Preparation of drug nanocrystals by controlled crystallization: Application of a 3-way nozzle to prevent premature crystallization for large scale production

European Journal of Pharmaceutical Sciences

Volumn 38, Issue 3, 2009, Pages 224-229

  de Waard, Hans ^a   Grasmeijer, Niels ^a   Hinrichs, Wouter L J ^a   Eissens, Anko C ^a   Pfaffenbach, Peter P F ^b   Frijlink, Henderik W ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b Solvay Pharmaceuticals GmbH   (Germany)

Author keywords

3 Way nozzle; Crystallization; Fenofibrate; Lipophilic drug; Scale up

Indexed keywords

FENOFIBRATE; LIQUID NITROGEN; MANNITOL; NANOCRYSTAL; TERT BUTYL ALCOHOL;

ARTICLE; BATCH PROCESS; CONTINUOUS PROCESS; CONTROLLED STUDY; CRYSTALLIZATION; DISPERSION; DRUG MANUFACTURE; DRUG SOLUBILITY; FREEZE DRYING; PARTICLE SIZE; PRIORITY JOURNAL;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; FREEZE DRYING; NANOPARTICLES; PHARMACEUTICAL PREPARATIONS; X-RAY DIFFRACTION;

EID: 70349084535     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.07.005     Document Type: Article

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