The Nuclear Factor-kappa B p50 subunit is involved in flow-induced outward arterial remodeling

Atherosclerosis

Volumn 202, Issue 2, 2009, Pages 424-430

  Keulen, J Karlijn van ^a,b   Timmers, Leo ^a   van Kuijk, Liza P ^a   Retnam, Leslie ^c   Hoefer, Imo E ^a   Pasterkamp, Gerard ^a   Lim, Sai K ^d   de Kleijn, Dominique P V ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c Centre for Life Sciences   (Singapore)

^d INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

Author keywords

Arteries; Inflammation; NF B; Remodeling

Indexed keywords

COLLAGEN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY; CAROTID ARTERY LIGATION; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYO; FLOW; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MODEL; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

ANIMALS; CAROTID ARTERY DISEASES; CELLS, CULTURED; COLLAGEN; CYTOKINES; FIBROBLASTS; MACROPHAGES; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; NF-KAPPA B P50 SUBUNIT; REGIONAL BLOOD FLOW; RNA, MESSENGER; VASCULITIS;

EID: 58549106113     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.05.049     Document Type: Article

References (30)

1. Pasterkamp G., and Smits P.C. Imaging of atherosclerosis. Remodelling of coronary arteries. J Cardiovasc Risk 9 (2002) 229-235
2. Pasterkamp G., Galis Z.S., and De Kleijn D.P. Expansive arterial remodeling: location, location, location. Arterioscler Thromb Vasc Biol 24 (2004) 650-657
3. Hollestelle S.C., De Vries M.R., Van Keulen J.K., et al. Toll-like receptor 4 is involved in outward arterial remodeling. Circulation 109 (2004) 393-398
4. Ghosh S., May M.J., and Kopp E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16 (1998) 225-260
5. Baer M., Dillner A., Schwartz R.C., Sedon C., Nedospasov S., and Johnson P.F. Tumor necrosis factor alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-kappaB p50. Mol Cell Biol 18 (1998) 5678-5689
6. Bohuslav J., Kravchenko V.V., Parry G.C., et al. Regulation of an essential innate immune response by the p50 subunit of NF-kappaB. J Clin Invest 102 (1998) 1645-1652
7. Ishikawa H., Claudio E., Dambach D., Raventos-Suarez C., Ryan C., and Bravo R. Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50. J Exp Med 187 (1998) 985-996
8. Kastenbauer S., and Ziegler-Heitbrock H.W. NF-kappaB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression. Infect Immun 67 (1999) 1553-1559
9. Gadjeva M., Tomczak M.F., Zhang M., et al. A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock. J Immunol 173 (2004) 5786-5793
10. Squadrito F., Deodato B., Bova A., et al. Crucial role of nuclear factor-kappaB in neointimal hyperplasia of the mouse carotid artery after interruption of blood flow. Atherosclerosis 166 (2003) 233-242
11. Ruusalepp A., Yan Z.Q., Carlsen H., et al. Gene deletion of NF-kappaB p105 enhances neointima formation in a mouse model of carotid artery injury. Cardiovasc Drugs Ther 20 (2006) 103-111
12. Kumar A., and Lindner V. Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow. Arterioscler Thromb Vasc Biol 17 (1997) 2238-2244
13. Frantz S., Hu K., Bayer B., et al. Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction. FASEB J 20 (2006) 1918-1920
14. Kawano S., Kubota T., Monden Y., et al. Blockade of NF-kappaB improves cardiac function and survival after myocardial infarction. Am J Physiol Heart Circ Physiol 291 (2006) H1337-H1344
15. Girerd X., London G., Boutouyrie P., Mourad J.J., Safar M., and Laurent S. Remodeling of the radial artery in response to a chronic increase in shear stress. Hypertension 27 (1996) 799-803
16. Cheng C., Tempel D., van H.R., et al. Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation 113 (2006) 2744-2753
17. Lan Q., Mercurius K.O., and Davies P.F. Stimulation of transcription factors NF kappa B and AP1 in endothelial cells subjected to shear stress. Biochem Biophys Res Commun 201 (1994) 950-956
18. Helderman F., Segers D., de C.R., et al. Effect of shear stress on vascular inflammation and plaque development. Curr Opin Lipidol 18 (2007) 527-533
19. Partridge J., Carlsen H., Enesa K., et al. Laminar shear stress acts as a switch to regulate divergent functions of NF-kappaB in endothelial cells. FASEB J 21 (2007) 3553-3561
20. Passerini A.G., Polacek D.C., Shi C., et al. Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta. Proc Natl Acad Sci USA 101 (2004) 2482-2487
21. Parhar K., Ray A., Steinbrecher U., Nelson C., and Salh B. The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells. Immunology 108 (2003) 502-512
22. Pedersen E.M., Oyre S., Agerbaek M., et al. Distribution of early atherosclerotic lesions in the human abdominal aorta correlates with wall shear stresses measured in vivo. Eur J Vasc Endovasc Surg 18 (1999) 328-333
23. Zhao X.Q., Yuan C., Hatsukami T.S., et al. Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI: a case-control study. Arterioscler Thromb Vasc Biol 21 (2001) 1623-1629
24. Sluijter J.P., Smeets M.B., Velema E., Pasterkamp G., and De Kleijn D.P. Increase in collagen turnover but not in collagen fiber content is associated with flow-induced arterial remodeling. J Vasc Res 41 (2004) 546-555
25. Arras M., Ito W.D., Scholz D., Winkler B., Schaper J., and Schaper W. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J Clin Invest 101 (1998) 40-50
26. Heil M., Ziegelhoeffer T., Pipp F., et al. Blood monocyte concentration is critical for enhancement of collateral artery growth. Am J Physiol Heart Circ Physiol 283 (2002) H2411-H2419
27. Bergmann C.E., Hoefer I.E., Meder B., et al. Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice. J Leukoc Biol 80 (2006) 59-65
28. Yamashita A., Shoji K., Tsuruda T., et al. Medial and adventitial macrophages are associated with expansive atherosclerotic remodeling in rabbit femoral artery. Histol Histopathol 23 (2008) 127-136
29. Sarafi M.N., Garcia-Zepeda E.A., MacLean J.A., Charo I.F., and Luster A.D. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med 185 (1997) 99-109
30. Aoki T., Kataoka H., Shimamura M., et al. NF-kappaB is a key mediator of cerebral aneurysm formation. Circulation 116 (2007) 2830-2840