Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-α in cultured human vascular endothelial cells

Journal of Clinical Investigation

Volumn 98, Issue 2, 1996, Pages 490-496

  Patterson, Cam ^a   Perrella, Mark A ^a   Endege, Wilson O ^a   Yoshizumi, Masao ^a   Lee, Mu En ^a   Haber, Edgar ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

angiogenesis; cytokines; gene regulation; phorbol ester; proliferation

Indexed keywords

ANTIBODY; DNA; MESSENGER RNA; PHORBOL ESTER; PROTEIN; RECEPTOR; THYMIDINE; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CATTLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DOSE RESPONSE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

EID: 0030017083     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118816     Document Type: Article

References (52)

1. Folkman, J. 1995. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1:27-31.
2. Millauer, B., L.K. Shawver, K.H. Plate, W. Risau, and A. Ullrich. 1994. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature (Lond.). 367:576-579.
3. Aiello, L., E. Pierce, E. Foley, H. Takagi, H. Chen, L. Riddle, N. Ferrara, G. King, and L. Smith. 1995. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor using soluble VEGF-receptor chimeric proteins. Proc. Natl. Acad. Sci. USA. 92:10457-10461.
4. Isner, J., K. Walsh, J. Symes, A. Pieczek, S. Takeshita, J. Lowry, S. Rossow, K. Rosenfield, L. Weir, E. Brogi, and R. Schainfeld. 1995. Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease. Circulation. 91:2687-2692.
5. Klagsbrun, M., and P.A. D'Amore. 1991. Regulators of angiogenesis. Ann. Rev. Physiol. 53:217-239.
6. Klagsbrun, M., and S. Soker. 1993. VEGF/VPF: the angiogenesis factor found? Curr. Biol. 3:699-702.
7. Leung, D.W., G. Cachianes, W.-J. Kuang, D.V. Goeddel, and N. Ferrarra. 1989. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science (Wash. DC). 246:1306-1309.
8. Connolly, D.T., D.M. Heuvelman, R. Nelson, J.V. Olander, B.L. Eppley, J.J. Delfino, R.M. Leingruber, and J. Feder. 1989. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J. Clin. Invest. 84: 1470-1478.
9. Aiello, L.P., R.L. Avery, P.G. Arrigg, B.A. Keyt, H.D. Jampel, S.T. Shah, L.R. Pasquale, H. Thieme, M.A. Iwamoto, J.E. Park, H.V. Nguyen, L.M. Aiello, N. Ferrara, and G.L. King. 1994. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331:1480-1487.
10. Berkman, R., M. Merrill, and W. Reinhold. 1993. Expression of the vascular permeability/vascular endothelial growth factor gene in central nervous system neoplasms. J. Clin. Invest. 91:153-159.
11. Shweiki, D., A. Itin, D. Soffer, and E. Keshet. 1992. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature (Lond.). 359:843-845.
12. Jakeman, L.B., M. Armanini, H.S. Phillips, and N. Ferrara. 1993. Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis. Endocrinology. 133:848-859.
13. Breier, G., U. Albrecht, S. Sterrer, and W. Risau. 1992. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development. 114:521-532.
14. Vilcek, J., and T. Lee. 1991. Tumor necrosis factor. J. Biol. Chem. 266: 7313-7316.
15. Sunderkotter, C., M. Goebeler, K. Schulze-Osthoff, R. Bhardwaj, and C. Sorg. 1991. Macrophage-derived angiogenesis factors. Pharmac. Ther. 51: 195-216.
16. Frater-Schroder, M., W. Risau, R. Hallmann, and P. Gautsch. 1987. Tumor necrosis factor type α, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo. Proc. Natl. Acad. Sci. USA. 84:5277-5281.
17. Leibovich, S., P. Polverini, H. Shepard, D. Wiseman, V. Shively, and N. Nuseir. 1987. Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α. Nature (Lond.). 329:630-632.
18. Pandey, A., H. Shao, R. Marks, P. Polverini, and V. Dixit. 1995. Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-α-induced angiogenesis. Science (Wash. DC). 268:567-569.
19. Stolpen, A., E. Guinan, W. Fiers, and J. Pober. 1986. Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers. Am. J. Path. 123:16-24.
20. Sato, N., T. Goto, K. Haranaka, N. Satomi, H. Nariuchi, Y. Mano-Hirano, and Y. Sawasaki. 1986. Actions of tumor necrosis factor on cultured vascular endothelial cells. J. Natl. Cancer Inst. 76:1113-1121.
21. Burke-Gaffney, A., and A. Keenan. 1993. Does TNF-α directly increase endothelial cell monolayer permeability? Agents Actions. 38:83-85.
22. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
23. Li, J., M.A. Perrella, J.-C. Tsai, S.-F. Yet, C-M. Hsieh, M. Yoshizumi, C. Patterson, W.O. Endege, F. Zhou, and M.-E. Lee. 1995. Induction of vascular endothelial growth factor gene expression by interleukin-1β in rat aortic smooth muscle cells. J. Biol. Chem. 270:308-312.
24. Yoshizumi, M., S. Kourembanas, D.H. Temizer, R.P. Cambria, T. Quertermous, and M.E. Lee. 1992. Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells. J. Biol. Chem. 267:9467-9469.
25. Patterson, C., M.A. Perrella, C.-M. Hsieh, M. Yoshizumi, M.-E. Lee, and E. Haber. 1995. Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. J. Biol. Chem. 270: 23111-23118.
26. Perrella, M.A., M. Yoshizumi, Z. Fen, J.-C. Tsai, C.-M. Hsieh, S. Kourembanas, and M.-E. Lee. 1994. Transforming growth factor-β1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1β in rat smooth muscle cells. J. Biol. Chem. 269:14595-14600.
27. Matsubara, N., S. Fuchimoto, and K. Orita. 1991. Tumour necrosis factor-alpha induces translocation of protein kinase C in tumour necrosis factor-sensitive cell lines. Immunology. 73:457-459.
28. Sanguedolce, M., C. Capo, P. Bongrand, and J. Mege. 1992. Zymosan-stimulated tumor necrosis factor-alpha production by human monocytes. Down-modulation by phorbol ester. J. Immunol. 148:2229-2236.
29. van de Stolpe, A., E. Caldenhoven, B. Stade, L. Koenderman, J. Raaijmakers, J. Johnson, and P. van der Saag. 1994. 12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone: functional analysis of the human intercellular adhesion molecule-1 promoter. J. Biol. Chem. 269:6185-6192.
30. Diaz, A., E. Munoz, R. Johnston, J. Korn, and S. Jimenez. 1993. Regulation of human lung fibroblast alpha 1(I) procollagen gene expression by tumor necrosis factor alpha, interleukin-1 beta, and prostaglandin E2. J. Biol. Chem. 268:10364-10371.
31. Koga, S., S. Morris, S. Ogawa, H. Liao, J. Bilezikian, G. Chen, W. Thompson, T. Ashikaga, J. Brett, D. Stern, and D. Pinsky. 1995. TNF modulates endothelial properties by decreasing cAMP. Am. J. Physiol. 268:C1104-C1113.
32. De Luca, L., D. Johnson, M. Whitley, T. Collins, and J. Pober. 1994. cAMP and tumor necrosis factor competitively regulate transcriptional activation through and nuclear factor binding to the cAMP-responsive element/activating transcription factor element of the endothelial leukocyte adhesion molecule-1 (E-selectin) promoter. J. Biol. Chem. 269:19193-19196.
33. Marui, N., M.K. Offermann, R. Swerlick, C. Kunsch, C.A. Rosen, M. Ahmad, R.W. Alexander, and R.M. Medford. 1993. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J. Clin. Invest. 92:1866-1874.
34. Quinn, T.P., K.G. Peters, C. De Vries, N. Ferrara, and L.T. Williams. 1993. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc. Natl. Acad. Sci. USA. 90:7533-7537.
35. Shalaby, F., J. Rossant, T. Yamaguchi, M. Gertsenstein, X.-F. Wu, M. Breitman, and A. Schuh. 1995. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature (Lond.). 376:62-66.
36. Alon, T., I. Hemo, A. Itin, J. Peer, J. Stone, and E. Keshet. 1995. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nature Med. 1: 1024-1028.
37. Neish, A., L. Khachigian, A. Park, V. Baichwal, and T. Collins. 1995. Sp1 is a component of the cytokine-inducible enhancer in the promoter of vascular cell adhesion molecule-1. J. Biol. Chem. 270:28903-28909.
38. Neish, A., M. Read, D. Thanos, R. Pine, T. Maniatis, and T. Collins. 1995. Endothelial IRF-1 cooperates with NF-κB as a transcriptional activator of vascular cell adhesion molecule-1. Mol. Cell. Biol. 15:2558-2569.
39. Kikkawa, U., A. Kishimoto, and Y. Nishizuka. 1989. The protein kinase C family: Heterogeneity and its implications. Ann. Rev. Biochem. 58:31-44.
40. Konig, H., H. Ponta, H. Rahmsdorf, and P. Herrlich. 1992. Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. EMBO (Eur. Mol. Biol. Organ.) J. 11:2241-2246.
41. Scheinman, R., P. Cogswell, A. Lofquist, and A. Baldwin. 1995. Role of transcriptional activation of 1 kappa B alpha in mediation of immunosuppression by glucocorticoids. Science (Wash. DC). 270:283-286.
42. Read, M., M. Whitley, A. Williams, and T. Collins. 1994. NFκB and IκB-α: An inducible regulatory system in endothelial activation. J. Exp. Med. 179:503-512.
43. Sancéau, J., T. Kaisho, T. Hirano, and J. Wietzerbin. 1995. Triggering of the human interleukin-6 gene by interferon-γ and tumor necrosis factor-α in monocytic cells involves cooperation between interferon regulatory factor-1. NFκB, and Sp1 transcription factors. J. Biol. Chem. 270:27920-27931.
44. Brenner, D.A., M. O'Hara, P. Angel, M. Chojkier, and M. Karin. 1989. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature (Lond.). 337:661-663.
45. Conway, E., and R. Rosenberg. 1988. Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol. Cell. Biol. 8:5588-5592.
46. Kuno, H., S. Kurian, G. Hendy, J. White, H. DeLuca, C.-O. Evans, and M. Nanes. 1994. Inhibition of 1,25-dihydroxy vitamin D3 stimulated osteocalcin gene transcription by tumor necrosis factor-α: structural determinants within the vitamin D response element. Endocrinology. 134:2524-2532.
47. Nanes, M., H. Kuno, M. Demay, M. Kurian, G. Hendy, H. DeLuca, L. Titus, and J. Rubin. 1994. A single up-stream element confers responsiveness to 1,25-dihydroxyvitamin D3 and tumor necrosis factor-α in the rat osteocalcin gene. Endocrinology. 134:1113-1120.
48. Inagaki, Y., S. Truter, S. Tanaka, M. Di Liberto, and F. Ramirez. 1995. Overlapping pathways mediate the opposing actions of tumor necrosis factor-α and transforming growth factor-β on α2(I) collagen gene transcription. J. Biol. Chem. 270:3353-3358.
49. Pober, J.S., and R.S. Cotran. 1990. The role of endothelial cells in inflammation. Transplantation. 50:537-544.
50. Brigham, K., and B. Meyrick. 1986. Endotoxin and lung injury. Am. Rev. Resp. Dis. 133:913-920.
51. Young, J.-E., C.-C. Liu, P.-M. Persechini, and Z. Cohn. 1988. Perforin-dependent and -independent pathways of cytotoxicity mediated by lymphocytes. Immunol. Rev 103:161-180.
52. ν integrins. Science (Wash. DC). 270:1500-1502.