메뉴 건너뛰기




Volumn 31, Issue 10, 2010, Pages 443-448

Evolutionary inspirations for drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; FLAVONOID; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 90 INHIBITOR; IDEBENONE; NORPHENAZONE; POLYPHENOL; QUERCETIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VEREGEN;

EID: 77956921528     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2010.07.003     Document Type: Article
Times cited : (37)

References (59)
  • 1
    • 77149134011 scopus 로고    scopus 로고
    • Deconstructing the drug development process: the new face of innovation
    • Kaitin K.I. Deconstructing the drug development process: the new face of innovation. Clin. Pharma. Therap. 2010, 87:356-361.
    • (2010) Clin. Pharma. Therap. , vol.87 , pp. 356-361
    • Kaitin, K.I.1
  • 3
    • 0000055057 scopus 로고
    • Pleiotropy, natural selection, and the evolution of senescence
    • Williams G.C. Pleiotropy, natural selection, and the evolution of senescence. Evolution 1957, 11:398-411.
    • (1957) Evolution , vol.11 , pp. 398-411
    • Williams, G.C.1
  • 4
    • 76649114394 scopus 로고    scopus 로고
    • Evolutionary perspectives on health and medicine
    • Stearns S.C., et al. Evolutionary perspectives on health and medicine. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(suppl. 1):1691-1695.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , Issue.SUPPL.. 1 , pp. 1691-1695
    • Stearns, S.C.1
  • 5
    • 76549134816 scopus 로고    scopus 로고
    • Making evolutionary biology a basic science for medicine
    • Nesse R.M., et al. Making evolutionary biology a basic science for medicine. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(suppl. 1):1800-1807.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , Issue.SUPPL.. 1 , pp. 1800-1807
    • Nesse, R.M.1
  • 6
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman D.J., Cragg G.M. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod. 2007, 70:461-477.
    • (2007) J. Nat. Prod. , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 7
    • 44649136637 scopus 로고    scopus 로고
    • The impact of Arabidopsis on human health research: " Diversifying our portfolio"
    • Jones A.M., et al. The impact of Arabidopsis on human health research: " Diversifying our portfolio" Cell 2008, 133:939-943.
    • (2008) Cell , vol.133 , pp. 939-943
    • Jones, A.M.1
  • 9
    • 0033787978 scopus 로고    scopus 로고
    • Medicinal chemicals and phytomedicines. Linking plant biochemistry and physiology to human health
    • Briskin D.P. Medicinal chemicals and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiol. 2000, 124:507-514.
    • (2000) Plant Physiol. , vol.124 , pp. 507-514
    • Briskin, D.P.1
  • 10
    • 33746001269 scopus 로고    scopus 로고
    • Antibacterial natural products in medicinal chemistry--exodus or revival?
    • von Nussbaum F., et al. Antibacterial natural products in medicinal chemistry--exodus or revival?. Angew. Chem. Int. Ed. 2007, 45:5072-5129.
    • (2007) Angew. Chem. Int. Ed. , vol.45 , pp. 5072-5129
    • von Nussbaum, F.1
  • 11
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: confronting the challenges of antibacterial discovery
    • Payne D.J., et al. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 2007, 6:29-40.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 29-40
    • Payne, D.J.1
  • 12
    • 69549111337 scopus 로고    scopus 로고
    • Antibiotics for emerging pathogens
    • Fischbach M.A., Walsh C.T. Antibiotics for emerging pathogens. Science 2009, 325:1089-1093.
    • (2009) Science , vol.325 , pp. 1089-1093
    • Fischbach, M.A.1    Walsh, C.T.2
  • 13
    • 0037379626 scopus 로고    scopus 로고
    • Between genotype and phenotype: protein chaperones and evolvability
    • Rutherford S.L. Between genotype and phenotype: protein chaperones and evolvability. Nature Rev. Genet. 2003, 4:263-274.
    • (2003) Nature Rev. Genet. , vol.4 , pp. 263-274
    • Rutherford, S.L.1
  • 14
    • 25844530060 scopus 로고    scopus 로고
    • Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi
    • Cowen L.E., Lindquist S. Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 2005, 309:2185-2189.
    • (2005) Science , vol.309 , pp. 2185-2189
    • Cowen, L.E.1    Lindquist, S.2
  • 15
    • 62949238913 scopus 로고    scopus 로고
    • New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential
    • Li Y.Y., et al. New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Drug Resist. Updat. 2009, 12:17-27.
    • (2009) Drug Resist. Updat. , vol.12 , pp. 17-27
    • Li, Y.Y.1
  • 16
    • 62449104891 scopus 로고    scopus 로고
    • Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
    • Cowen L.E., et al. Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:2818-2823.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 2818-2823
    • Cowen, L.E.1
  • 17
    • 66649132872 scopus 로고    scopus 로고
    • Chaperonin overexpression promotes genetic variation and enzyme evolution
    • Tokuriki N., Tawfik D.S. Chaperonin overexpression promotes genetic variation and enzyme evolution. Nature 2009, 459:668-673.
    • (2009) Nature , vol.459 , pp. 668-673
    • Tokuriki, N.1    Tawfik, D.S.2
  • 18
    • 4644351908 scopus 로고    scopus 로고
    • SOS response induction by ß-lactams and bacterial defense against antibiotic lethality
    • Miller C., et al. SOS response induction by ß-lactams and bacterial defense against antibiotic lethality. Science 2004, 305:1629-1631.
    • (2004) Science , vol.305 , pp. 1629-1631
    • Miller, C.1
  • 19
    • 21344460325 scopus 로고    scopus 로고
    • Inhibition of mutation and combating the evolution of antibiotic resistance
    • Cirz R.T., et al. Inhibition of mutation and combating the evolution of antibiotic resistance. PLoS Biol. 2005, 3:e176.
    • (2005) PLoS Biol. , vol.3
    • Cirz, R.T.1
  • 20
    • 26444517727 scopus 로고    scopus 로고
    • Evolutionary algorithms in drug design
    • Lameijer E.W., et al. Evolutionary algorithms in drug design. Nat. Comput. 2005, 4:177-243.
    • (2005) Nat. Comput. , vol.4 , pp. 177-243
    • Lameijer, E.W.1
  • 21
    • 38349105591 scopus 로고    scopus 로고
    • The rise of atmospheric oxygen
    • Kump L.R. The rise of atmospheric oxygen. Nature 2008, 451:277-278.
    • (2008) Nature , vol.451 , pp. 277-278
    • Kump, L.R.1
  • 22
    • 21444457397 scopus 로고    scopus 로고
    • 2 is required by complex life on habitable planets and the concept of planetary " oxygenation time"
    • 2 is required by complex life on habitable planets and the concept of planetary " oxygenation time" Astrobiology 2005, 5:415-438.
    • (2005) Astrobiology , vol.5 , pp. 415-438
    • Catling, D.C.1
  • 23
    • 33645211903 scopus 로고    scopus 로고
    • The effect of oxygen on biochemical networks and the evolution of complex life
    • Raymond J., Segrè D. The effect of oxygen on biochemical networks and the evolution of complex life. Science 2006, 311:1764-1767.
    • (2006) Science , vol.311 , pp. 1764-1767
    • Raymond, J.1    Segrè, D.2
  • 26
    • 33747110376 scopus 로고    scopus 로고
    • The antioxidant myth: a medical fairy tale
    • Melton L. The antioxidant myth: a medical fairy tale. New Sci. 2006, 190:40-43.
    • (2006) New Sci. , vol.190 , pp. 40-43
    • Melton, L.1
  • 27
    • 70349333522 scopus 로고    scopus 로고
    • Natural inspirations for antioxidant drug discovery
    • Li X.-J., et al. Natural inspirations for antioxidant drug discovery. Drug Discov. Today 2009, 14:910-912.
    • (2009) Drug Discov. Today , vol.14 , pp. 910-912
    • Li, X.-J.1
  • 28
    • 72649099361 scopus 로고    scopus 로고
    • Comment on " Temperature and solvent effects on radical scavenging ability of phenols"
    • Litwinienko G., Mulder P. Comment on " Temperature and solvent effects on radical scavenging ability of phenols" J. Phys. Chem. A 2009, 113:14014-14016.
    • (2009) J. Phys. Chem. A , vol.113 , pp. 14014-14016
    • Litwinienko, G.1    Mulder, P.2
  • 29
    • 23744500296 scopus 로고    scopus 로고
    • Structure-activity relationships and rational design strategies for radical-scavenging antioxidants
    • Zhang H.-Y. Structure-activity relationships and rational design strategies for radical-scavenging antioxidants. Curr. Comput.-Aided Drug Design 2005, 1:257-273.
    • (2005) Curr. Comput.-Aided Drug Design , vol.1 , pp. 257-273
    • Zhang, H.-Y.1
  • 30
    • 84962393654 scopus 로고    scopus 로고
    • How vitamin E scavenges DPPH radicals in polar protic media
    • Zhang H.-Y., Ji H.-F. How vitamin E scavenges DPPH radicals in polar protic media. New J. Chem. 2006, 30:503-504.
    • (2006) New J. Chem. , vol.30 , pp. 503-504
    • Zhang, H.-Y.1    Ji, H.-F.2
  • 31
    • 73449135823 scopus 로고    scopus 로고
    • Ageing in nematodes: do antioxidants extend lifespan in Caenorhabditis elegans?
    • Pun P.B., et al. Ageing in nematodes: do antioxidants extend lifespan in Caenorhabditis elegans?. Biogerontology 2010, 11:17-30.
    • (2010) Biogerontology , vol.11 , pp. 17-30
    • Pun, P.B.1
  • 32
    • 4344691399 scopus 로고    scopus 로고
    • A review of the epidemiological evidence for the 'antioxidant hypothesis'
    • Stanner S.A., et al. A review of the epidemiological evidence for the 'antioxidant hypothesis'. Public Health Nutr. 2004, 7:407-422.
    • (2004) Public Health Nutr. , vol.7 , pp. 407-422
    • Stanner, S.A.1
  • 33
    • 13844298231 scopus 로고    scopus 로고
    • Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? antioxidant or not?
    • Halliwell B., et al. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? antioxidant or not?. Am. J. Clin. Nutr. 2005, 81:268S-276S.
    • (2005) Am. J. Clin. Nutr. , vol.81
    • Halliwell, B.1
  • 34
    • 0035954018 scopus 로고    scopus 로고
    • Antioxidant strategy for cardiovascular disease
    • Violi F., et al. Antioxidant strategy for cardiovascular disease. Lancet 2001, 357:1704.
    • (2001) Lancet , vol.357 , pp. 1704
    • Violi, F.1
  • 35
    • 33646022817 scopus 로고    scopus 로고
    • Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation
    • Gaut J.P., et al. Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation. Free Radic. Biol. Med. 2006, 40:1494-1501.
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 1494-1501
    • Gaut, J.P.1
  • 36
    • 74549156348 scopus 로고    scopus 로고
    • Quercetin supplementation does not alter antioxidant status in humans
    • Shanely R.A., et al. Quercetin supplementation does not alter antioxidant status in humans. Free Radic. Res. 2010, 44:224-231.
    • (2010) Free Radic. Res. , vol.44 , pp. 224-231
    • Shanely, R.A.1
  • 37
    • 34447570834 scopus 로고    scopus 로고
    • Carbon radicals of low reactivity against oxygen: radically different antioxidants
    • Korth H.-G. Carbon radicals of low reactivity against oxygen: radically different antioxidants. Angew. Chem. Int. Ed. 2007, 46:5274-5276.
    • (2007) Angew. Chem. Int. Ed. , vol.46 , pp. 5274-5276
    • Korth, H.-G.1
  • 38
    • 0029888128 scopus 로고    scopus 로고
    • Structure-antioxidant activity relationships of flavonoids and phenolic acids
    • Rice-Evans C.A., et al. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 1996, 20:933-956.
    • (1996) Free Radic. Biol. Med. , vol.20 , pp. 933-956
    • Rice-Evans, C.A.1
  • 39
    • 33947610393 scopus 로고    scopus 로고
    • SAR and QSAR of the antioxidant activity of flavonoids
    • Amić D., et al. SAR and QSAR of the antioxidant activity of flavonoids. Curr. Med. Chem. 2007, 14:827-845.
    • (2007) Curr. Med. Chem. , vol.14 , pp. 827-845
    • Amić, D.1
  • 40
    • 0033921305 scopus 로고    scopus 로고
    • Evolution of antioxidant defence mechanisms
    • Benzie I.F. Evolution of antioxidant defence mechanisms. Eur. J. Nutr. 2000, 39:53-61.
    • (2000) Eur. J. Nutr. , vol.39 , pp. 53-61
    • Benzie, I.F.1
  • 41
    • 18244404614 scopus 로고    scopus 로고
    • The role of UV-B radiation in aquatic and terrestrial ecosystems-an experimental and functional analysis of the evolution of UV-absorbing compounds
    • Rozema J., et al. The role of UV-B radiation in aquatic and terrestrial ecosystems-an experimental and functional analysis of the evolution of UV-absorbing compounds. J. Photochem. Photobiol. B 2002, 66:2-12.
    • (2002) J. Photochem. Photobiol. B , vol.66 , pp. 2-12
    • Rozema, J.1
  • 42
    • 29144433413 scopus 로고    scopus 로고
    • A UV-B-specific signaling component orchestrates plant UV protection
    • Brown B.A., et al. A UV-B-specific signaling component orchestrates plant UV protection. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:18225-18230.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 18225-18230
    • Brown, B.A.1
  • 43
    • 0442314370 scopus 로고    scopus 로고
    • UV screening by phenolics in berries of grapevine (Vitis vinifera)
    • Kolb C.A., et al. UV screening by phenolics in berries of grapevine (Vitis vinifera). Funct. Plant Biol. 2003, 30:1177-1186.
    • (2003) Funct. Plant Biol. , vol.30 , pp. 1177-1186
    • Kolb, C.A.1
  • 44
    • 35348914410 scopus 로고    scopus 로고
    • Transcriptomic profile of Arabidopsis rosette leaves during the reproductive stage after exposure to ionizing radiation
    • Kim J.H., et al. Transcriptomic profile of Arabidopsis rosette leaves during the reproductive stage after exposure to ionizing radiation. Radiat. Res. 2007, 168:267-280.
    • (2007) Radiat. Res. , vol.168 , pp. 267-280
    • Kim, J.H.1
  • 45
    • 0034091606 scopus 로고    scopus 로고
    • Physiologic determinants of radiation resistance in Deinococcus radiodurans
    • Venkateswaran A., et al. Physiologic determinants of radiation resistance in Deinococcus radiodurans. Appl. Environ. Microbiol. 2000, 66:2620-2626.
    • (2000) Appl. Environ. Microbiol. , vol.66 , pp. 2620-2626
    • Venkateswaran, A.1
  • 46
    • 60749095652 scopus 로고    scopus 로고
    • A new perspective on radiation resistance based on Deinococcus radiodurans
    • Daly M.J. A new perspective on radiation resistance based on Deinococcus radiodurans. Nat. Rev. Microbiol. 2009, 7:237-245.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 237-245
    • Daly, M.J.1
  • 47
    • 65649119296 scopus 로고    scopus 로고
    • Antioxidants used by Deinococcus radiodurans and implications for antioxidant drug discovery
    • Zhang H.-Y., et al. Antioxidants used by Deinococcus radiodurans and implications for antioxidant drug discovery. Nat. Rev. Microbiol. 2009, 7:476. 10.1038/nrmicro2073-c1.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 476
    • Zhang, H.-Y.1
  • 48
    • 77956913202 scopus 로고    scopus 로고
    • Gene expression analysis of four radiation-resistant bacteria
    • Gao N., et al. Gene expression analysis of four radiation-resistant bacteria. Genomics Insights 2009, 2:11-22.
    • (2009) Genomics Insights , vol.2 , pp. 11-22
    • Gao, N.1
  • 49
    • 1642452919 scopus 로고    scopus 로고
    • Chalcone isomerase family and fold: no longer unique to plants
    • Gensheimer M., Mushegian A. Chalcone isomerase family and fold: no longer unique to plants. Protein Sci. 2004, 13:540-544.
    • (2004) Protein Sci. , vol.13 , pp. 540-544
    • Gensheimer, M.1    Mushegian, A.2
  • 50
    • 0030796013 scopus 로고    scopus 로고
    • Actinoflavoside, a novel flavonoid-like glycoside produced by a marine bacterium of the genus Streptomyces
    • Jiang Z.-D., et al. Actinoflavoside, a novel flavonoid-like glycoside produced by a marine bacterium of the genus Streptomyces. Tetrahedron Lett. 1997, 38:5065-5068.
    • (1997) Tetrahedron Lett. , vol.38 , pp. 5065-5068
    • Jiang, Z.-D.1
  • 51
    • 34548414486 scopus 로고    scopus 로고
    • How to understand the dichotomy of antioxidants
    • Shen L., et al. How to understand the dichotomy of antioxidants. Biochem. Biophys. Res. Commun. 2007, 362:543-545.
    • (2007) Biochem. Biophys. Res. Commun. , vol.362 , pp. 543-545
    • Shen, L.1
  • 52
    • 0034211776 scopus 로고    scopus 로고
    • Inhibition of lipid peroxidation by quercetin and quercetin derivatives: antioxidant and prooxidant effects
    • Dangles O., et al. Inhibition of lipid peroxidation by quercetin and quercetin derivatives: antioxidant and prooxidant effects. J. Chem. Soc. Perkin Trans. 2000, 2(6):1215-1222.
    • (2000) J. Chem. Soc. Perkin Trans. , vol.2 , Issue.6 , pp. 1215-1222
    • Dangles, O.1
  • 53
  • 54
    • 61849148824 scopus 로고    scopus 로고
    • Natural products and drug discovery
    • Ji H.-F., et al. Natural products and drug discovery. EMBO Rep. 2009, 10:194-200.
    • (2009) EMBO Rep. , vol.10 , pp. 194-200
    • Ji, H.-F.1
  • 55
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer
    • Middleton E., et al. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 2000, 52:673-751.
    • (2000) Pharmacol. Rev. , vol.52 , pp. 673-751
    • Middleton, E.1
  • 56
    • 34249884856 scopus 로고    scopus 로고
    • Cancer preventive mechanisms of the green tea polyphenol (-)-epigallocatechin-3-gallate
    • Chen L., Zhang H.-Y. Cancer preventive mechanisms of the green tea polyphenol (-)-epigallocatechin-3-gallate. Molecules 2007, 12:946-957.
    • (2007) Molecules , vol.12 , pp. 946-957
    • Chen, L.1    Zhang, H.-Y.2
  • 57
    • 63049125250 scopus 로고    scopus 로고
    • The impact of flavonoids on memory: physiological and molecular considerations
    • Spencer J.P. The impact of flavonoids on memory: physiological and molecular considerations. Chem. Soc. Rev. 2009, 38:1152-1161.
    • (2009) Chem. Soc. Rev. , vol.38 , pp. 1152-1161
    • Spencer, J.P.1
  • 58
    • 68149124472 scopus 로고    scopus 로고
    • Dietary phenolics: chemistry, bioavailability and effects on health, Nat
    • Crozier A., et al. Dietary phenolics: chemistry, bioavailability and effects on health, Nat. Prod. Rep. 2009, 26:1001-1043.
    • (2009) Prod. Rep. , vol.26 , pp. 1001-1043
    • Crozier, A.1
  • 59
    • 34250702156 scopus 로고    scopus 로고
    • Revisiting the ancient concept of botanical therapeutics
    • Schmidt B.M., et al. Revisiting the ancient concept of botanical therapeutics. Nat. Chem. Biol. 2007, 3:360-366.
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 360-366
    • Schmidt, B.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.