Distribution of an intravenous injectable nimodipine nanosuspension in mice

Journal of Pharmacy and Pharmacology

Volumn 60, Issue 9, 2008, Pages 1155-1159

  Xiong, Ruolan ^a   Lu, Weigen ^a   Yue, Peng ^a   Xu, Rong ^a   Li, Jun ^a   Chen, Tingting ^a   Wang, Peiquan ^a  

^a SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

NANOPARTICLE; NIMODIPINE;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG LIVER LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN;

ANIMALS; CALCIUM CHANNEL BLOCKERS; ETHANOL; EXCIPIENTS; INJECTIONS, INTRAVENOUS; KUPFFER CELLS; MALE; MICE; NANOPARTICLES; NIMODIPINE; PARTICLE SIZE; POLYSORBATES; SOLVENTS; SUSPENSIONS; TISSUE DISTRIBUTION;

EID: 49749102777     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.60.9.0006     Document Type: Article

References (12)

1. Gao, K., Jiang, X. (2006) Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Int. J. Pharm. 310: 213-219
2. Kreuter, J. (2001) Nanoparticulate systems for brain delivery of drugs. Adv. Drug Deliv. Rev. 47: 65-81
3. Lück, M., Paulke, B. R., Schröder, W., Blunk, T., Müller, R. H. (1998) Analysis of plasma protein adsorption on polymeric nanoparticles with different surface characteristics. J. Biomed. Mater. Res. 39: 478-485
4. Müller, R. H., Jacobs, C., Kayser, O. (2001) Nanosuspensions as particulate drug formulation in therapy. Rationale for development and what we can expect for the future. Adv. Drug Deliv. Rev. 47: 3-19
5. Peters, K., Leitzke, S., Diederichs, J. E., Borner, K., Hahn, H., Müller, R. H., Ehlers, S. (2000) Preparation of a clofazimine nano-suspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection. J. Antimicrob. Chemother. 45: 77-83
6. Rabinow, B. E. (2005) Characterization of drug nanosuspensions. Available online at: http://ncl.cancer.gov/about_ncl/event_2005-5-19_drug-nanosuspension. pdf (accessed 15 June 2008)
7. Sun, W., Xie, C., Wang, H., Hu, Y. (2004) Specific role of polysorbate 80 coating the targeting of nanoparticles to the brain. Biomaterials 25: 3065-3071
8. Vinge, E., Andersson, K. E., Brandt, L., Ljunggren, B., Nilsson, L. G., Rosendal-Helgesen, S. (1986) Pharmacokinetics of nimodipine in patients with aneurysmal subarachnoid haemorrhage. Eur. J. Clin. Pharmacol. 30: 421-425
9. Xiong, R. L., Lu, W. G., Li, J., Wang, P. Q., Xu, R., Chen, T. T. (2008) Preparation and characterization of intravenously injectable nimodipine nanosuspension. Int. J. Pharm. 350: 338-343
10. Yuan, J. (1993) Estimation of variance for AUC in animal studies. J. Pharm. Sci. 82: 761-763
11. Zhang, Q., Jiang, X., Jiang, W., Lu, W., Su, L., Shi, Z. (2004) Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain. Int. J. Pharm. 275: 85-96
12. Zhao, L., Guan, J., Zhao, J., Sun, Q., Cao, S. (2006) Mouse cerebrovascular pathological changes and cerebral trauma in alcoholism. Theory Pract. Chin. Med. 16: 1107-1108