Targeted deletion of the inhibitory NF-κB p50 subunit in bone marrow-derived cells improves collateral growth after arterial occlusion

Cardiovascular Research

Volumn 88, Issue 1, 2010, Pages 179-185

  De Groot, Daphne ^a   Haverslag, René T ^a   Pasterkamp, Gerard ^a   De Kleijn, Dominique P V ^a,b   Hoefer, Imo E ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

Author keywords

Arterial occlusion; Collateral artery growth; Nuclear factor kappa B

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN; INTERLEUKIN 6; PROTEIN P50;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTERY OCCLUSION; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL COUNT; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXTRAVASATION; FEMORAL ARTERY; HINDLIMB; HISTOLOGY; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; TISSUE PERFUSION; WILD TYPE;

ANIMALS; ARTERIAL OCCLUSIVE DISEASES; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CHEMOTAXIS, LEUKOCYTE; COLLATERAL CIRCULATION; DISEASE MODELS, ANIMAL; FEMALE; FEMORAL ARTERY; GENE DELETION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LIGATION; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; MONOCYTES; NEOVASCULARIZATION, PHYSIOLOGIC; NF-KAPPA B P50 SUBUNIT; TIME FACTORS;

EID: 77956849830     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvq150     Document Type: Article

References (34)

1. Eitenmuller I, Volger O, Kluge A, Troidl K, Barancik M, Cai WJ et al. The range of adaptation by collateral vessels after femoral artery occlusion. Circ Res 2006;99: 656-662.
2. Pipp F, Boehm S, Cai WJ, Adili F, Ziegler B, Karanovic G et al. Elevated fluid shear stress enhances postocclusive collateral artery growth and gene expression in the pig hind limb. Arterioscler Thromb Vasc Biol 2004;24:1664-1668.
3. Lan Q, Mercurius KO, Davies PF. Stimulation of transcription factors NF kappa B and AP1 in endothelial cells subjected to shear stress. Biochem Biophys Res Commun 1994; 201:950-956.
4. Nagel T, Resnick N, Dewey CF Jr, Gimbrone MA Jr. Vascular endothelial cells respond to spatial gradients in fluid shear stress by enhanced activation of transcription factors. Arterioscler Thromb Vasc Biol 1999;19:1825-1834.
5. Cinamon G, Shinder V, Alon R. Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines. Nat Immunol 2001;2:515-522.
6. Buschmann I, Heil M, Jost M, Schaper W. Influence of inflammatory cytokines on arteriogenesis. Microcirculation 2003;10:371-379.
7. Fujii T, Yonemitsu Y, Onimaru M, Tanii M, Nakano T, Egashira K et al. Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovas-cularization: critical role of the inflammatory/arteriogenic pathway. Arterioscler Thromb Vasc Biol 2006;26:2483-2489.
8. Silvestre JS, Mallat Z, Tedgui A, Levy BI. Post-ischaemic neovascularization and inflammation. Cardiovasc Res 2008;78:242-249.
9. Bergmann CE, Hoefer IE, Meder B, Roth H, Van RN, Breit SM et al. Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice. J Leukoc Biol 2006;80:59-65.
10. Herold J, Pipp F, Fernandez B, Xing Z, Heil M, Tillmanns H et al. Transplantation of monocytes: a novel strategy for in vivo augmentation of collateral vessel growth. Hum Gene Ther 2004;15:1-12.
11. Hoefer IE, Van RN, Rectenwald JE, Deindl E, Hua J, Jost M et al. Arteriogenesis proceeds via ICAM-1/Mac-1-mediated mechanisms. Circ Res 2004;94:1179-1185.
12. Ito WD, Arras M, Winkler B, Scholz D, Schaper J, Schaper W. Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion. Circ Res 1997;80:829-837.
13. Kocaman SA, Arslan U, Tavil Y, Okuyan H, Abaci A, Cengel A. Increased circulating monocyte count is related to good collateral development in coronary artery disease. Atherosclerosis 2008;197:753-756.
14. Stabile E, Burnett MS, Watkins C, Kinnaird T, Bachis A, la SA et al. Impaired arterio-genic response to acute hindlimb ischemia in CD4-knockout mice. Circulation 2003; 108:205-210.
15. Van Weel V, Toes RE, Seghers L, Deckers MM, De Vries MR, Eilers PH et al. Natural killer cells and CD4+ T-cells modulate collateral artery development. Arterioscler Thromb Vasc Biol 2007;27:2310-2318.
16. Arras M, Ito WD, Scholz D, Winkler B, Schaper J, Schaper W. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J Clin Invest 1998;101:40-50.
17. Hoefer IE, Van RN, Rectenwald JE, Bray EJ, Abouhamze Z, Moldawer LL et al. Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis. Circulation 2002; 105:1639-1641.
18. Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997;336:1066-1071.
19. Gilmore TD. The Rel/NF-kappaB signal transduction pathway: introduction. Oncogene 1999;18:6842-6844.
20. Plaksin D, Baeuerle PA, Eisenbach L. KBF1 p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells. J Exp Med 1993; 177:1651-1662.
21. Driessler F, Venstrom K, Sabat R, Asadullah K, Schottelius AJ. Molecular mechanisms of interleukin-10-mediated inhibition of NF-kappaB activity: a role for p50. Clin Exp Immunol 2004;135:64-73.
22. Kang SM, Tran AC, Grilli M, Lenardo MJ. NF-kappa B subunit regulation in nontrans-formed CD4+ T lymphocytes. Science 1992;256:1452-1456.
23. Timmers L, Van Keulen JK, Hoefer IE, Meijs MF, Van MB, Den OK et al. Targeted deletion of nuclear factor kappaB p50 enhances cardiac remodeling and dysfunction following myocardial infarction. Circ Res 2009;104:699-706.
24. Van Keulen JK, Timmers L, Van Kuijk LP, Retnam L, Hoefer IE, Pasterkamp G et al. The Nuclear Factor-kappa B p50 subunit is involved in flow-induced outward arterial remodeling. Atherosclerosis 2009;202:424-430.
25. Glenny RW. Manual for Using Fluorescent Microspheres to Measure Regional Organ Per-fusion. Seattle: Fluorescent Microsphere Resource Center, University of Washington; 1996.
26. Arslan F, Smeets MB, O'Neill LA, Keogh B, McGuirk P, Timmers L et al. Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody. Circulation 2010;121:80-90.
27. Scholz D, Ito W, Fleming I, Deindl E, Sauer A, Wiesnet M et al. Ultrastructure and molecular histology of rabbit hind-limb collateral artery growth arteriogenesis. Virch-ows Arch 2000;436:257-270.
28. Schirmer SH, Buschmann IR, Jost MM, Hoefer IE, Grundmann S, Andert JP et al. Differential effects of MCP-1 and leptin on collateral flow and arteriogenesis. Cardio-vasc Res 2004;64:356-364.
29. Van Royen N, Hoefer I, Buschmann I, Kostin S, Voskuil M, Bode C et al. Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits. Cardiovasc Res 2003;57:178-185.
30. Bohuslav J, Kravchenko VV, Parry GC, Erlich JH, Gerondakis S, Mackman N et al. Regulation of an essential innate immune response by the p50 subunit of NF-kappaB. J Clin Invest 1998;102:1645-1652.
31. Moller AS, Ovstebo R, Westvik AB, Joo GB, Haug KB, Kierulf P. Effects of bacterial cell wall components PAMPs) on the expression of monocyte chemoattractant protein-1 MCP-1), macrophage inflammatory protein-1alpha MIP-1alpha) and the chemokine receptor CCR2 by purified human blood monocytes. J Endotoxin Res 2003;9:349-360.
32. Arnaout MA. Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood 1990;75:1037-1050.
33. Meerschaert J, Furie MB. The adhesion molecules used by monocytes for migration across endothelium include CD11a/CD18, CD11b/CD18, and VLA-4 on monocytes and ICAM-1, VCAM-1, and other ligands on endothelium. J Immunol 1995;154: 4099-4112.
34. Ostermann G, Weber KS, Zernecke A, Schroder A, Weber C. JAM-1 is a ligand of the beta2) integrin LFA-1 involved in transendothelial migration of leukocytes. Nat Immunol 2002;3:151-158.