Synthesis and characterization of novel indole derivatives reveal improved therapeutic agents for treatment of ischemia/reperfusion (I/R) injury

Journal of Medicinal Chemistry

Volumn 53, Issue 18, 2010, Pages 6763-6767

  Bi, Wei ^b   Bi, Yue ^b   Xue, Ping ^b   Zhang, Yanrong ^b   Gao, Xiang ^b   Wang, Zhibo ^b   Li, Meng ^b   Baudy Floch, Michèle ^c   Ngerebara, Nathaniel ^a   Gibson, K Michael ^a   Bi, Lanrong ^a  

^a MICHIGAN TECHNOLOGICAL UNIVERSITY   (United States)

^b HEBEI MEDICAL UNIVERSITY   (China)

^c UNIVERSITÉ DE RENNES 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INDOLE DERIVATIVE; MELATONIN; ANTIOXIDANT; NONSTEROID ANTIINFLAMMATORY AGENT; SCAVENGER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; LIMB ISCHEMIA; LUNG INJURY; MUSCLE INJURY; NONHUMAN; OXIDATIVE STRESS; PHARMACOPHORE; RAT; REPERFUSION INJURY; SKELETAL MUSCLE; STRUCTURE ACTIVITY RELATION; ANIMAL; CAPILLARY PERMEABILITY; CHEMISTRY; DRUG EFFECTS; HINDLIMB; INFLAMMATION; LIPID PEROXIDATION; METABOLISM; MOUSE; PATHOLOGY; PC12 CELL LINE; SYNTHESIS; VASCULARIZATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; CAPILLARY PERMEABILITY; FREE RADICAL SCAVENGERS; HINDLIMB; INDOLES; INFLAMMATION; LIPID PEROXIDATION; LUNG INJURY; MICE; MUSCLE, SKELETAL; PC12 CELLS; RATS; REPERFUSION INJURY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956785607     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100529e     Document Type: Article

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