928)
6. Comparison of 1,2-dihydropyrido[3,4-b] pyrazines (1-deaza-7,8-dihydropteridines) with several other inhibitors of mitosis
7. Crystal structure of the bacterial cell-division protein FtsZ
8. Antimycobacterial activities of 2.4-diamino-5-deazapteridine derivatives and effects on mycobacterial dihydrofolate reductase
9. The inhibition of dihydrofolate reductase by folate analogues: Structural requirements for slow- and tight-binding inhibition
10. Slow polymerization of Mycobacterium tuberculosis FtsZ