Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 20, 2010, Pages 6040-6044

  Dong, Maoqing ^a   Pinon, Delia I ^a   Bordner, Andrew J ^a   Miller, Laurence J ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

Active peptide conformation; Family B G protein coupled receptor; Ligand binding; Secretin; Secretin receptor

Indexed keywords

CYSTEINE; SECRETIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; DISULFIDE BOND; MOLECULAR MECHANICS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DISULFIDES; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GASTROINTESTINAL HORMONE; SECRETIN;

EID: 77956898278     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.062     Document Type: Article

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