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Volumn 299, Issue 3, 2010, Pages

Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization

Author keywords

Ghrelin receptor fatty acids

Indexed keywords

CHOLESTEROL; GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR; LINOLEIC ACID; LIPID; OLEIC ACID; UNSATURATED FATTY ACID; AEQUORIN; GHRELIN RECEPTOR;

EID: 77956807621     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00414.2009     Document Type: Article
Times cited : (15)

References (64)
  • 1
    • 38949161289 scopus 로고    scopus 로고
    • Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome
    • Aguilera CM, Gil-Campos M, Canete R, Gil A. Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome. Clin Sci (Lond) 114: 183-193, 2008.
    • (2008) Clin Sci (Lond) , vol.114 , pp. 183-193
    • Aguilera, C.M.1    Gil-Campos, M.2    Canete, R.3    Gil, A.4
  • 2
    • 0035210810 scopus 로고    scopus 로고
    • Allosteric modulation of the human 5-HT(7A) receptor by lipidic amphipathic compounds
    • Alberts GL, Chio CL, Im WB. Allosteric modulation of the human 5-HT(7A) receptor by lipidic amphipathic compounds. Mol Pharmacol 60: 1349-1355, 2001.
    • (2001) Mol Pharmacol , vol.60 , pp. 1349-1355
    • Alberts, G.L.1    Chio, C.L.2    Im, W.B.3
  • 4
    • 0037184054 scopus 로고    scopus 로고
    • Oleate and linoleate enhance the growth-promoting effects of insulin-like growth factor-I through a phospholipase D-dependent pathway in arterial smooth muscle cells
    • Askari B, Carroll MA, Capparelli M, Kramer F, Gerrity RG, Bornfeldt KE. Oleate and linoleate enhance the growth-promoting effects of insulin-like growth factor-I through a phospholipase D-dependent pathway in arterial smooth muscle cells. J Biol Chem 277: 36338-36344, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 36338-36344
    • Askari, B.1    Carroll, M.A.2    Capparelli, M.3    Kramer, F.4    Gerrity, R.G.5    Bornfeldt, K.E.6
  • 6
    • 24144500631 scopus 로고    scopus 로고
    • Sterol structure determines miscibility versus melting transitions in lipid vesicles
    • Beattie ME, Veatch SL, Stottrup BL, Keller SL. Sterol structure determines miscibility versus melting transitions in lipid vesicles. Biophys J 89: 1760-1768, 2005.
    • (2005) Biophys J , vol.89 , pp. 1760-1768
    • Beattie, M.E.1    Veatch, S.L.2    Stottrup, B.L.3    Keller, S.L.4
  • 7
    • 15544387138 scopus 로고    scopus 로고
    • Consequences of lipid raft association on G-protein-coupled receptor function
    • Becher A, McIlhinney RA. Consequences of lipid raft association on G-protein-coupled receptor function. Biochem Soc Symp: 151-164, 2005.
    • (2005) Biochem Soc Symp , pp. 151-164
    • Becher, A.1    McIlhinney, R.A.2
  • 9
    • 64649087039 scopus 로고    scopus 로고
    • Mice with hyperghrelinemia are hyperphagic and glucose intolerant and have reduced leptin sensitivity
    • Bewick GA, Kent A, Campbell D, Patterson M, Ghatei MA, Bloom SR, Gardiner JV. Mice with hyperghrelinemia are hyperphagic and glucose intolerant and have reduced leptin sensitivity. Diabetes 58: 840-846, 2009.
    • (2009) Diabetes , vol.58 , pp. 840-846
    • Bewick, G.A.1    Kent, A.2    Campbell, D.3    Patterson, M.4    Ghatei, M.A.5    Bloom, S.R.6    Gardiner, J.V.7
  • 10
    • 33748752139 scopus 로고    scopus 로고
    • Impact of impaired receptor internalization on calcium homeostasis in knock-in mice expressing a phosphorylation-deficient parathyroid hormone (PTH)/PTH-related peptide receptor
    • Bounoutas GS, Tawfeek H, Fröhlich LF, Chung UI, Abou-Samra AB. Impact of impaired receptor internalization on calcium homeostasis in knock-in mice expressing a phosphorylation-deficient parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology 147: 4674-4679, 2006.
    • (2006) Endocrinology , vol.147 , pp. 4674-4679
    • Bounoutas, G.S.1    Tawfeek, H.2    Fröhlich, L.F.3    Chung, U.I.4    Abou-Samra, A.B.5
  • 12
    • 0023220137 scopus 로고
    • Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells
    • DOI 10.1016/0167-4889(87)90189-3
    • Bruneau C, Hubert P, Waksman A, Beck JP, Staedel-Flaig C. Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells. Biochim Biophys Acta 928: 297-304, 1987. (Pubitemid 17116161)
    • (1987) Biochimica et Biophysica Acta - Molecular Cell Research , vol.928 , Issue.3 , pp. 297-304
    • Bruneau, C.1    Hubert, P.2    Waksman, A.3
  • 14
    • 0842313044 scopus 로고    scopus 로고
    • Desensitization and Endocytosis Mechanisms of Ghrelin-Activated Growth Hormone Secretagogue Receptor 1a
    • DOI 10.1210/en.2003-0974
    • Camiña JP, Carreira MC, El Messari S, Llorens-Cortes C, Smith RG, Casanueva FF. Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a. Endocrinology 145: 930-940, 2004. (Pubitemid 38183837)
    • (2004) Endocrinology , vol.145 , Issue.2 , pp. 930-940
    • Camina, J.P.1    Carreira, M.C.2    Messari, S.E.3    Llorens-Cortes, C.4    Smith, R.G.5    Casanueva, F.F.6
  • 17
    • 0015124395 scopus 로고
    • High-frequency oscillation of blood free fatty acid levels in man
    • Court JM, Dunlop ME, Leonard RF. High-frequency oscillation of blood free fatty acid levels in man. J Appl Physiol 31: 345-347, 1971.
    • (1971) J Appl Physiol , vol.31 , pp. 345-347
    • Court, J.M.1    Dunlop, M.E.2    Leonard, R.F.3
  • 19
    • 33847378878 scopus 로고    scopus 로고
    • The membrane and lipids as integral participants in signal transduction: Lipid signal transduction for the non-lipid biochemist
    • Eyster KM. The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist. Adv Physiol Educ 31: 5-16, 2007.
    • (2007) Adv Physiol Educ , vol.31 , pp. 5-16
    • Eyster, K.M.1
  • 20
    • 1442358521 scopus 로고    scopus 로고
    • Membrane cholesterol and the regulation of signal transduction
    • DOI 10.1042/BST0320065
    • Fielding CJ, Fielding PE. Membrane cholesterol and the regulation of signal transduction. Biochem Soc Trans 32: 65-69, 2004. (Pubitemid 38283015)
    • (2004) Biochemical Society Transactions , vol.32 , Issue.1 , pp. 65-69
    • Fielding, C.J.1    Fielding, P.E.2
  • 21
    • 0037429690 scopus 로고    scopus 로고
    • Relationship between cholesterol trafficking and signaling in rafts and caveolae
    • Fielding CJ, Fielding PE. Relationship between cholesterol trafficking and signaling in rafts and caveolae. Biochim Biophys Acta 1610: 219-228, 2003.
    • (2003) Biochim Biophys Acta , vol.1610 , pp. 219-228
    • Fielding, C.J.1    Fielding, P.E.2
  • 22
    • 0037944235 scopus 로고    scopus 로고
    • Effects of oleic acid and its congeners, elaidic and stearic acids, on the structural properties of phosphatidylethanolamine membranes
    • Funari SS, Barcelo F, Escriba PV. Effects of oleic acid and its congeners, elaidic and stearic acids, on the structural properties of phosphatidylethanolamine membranes. J Lipid Res 44: 567-575, 2003.
    • (2003) J Lipid Res , vol.44 , pp. 567-575
    • Funari, S.S.1    Barcelo, F.2    Escriba, P.V.3
  • 23
    • 34547157499 scopus 로고    scopus 로고
    • Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R)
    • Gauna C, van de Zande B, van Kerkwijk A, Themmen AP, van der Lely AJ, Delhanty PJ. Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R). Mol Cell Endocrinol 274: 30-34, 2007.
    • (2007) Mol Cell Endocrinol , vol.274 , pp. 30-34
    • Gauna, C.1    Van De Zande, B.2    Van Kerkwijk, A.3    Themmen, A.P.4    Van Der Lely, A.J.5    Delhanty, P.J.6
  • 24
    • 2142797806 scopus 로고
    • Manipulation of the phospholipid composition of tissue culture cells
    • Glaser M, Ferguson KA, Vagelos PR. Manipulation of the phospholipid composition of tissue culture cells. Proc Natl Acad Sci USA 71: 4072-4076, 1974.
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 4072-4076
    • Glaser, M.1    Ferguson, K.A.2    Vagelos, P.R.3
  • 25
    • 36849039489 scopus 로고    scopus 로고
    • Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor
    • DOI 10.1210/me.2007-0254
    • Holliday ND, Holst B, Rodionova EA, Schwartz TW, Cox HM. Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor. Mol Endocrinol 21: 3100-3112, 2007. (Pubitemid 350223518)
    • (2007) Molecular Endocrinology , vol.21 , Issue.12 , pp. 3100-3112
    • Holliday, N.D.1    Holst, B.2    Rodionova, E.A.3    Schwartz, T.W.4    Cox, H.M.5
  • 26
    • 0242330291 scopus 로고    scopus 로고
    • High constitutive signaling of the ghrelin receptor - Identification of a potent inverse agonist
    • Holst B, Cygankiewicz A, Jensen TH, Ankersen M, Schwartz TW. High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist. Mol Endocrinol 17: 2201-2210, 2003.
    • (2003) Mol Endocrinol , vol.17 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Jensen, T.H.3    Ankersen, M.4    Schwartz, T.W.5
  • 28
  • 30
    • 33645877973 scopus 로고    scopus 로고
    • Human melanocortin receptor 2 expression and functionality: Effects of protein kinase a and protein kinase C on desensitization and internalization
    • Kilianova Z, Basora N, Kilian P, Payet MD, Gallo-Payet N. Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. Endocrinology 147: 2325-2337, 2006.
    • (2006) Endocrinology , vol.147 , pp. 2325-2337
    • Kilianova, Z.1    Basora, N.2    Kilian, P.3    Payet, M.D.4    Gallo-Payet, N.5
  • 31
    • 0034463062 scopus 로고    scopus 로고
    • The C-terminal tail of the rat lutropin/choriogonadotropin (CG) receptor independently modulates human (h)CG-induced internalization of the cell surface receptor and the lysosomal targeting of the internalized hCG-receptor complex
    • Kishi M, Ascoli M. The C-terminal tail of the rat lutropin/ choriogonadotropin (CG) receptor independently modulates human (h)CG-induced internalization of the cell surface receptor and the lysosomal targeting of the internalized hCG-receptor complex. Mol Endocrinol 14: 926-936, 2000.
    • (2000) Mol Endocrinol , vol.14 , pp. 926-936
    • Kishi, M.1    Ascoli, M.2
  • 32
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev 85: 495-522, 2005.
    • (2005) Physiol Rev , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 34
    • 0942287339 scopus 로고    scopus 로고
    • Metabolic regulation of growth hormone by free fatty acids, somatostatin, and ghrelin in HIV-lipodystrophy
    • Koutkia P, Meininger G, Canavan B, Breu J, Grinspoon S. Metabolic regulation of growth hormone by free fatty acids, somatostatin, and ghrelin in HIV-lipodystrophy. Am J Physiol Endocrinol Metab 286: E296-E303, 2004.
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • Koutkia, P.1    Meininger, G.2    Canavan, B.3    Breu, J.4    Grinspoon, S.5
  • 35
    • 0028361732 scopus 로고
    • 2-stimulated adenylate cyclase activity in a model for atopy
    • DOI 10.1016/0898-6568(94)90076-0
    • Loesberg C, Spence S, Nijkamp FP, Houslay MD. Dietary linoleic acid-induced changes in respiratory beta-adrenergic receptor function and the form of arrhenius plots of isoprenaline- and prostaglandin E2-stimulated adenylate cyclase activity in a model for atopy. Cell Signal 6: 187-199, 1994. (Pubitemid 24185998)
    • (1994) Cellular Signalling , vol.6 , Issue.2 , pp. 187-199
    • Loesberg, C.1    Spence, S.2    Nijkamp, F.P.3    Houslay, M.D.4
  • 36
    • 54049107339 scopus 로고    scopus 로고
    • Brain lipogenesis and regulation of energy metabolism
    • Lopez M, Vidal-Puig A. Brain lipogenesis and regulation of energy metabolism. Curr Opin Clin Nutr Metab Care 11: 483-490, 2008.
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , pp. 483-490
    • Lopez, M.1    Vidal-Puig, A.2
  • 37
    • 33646864114 scopus 로고    scopus 로고
    • Membrane and protein interactions of oxysterols
    • Massey JB. Membrane and protein interactions of oxysterols. Curr Opin Lipidol 17: 296-301, 2006.
    • (2006) Curr Opin Lipidol , vol.17 , pp. 296-301
    • Massey, J.B.1
  • 38
    • 0032964210 scopus 로고    scopus 로고
    • Incorporation of exogenous lipids modulates insulin signaling in the hepatoma cell line, HepG2
    • Meuillet EJ, Leray V, Hubert P, Leray C, Cremel G. Incorporation of exogenous lipids modulates insulin signaling in the hepatoma cell line, HepG2. Biochim Biophys Acta 1454: 38-48, 1999.
    • (1999) Biochim Biophys Acta , vol.1454 , pp. 38-48
    • Meuillet, E.J.1    Leray, V.2    Hubert, P.3    Leray, C.4    Cremel, G.5
  • 39
    • 0034695484 scopus 로고    scopus 로고
    • Lipid-dependent targeting of G proteins into rafts
    • Moffett S, Brown DA, Linder ME. Lipid-dependent targeting of G proteins into rafts. J Biol Chem 275: 2191-2198, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 2191-2198
    • Moffett, S.1    Brown, D.A.2    Linder, M.E.3
  • 41
    • 18844414312 scopus 로고    scopus 로고
    • Enhanced serum cholesterol and triglyceride levels in bulimia nervosa: Relationships to psychiatric comorbidity, psychopathology and hormonal variables
    • Monteleone P, Santonastaso P, Pannuto M, Favaro A, Caregaro L, Castaldo E, Zanetti T, Maj M. Enhanced serum cholesterol and triglyceride levels in bulimia nervosa: relationships to psychiatric comorbidity, psychopathology and hormonal variables. Psychiatry Res 134: 267-273, 2005.
    • (2005) Psychiatry Res , vol.134 , pp. 267-273
    • Monteleone, P.1    Santonastaso, P.2    Pannuto, M.3    Favaro, A.4    Caregaro, L.5    Castaldo, E.6    Zanetti, T.7    Maj, M.8
  • 42
    • 0030807432 scopus 로고    scopus 로고
    • Direct modulation of G-proteins by polyunsaturated fatty acids: A novel eicosanoid-independent regulatory mechanism in the developing lung
    • Mukhopadhyay S, Ramminger SJ, McLaughlin M, Gambling L, Olver RE, Kemp PJ. Direct modulation of G-proteins by polyunsaturated fatty acids: a novel eicosanoid-independent regulatory mechanism in the developing lung. Biochem J 326: 725-730, 1997. (Pubitemid 27438045)
    • (1997) Biochemical Journal , vol.326 , Issue.3 , pp. 725-730
    • Mukhopadhyay, S.1    Ramminger, S.J.2    McLaughlin, M.3    Gambling, L.4    Olver, R.E.5    Kemp, P.J.6
  • 43
    • 0030936492 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase II
    • Nishizaki T, Ikeuchi Y, Matsuoka T, Sumikawa K. Oleic acid enhances ACh receptor currents by activation of Ca2+/calmodulin-dependent protein kinase II. Neuroreport 8: 597-601, 1997. (Pubitemid 27128200)
    • (1997) NeuroReport , vol.8 , Issue.3 , pp. 597-601
    • Nishizaki, T.1    Ikeuchi, Y.2    Matsuoka, T.3    Sumikawa, K.4
  • 44
    • 0030981895 scopus 로고    scopus 로고
    • Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid
    • Nishizaki T, Ikeuchi Y, Matsuoka T, Sumikawa K. Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. Brain Res 751: 253-258, 1997.
    • (1997) Brain Res , vol.751 , pp. 253-258
    • Nishizaki, T.1    Ikeuchi, Y.2    Matsuoka, T.3    Sumikawa, K.4
  • 45
    • 0035971086 scopus 로고    scopus 로고
    • Cholesterol Depletion Disrupts Caveolae and Insulin Receptor Signaling for Metabolic Control via Insulin Receptor Substrate-1, but Not for Mitogen-activated Protein Kinase Control
    • DOI 10.1074/jbc.M007454200
    • Parpal S, Karlsson M, Thorn H, Stralfors P. Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control. J Biol Chem 276: 9670-9678, 2001. (Pubitemid 37391862)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.13 , pp. 9670-9678
    • Parpal, S.1    Karlsson, M.2    Thorn, H.3    Stralfors, P.4
  • 46
    • 0032034459 scopus 로고    scopus 로고
    • Cis-unsaturated free fatty acids block VIP-mediated GH and PRL secretion by perturbing the cAMP/protein kinase A pathway
    • Pérez FR, Camiña JP, Menéndez C, Beiras A, Casabiell X, Casanueva FF. Cis-unsaturated free fatty acids block VIP-mediated GH and PRL secretion by perturbing the cAMP/protein kinase A pathway. Pituitary 1: 25-32, 1998.
    • (1998) Pituitary , vol.1 , pp. 25-32
    • Pérez, F.R.1    Camiña, J.P.2    Menéndez, C.3    Beiras, A.4    Casabiell, X.5    Casanueva, F.F.6
  • 47
    • 0031024191 scopus 로고    scopus 로고
    • Cisunsaturated free fatty acids block growth hormone and prolactin secretion in thyrotropin-releasing hormone-stimulated GH3 cells by perturbing the function of plasma membrane integral proteins
    • Pérez FR, Casabiell X, Camiña JP, Zugaza JL, Casanueva FF. cisunsaturated free fatty acids block growth hormone and prolactin secretion in thyrotropin-releasing hormone-stimulated GH3 cells by perturbing the function of plasma membrane integral proteins. Endocrinology 138: 264-272, 1997.
    • (1997) Endocrinology , vol.138 , pp. 264-272
    • Pérez, F.R.1    Casabiell, X.2    Camiña, J.P.3    Zugaza, J.L.4    Casanueva, F.F.5
  • 48
    • 0041494100 scopus 로고    scopus 로고
    • Lipid rafts: Bringing order to chaos
    • Pike LJ. Lipid rafts: bringing order to chaos. J Lipid Res 44: 655-667, 2003.
    • (2003) J Lipid Res , vol.44 , pp. 655-667
    • Pike, L.J.1
  • 49
    • 6344231396 scopus 로고    scopus 로고
    • Leydig cell hypoplasia: Absent luteinizing hormone receptor cell surface expression caused by a novel homozygous mutation in the extracellular domain
    • Richter-Unruh A, Verhoef-Post M, Malak S, Homoki J, Hauffa BP, Themmen AP. Leydig cell hypoplasia: absent luteinizing hormone receptor cell surface expression caused by a novel homozygous mutation in the extracellular domain. J Clin Endocrinol Metab 89: 5161-5167, 2004.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5161-5167
    • Richter-Unruh, A.1    Verhoef-Post, M.2    Malak, S.3    Homoki, J.4    Hauffa, B.P.5    Themmen, A.P.6
  • 50
    • 31444450221 scopus 로고    scopus 로고
    • Internalization and desensitization of the oxytocin receptor is inhibited by dynamin and clathrin mutants in human embryonic kidney 293 cells
    • DOI 10.1210/me.2005-0031
    • Smith MP, Ayad VJ, Mundell SJ, McArdle CA, Kelly E, López Bernal A. Internalization and desensitization of the oxytocin receptor is inhibited by Dynamin and clathrin mutants in human embryonic kidney 293 cells. Mol Endocrinol 20: 379-388, 2006. (Pubitemid 43152511)
    • (2006) Molecular Endocrinology , vol.20 , Issue.2 , pp. 379-388
    • Smith, M.P.1    Ayad, V.J.2    Mundell, S.J.3    McArdle, C.A.4    Kelly, E.5    Lopez Bernal, A.6
  • 51
    • 0242580169 scopus 로고    scopus 로고
    • Deletion of Ghrelin Impairs neither Growth nor Appetite
    • DOI 10.1128/MCB.23.22.7973-7981.2003
    • Sun Y, Ahmed S, Smith RG. Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol 23: 7973-7981, 2003. (Pubitemid 37377491)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.22 , pp. 7973-7981
    • Sun, Y.1    Ahmed, S.2    Smith, R.G.3
  • 52
    • 33646141847 scopus 로고    scopus 로고
    • Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    • Sun Y, Asnicar M, Saha PK, Chan L, Smith RG. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 3: 379-386, 2006.
    • (2006) Cell Metab , vol.3 , pp. 379-386
    • Sun, Y.1    Asnicar, M.2    Saha, P.K.3    Chan, L.4    Smith, R.G.5
  • 53
    • 38549133092 scopus 로고    scopus 로고
    • Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance
    • Sun Y, Butte NF, Garcia JM, Smith RG. Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology 149: 843-850, 2008.
    • (2008) Endocrinology , vol.149 , pp. 843-850
    • Sun, Y.1    Butte, N.F.2    Garcia, J.M.3    Smith, R.G.4
  • 55
    • 0036139163 scopus 로고    scopus 로고
    • Phosphorylation of the receptor for PTH and PTHrP is required for internalization and regulates receptor signaling
    • Tawfeek HA, Qian F, Abou-Samra AB. Phosphorylation of the receptor for PTH and PTHrP is required for internalization and regulates receptor signaling. Mol Endocrinol 16: 1-13, 2002.
    • (2002) Mol Endocrinol , vol.16 , pp. 1-13
    • Tawfeek, H.A.1    Qian, F.2    Abou-Samra, A.B.3
  • 58
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • van der Lely AJ, Tschöp M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25: 426-457, 2004.
    • (2004) Endocr Rev , vol.25 , pp. 426-457
    • Van Der Lely, A.J.1    Tschöp, M.2    Heiman, M.L.3    Ghigo, E.4
  • 59
    • 0028225462 scopus 로고
    • SREBP-1, a membrane-bound transcription factor released by sterol- Regulated proteolysis
    • DOI 10.1016/0092-8674(94)90234-8
    • Wang X, Sato R, Brown MS, Hua X, Goldstein JL. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77: 53-62, 1994. (Pubitemid 24184687)
    • (1994) Cell , vol.77 , Issue.1 , pp. 53-62
    • Wang, X.1    Sato, R.2    Brown, M.S.3    Hua, X.4    Goldstein, J.L.5
  • 60
    • 0029797120 scopus 로고    scopus 로고
    • Unsaturated free fatty acids increase benzodiazepine receptor agonist binding depending on the subunit composition of the GABAA receptor complex
    • Witt MR, Westh-Hansen SE, Rasmussen PB, Hastrup S, Nielsen M. Unsaturated free fatty acids increase benzodiazepine receptor agonist binding depending on the subunit composition of the GABAA receptor complex. J Neurochem 67: 2141-2145, 1996.
    • (1996) J Neurochem , vol.67 , pp. 2141-2145
    • Witt, M.R.1    Westh-Hansen, S.E.2    Rasmussen, P.B.3    Hastrup, S.4    Nielsen, M.5
  • 61
    • 13844269138 scopus 로고    scopus 로고
    • Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses
    • DOI 10.1016/j.molbrainres.2004.10.031
    • Yaguchi T, Yamamoto S, Nagata T, Kanno T, Tanaka A, Nishizaki T. Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses. Brain Res Mol Brain Res 133: 320-324, 2005. (Pubitemid 40248423)
    • (2005) Molecular Brain Research , vol.133 , Issue.2 , pp. 320-324
    • Yaguchi, T.1    Yamamoto, S.2    Nagata, T.3    Kanno, T.4    Tanaka, A.5    Nishizaki, T.6
  • 62
    • 34249064912 scopus 로고    scopus 로고
    • Use of cyclodextrins to manipulate plasma membrane cholesterol content: Evidence, misconceptions and control strategies
    • Zidovetzki R, Levitan I. Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies. Biochim Biophys Acta 1768: 1311-1324, 2007.
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 1311-1324
    • Zidovetzki, R.1    Levitan, I.2
  • 64
    • 0029161816 scopus 로고
    • Pretreatment with oleic acid accelerates the entrance into the mitotic cycle of EGF-stimulated fibroblasts
    • Zugaza JL, Casabiell XA, Bokser L, Eiras A, Beiras A, Casanueva FF. Pretreatment with oleic acid accelerates the entrance into the mitotic cycle of EGF-stimulated fibroblasts. Exp Cell Res 219: 54-63, 1995.
    • (1995) Exp Cell Res , vol.219 , pp. 54-63
    • Zugaza, J.L.1    Casabiell, X.A.2    Bokser, L.3    Eiras, A.4    Beiras, A.5    Casanueva, F.F.6


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