메뉴 건너뛰기




Volumn 7, Issue C, 1999, Pages 25-57

Vascular Endothelial Growth Factor Molecular and Biological Aspects

Author keywords

[No Author keywords available]

Indexed keywords


EID: 77956802838     PISSN: 15692590     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1569-2590(08)60162-7     Document Type: Article
Times cited : (10)

References (211)
  • 1
    • 0028123090 scopus 로고
    • Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
    • Adamis A.P., Miller J.W., Bernal M.T., D'Amico D.J., Folkman J., Yeo T.K., and Yeo K.T. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am. J. Ophthalmol. 118 (1994) 445-450
    • (1994) Am. J. Ophthalmol. , vol.118 , pp. 445-450
    • Adamis, A.P.1    Miller, J.W.2    Bernal, M.T.3    D'Amico, D.J.4    Folkman, J.5    Yeo, T.K.6    Yeo, K.T.7
  • 4
    • 0028786651 scopus 로고
    • Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
    • Aiello L.P., Pierce E.A., Foley E.D., Takagi H., Chen H., Riddle L., Ferrara N., King G.L., and Smith L.E. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 10457-10461
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 10457-10461
    • Aiello, L.P.1    Pierce, E.A.2    Foley, E.D.3    Takagi, H.4    Chen, H.5    Riddle, L.6    Ferrara, N.7    King, G.L.8    Smith, L.E.9
  • 7
    • 84959830787 scopus 로고
    • Vascular reactions of normal and malignant tissues in vivo. I. Vascular recations of mice to wounds and to normal and neoplastic transplants
    • Algire G.H., and Chalkley H.W. Vascular reactions of normal and malignant tissues in vivo. I. Vascular recations of mice to wounds and to normal and neoplastic transplants. J. Natl. Cancer Inst. 6 (1945) 73-85
    • (1945) J. Natl. Cancer Inst. , vol.6 , pp. 73-85
    • Algire, G.H.1    Chalkley, H.W.2
  • 8
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon T., Hemo I., Itin A., Pe'er J., Stone J., and Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nature Med. 1 (1995) 1024-1028
    • (1995) Nature Med. , vol.1 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3    Pe'er, J.4    Stone, J.5    Keshet, E.6
  • 9
    • 0029028527 scopus 로고
    • Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery
    • Asahara T., Bauters C., Pastore C., Kearney M., Rossow S., Bunting S., Ferrara N., Symes J.F., and Isner J.M. Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery. Circulation 91 (1995) 2793-2801
    • (1995) Circulation , vol.91 , pp. 2793-2801
    • Asahara, T.1    Bauters, C.2    Pastore, C.3    Kearney, M.4    Rossow, S.5    Bunting, S.6    Ferrara, N.7    Symes, J.F.8    Isner, J.M.9
  • 10
    • 0028824336 scopus 로고
    • Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor121
    • Asano M., Yukita A., Matsumoto T., Kondo S., and Suzuki H. Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor121. Cancer Res. 55 (1995) 5296-5301
    • (1995) Cancer Res. , vol.55 , pp. 5296-5301
    • Asano, M.1    Yukita, A.2    Matsumoto, T.3    Kondo, S.4    Suzuki, H.5
  • 11
    • 0028288687 scopus 로고
    • Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor
    • Banai S., Jaktlish M.T., Shou M., Lazarous D., Scheinowitz M., Biro S., Epstein S., and Unger E. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor. Circulation (1994) 2183-2189
    • (1994) Circulation , pp. 2183-2189
    • Banai, S.1    Jaktlish, M.T.2    Shou, M.3    Lazarous, D.4    Scheinowitz, M.5    Biro, S.6    Epstein, S.7    Unger, E.8
  • 12
    • 0028030470 scopus 로고
    • Upregulation of vascular endothelial growth factor expression induced by myocardial ischemia: Implications for coronary angiogenesis
    • Banai S., Shweiki D., Pinson A., Chandra M., Lazarovich G., and Keshet E. Upregulation of vascular endothelial growth factor expression induced by myocardial ischemia: Implications for coronary angiogenesis. Cardiovasc. Res. 28 (1994) 1176-1179
    • (1994) Cardiovasc. Res. , vol.28 , pp. 1176-1179
    • Banai, S.1    Shweiki, D.2    Pinson, A.3    Chandra, M.4    Lazarovich, G.5    Keshet, E.6
  • 13
    • 0029867554 scopus 로고    scopus 로고
    • Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    • Barleon B., Sozzani S., Zhou D., Weich H.A., Mantovani A., and Marme D. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87 (1996) 3336-3343
    • (1996) Blood , vol.87 , pp. 3336-3343
    • Barleon, B.1    Sozzani, S.2    Zhou, D.3    Weich, H.A.4    Mantovani, A.5    Marme, D.6
  • 15
    • 0028999602 scopus 로고
    • Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor
    • Bauters C., Asahara T., Zheng L.P., Takeshita S., Bunting S., Ferrara N., Symes J.F., and Isner J.M. Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor. Circulation 91 (1995) 2802-2809
    • (1995) Circulation , vol.91 , pp. 2802-2809
    • Bauters, C.1    Asahara, T.2    Zheng, L.P.3    Takeshita, S.4    Bunting, S.5    Ferrara, N.6    Symes, J.F.7    Isner, J.M.8
  • 16
    • 0029083832 scopus 로고
    • Induction of vascular endothelial growth factor expression in synovial fibroblasts
    • Ben-Av P., Crofford L.J., Wilder R.L., and Hla T. Induction of vascular endothelial growth factor expression in synovial fibroblasts. FEBS Letters 372 (1995) 83-87
    • (1995) FEBS Letters , vol.372 , pp. 83-87
    • Ben-Av, P.1    Crofford, L.J.2    Wilder, R.L.3    Hla, T.4
  • 19
    • 0029816983 scopus 로고    scopus 로고
    • Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy
    • Borgström P., Hillan K.J., Sriramarao P., and Ferrara N. Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res. 56 (1996) 4032-4039
    • (1996) Cancer Res. , vol.56 , pp. 4032-4039
    • Borgström, P.1    Hillan, K.J.2    Sriramarao, P.3    Ferrara, N.4
  • 20
    • 77956798667 scopus 로고    scopus 로고
    • Anti-Vascular endothelial growth factor antibody inhibits angiogenesis and growth of human prostate cancer in vivo
    • Borgström P., Hillan K., Sriramarao P., and Ferrara N. Anti-Vascular endothelial growth factor antibody inhibits angiogenesis and growth of human prostate cancer in vivo. Prostate 1 (1998) 1-10
    • (1998) Prostate , vol.1 , pp. 1-10
    • Borgström, P.1    Hillan, K.2    Sriramarao, P.3    Ferrara, N.4
  • 21
    • 77956837736 scopus 로고    scopus 로고
    • Combination treatment with anti-vascular endothelial growth factor antibody and doxorubicin suppresses growth of breast carcinoma cells
    • Submitted for publication
    • Borgström, P., Hillan, K.J., Sriraramao, P. and Ferrara, N. Combination treatment with anti-vascular endothelial growth factor antibody and doxorubicin suppresses growth of breast carcinoma cells. Submitted for publication.
    • Borgström, P.1    Hillan, K.J.2    Sriraramao, P.3    Ferrara, N.4
  • 22
    • 0029347193 scopus 로고
    • Targeting the mouse genome: a compendium of knockouts (part III)
    • Brandon E.P., Idzerda R.L., and McKnight G.S. Targeting the mouse genome: a compendium of knockouts (part III). Curr. Biol. 5 (1995) 873-881
    • (1995) Curr. Biol. , vol.5 , pp. 873-881
    • Brandon, E.P.1    Idzerda, R.L.2    McKnight, G.S.3
  • 23
    • 0026593331 scopus 로고
    • Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
    • Breier G., Albrecht U., Sterrer S., and Risau W. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 114 (1992) 521-532
    • (1992) Development , vol.114 , pp. 521-532
    • Breier, G.1    Albrecht, U.2    Sterrer, S.3    Risau, W.4
  • 24
    • 0030030668 scopus 로고    scopus 로고
    • Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression
    • Brogi E., Schatteman G., Wu T., Kim E.A., Varticovski L., Keyt B., and Isner J.M. Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression. J. Clin. Invest. 97 (1996) 469-476
    • (1996) J. Clin. Invest. , vol.97 , pp. 469-476
    • Brogi, E.1    Schatteman, G.2    Wu, T.3    Kim, E.A.4    Varticovski, L.5    Keyt, B.6    Isner, J.M.7
  • 26
    • 0027768808 scopus 로고
    • Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas
    • Brown L.F., Berse B., Jackman R.W., Tognazzi K., Manseau E.J., Dvorak H.F., and Senger D.R. Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am. J. Pathol. 143 (1993) 1255-1262
    • (1993) Am. J. Pathol. , vol.143 , pp. 1255-1262
    • Brown, L.F.1    Berse, B.2    Jackman, R.W.3    Tognazzi, K.4    Manseau, E.J.5    Dvorak, H.F.6    Senger, D.R.7
  • 27
    • 0027482251 scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract
    • Brown L.F., Berse B., Jackman R.W., Tognazzi K., Manseau E.J., Senger D.R., and Dvorak H.F. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res. 53 (1993) 4727-4735
    • (1993) Cancer Res. , vol.53 , pp. 4727-4735
    • Brown, L.F.1    Berse, B.2    Jackman, R.W.3    Tognazzi, K.4    Manseau, E.J.5    Senger, D.R.6    Dvorak, H.F.7
  • 28
    • 0028998682 scopus 로고
    • Increased expression of vascular permeability factor (vascular endothelial growth factor) in bullous pemphigoid, dermatitis herpetiformis, and erythema multiforme
    • Brown L.F., Harrist T.J., Yeo K.T., Stahle-Backdahl M., Jackman R.W., Berse B., Tognazzi K., Dvorak H.F., and Detmar M. Increased expression of vascular permeability factor (vascular endothelial growth factor) in bullous pemphigoid, dermatitis herpetiformis, and erythema multiforme. J. Invest. Dermatol. 104 (1995) 744-749
    • (1995) J. Invest. Dermatol. , vol.104 , pp. 744-749
    • Brown, L.F.1    Harrist, T.J.2    Yeo, K.T.3    Stahle-Backdahl, M.4    Jackman, R.W.5    Berse, B.6    Tognazzi, K.7    Dvorak, H.F.8    Detmar, M.9
  • 31
    • 13344259980 scopus 로고    scopus 로고
    • Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR
    • Cao Y., Chen H., Zhou L., Chiang M.K., Anand Apte B., Weatherbee J.A., Wang Y., Fang F., Flanagan J.G., and Tsang M.L. Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR. J. Biol. Chem. 271 (1996) 3154-3162
    • (1996) J. Biol. Chem. , vol.271 , pp. 3154-3162
    • Cao, Y.1    Chen, H.2    Zhou, L.3    Chiang, M.K.4    Anand Apte, B.5    Weatherbee, J.A.6    Wang, Y.7    Fang, F.8    Flanagan, J.G.9    Tsang, M.L.10
  • 33
    • 0026660977 scopus 로고
    • Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways
    • Claffey K.P., Wilkison W.O., and Spiegelman B.M. Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways. J. Biol. Chem. 267 (1992) 16317-16322
    • (1992) J. Biol. Chem. , vol.267 , pp. 16317-16322
    • Claffey, K.P.1    Wilkison, W.O.2    Spiegelman, B.M.3
  • 34
    • 0039415138 scopus 로고    scopus 로고
    • Prolactins: Novel regulators of ongiogenesis
    • Clapp C., and de la Escalera G.M. Prolactins: Novel regulators of ongiogenesis. News Physiol. Sci. 12 (1997) 231-237
    • (1997) News Physiol. Sci. , vol.12 , pp. 231-237
    • Clapp, C.1    de la Escalera, G.M.2
  • 35
    • 0025688912 scopus 로고
    • Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
    • Clauss M., Gerlach M., Gerlach H., Brett J., Wang F., Familletti P.C., Pan Y.C., Olander J.V., Connolly D.T., and Stern D. Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J. Exp. Med. 172 (1990) 1535-1545
    • (1990) J. Exp. Med. , vol.172 , pp. 1535-1545
    • Clauss, M.1    Gerlach, M.2    Gerlach, H.3    Brett, J.4    Wang, F.5    Familletti, P.C.6    Pan, Y.C.7    Olander, J.V.8    Connolly, D.T.9    Stern, D.10
  • 36
    • 0030046481 scopus 로고    scopus 로고
    • Interleukin 6 induces the expression of vascular endothelial growth factor
    • Cohen T., Nahari D., Cerem L.W., Neufeld G., and Levi B.Z. Interleukin 6 induces the expression of vascular endothelial growth factor. J. Biol. Chem. 271 (1996) 736-741
    • (1996) J. Biol. Chem. , vol.271 , pp. 736-741
    • Cohen, T.1    Nahari, D.2    Cerem, L.W.3    Neufeld, G.4    Levi, B.Z.5
  • 40
    • 0027183674 scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: Rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth
    • Cullinan-Bove K., and Koos R.D. Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: Rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth. Endocrinology 133 (1993) 829-837
    • (1993) Endocrinology , vol.133 , pp. 829-837
    • Cullinan-Bove, K.1    Koos, R.D.2
  • 41
    • 0029047382 scopus 로고
    • Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding
    • Cunningham S.A., Waxham M.N., Arrate P.M., and Brock T.A. Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding. J. Biol. Chem. 270 (1995) 20254-20257
    • (1995) J. Biol. Chem. , vol.270 , pp. 20254-20257
    • Cunningham, S.A.1    Waxham, M.N.2    Arrate, P.M.3    Brock, T.A.4
  • 43
    • 0029790466 scopus 로고    scopus 로고
    • The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade
    • Davis-Smyth T., Chen H., Park J., Presta L.G., and Ferrara N. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade. EMBO J. 15 (1996) 4919-4927
    • (1996) EMBO J. , vol.15 , pp. 4919-4927
    • Davis-Smyth, T.1    Chen, H.2    Park, J.3    Presta, L.G.4    Ferrara, N.5
  • 44
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • de Vries C., Escobedo J.A., Ueno H., Houck K., Ferrara N., and Williams L.T. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255 (1992) 989-991
    • (1992) Science , vol.255 , pp. 989-991
    • de Vries, C.1    Escobedo, J.A.2    Ueno, H.3    Houck, K.4    Ferrara, N.5    Williams, L.T.6
  • 45
    • 0027980960 scopus 로고
    • Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis
    • Detmar M., Brown L.F., Claffey K.P., Yeo K.T., Kocher O., Jackman R.W., Berse B., and Dvorak H.F. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J. Exp. Med. 180 (1994) 1141-1146
    • (1994) J. Exp. Med. , vol.180 , pp. 1141-1146
    • Detmar, M.1    Brown, L.F.2    Claffey, K.P.3    Yeo, K.T.4    Kocher, O.5    Jackman, R.W.6    Berse, B.7    Dvorak, H.F.8
  • 46
    • 0030638653 scopus 로고    scopus 로고
    • Thrombospondin as a regulator of angiogenesis
    • Rosen E., and Goldberg I.D. (Eds), Springer Verlag, New York
    • DiPietro L.A. Thrombospondin as a regulator of angiogenesis. In: Rosen E., and Goldberg I.D. (Eds). Regulation of angiogenesis (1997), Springer Verlag, New York 295-314
    • (1997) Regulation of angiogenesis , pp. 295-314
    • DiPietro, L.A.1
  • 48
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak H.F. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315 (1986) 1650-1659
    • (1986) N. Engl. J. Med. , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 49
    • 0029004025 scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
    • Dvorak H.F., Brown L.F., Detmar M., and Dvorak A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146 (1995) 1029-1039
    • (1995) Am. J. Pathol. , vol.146 , pp. 1029-1039
    • Dvorak, H.F.1    Brown, L.F.2    Detmar, M.3    Dvorak, A.M.4
  • 50
    • 0023610220 scopus 로고
    • Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing
    • Dvorak H.F., Harvey V.S., Estrella P., Brown L.F., McDonagh J., and Dvorak A.M. Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing. Lab. Invest. 57 (1987) 673-686
    • (1987) Lab. Invest. , vol.57 , pp. 673-686
    • Dvorak, H.F.1    Harvey, V.S.2    Estrella, P.3    Brown, L.F.4    McDonagh, J.5    Dvorak, A.M.6
  • 51
    • 0020583152 scopus 로고
    • Transluminal coronary angioplasty and early restenosis
    • Essed C.D., Brand M.V.D., and Becker A.E. Transluminal coronary angioplasty and early restenosis. Brit. Heart J. 49 (1983) 393-402
    • (1983) Brit. Heart J. , vol.49 , pp. 393-402
    • Essed, C.D.1    Brand, M.V.D.2    Becker, A.E.3
  • 52
    • 77956861595 scopus 로고
    • The potential aggressiveness of synovial tissue in rheumatoid arthritis
    • Fassbender H.J., and Simling-Annenfeld M. The potential aggressiveness of synovial tissue in rheumatoid arthritis. J. Pathol. 10 (1983) 845-851
    • (1983) J. Pathol. , vol.10 , pp. 845-851
    • Fassbender, H.J.1    Simling-Annenfeld, M.2
  • 53
    • 0028216495 scopus 로고
    • Vascular permeability factor/endothelial growth factor (VPF/VEGF): Accumulation and expression in human synovial fluids and rheumatoid synovial tissue
    • Fava R.A., Olsen N.J., Spencer-Green G., Yeo K.T., Yeo T.K., Berse B., Jackman R.W., Senger D.R., Dvorak H.F., and Brown L.F. Vascular permeability factor/endothelial growth factor (VPF/VEGF): Accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J. Exp. Med. 180 (1994) 341-346
    • (1994) J. Exp. Med. , vol.180 , pp. 341-346
    • Fava, R.A.1    Olsen, N.J.2    Spencer-Green, G.3    Yeo, K.T.4    Yeo, T.K.5    Berse, B.6    Jackman, R.W.7    Senger, D.R.8    Dvorak, H.F.9    Brown, L.F.10
  • 55
    • 0025949596 scopus 로고
    • The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells
    • Ferrara N., Clapp C., and Weiner R. The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells. Endocr. 129 (1991) 896-900
    • (1991) Endocr. , vol.129 , pp. 896-900
    • Ferrara, N.1    Clapp, C.2    Weiner, R.3
  • 56
    • 0031039243 scopus 로고    scopus 로고
    • The Biology of Vascular Endothelial Growth Factor
    • Ferrara N., and Davis-Smyth T. The Biology of Vascular Endothelial Growth Factor. Endocr. Rev. 18 (1997) 4-25
    • (1997) Endocr. Rev. , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 57
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara N., and Henzel W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 161 (1989) 851-858
    • (1989) Biochem. Biophys. Res. Commun. , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 58
    • 0026505773 scopus 로고
    • Molecular and biological properties of the vascular endothelial growth facmily of proteins
    • Ferrara N., Houck K., Jakeman L., and Leung D.W. Molecular and biological properties of the vascular endothelial growth facmily of proteins. Endocr. Rev. (1992) 18-32
    • (1992) Endocr. Rev. , pp. 18-32
    • Ferrara, N.1    Houck, K.2    Jakeman, L.3    Leung, D.W.4
  • 59
    • 0027460023 scopus 로고
    • Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells
    • Ferrara N., Winer J., Burton T., Rowland A., Siegel M., Phillips H.S., Terrell T., Keller G.A., and Levinson A.D. Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells. J. Clin. Invest. 91 (1993) 160-170
    • (1993) J. Clin. Invest. , vol.91 , pp. 160-170
    • Ferrara, N.1    Winer, J.2    Burton, T.3    Rowland, A.4    Siegel, M.5    Phillips, H.S.6    Terrell, T.7    Keller, G.A.8    Levinson, A.D.9
  • 61
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285 (1971) 1182-1186
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 62
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med. 1 (1995) 27-31
    • (1995) Nature Med. , vol.1 , pp. 27-31
    • Folkman, J.1
  • 64
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong G.H., Rossant J., Gertsenstein M., and Breitman M.L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376 (1995) 66-70
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 66
    • 0029045246 scopus 로고
    • Regulation of VEGF expression in cultured keratinocytes. Implications for normal and impaited wound healing
    • Frank S., Hubner G., Breier G., Longaker M.T., Greenhalg D.G., and Werner S. Regulation of VEGF expression in cultured keratinocytes. Implications for normal and impaited wound healing. J. Biol. Chem. 270 (1995) 12607-12613
    • (1995) J. Biol. Chem. , vol.270 , pp. 12607-12613
    • Frank, S.1    Hubner, G.2    Breier, G.3    Longaker, M.T.4    Greenhalg, D.G.5    Werner, S.6
  • 70
    • 0002418099 scopus 로고
    • Vascular diseases
    • Garner A., and Klintworth G.K. (Eds), Marcel Dekker, New York
    • Garner A. Vascular diseases. In: Garner A., and Klintworth G.K. (Eds). Pathobiology of Ocular Disease (1994), Marcel Dekker, New York
    • (1994) Pathobiology of Ocular Disease
    • Garner, A.1
  • 72
    • 0030751493 scopus 로고    scopus 로고
    • Differential transcriptional regulation of the two VEGF receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia
    • Gerber H.P., Condorelli F., Park J., and Ferrara N. Differential transcriptional regulation of the two VEGF receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J. Biol. Chem. 272 (1997) 23659-23667
    • (1997) J. Biol. Chem. , vol.272 , pp. 23659-23667
    • Gerber, H.P.1    Condorelli, F.2    Park, J.3    Ferrara, N.4
  • 73
    • 0028095127 scopus 로고
    • Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
    • Goldberg M.A., and Schneider T.J. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J. Biol. Chem. 269 (1994) 4355-4361
    • (1994) J. Biol. Chem. , vol.269 , pp. 4355-4361
    • Goldberg, M.A.1    Schneider, T.J.2
  • 74
    • 0027412319 scopus 로고
    • Epidermal growth factor stimulates vascular endothelial growth factor production by malignant glioma cells. A model of glioblastoma multiforme pathophysiology
    • Goldman C., Kim J., Wonf W.-L., King V., Brock T., and Gillespie Y. Epidermal growth factor stimulates vascular endothelial growth factor production by malignant glioma cells. A model of glioblastoma multiforme pathophysiology. Molec. Biol. Cell 4 (1993) 121-133
    • (1993) Molec. Biol. Cell , vol.4 , pp. 121-133
    • Goldman, C.1    Kim, J.2    Wonf, W.-L.3    King, V.4    Brock, T.5    Gillespie, Y.6
  • 75
    • 0025147371 scopus 로고
    • A tumor suppressor-dependent inhibition of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin
    • Good D., Polverini P., Rastinejad F., Beau M., Lemons R., Frazier W., and Bouck N. A tumor suppressor-dependent inhibition of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 6624-6628
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 6624-6628
    • Good, D.1    Polverini, P.2    Rastinejad, F.3    Beau, M.4    Lemons, R.5    Frazier, W.6    Bouck, N.7
  • 76
    • 6544243718 scopus 로고
    • Interventional treatment of peripheral vascular disease
    • Young J.R., Graor R.A., Olin J.W., and Bartholomew J.R. (Eds), Mosby, St. Louis
    • Graor R.A., and Gray B.H. Interventional treatment of peripheral vascular disease. In: Young J.R., Graor R.A., Olin J.W., and Bartholomew J.R. (Eds). Peripheral Vascular Diseases (1991), Mosby, St. Louis
    • (1991) Peripheral Vascular Diseases
    • Graor, R.A.1    Gray, B.H.2
  • 77
    • 0028834638 scopus 로고
    • Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells
    • Grugel S., Finkenzeller G., Weindel K., Barleon B., and Marme D. Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J. Biol. Chem. 270 (1995) 25915-25919
    • (1995) J. Biol. Chem. , vol.270 , pp. 25915-25919
    • Grugel, S.1    Finkenzeller, G.2    Weindel, K.3    Barleon, B.4    Marme, D.5
  • 78
    • 0029155712 scopus 로고
    • Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia
    • Guidi A.J., Abu-Jawdeh G., Berse B., Jackman R.W., Tognazzi K., Dvorak H.F., and Brown L.F. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J. Natl. Cancer Inst. 87 (1995) 1237-1245
    • (1995) J. Natl. Cancer Inst. , vol.87 , pp. 1237-1245
    • Guidi, A.J.1    Abu-Jawdeh, G.2    Berse, B.3    Jackman, R.W.4    Tognazzi, K.5    Dvorak, H.F.6    Brown, L.F.7
  • 79
    • 0029942159 scopus 로고    scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in endometrial carcinoma
    • Guidi A.J., Abu Jawdeh G., Tognazzi K., Dvorak H.F., and Brown L.F. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in endometrial carcinoma. Cancer 78 (1996) 454-460
    • (1996) Cancer , vol.78 , pp. 454-460
    • Guidi, A.J.1    Abu Jawdeh, G.2    Tognazzi, K.3    Dvorak, H.F.4    Brown, L.F.5
  • 80
    • 0028899424 scopus 로고
    • Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation
    • Guo D., Jia Q., Song H.Y., Warren R.S., and Donner D.B. Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation. J. Biol. Chem. 270 (1995) 6729-6733
    • (1995) J. Biol. Chem. , vol.270 , pp. 6729-6733
    • Guo, D.1    Jia, Q.2    Song, H.Y.3    Warren, R.S.4    Donner, D.B.5
  • 82
    • 0028051712 scopus 로고
    • Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart
    • Hashimoto E., Ogita T., Nakaoka T., Matsuoka R., Takao A., and Kira Y. Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart. Am. J. Physiol. 267 (1994) H1948-H1954
    • (1994) Am. J. Physiol. , vol.267
    • Hashimoto, E.1    Ogita, T.2    Nakaoka, T.3    Matsuoka, R.4    Takao, A.5    Kira, Y.6
  • 84
    • 0026395163 scopus 로고
    • The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
    • Houck K.A., Ferrara N., Winer J., Cachianes G., Li B., and Leung D.W. The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocr. 5 (1991) 1806-1814
    • (1991) Mol. Endocr. , vol.5 , pp. 1806-1814
    • Houck, K.A.1    Ferrara, N.2    Winer, J.3    Cachianes, G.4    Li, B.5    Leung, D.W.6
  • 85
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
    • Houck K.A., Leung D.W., Rowland A.M., Winer J., and Ferrara N. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J. Biol. Chem. 267 (1992) 26031-26037
    • (1992) J. Biol. Chem. , vol.267 , pp. 26031-26037
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3    Winer, J.4    Ferrara, N.5
  • 86
    • 0029117223 scopus 로고
    • Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells
    • Ikeda E., Achen M.G., Breier G., and Risau W. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J. Biol. Chem. 270 (1995) 19761-19766
    • (1995) J. Biol. Chem. , vol.270 , pp. 19761-19766
    • Ikeda, E.1    Achen, M.G.2    Breier, G.3    Risau, W.4
  • 90
    • 0027171960 scopus 로고
    • Developmental expression of binding sites and mRNA for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis
    • Jakeman L.B., Armanini M., Philips H.S., and Ferrara N. Developmental expression of binding sites and mRNA for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis. Endocrinology 133 (1993) 848-859
    • (1993) Endocrinology , vol.133 , pp. 848-859
    • Jakeman, L.B.1    Armanini, M.2    Philips, H.S.3    Ferrara, N.4
  • 91
    • 0026502754 scopus 로고
    • Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues
    • Jakeman L.B., Winer J., Bennett G.L., Altar C.A., and Ferrara N. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J. Clin. Invest. 89 (1992) 244-253
    • (1992) J. Clin. Invest. , vol.89 , pp. 244-253
    • Jakeman, L.B.1    Winer, J.2    Bennett, G.L.3    Altar, C.A.4    Ferrara, N.5
  • 93
    • 0030026897 scopus 로고    scopus 로고
    • A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
    • Joukov V., Pajusola K., Kaipainen A., Chilov D., Lahtinen I., Kukk E., Saksela O., Kalkkinen N., and Alitalo K. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 15 (1996) 1751-1758
    • (1996) EMBO J. , vol.15 , pp. 1751-1758
    • Joukov, V.1    Pajusola, K.2    Kaipainen, A.3    Chilov, D.4    Lahtinen, I.5    Kukk, E.6    Saksela, O.7    Kalkkinen, N.8    Alitalo, K.9
  • 95
    • 0028982229 scopus 로고
    • Expression of vascular permeability factor/vascular endothelial growth factor by human granulosa and theca lutein cells. Role in corpus luteum development
    • Kamat B.R., Brown L.F., Manseau E.J., Senger D.R., and Dvorak H.F. Expression of vascular permeability factor/vascular endothelial growth factor by human granulosa and theca lutein cells. Role in corpus luteum development. Am. J. Pathol. 146 (1995) 157-165
    • (1995) Am. J. Pathol. , vol.146 , pp. 157-165
    • Kamat, B.R.1    Brown, L.F.2    Manseau, E.J.3    Senger, D.R.4    Dvorak, H.F.5
  • 96
    • 0030582384 scopus 로고    scopus 로고
    • Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR
    • Kendall R.L., Wang G., and Thomas K.A. Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem. Biophys. Res. Commun. 226 (1996) 324-328
    • (1996) Biochem. Biophys. Res. Commun. , vol.226 , pp. 324-328
    • Kendall, R.L.1    Wang, G.2    Thomas, K.A.3
  • 97
    • 0029937679 scopus 로고    scopus 로고
    • The carboxyl-terminal domain (111--165) of vascular endothelial growth factor is critical for its mitogenic potency
    • Keyt B.A., Berleau L.T., Nguyen H.V., Chen H., Heinsohn H., Vandlen R., and Ferrara N. The carboxyl-terminal domain (111--165) of vascular endothelial growth factor is critical for its mitogenic potency. J. Biol. Chem. 271 (1996) 7788-7795
    • (1996) J. Biol. Chem. , vol.271 , pp. 7788-7795
    • Keyt, B.A.1    Berleau, L.T.2    Nguyen, H.V.3    Chen, H.4    Heinsohn, H.5    Vandlen, R.6    Ferrara, N.7
  • 98
    • 0029920944 scopus 로고    scopus 로고
    • Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis
    • Keyt B.A., Nguyen H.V., Berleau L.T., Duarte C.M., Park J., Chen H., and Ferrara N. Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis. J. Biol. Chem. 271 (1996) 5638-5646
    • (1996) J. Biol. Chem. , vol.271 , pp. 5638-5646
    • Keyt, B.A.1    Nguyen, H.V.2    Berleau, L.T.3    Duarte, C.M.4    Park, J.5    Chen, H.6    Ferrara, N.7
  • 99
    • 0027958348 scopus 로고
    • Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression
    • Kieser A., Weich H., Brandner G., Marme D., and Kolch W. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene 9 (1994) 963-969
    • (1994) Oncogene , vol.9 , pp. 963-969
    • Kieser, A.1    Weich, H.2    Brandner, G.3    Marme, D.4    Kolch, W.5
  • 100
    • 0026708632 scopus 로고
    • The vascular endothelial growth factor proteins: Identification of biologically relevant regions by neutralizing monoclonal antibodies
    • Kim K.J., Li B., Houck K., Winer J., and Ferrara N. The vascular endothelial growth factor proteins: Identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors 7 (1992) 53-64
    • (1992) Growth Factors , vol.7 , pp. 53-64
    • Kim, K.J.1    Li, B.2    Houck, K.3    Winer, J.4    Ferrara, N.5
  • 101
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
    • Kim K.J., Li B., Winer J., Armanini M., Gillett N., Phillips H.S., and Ferrara N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 362 (1993) 841-844
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 103
    • 0028295661 scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor is detectable in the sera of tumor-bearing mice and cancer patients
    • Kondo S., Asano M., Matsuo K., Ohmori I., and Suzuki H. Vascular endothelial growth factor/vascular permeability factor is detectable in the sera of tumor-bearing mice and cancer patients. Biochim. Biophys. Acta 1221 (1994) 211-214
    • (1994) Biochim. Biophys. Acta , vol.1221 , pp. 211-214
    • Kondo, S.1    Asano, M.2    Matsuo, K.3    Ohmori, I.4    Suzuki, H.5
  • 104
    • 0027217832 scopus 로고
    • Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries
    • Ku D.D., Zaleski J.K., Liu S., and Brock T.A. Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries. Am. J. Physiol. 265 (1993) H586-H592
    • (1993) Am. J. Physiol. , vol.265
    • Ku, D.D.1    Zaleski, J.K.2    Liu, S.3    Brock, T.A.4
  • 105
  • 106
    • 0029831672 scopus 로고    scopus 로고
    • Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor
    • Kvanta A., Algvere P.V., Berglin L., and Seregard S. Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor. Invest. Ophthalmol. Vis. Sci. 37 (1996) 1929-1934
    • (1996) Invest. Ophthalmol. Vis. Sci. , vol.37 , pp. 1929-1934
    • Kvanta, A.1    Algvere, P.V.2    Berglin, L.3    Seregard, S.4
  • 107
    • 0029962242 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-related protein: A ligand and specific activator of the tyrosine kinase receptor Flt4
    • Lee J., Gray A., Yuan J., Luoh S.M., Avraham H., and Wood W.I. Vascular endothelial growth factor-related protein: A ligand and specific activator of the tyrosine kinase receptor Flt4. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 1988-1992
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 1988-1992
    • Lee, J.1    Gray, A.2    Yuan, J.3    Luoh, S.M.4    Avraham, H.5    Wood, W.I.6
  • 108
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung D.W., Cachianes G., Kuang W.J., Goeddel D.V., and Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246 (1989) 1306-1309
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 109
    • 0030044039 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
    • Levy A.P., Levy N.S., and Goldberg M.A. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J. Biol. Chem. 271 (1996) 2746-2753
    • (1996) J. Biol. Chem. , vol.271 , pp. 2746-2753
    • Levy, A.P.1    Levy, N.S.2    Goldberg, M.A.3
  • 110
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • Levy A.P., Levy N.S., Wegner S., and Goldberg M.A. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J. Biol. Chem. 270 (1995) 13333-13340
    • (1995) J. Biol. Chem. , vol.270 , pp. 13333-13340
    • Levy, A.P.1    Levy, N.S.2    Wegner, S.3    Goldberg, M.A.4
  • 111
  • 113
    • 0029103274 scopus 로고
    • Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer
    • Liu Y., Cox S.R., Morita T., and Kourembanas S. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer. Circ. Res. 77 (1995) 638-643
    • (1995) Circ. Res. , vol.77 , pp. 638-643
    • Liu, Y.1    Cox, S.R.2    Morita, T.3    Kourembanas, S.4
  • 114
    • 0029879849 scopus 로고    scopus 로고
    • Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes
    • Lopez P.F., Sippy B.D., Lambert H.M., Thach A.B., and Hinton D.R. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Invest. Ophthalmol. Vis. Sci. 37 (1996) 855-868
    • (1996) Invest. Ophthalmol. Vis. Sci. , vol.37 , pp. 855-868
    • Lopez, P.F.1    Sippy, B.D.2    Lambert, H.M.3    Thach, A.B.4    Hinton, D.R.5
  • 115
    • 0027979253 scopus 로고
    • Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus
    • Lyttle D.J., Fraser K.M., Flemings S.B., Mercer A.A., and Robinson A.J. Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus. J. Virology 68 (1994) 84-92
    • (1994) J. Virology , vol.68 , pp. 84-92
    • Lyttle, D.J.1    Fraser, K.M.2    Flemings, S.B.3    Mercer, A.A.4    Robinson, A.J.5
  • 116
    • 0027230099 scopus 로고
    • A 24-base-pair sequence 3′ to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer
    • Madan A., and Curtin P.T. A 24-base-pair sequence 3′ to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 3928-3932
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 3928-3932
    • Madan, A.1    Curtin, P.T.2
  • 117
    • 0001199563 scopus 로고    scopus 로고
    • The biphasic effects of transforming growth factor beta in angiogenesis
    • Bicknell R., Lewis C., and Ferrara N. (Eds), Oxford University Press, Oxford
    • Madri J.A., and Sankar S. The biphasic effects of transforming growth factor beta in angiogenesis. In: Bicknell R., Lewis C., and Ferrara N. (Eds). Tumour Angiogenesis (1997), Oxford University Press, Oxford 239-249
    • (1997) Tumour Angiogenesis , pp. 239-249
    • Madri, J.A.1    Sankar, S.2
  • 118
    • 0030066037 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor expression in gastric carcinoma
    • Maeda K., Chung Y.S., Ogawa Y., Takatsuka S., Kang S.M., Ogawa M., Sawada T., and Sowa M. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma. Cancer 77 (1996) 858-963
    • (1996) Cancer , vol.77 , pp. 858-963
    • Maeda, K.1    Chung, Y.S.2    Ogawa, Y.3    Takatsuka, S.4    Kang, S.M.5    Ogawa, M.6    Sawada, T.7    Sowa, M.8
  • 121
    • 0027962667 scopus 로고
    • Detection of vascular endothelial growth factor mRNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy
    • Malecaze F., Clemens S., Simorer-Pinotel V., Mathis A., Chollet P., Favard P., Bayard F., and Plouet J. Detection of vascular endothelial growth factor mRNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch. Ophthal. 112 (1994) 1476-1482
    • (1994) Arch. Ophthal. , vol.112 , pp. 1476-1482
    • Malecaze, F.1    Clemens, S.2    Simorer-Pinotel, V.3    Mathis, A.4    Chollet, P.5    Favard, P.6    Bayard, F.7    Plouet, J.8
  • 122
    • 17544372403 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 down-regulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells
    • Mandriota S.J., Menoud P.A., and Pepper M.S. Transforming growth factor beta 1 down-regulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells. J. Biol. Chem. 271 (1996) 11500-11505
    • (1996) J. Biol. Chem. , vol.271 , pp. 11500-11505
    • Mandriota, S.J.1    Menoud, P.A.2    Pepper, M.S.3
  • 124
    • 0025998533 scopus 로고
    • A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit
    • Matthews W., Jordan C.T., Gavin M., Jenkins N.A., Copeland N.G., and Lemischka I.R. A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 9026-9030
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 9026-9030
    • Matthews, W.1    Jordan, C.T.2    Gavin, M.3    Jenkins, N.A.4    Copeland, N.G.5    Lemischka, I.R.6
  • 125
    • 0029681850 scopus 로고    scopus 로고
    • Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression
    • Mazure N.M., Chen E.Y., Yeh P., Laderoute K.R., and Giaccia A.J. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res. 56 (1996) 3436-3440
    • (1996) Cancer Res. , vol.56 , pp. 3436-3440
    • Mazure, N.M.1    Chen, E.Y.2    Yeh, P.3    Laderoute, K.R.4    Giaccia, A.J.5
  • 126
    • 0030058194 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis
    • McLaren J., Prentice A., Charnock-Jones D.S., and Smith S.K. Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis. Human Reprod. 11 (1996) 220-223
    • (1996) Human Reprod. , vol.11 , pp. 220-223
    • McLaren, J.1    Prentice, A.2    Charnock-Jones, D.S.3    Smith, S.K.4
  • 127
    • 0029793371 scopus 로고    scopus 로고
    • During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium
    • Melder R.J., Koenig G.C., Witwer B.P., Safabakhsh N., Munn L.L., and Jain R.K. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nature Med. 2 (1996) 992-997
    • (1996) Nature Med. , vol.2 , pp. 992-997
    • Melder, R.J.1    Koenig, G.C.2    Witwer, B.P.3    Safabakhsh, N.4    Munn, L.L.5    Jain, R.K.6
  • 128
    • 0030059075 scopus 로고    scopus 로고
    • Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth
    • Melnyk O., Shuman M.A., and Kim K.J. Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth. Cancer-Res. 56 (1996) 921-924
    • (1996) Cancer-Res. , vol.56 , pp. 921-924
    • Melnyk, O.1    Shuman, M.A.2    Kim, K.J.3
  • 129
    • 0000230096 scopus 로고
    • The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders
    • Michaelson I.C. The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders. Trans. Ophthalmol. Soc. U.K. 68 (1948) 137-180
    • (1948) Trans. Ophthalmol. Soc. U.K. , vol.68 , pp. 137-180
    • Michaelson, I.C.1
  • 130
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
    • Millauer B., Shawver L.K., Plate K.H., Risau W., and Ullrich A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367 (1994) 576-579
    • (1994) Nature , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3    Risau, W.4    Ullrich, A.5
  • 131
    • 0027466849 scopus 로고
    • High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
    • Millauer B., Wizigmann Voos S., Schnurch H., Martinez R., Moller N.P., Risau W., and Ullrich A. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72 (1993) 835-846
    • (1993) Cell , vol.72 , pp. 835-846
    • Millauer, B.1    Wizigmann Voos, S.2    Schnurch, H.3    Martinez, R.4    Moller, N.P.5    Risau, W.6    Ullrich, A.7
  • 133
    • 0028147863 scopus 로고
    • Hypoxic stimulation of vascular endothelial growth factor expression in vivo and in vitro
    • Minchenko A., Bauer T., Salceda S., and Caro J. Hypoxic stimulation of vascular endothelial growth factor expression in vivo and in vitro. Lab. Invest. 71 (1994) 374-379
    • (1994) Lab. Invest. , vol.71 , pp. 374-379
    • Minchenko, A.1    Bauer, T.2    Salceda, S.3    Caro, J.4
  • 134
    • 0027461981 scopus 로고
    • Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues
    • Monacci W.T., Merrill M.J., and Oldfield E.H. Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues. Am. J. Physiol. 264 (1993) C995-C1002
    • (1993) Am. J. Physiol. , vol.264
    • Monacci, W.T.1    Merrill, M.J.2    Oldfield, E.H.3
  • 135
    • 0028880451 scopus 로고
    • A novel promoter for vascular endothelial growth factor receptor (flt-1) that confers endothelial-specific gene expression
    • Morishita K., Johnson D.E., and Williams L.T. A novel promoter for vascular endothelial growth factor receptor (flt-1) that confers endothelial-specific gene expression. J. Biol. Chem. 270 (1995) 27948-27953
    • (1995) J. Biol. Chem. , vol.270 , pp. 27948-27953
    • Morishita, K.1    Johnson, D.E.2    Williams, L.T.3
  • 136
    • 0028139239 scopus 로고
    • Vascular endothelial growth factor, platelet-derived growth factor and indulin-like growth factor stimulate angiogenesis in vitro
    • Nicosia R., Nicosia S.V., and Smith M. Vascular endothelial growth factor, platelet-derived growth factor and indulin-like growth factor stimulate angiogenesis in vitro. Am. J. Pathol. 145 (1994) 1023-1029
    • (1994) Am. J. Pathol. , vol.145 , pp. 1023-1029
    • Nicosia, R.1    Nicosia, S.V.2    Smith, M.3
  • 141
    • 0028153737 scopus 로고
    • Vascular permeability factor gene expression in normal and neoplastic human ovaries
    • Olson T.A., Mohanraj D., Carson L.F., and Ramakrishnan S. Vascular permeability factor gene expression in normal and neoplastic human ovaries. Cancer Res. 54 (1994) 276-280
    • (1994) Cancer Res. , vol.54 , pp. 276-280
    • Olson, T.A.1    Mohanraj, D.2    Carson, L.F.3    Ramakrishnan, S.4
  • 142
    • 0026699255 scopus 로고
    • FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines
    • Pajusola K., Aprelikova O., Korhonen J., Kaipainen A., Pertovaara L., Alitalo R., and Alitalo K. FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res. 52 (1992) 5738-5743
    • (1992) Cancer Res. , vol.52 , pp. 5738-5743
    • Pajusola, K.1    Aprelikova, O.2    Korhonen, J.3    Kaipainen, A.4    Pertovaara, L.5    Alitalo, R.6    Alitalo, K.7
  • 143
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • Park J.E., Chen H.H., Winer J., Houck K.A., and Ferrara N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem. 269 (1994) 25646-25654
    • (1994) J. Biol. Chem. , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3    Houck, K.A.4    Ferrara, N.5
  • 144
    • 0027751890 scopus 로고
    • The vascular endothelial growth factor isoforms (VEGF): Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
    • Park J.E., Keller H.-A., and Ferrara N. The vascular endothelial growth factor isoforms (VEGF): Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Molec. Biol. Cell 4 (1993) 1317-1326
    • (1993) Molec. Biol. Cell , vol.4 , pp. 1317-1326
    • Park, J.E.1    Keller, H.-A.2    Ferrara, N.3
  • 145
    • 0030017083 scopus 로고    scopus 로고
    • Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells
    • Patterson C., Perrella M.A., Endege W.O., Yoshizumi M., Lee M.E., and Haber E. Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells. J. Clin. Invest. 98 (1996) 490-496
    • (1996) J. Clin. Invest. , vol.98 , pp. 490-496
    • Patterson, C.1    Perrella, M.A.2    Endege, W.O.3    Yoshizumi, M.4    Lee, M.E.5    Haber, E.6
  • 146
    • 0029147486 scopus 로고
    • Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor
    • Patterson C., Perrella M.A., Hsieh C.M., Yoshizumi M., Lee M.E., and Haber E. Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. J. Biol. Chem. 270 (1995) 23111-23118
    • (1995) J. Biol. Chem. , vol.270 , pp. 23111-23118
    • Patterson, C.1    Perrella, M.A.2    Hsieh, C.M.3    Yoshizumi, M.4    Lee, M.E.5    Haber, E.6
  • 147
    • 0019230758 scopus 로고
    • Studies on retinal neovascularization
    • Patz A. Studies on retinal neovascularization. Invest. Ophthalmol. Vis. Sci. 19 (1980) 1133-1138
    • (1980) Invest. Ophthalmol. Vis. Sci. , vol.19 , pp. 1133-1138
    • Patz, A.1
  • 148
    • 0029920567 scopus 로고    scopus 로고
    • Upregulated expression of vascular endothelial growth factor in proliferative diabetic retinopathy
    • Pe'er J., Folberg R., Itin A., Gnessin H., Hemo I., and Keshet E. Upregulated expression of vascular endothelial growth factor in proliferative diabetic retinopathy. Br. J. Ophthalmol. 80 (1996) 241-245
    • (1996) Br. J. Ophthalmol. , vol.80 , pp. 241-245
    • Pe'er, J.1    Folberg, R.2    Itin, A.3    Gnessin, H.4    Hemo, I.5    Keshet, E.6
  • 150
    • 0024994317 scopus 로고
    • Regulation of hexose transport in aortic endothelial cells by vascular permeability factor and tumor necrosis factor-alpha, but not by insulin
    • Pekala P., Marlow M., Heuvelman D., and Connolly D. Regulation of hexose transport in aortic endothelial cells by vascular permeability factor and tumor necrosis factor-alpha, but not by insulin. J. Biol. Chem. 265 (1990) 18051-18054
    • (1990) J. Biol. Chem. , vol.265 , pp. 18051-18054
    • Pekala, P.1    Marlow, M.2    Heuvelman, D.3    Connolly, D.4
  • 151
    • 0026321129 scopus 로고
    • Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells
    • Pepper M.S., Ferrara N., Orci L., and Montesano R. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem. Biophys. Res. Commun. 181 (1991) 902-906
    • (1991) Biochem. Biophys. Res. Commun. , vol.181 , pp. 902-906
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3    Montesano, R.4
  • 152
    • 0027053487 scopus 로고
    • Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro
    • Pepper M.S., Ferrara N., Orci L., and Montesano R. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem. Biophys. Res. Commun. 189 (1992) 824-831
    • (1992) Biochem. Biophys. Res. Commun. , vol.189 , pp. 824-831
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3    Montesano, R.4
  • 153
    • 0028221238 scopus 로고
    • Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells
    • Pertovaara L., Kaipainen A., Mustonen T., Orpana A., Ferrara N., Saksela O., and Alitalo K. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J. Biol. Chem. 269 (1994) 6271-6274
    • (1994) J. Biol. Chem. , vol.269 , pp. 6271-6274
    • Pertovaara, L.1    Kaipainen, A.2    Mustonen, T.3    Orpana, A.4    Ferrara, N.5    Saksela, O.6    Alitalo, K.7
  • 154
    • 0027424647 scopus 로고
    • Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth
    • Peters K.G., De Vries C., and Williams L.T. Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 8915-8919
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 8915-8919
    • Peters, K.G.1    De Vries, C.2    Williams, L.T.3
  • 155
    • 0027196461 scopus 로고
    • Intense focal expression of vascular endothelial growth factor mRNA in human intracranial neoplasms: Association with regions of necrosis
    • Phillips H.S., Armanini M., Stavrou D., Ferrara N., and Westphal M. Intense focal expression of vascular endothelial growth factor mRNA in human intracranial neoplasms: Association with regions of necrosis. Int. J. Oncol. 2 (1993) 913-919
    • (1993) Int. J. Oncol. , vol.2 , pp. 913-919
    • Phillips, H.S.1    Armanini, M.2    Stavrou, D.3    Ferrara, N.4    Westphal, M.5
  • 156
    • 0025002792 scopus 로고
    • Vascular endothelial growth factor is expressed in rat corpus luteum
    • Phillips H.S., Hains J., Leung D.W., and Ferrara N. Vascular endothelial growth factor is expressed in rat corpus luteum. Endocrinology 127 (1990) 965-967
    • (1990) Endocrinology , vol.127 , pp. 965-967
    • Phillips, H.S.1    Hains, J.2    Leung, D.W.3    Ferrara, N.4
  • 157
    • 0028815295 scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization
    • Pierce E.A., Avery R.L., Foley E.D., Aiello L.P., and Smith L.E. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 905-909
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 905-909
    • Pierce, E.A.1    Avery, R.L.2    Foley, E.D.3    Aiello, L.P.4    Smith, L.E.5
  • 158
    • 0027432324 scopus 로고
    • Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis
    • Plate K.H., Breier G., Millauer B., Ullrich A., and Risau W. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res. 53 (1993) 5822-5827
    • (1993) Cancer Res. , vol.53 , pp. 5822-5827
    • Plate, K.H.1    Breier, G.2    Millauer, B.3    Ullrich, A.4    Risau, W.5
  • 159
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • Plate K.H., Breier G., Weich H.A., and Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359 (1992) 845-848
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 160
    • 0025695869 scopus 로고
    • Characterization of the receptors for vasculotropin on bovine adrenal cortex-derived capillary endothelial cells
    • Plouet J., and Moukadiri H.J. Characterization of the receptors for vasculotropin on bovine adrenal cortex-derived capillary endothelial cells. J. Biol. Chem. 265 (1990) 22071-22075
    • (1990) J. Biol. Chem. , vol.265 , pp. 22071-22075
    • Plouet, J.1    Moukadiri, H.J.2
  • 162
    • 0028933926 scopus 로고
    • Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium
    • Qu H., Nagy J.A., Senger D.R., Dvorak H.F., and Dvorak A.M. Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium. J. Histochem. Cytochem. 43 (1995) 381-389
    • (1995) J. Histochem. Cytochem. , vol.43 , pp. 381-389
    • Qu, H.1    Nagy, J.A.2    Senger, D.R.3    Dvorak, H.F.4    Dvorak, A.M.5
  • 163
    • 0027249239 scopus 로고
    • Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium
    • Quinn T.P., Peters K.G., De Vries C., Ferrara N., and Williams L.T. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 7533-7537
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 7533-7537
    • Quinn, T.P.1    Peters, K.G.2    De Vries, C.3    Ferrara, N.4    Williams, L.T.5
  • 164
    • 0028822834 scopus 로고
    • Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
    • Rak J., Mitsuhashi Y., Bayko L., Filmus J., Shirasawa S., Sasazuki T., and Kerbel R.S. Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis. Cancer Res. 55 (1995) 4575-4580
    • (1995) Cancer Res. , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, Y.2    Bayko, L.3    Filmus, J.4    Shirasawa, S.5    Sasazuki, T.6    Kerbel, R.S.7
  • 165
    • 0026755531 scopus 로고
    • Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary
    • Ravindranath N., Little-Ihrig L., Phillips H.S., Ferrara N., and Zeleznik A.J. Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary. Endocrinology 131 (1992) 254-260
    • (1992) Endocrinology , vol.131 , pp. 254-260
    • Ravindranath, N.1    Little-Ihrig, L.2    Phillips, H.S.3    Ferrara, N.4    Zeleznik, A.J.5
  • 166
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 386 (1997) 671-674
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 167
    • 0029010434 scopus 로고
    • Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
    • Roberts W.G., and Palade G.E. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J. Cell Sci. 108 (1995) 2369-2379
    • (1995) J. Cell Sci. , vol.108 , pp. 2369-2379
    • Roberts, W.G.1    Palade, G.E.2
  • 168
    • 0031045279 scopus 로고    scopus 로고
    • Neovasculature induced by vascular endothelial growth factor is fenestrated
    • Roberts W.G., and Palade G.E. Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res. 57 (1997) 765-772
    • (1997) Cancer Res. , vol.57 , pp. 765-772
    • Roberts, W.G.1    Palade, G.E.2
  • 169
    • 0030636058 scopus 로고    scopus 로고
    • Regulation of angiogenesis by scatter factor
    • Rosen E., and Goldberg I.D. (Eds), Springer Verlag, Berlin
    • Rosen E.M., and Goldberg I.D. Regulation of angiogenesis by scatter factor. In: Rosen E., and Goldberg I.D. (Eds). Regulation of Angiogenesis (1997), Springer Verlag, Berlin 193-208
    • (1997) Regulation of Angiogenesis , pp. 193-208
    • Rosen, E.M.1    Goldberg, I.D.2
  • 170
    • 0029090032 scopus 로고
    • Stimulation by thyroid-stimulating hormone and Grave's immunoglobulin G of vascular endothelial growth factor mRNA expression in human thyroid follicles in vitro and fit mRNA expression in the rat thyroid in vivo
    • Sato K., Yamazaki K., Shizume K., Kanaji Y., Obara T., Ohsumi K., Demura H., Yamaguchi S., and Shibuya M. Stimulation by thyroid-stimulating hormone and Grave's immunoglobulin G of vascular endothelial growth factor mRNA expression in human thyroid follicles in vitro and fit mRNA expression in the rat thyroid in vivo. J. Clin. Invest. 96 (1995) 1295-1302
    • (1995) J. Clin. Invest. , vol.96 , pp. 1295-1302
    • Sato, K.1    Yamazaki, K.2    Shizume, K.3    Kanaji, Y.4    Obara, T.5    Ohsumi, K.6    Demura, H.7    Yamaguchi, S.8    Shibuya, M.9
  • 171
    • 0028798083 scopus 로고
    • A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF
    • Seetharam L., Gotoh N., Maru Y., Neufeld G., Yamaguchi S., and Shibuya M. A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF. Oncogene 10 (1995) 135-147
    • (1995) Oncogene , vol.10 , pp. 135-147
    • Seetharam, L.1    Gotoh, N.2    Maru, Y.3    Neufeld, G.4    Yamaguchi, S.5    Shibuya, M.6
  • 173
    • 0027298573 scopus 로고
    • Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes
    • Shen H., Clauss M., Ryan J., Schmidt A.M., Tijburg P., Borden L., Connolly D., Stern D., and Kao J. Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes. Blood 81 (1993) 2767-2773
    • (1993) Blood , vol.81 , pp. 2767-2773
    • Shen, H.1    Clauss, M.2    Ryan, J.3    Schmidt, A.M.4    Tijburg, P.5    Borden, L.6    Connolly, D.7    Stern, D.8    Kao, J.9
  • 174
    • 0025259592 scopus 로고
    • Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (fit) closely related to the fms family
    • Shibuya M., Yamaguchi S., Yamane A., Ikeda T., Tojo A., Matsushime H., and Sato M. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (fit) closely related to the fms family. Oncogene 8 (1990) 519-527
    • (1990) Oncogene , vol.8 , pp. 519-527
    • Shibuya, M.1    Yamaguchi, S.2    Yamane, A.3    Ikeda, T.4    Tojo, A.5    Matsushime, H.6    Sato, M.7
  • 175
    • 0028222333 scopus 로고
    • In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: Implications for mode of action
    • Shifren J.L., Doldi N., Ferrara N., Mesiano S., and Jaffe R.B. In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: Implications for mode of action. J. Clin. Endocrinol. Metab. 79 (1994) 316-322
    • (1994) J. Clin. Endocrinol. Metab. , vol.79 , pp. 316-322
    • Shifren, J.L.1    Doldi, N.2    Ferrara, N.3    Mesiano, S.4    Jaffe, R.B.5
  • 176
    • 0029829884 scopus 로고    scopus 로고
    • Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: Implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis J
    • Shifren J.L., Tseng J.F., Zaloudek C.J., Ryan I.P., Meng Y.G., Ferrara N., Jaffe R.B., and Taylor R.N. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: Implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis J. Clin. Endocrinol. Metab. 81 (1996) 3112-3118
    • (1996) Clin. Endocrinol. Metab. , vol.81 , pp. 3112-3118
    • Shifren, J.L.1    Tseng, J.F.2    Zaloudek, C.J.3    Ryan, I.P.4    Meng, Y.G.5    Ferrara, N.6    Jaffe, R.B.7    Taylor, R.N.8
  • 177
    • 0029171581 scopus 로고
    • Hypoxic induction of endothelial cell growth factors in retinal cells: Identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen
    • Shima D.T., Adamis A.P., Ferrara N., Yeo K.T., Yeo T.K., Allende R., Folkman J., and D'Amore P.A. Hypoxic induction of endothelial cell growth factors in retinal cells: Identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. Molec. Med. 1 (1995) 182-193
    • (1995) Molec. Med. , vol.1 , pp. 182-193
    • Shima, D.T.1    Adamis, A.P.2    Ferrara, N.3    Yeo, K.T.4    Yeo, T.K.5    Allende, R.6    Folkman, J.7    D'Amore, P.A.8
  • 178
    • 0030021835 scopus 로고    scopus 로고
    • The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences
    • Shima D.T., Kuroki M., Deutsch U., Ng Y.S., Adamis A.P., and D'Amore P.A. The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences. J. Biol. Chem. 271 (1996) 3877-3883
    • (1996) J. Biol. Chem. , vol.271 , pp. 3877-3883
    • Shima, D.T.1    Kuroki, M.2    Deutsch, U.3    Ng, Y.S.4    Adamis, A.P.5    D'Amore, P.A.6
  • 179
    • 0027241752 scopus 로고
    • Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally-mediated angiogenesis
    • Shweiki D., Itin A., Neufeld G., Gitay-Goren H., and Keshet E. Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally-mediated angiogenesis. J. Clin. Invest. 91 (1993) 2235-2243
    • (1993) J. Clin. Invest. , vol.91 , pp. 2235-2243
    • Shweiki, D.1    Itin, A.2    Neufeld, G.3    Gitay-Goren, H.4    Keshet, E.5
  • 180
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki D., Itin A., Soffer D., and Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359 (1992) 843-845
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 181
    • 0029920054 scopus 로고    scopus 로고
    • Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein
    • Siemeister G., Weindel K., Mohrs K., Barleon B., Martiny Baron G., and Marme D. Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res. 56 (1996) 2299-2301
    • (1996) Cancer Res. , vol.56 , pp. 2299-2301
    • Siemeister, G.1    Weindel, K.2    Mohrs, K.3    Barleon, B.4    Martiny Baron, G.5    Marme, D.6
  • 182
    • 0029074024 scopus 로고
    • Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia
    • Stone J., Itin A., Alon T., Pe'er J., Gnessin H., Chan Ling T., and Keshet E. Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J. Neurosci. 15 (1995) 4738-4747
    • (1995) J. Neurosci. , vol.15 , pp. 4738-4747
    • Stone, J.1    Itin, A.2    Alon, T.3    Pe'er, J.4    Gnessin, H.5    Chan Ling, T.6    Keshet, E.7
  • 185
    • 0029884640 scopus 로고    scopus 로고
    • Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells
    • Takagi H., King G.L., Ferrara N., and Aiello L.P. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. Invest. Ophthalmol. Vis. Sci. 37 (1996) 1311-1321
    • (1996) Invest. Ophthalmol. Vis. Sci. , vol.37 , pp. 1311-1321
    • Takagi, H.1    King, G.L.2    Ferrara, N.3    Aiello, L.P.4
  • 186
    • 0029958320 scopus 로고    scopus 로고
    • Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo
    • Takeshita S., Tsurumi Y., Couffinahl T., Asahara T., Bauters C., Symes J., Ferrara N., and Isner J.M. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo. Lab. Invest. 75 (1996) 487-501
    • (1996) Lab. Invest. , vol.75 , pp. 487-501
    • Takeshita, S.1    Tsurumi, Y.2    Couffinahl, T.3    Asahara, T.4    Bauters, C.5    Symes, J.6    Ferrara, N.7    Isner, J.M.8
  • 188
    • 0028344109 scopus 로고
    • Therapeutic angiogenesis: A single intra-arterial bolus of vascular endothelial growth factor augments collateral vessel formation in a rabbit ischemic hind-limb model
    • Takeshita S., Zhung L., Brogi E., Kearney M., Pu L.-Q., Bunting S., Ferrara N., Symes J.F., and Isner J.M. Therapeutic angiogenesis: A single intra-arterial bolus of vascular endothelial growth factor augments collateral vessel formation in a rabbit ischemic hind-limb model. J. Clin. Invest. 93 (1994) 662-670
    • (1994) J. Clin. Invest. , vol.93 , pp. 662-670
    • Takeshita, S.1    Zhung, L.2    Brogi, E.3    Kearney, M.4    Pu, L.-Q.5    Bunting, S.6    Ferrara, N.7    Symes, J.F.8    Isner, J.M.9
  • 189
  • 191
    • 0025999033 scopus 로고
    • The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
    • Tischer E., Mitchell R., Hartman T., Silva M., Gospodarowicz D., Fiddes J.C., and Abraham J.A. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem. 266 (1991) 11947-11954
    • (1991) J. Biol. Chem. , vol.266 , pp. 11947-11954
    • Tischer, E.1    Mitchell, R.2    Hartman, T.3    Silva, M.4    Gospodarowicz, D.5    Fiddes, J.C.6    Abraham, J.A.7
  • 193
    • 0029739620 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate
    • Tolentino M.J., Miller J.W., Gragoudas E.S., Chatzistefanou K., Ferrara N., and Adamis A.P. Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate. Arch. Ophthalmol. 114 (1996) 964-970
    • (1996) Arch. Ophthalmol. , vol.114 , pp. 964-970
    • Tolentino, M.J.1    Miller, J.W.2    Gragoudas, E.S.3    Chatzistefanou, K.4    Ferrara, N.5    Adamis, A.P.6
  • 194
    • 0028940664 scopus 로고
    • Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide
    • Tuder R.M., Flook B.E., and Voelkel N.F. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. J. Clin. Invest. 95 (1995) 1798-1807
    • (1995) J. Clin. Invest. , vol.95 , pp. 1798-1807
    • Tuder, R.M.1    Flook, B.E.2    Voelkel, N.F.3
  • 195
    • 0026446859 scopus 로고
    • Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells
    • Unemori E.N., Ferrara N., Bauer E.A., and Amento E.P. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J. Cell. Physiol. 153 (1992) 557-562
    • (1992) J. Cell. Physiol. , vol.153 , pp. 557-562
    • Unemori, E.N.1    Ferrara, N.2    Bauer, E.A.3    Amento, E.P.4
  • 196
    • 0025203676 scopus 로고
    • Characterization of the receptors for vascular endothelial growth factor
    • Vaisman N., Gospodarowicz D., and Neufeld G. Characterization of the receptors for vascular endothelial growth factor. J. Biol. Chem. 265 (1990) 19461-19466
    • (1990) J. Biol. Chem. , vol.265 , pp. 19461-19466
    • Vaisman, N.1    Gospodarowicz, D.2    Neufeld, G.3
  • 198
    • 0029868465 scopus 로고    scopus 로고
    • Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3
    • Vincenti V., Cassano C., Rocchi M., and Persico G. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation 93 (1996) 1493-1495
    • (1996) Circulation , vol.93 , pp. 1493-1495
    • Vincenti, V.1    Cassano, C.2    Rocchi, M.3    Persico, G.4
  • 199
    • 1842328560 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer
    • Volm M., Koomagi R., and Mattern J. Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer. Int. J. Cancer 74 (1997) 64-68
    • (1997) Int. J. Cancer , vol.74 , pp. 64-68
    • Volm, M.1    Koomagi, R.2    Mattern, J.3
  • 200
    • 1842408971 scopus 로고    scopus 로고
    • Angiogenic growth factors and their receptors in non-small cell lung carcinomas and their relationships to drug response in vitro
    • Volm M., Koomagi R., Mattern J., and Stammler G. Angiogenic growth factors and their receptors in non-small cell lung carcinomas and their relationships to drug response in vitro. Anticancer Res. 17 (1997) 99-103
    • (1997) Anticancer Res. , vol.17 , pp. 99-103
    • Volm, M.1    Koomagi, R.2    Mattern, J.3    Stammler, G.4
  • 202
    • 0027997863 scopus 로고
    • Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
    • Waltenberger J., Claesson Welsh L., Siegbahn A., Shibuya M., and Heldin C.H. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 269 (1994) 26988-26995
    • (1994) J. Biol. Chem. , vol.269 , pp. 26988-26995
    • Waltenberger, J.1    Claesson Welsh, L.2    Siegbahn, A.3    Shibuya, M.4    Heldin, C.H.5
  • 203
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang G.L., and Semenza G.L. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270 (1995) 1230-1237
    • (1995) J. Biol. Chem. , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 204
    • 16944362446 scopus 로고    scopus 로고
    • Angiogenesis in ischemic heart disease
    • Ware J.A., and Simons M. Angiogenesis in ischemic heart disease. Nature Med. 3 (1997) 158-164
    • (1997) Nature Med. , vol.3 , pp. 158-164
    • Ware, J.A.1    Simons, M.2
  • 205
    • 0029805574 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma
    • Warren R.S., Yuan H., Matli M.R., Ferrara N., and Donner D.B. Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J. Biol. Chem. 271 (1996) 29483-29488
    • (1996) J. Biol. Chem. , vol.271 , pp. 29483-29488
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3    Ferrara, N.4    Donner, D.B.5
  • 206
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • Warren R.S., Yuan H., Matli M.R., Gillett N.A., and Ferrara N. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J. Clin. Invest. 95 (1995) 1789-1797
    • (1995) J. Clin. Invest. , vol.95 , pp. 1789-1797
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3    Gillett, N.A.4    Ferrara, N.5
  • 207
    • 0028929991 scopus 로고
    • Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas
    • Wizigmann Voos S., Breier G., Risau W., and Plate K.H. Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res. 55 (1995) 1358-1364
    • (1995) Cancer Res. , vol.55 , pp. 1358-1364
    • Wizigmann Voos, S.1    Breier, G.2    Risau, W.3    Plate, K.H.4
  • 208
    • 0027336995 scopus 로고
    • Flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors
    • Yamaguchi T.P., Dumont D.J., Conlon R.A., Breitman M.L., and Rossant J. Flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development 118 (1993) 489-498
    • (1993) Development , vol.118 , pp. 489-498
    • Yamaguchi, T.P.1    Dumont, D.J.2    Conlon, R.A.3    Breitman, M.L.4    Rossant, J.5
  • 210
    • 0029935566 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer
    • Yoshiji H., Gomez D.E., Shibuya M., and Thorgeirsson U.P. Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer. Cancer Res. 56 (1996) 2013-2016
    • (1996) Cancer Res. , vol.56 , pp. 2013-2016
    • Yoshiji, H.1    Gomez, D.E.2    Shibuya, M.3    Thorgeirsson, U.P.4
  • 211
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • Yuan F., Chen Y., Dellian M., Safabakhsh N., Ferrara N., and Jain R.K. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 14765-14770
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 14765-14770
    • Yuan, F.1    Chen, Y.2    Dellian, M.3    Safabakhsh, N.4    Ferrara, N.5    Jain, R.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.