Inflammatory mediators of liver ischemia-reperfusion injury

Experimental and Clinical Transplantation

Volumn 7, Issue 2, 2009, Pages 78-93

  Walsh, Kyle B ^a   Toledo, Alexander H ^b   Rivera Chavez, Fernando A ^c   Lopez Neblina, Fernando ^d   Toledo Pereyra, Luis H ^a,e  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSIDAD AUTÓNOMA DE BAJA CALIFORNIA   (Mexico)

^e MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Inflammatory mediators; Ischemia and reperfusion; Liver; Transplant; Trauma

Indexed keywords

ACETYLCYSTEINE; ADENOVIRUS VECTOR; ALLOPURINOL; ASCORBIC ACID; AUTACOID; CARNOSINE; CATALASE; CYTOKINE; ERYTHROPOIETIN; FINGOLIMOD; HEAT SHOCK PROTEIN; HEME OXYGENASE 1; MANNITOL; MATRIX METALLOPROTEINASE; MELATONIN; MESNA; METALLOPORPHYRIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NORPHENAZONE; PROSTAGLANDIN E1 DERIVATIVE; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; RESVERATROL; SELECTIN; SUPEROXIDE DISMUTASE; THIOCTIC ACID; TOLL LIKE RECEPTOR; UNINDEXED DRUG; XANTHINE OXIDASE;

ENZYME INHIBITION; HUMAN; ISCHEMIC PRECONDITIONING; LIVER INJURY; LIVER ISCHEMIA; LIVER TRANSPLANTATION; MEDICAL RESEARCH; OXIDATION REDUCTION STATE; PATHOPHYSIOLOGY; REPERFUSION INJURY; REVIEW; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM; ANIMAL; ANIMAL MODEL; INFLAMMATION; LIVER; LIVER DISEASE; METABOLISM; PATHOLOGY; VASCULARIZATION;

ANIMALS; HUMANS; INFLAMMATION; LIVER; LIVER DISEASES; MODELS, ANIMAL; NITRIC OXIDE; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY;

EID: 70350496017     PISSN: 13040855     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (235)

1. Vardanian AJ, Busuttil RW, Kupiec-Weglinski JW. Molecular mediators of liver ischemia and reperfusion injury: a brief review. Mol Med. 2008;14(5-6):337-345. (Pubitemid 351785707)
2. Montalvo-Jave EE, Escalante-Tattersfield T, Ortega-Salgado JA, Piña E, Geller DA. Factors in the pathophysiology of the liver ischemia-reperfusion injury. J Surg Res. 2008;147(1):153-159. (Pubitemid 351626076)
3. Wink DA, Miranda KM, Espey MG, et al. Mechanisms of the antioxidant effects of nitric oxide. Antioxid Redox Signal. 2001;3(2):203-213. (Pubitemid 32473337)
4. Chen T, Zamora R, Zuckerbraun B, Billiar TR. Role of nitric oxide in liver injury. Curr Mol Med. 2003;3(6):519-526. (Pubitemid 37168596)
5. Albrecht EW, Stegeman CA, Heeringa P, Henning RH, van Goor H. Protective role of endothelial nitric oxide synthase. J Pathol. 2003;199(1):8-17. (Pubitemid 36061187)
6. Gurusamy KS, Kumar Y, Sharma D, Davidson BR. Ischaemic preconditioning for liver transplantation. Cochrane Database Syst Rev. 2008;Jan 23(1):CD006315.
7. Caldwell CC, Tschoep J, Lentsch AB. Lymphocyte function during hepatic ischemia/reperfusion injury. J Leukoc Biol. 2007;82(3):457-464. (Pubitemid 47367135)
8. Huang Y, Rabb H, Womer KL. Ischemia-reperfusion and immediate T cell responses. Cell Immunol. 2007;248(1):4-11.
9. Ferrándiz ML, Devesa I. Inducers of heme oxygenase-1. Curr Pharm Des. 2008;14(5):473-486.
10. Joyeux-Faure M. Cellular protection by erythropoietin: new therapeutic implications? J Pharmacol Exp Ther. 2007;323(3):759-762.
11. Johnson GL, Nakamura K. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Biochim Biophys Acta. 2007;1773(8):1341-1348. (Pubitemid 47125977)
12. Viappiani S, Sariahmetoglu M, Schulz R. The role of matrix metalloproteinase inhibitors in ischemia-reperfusion injury in the liver. Curr Pharm Des. 2006;12(23):2923-2934. (Pubitemid 44184626)
13. Zhai Y, Shen XD, Gao F, et al. CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Hepatology. 2008;47(1):207-214. (Pubitemid 351171058)
14. Zhang W, Wang M, Xie HY, et al. Role of reactive oxygen species in mediating hepatic ischemia-reperfusion injury and its therapeutic applications in liver transplantation. Transplant Proc. 2007;39(5):1332-1337. (Pubitemid 46915523)
15. Harada H, Hines IN, Flores S, et al. Role of NADPH oxidase-derived superoxide in reduced size liver ischemia and reperfusion injury. Arch Biochem Biophys. 2004;423(1):103-108. (Pubitemid 38198219)
16. Fukai M, Hayashi T, Yokota R, et al. Lipid peroxidation during ischemia depends on ischemia time in warm ischemia and reperfusion of rat liver. Free Radic Biol Med. 2005;38(10):1372-1381. (Pubitemid 40602839)
17. Boin Ide F, Silva Ode C, Souza ME, Santos AC, Leonardi LS. Pyruvate kinase activation and lipoperoxidation after selective hepatic ischemia in Wistar rats. Acta Cir Bras. 2006;21(suppl 1):19-23.
18. Wheeler MD, Katuna M, Smutney OM, et al. Comparison of the effect of adenoviral delivery of three superoxide dismutase genes against hepatic ischemia-reperfusion injury. Hum Gene Ther. 2001;12(18):2167-2177. (Pubitemid 34081176)
19. Wheeler MD, Nakagami M, Bradford BU, et al. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. J Biol Chem. 2001;276(39):36664-36672. (Pubitemid 37384280)
20. Lehmann TG, Luedde T, Schwabe RF, et al. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Liver Transpl. 2006 ;12(4):550-559.
21. Lehmann TG, Wheeler MD, Froh M, et al. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Transplantation. 2003;76(1):28-37. (Pubitemid 36877111)
22. Hiranuma S, Ito K, Noda Y, Ozasa H, Koike Y, Horikawa S. Amelioration of hepatic ischemia/reperfusion injury in the remnant liver after partial hepatectomy in rats. J Gastroenterol Hepatol. 2007;22(12):2167-2172. (Pubitemid 350145616)
23. Nakamoto N, Tada S, Kameyama K, et al. A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury. Free Radic Res. 2003;37(8):849-859. (Pubitemid 36939601)
24. Taniguchi M, Uchinami M, Doi K, et al. Edaravone reduces ischemia-reperfusion injury mediators in rat liver. J Surg Res. 2007;137(1):69-74. (Pubitemid 44879433)
25. Ninomiya M, Shimada M, Harada N, et al. Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat. Transplantation. 2002;74(10):1470-1472. (Pubitemid 35379556)
26. Ninomiya M, Shimada M, Harada N, Soejima Y, Suehiro T, Maehara Y. The hydroxyl radical scavenger MCI-186 protects the liver from experimental cold ischaemia-reperfusion injury. Br J Surg. 2004;91(2):184-190. (Pubitemid 38233963)
27. Sener G, Sehirli O, Ercan F, Sirvanci S, Gedik N, Kacmaz A. Protective effect of MESNA (2-mercaptoethane sulfonate) against hepatic ischemia/reperfusion injury in rats. Surg Today. 2005;35(7):575-580. (Pubitemid 40854023)
28. Sener G, Kabasakal L, Sehirli O, Ercan F, Gedik N. 2-Mercaptoethane sulfonate (MESNA) protects against biliary obstruction-induced oxidative damage in rats. Hepatol Res. 2006;35(2):140-146. (Pubitemid 43758352)
29. Bi W, Cai J, Xue P, et al. Protective effect of nitronyl nitroxide-amino acid conjugates on liver ischemia-reperfusion induced injury in rats. Bioorg Med Chem Lett. 2008;18(6):1788-1794.
30. Dulundu E, Ozel Y, Topaloglu U, et al. Alpha-lipoic acid protects against hepatic ischemia-reperfusion injury in rats. Pharmacology. 2007;79(3):163-170. (Pubitemid 46631930)
31. Tselepidis S, Papazoglou L, Dessiris A, et al. Liver injury after ischemia and reperfusion: the role of oxygen free radicals. Mil Med. 2004;169(7):531-535. (Pubitemid 40247461)
32. Wu TJ, Khoo NH, Zhou F, Day BJ, Parks DA. Decreased hepatic ischemia-reperfusion injury by manganese-porphyrin complexes. Free Radic Res. 2007;41(2):127-134. (Pubitemid 46992862)
33. Park SW, Choi SM, Lee SM. Effect of melatonin on altered expression of vasoregulatory genes during hepatic ischemia/reperfusion. Arch Pharm Res. 2007;30(12):1619-1624.
34. Chen JC, Ng CJ, Chiu TF, Chen HM. Altered neutrophil apoptosis activity is reversed by melatonin in liver ischemia-reperfusion. J Pineal Res. 2003;34(4):260-264.
35. Liang R, Nickkholgh A, Hoffmann K, et al. Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation. J Pineal Res. 2009;46(1):8-14.
36. Kim SH, Lee SM. Cytoprotective effects of melatonin against necrosis and apoptosis induced by ischemia/reperfusion injury in rat liver. J Pineal Res. 2008;44(2):165-171. (Pubitemid 351252919)
37. Okatani Y, Wakatsuki A, Reiter RJ, Enzan H, Miyahara Y. Protective effect of melatonin against mitochondrial injury induced by ischemia and reperfusion of rat liver. Eur J Pharmacol. 2003;469(1-3):145-152. (Pubitemid 36629560)
38. Zhang WH, Li JY, Zhou Y. Melatonin abates liver ischemia/reperfusion injury by improving the balance between nitric oxide and endothelin. Hepatobiliary Pancreat Dis Int. 2006;5(4):574-579. (Pubitemid 44782099)
39. Rodríguez-Reynoso S, Leal C, Portilla E, Olivares N, Muñiz J. Effect of exogenous melatonin on hepatic energetic status during ischemia/reperfusion: possible role of tumor necrosis factor-alpha and nitric oxide. J Surg Res. 2001;100(2):141-149. (Pubitemid 32989353)
40. Mathes AM, Kubulus D, Weiler J, et al. Melatonin receptors mediate improvements of liver function but not of hepatic perfusion and integrity after hemorrhagic shock in rats. Crit Care Med. 2008;36(1):24-29.
41. Baykara B, Tekmen I, Pekcetin C, et al. The protective effects of carnosine and melatonin in ischemia-reperfusion injury in the rat liver. Acta Histochem. 2009;111(1):42-51.
42. Sener G, Tosun O, Sehirli AO, et al. Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci. 2003;72(24):2707-2718. (Pubitemid 36388760)
43. Bülbüller N, Cetinkaya Z, Akkus MA, et al. The effects of melatonin and prostaglandin E1 analogue on experimental hepatic ischaemia reperfusion damage. Int J Clin Pract. 2003;57(10):857-860. (Pubitemid 38088800)
44. Kirimlioglu H, Ecevit A, Yilmaz S, Kirimlioglu V, Karabulut AB. Effect of resveratrol and melatonin on oxidative stress enzymes, regeneration, and hepatocyte ultrastructure in rats subjected to 70% partial hepatectomy. Transplant Proc. 2008;40(1):285-289. (Pubitemid 351186648)
45. Stuehr DJ. Enzymes of the L-arginine to nitric oxide pathway. J Nutr. 2004;134(10 suppl):2748S-2751S; discussion 2765S-2767S.
46. Yanagida H, Kaibori M, Yamada M, et al. Induction of inducible nitric oxide synthase in hepatocytes isolated from rats with ischemia-reperfusion injury. Transplant Proc. 2004;36(7):1962-1964. (Pubitemid 39424292)
47. Yanagida H, Kaibori M, Yoshida H, et al. Hepatic ischemia/reperfusion upregulates the susceptibility of hepatocytes to confer the induction of inducible nitric oxide synthase gene expression. Shock. 2006;26(2):162-168. (Pubitemid 44162502)
48. Teshima S, Nakanishi H, Nishizawa M, et al. Up-regulation of IL-1 receptor through PI3K/Akt is essential for the induction of iNOS gene expression in hepatocytes. J Hepatol. 2004;40(4):616-623. (Pubitemid 38367783)
49. Hines IN, Harada H, Flores S, Gao B, McCord JM, Grisham MB. Endothelial nitric oxide synthase protects the post-ischemic liver: potential interactions with superoxide. Biomed Pharmacother. 2005;59(4):183-189. (Pubitemid 40603331)
50. Lin HI, Wang D, Leu FJ, Chen CF, Chen HI. Ischemia and reperfusion of liver induces eNOS and iNOS expression: effects of a NO donor and NOS inhibitor. Chin J Physiol. 2004;47(3):121-127. (Pubitemid 39295047)
51. Hines IN, Kawachi S, Harada H, et al. Role of nitric oxide in liver ischemia and reperfusion injury. Mol Cell Biochem. 2002;234-235(1-2):229-237. (Pubitemid 34777862)
52. Koti RS, Tsui J, Lobos E, Yang W, Seifalian AM, Davidson BR. Nitric oxide synthase distribution and expression with ischemic preconditioning of the rat liver. FASEB J. 2005;19(9):1155-1157. (Pubitemid 40946449)
53. Theruvath TP, Zhong Z, Currin RT, Ramshesh VK, Lemasters JJ. Endothelial nitric oxide synthase protects transplanted mouse livers against storage/reperfusion injury: Role of vasodilatory and innate immunity pathways. Transplant Proc. 2006;38(10):3351-3357. (Pubitemid 44908546)
54. Serracino-Inglott F, Virlos IT, Habib NA, Williamson RC, Mathie RT. Differential nitric oxide synthase expression during hepatic ischemia-reperfusion. Am J Surg. 2003;185(6):589-595. (Pubitemid 36627855)
55. Taniai H, Hines IN, Bharwani S, et al. Susceptibility of murine periportal hepatocytes to hypoxia-reoxygenation: role for NO and Kupffer cell-derived oxidants. Hepatology. 2004;39(6):1544-1552. (Pubitemid 38702655)
56. Wang LM, Tian XF, Song QY, Gao ZM, Luo FW, Yang CM. Expression and role of inducible nitric oxide synthase in ischemia-reperfusion liver in rats. Hepatobiliary Pancreat Dis Int. 2003;2(2):252-258. (Pubitemid 36748272)
57. Kimura H, Katsuramaki T, Isobe M, et al. Role of inducible nitric oxide synthase in pig liver transplantation. J Surg Res. 2003;111(1):28-37. (Pubitemid 36808697)
58. Takamatsu Y, Shimada K, Yamaguchi K, Kuroki S, Chijiiwa K, Tanaka M. Inhibition of inducible nitric oxide synthase prevents hepatic, but not pulmonary, injury following ischemia-reperfusion of rat liver. Dig Dis Sci. 2006;51(3):571-579.
59. Meguro M, Katsuramaki T, Nagayama M, et al. A novel inhibitor of inducible nitric oxide synthase (ONO-1714) prevents critical warm ischemia-reperfusion injury in the pig liver. Transplantation. 2002;73(9):1439-1446. (Pubitemid 34547465)
60. Tsuchihashi S, Kaldas F, Chida N, et al. FK330, a novel inducible nitric oxide synthase inhibitor, prevents ischemia and reperfusion injury in rat liver transplantation. Am J Transplant. 2006;6(9):2013-2022. (Pubitemid 44199536)
61. Lee VG, Johnson ML, Baust J, Laubach VE, Watkins SC, Billiar TR. The roles of iNOS in liver ischemia-reperfusion injury. Shock. 2001;16(5):355-360. (Pubitemid 33598210)
62. Kurabayashi M, Takeyoshi I, Yoshinari D, et al. NO donor ameliorates ischemia-reperfusion injury of the rat liver with iNOS attenuation. J Invest Surg. 2005;18(4):193-200. (Pubitemid 41200611)
63. Yaylak F, Canbaz H, Caglikulekci M, et al. Liver tissue inducible nitric oxide synthase (iNOS) expression and lipid peroxidation in experimental hepatic ischemia reperfusion injury stimulated with lipopolysaccharide: the role of aminoguanidine. J Surg Res. 2008;148(2):214-223.
64. Carlucci F, Marinello E, Rosi F, et al. Nitric oxide generation is associated with an unbalance of protein tyrosine phosphatases during liver transplantation. Biomed Pharmacother. 2007;61(4):216-221. (Pubitemid 46691336)
65. Koeppel TA, Mihaljevic N, Kraenzlin B, et al. Enhanced iNOS gene expression in the steatotic rat liver after normothermic ischemia. Eur Surg Res. 2007;39(5):303-311. (Pubitemid 47294442)
66. Jeyabalan G, Klune JR, Nakao A, et al. Arginase blockade protects against hepatic damage in warm ischemia-reperfusion. Nitric Oxide. 2008;19(1):29-35.
67. Kaizu T, Ikeda A, Nakao A, et al. Donor graft adenoviral iNOS gene transfer ameliorates rat liver transplant preservation injury and improves survival. Hepatology. 2006;43(3):464-473.
68. Hsu CM, Wang JS, Liu CH, Chen LW. Kupffer cells protect liver from ischemia-reperfusion injury by an inducible nitric oxide synthase-dependent mechanism. Shock. 2002;17(4):280-285.
69. Aram G, Potter JJ, Liu X, Torbenson MS, Mezey E. Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration. Hepatology. 2008;47(6):2051-2058. (Pubitemid 351945571)
70. Hines IN, Harada H, Bharwani S, Pavlick KP, Hoffman JM, Grisham MB. Enhanced post-ischemic liver injury in iNOS-deficient mice: a cautionary note. Biochem Biophys Res Commun. 2001 22;284(4):972-976. (Pubitemid 32924743)
71. Rivera-Chavez FA, Toledo-Pereyra LH, Dean RE, Crouch L, Ward PA. Exogenous and endogenous nitric oxide but not iNOS inhibition improves function and survival of ischemically injured livers. J Invest Surg. 2001;14(5):267-273. (Pubitemid 33040153)
72. Lu P, Liu F, Yao Z, et al. Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia-reperfusion injury. Hepatobiliary Pancreat Dis Int. 2005;4(3):350-355. (Pubitemid 41207532)
73. Von Knethen A, Brüne B. Activation of peroxisome proliferator-activated receptor gamma by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst. J Immunol. 2002;169(5):2619-2626. (Pubitemid 34921008)
74. Crosby MB, Svenson J, Gilkeson GS, Nowling TK. A novel PPAR response element in the murine iNOS promoter. Mol Immunol. 2005;42(11):1303-1310. (Pubitemid 40798946)
75. Crosby MB, Svenson JL, Zhang J, Nicol CJ, Gonzalez FJ, Gilkeson GS. Peroxisome proliferation-activated receptor (PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxide. J Pharmacol Exp Ther. 2005;312(1):69-76. (Pubitemid 40096454)
76. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol. 2003;21:335-376.
77. Hopkins PA, Sriskandan S. Mammalian Toll-like receptors: to immunity and beyond. Clin Exp Immunol. 2005;140(3):395-407. (Pubitemid 40813950)
78. Jin X, Wang L, Wu HS, et al. N-acetylcysteine inhibits activation of toll-like receptor 2 and 4 gene expression in the liver and lung after partial hepatic ischemia-reperfusion injury in mice. Hepatobiliary Pancreat Dis Int. 2007;6(3):284-289. (Pubitemid 46925250)
79. Zhang JX, Wu HS, Wang H, Zhang JH, Wang Y, Zheng QC. Protection against hepatic ischemia/reperfusion injury via downregulation of toll-like receptor 2 expression by inhibition of Kupffer cell function. World J Gastroenterol. 2005;11(28):4423-4426. (Pubitemid 41093966)
80. Prince JM, Levy RM, Yang R, et al. Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. J Am Coll Surg. 2006;202(3):407-417. (Pubitemid 43356214)
81. Zhai Y, Shen XD, O'Connell R, et al. Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol. 2004;173(12):7115-7119. (Pubitemid 39628144)
82. Shen XD, Ke B, Zhai Y, et al. Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model. Liver Transpl. 2007;13(10):1435-1443. (Pubitemid 47629578)
83. Wang H, Li ZY, Wu HS, et al. Endogenous danger signals trigger hepatic ischemia/reperfusion injury through toll-like receptor 4/nuclear factor-kappa B pathway. Chin Med J (Engl). 2007;120(6):509-514. (Pubitemid 46510764)
84. Yin H, Huang BJ, Yang H, et al. Pretreatment with soluble ST2 reduces warm hepatic ischemia/reperfusion injury. Biochem Biophys Res Commun. 2006;351(4):940-946. (Pubitemid 44717530)
85. Wang L, Xu JB, Wu HS, et al. The relationship between activation of TLR4 and partial hepatic ischemia/reperfusion injury in mice. Hepatobiliary Pancreat Dis Int. 2006;5(1):101-104. (Pubitemid 43298712)
86. Peng Y, Gong JP, Liu CA, Li XH, Gan L, Li SB. Expression of toll-like receptor 4 and MD-2 gene and protein in Kupffer cells after ischemia-reperfusion in rat liver graft. World J Gastroenterol. 2004;10(19):2890-2893. (Pubitemid 39303013)
87. Wu HS, Zhang JX, Wang L, Tian Y, Wang H, Rotstein O. Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice. Hepatobiliary Pancreat Dis Int. 2004;3(2):250-253. (Pubitemid 38660160)
88. Hua J, Qiu de K, Li JQ, Li EL, Chen XY, Peng YS. Expression of Toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury. J Gastroenterol Hepatol. 2007;22(6):862-869. (Pubitemid 46911031)
89. Tsung A, Hoffman RA, Izuishi K, et al. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol. 2005;175(11):7661-7668. (Pubitemid 41713466)
90. Tsung A, Sahai R, Tanaka H, et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med. 2005;201(7):1135-1143. (Pubitemid 40524681)
91. Tsung A, Klune JR, Zhang X, et al. HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med. 2007;204(12):2913-2923. (Pubitemid 350179560)
92. DeOliveira ML, Graf R, Clavien PA. Ischemic preconditioning: promises from the laboratory to patients - sustained or disillusioned? Am J Transplant. 2008;8(3):489-491.
93. Koneru B, Shareef A, Dikdan G, et al. The ischemic preconditioning paradox in deceased donor liver transplantation-evidence from a prospective randomized single blind clinical trial. Am J Transplant. 2007;7(12):2788-2796. (Pubitemid 350045783)
94. Funaki H, Shimizu K, Harada S, et al. Essential role for nuclear factor kappaB in ischemic preconditioning for ischemia-reperfusion injury of the mouse liver. Transplantation. 2002;74(4):551-556. (Pubitemid 34977688)
95. Heizmann O, Loehe F, Volk A, Schauer RJ. Ischemic preconditioning improves postoperative outcome after liver resections: a randomized controlled study. Eur J Med Res. 2008;13(2):79-86.
96. Jang JH, Kang KJ, Kang Y, Lee IS, Graf R, Clavien PA. Ischemic preconditioning and intermittent clamping confer protection against ischemic injury in the cirrhotic mouse liver. Liver Transpl. 2008;14(7):980-988. (Pubitemid 352003897)
97. Saidi RF, Chang J, Brooks S, Nalbantoglu I, Adsay V, Jacobs MJ. Ischemic preconditioning and intermittent clamping increase the tolerance of fatty liver to hepatic ischemia-reperfusion injury in the rat. Transplant Proc. 2007;39(10):3010-3014. (Pubitemid 350251518)
98. Amador A, Grande L, Martí J, et al. Ischemic pre-conditioning in deceased donor liver transplantation: a prospective randomized clinical trial. Am J Transplant. 2007;7(9):2180-2189. (Pubitemid 47247061)
99. Jassem W, Fuggle SV, Cerundolo L, Heaton ND, Rela M. Ischemic preconditioning of cadaver donor livers protects allografts following transplantation. Transplantation. 2006;81(2):169-174.
100. Lee WY, Lee SM. Ischemic preconditioning protects post-ischemic oxidative damage to mitochondria in rat liver. Shock. 2005;24(4):370-375. (Pubitemid 41416524)
101. Arai M, Tejima K, Ikeda H, et al. Ischemic preconditioning in liver pathophysiology. J Gastroenterol Hepatol. 2007;22(suppl 1):S65-S67.
102. Choukèr A, Martignoni A, Schauer RJ, et al. Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man. Eur Surg Res. 2005;37(3):144-152. (Pubitemid 41160146)
103. Schauer RJ, Gerbes AL, Vonier D, op den Winkel M, Fraunberger P, Bilzer M. Induction of cellular resistance against Kupffer cell-derived oxidant stress: a novel concept of hepatoprotection by ischemic preconditioning. Hepatology. 2003;37(2):286-295. (Pubitemid 36152527)
104. Choukèr A, Martignoni A, Schauer R, et al. Beneficial effects of ischemic preconditioning in patients undergoing hepatectomy: the role of neutrophils. Arch Surg. 2005;140(2):129-136. (Pubitemid 40229099)
105. Teoh N, Field J, Farrell G. Interleukin-6 is a key mediator of the hepatoprotective and pro-proliferative effects of ischaemic preconditioning in mice. J Hepatol. 2006;45(1):20-27. (Pubitemid 43850619)
106. Matsumoto T, O'Malley K, Efron PA, et al. Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning. Surgery. 2006;140(5):793-802. (Pubitemid 44648189)
107. Iñiguez M, Berasain C, Martinez-Ansó E, et al. Cardiotrophin-1 defends the liver against ischemia-reperfusion injury and mediates the protective effect of ischemic preconditioning. J Exp Med. 2006;203(13):2809-2815. (Pubitemid 46026159)
108. Shinoda M, Shimazu M, Wakabayashi G, Tanabe M, Hoshino K, Kitajima M. Tumor necrosis factor suppression and microcirculatory disturbance amelioration in ischemia/reperfusion injury of rat liver after ischemic preconditioning. J Gastroenterol Hepatol. 2002;17(11):1211-1219. (Pubitemid 36015618)
109. Massip-Salcedo M, Casillas-Ramirez A, Franco-Gou R, et al. Heat shock proteins and mitogen-activated protein kinases in steatotic livers undergoing ischemia-reperfusion: some answers. Am J Pathol. 2006;168(5):1474-1485.
110. Ricciardi R, Schaffer BK, Kim RD, et al. Protective effects of ischemic preconditioning on the cold-preserved liver are tyrosine kinase dependent. Transplantation. 2001;72(3):406-412. (Pubitemid 32769623)
111. Ricciardi R, Meyers WC, Schaffer BK, et al. Protein kinase C inhibition abrogates hepatic ischemic preconditioning responses. J Surg Res. 2001;97(2):144-149. (Pubitemid 34951169)
112. Ricciardi R, Shah SA, Wheeler SM, et al. Regulation of NFkappaB in hepatic ischemic preconditioning. J Am Coll Surg. 2002;195(3):319-326. (Pubitemid 35006285)
113. Sahin DA, Haliloglu B, Sahin FK, et al. Stepwise rising CO2 insufflation as an ischemic preconditioning method. J Laparoendosc Adv Surg Tech A. 2007;17(6):723-729.
114. Jang JH, Moritz W, Graf R, Clavien PA. Preconditioning with death ligands FasL and TNF-alpha protects the cirrhotic mouse liver against ischaemic injury. Gut. 2008;57(4):492-499. Erratum in: Gut. 2008;57(9):1340.
115. Lü H, Yang LQ, Yu WF, et al. [Protection of liver against ischemia/reperfusion injury by Kupffer cell mediated emulsified isoflurane preconditioning: experiment with rats] Zhonghua Yi Xue Za Zhi. 2007;87(35):2468-2471. Chinese.
116. Izuishi K, Tsung A, Jeyabalan G, et al. Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury. J Immunol. 2006;176(12):7154-7158. (Pubitemid 43849015)
117. Van As AB, Foroutan HR, Lotz Z, Tyler M, Millar AJ, Kahn D. Ischaemic preconditioning of the liver before transplantation. S Afr J Surg. 2007;45(4):122-124, 126.
118. Azoulay D, Del Gaudio M, Andreani P, et al. Effects of 10 minutes of ischemic preconditioning of the cadaveric liver on the graft's preservation and function: the ying and the yang. Ann Surg. 2005;242(1):133-139. (Pubitemid 40917977)
119. Caldwell CC, Okaya T, Martignoni A, Husted T, Schuster R, Lentsch AB. Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2005;289(5):G969-G976. (Pubitemid 41532590)
120. Zhai Y, Shen XD, Hancock WW, et al. CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury. J Immunol. 2006;176(10):6313-6322.
121. Anselmo DM, Amersi FF, Shen XD, et al. FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration. Am J Transplant. 2002;2(9):843-849.
122. Shen XD, Ke B, Zhai Y, et al. CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection. Transplantation. 2002;74(3):315-319. (Pubitemid 34894279)
123. Ke B, Shen XD, Gao F, et al. The CD154-CD40 T-cell co-stimulation pathway in liver ischemia and reperfusion inflammatory responses. Transplantation. 2005;79(9):1078-1083. (Pubitemid 40664001)
124. Shimamura K, Kawamura H, Nagura T, et al. Association of NKT cells and granulocytes with liver injury after reperfusion of the portal vein. Cell Immunol. 2005;234(1):31-38. (Pubitemid 41140389)
125. Khandoga A, Hanschen M, Kessler JS, Krombach F. CD4+ T cells contribute to postischemic liver injury in mice by interacting with sinusoidal endothelium and platelets. Hepatology. 2006;43(2):306-315. (Pubitemid 43303998)
126. Li W, Lu L, Wang Z, et al. Il-12 antagonism enhances apoptotic death of T cells within hepatic allografts from Flt3 ligand-treated donors and promotes graft acceptance. J Immunol. 2001;166(9):5619-5628. (Pubitemid 32374185)
127. Lappas CM, Day YJ, Marshall MA, Engelhard VH, Linden J. Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. J Exp Med. 2006;203(12):2639-2648. (Pubitemid 44833340)
128. Odashima M, Otaka M, Jin M, et al. A selective adenosine A2A receptor agonist, ATL-146e, prevents concanavalin A-induced acute liver injury in mice. Biochem Biophys Res Commun. 2006;347(4):949-954. (Pubitemid 44118210)
129. Hamada T, Tsuchihashi S, Avanesyan A, et al. Cyclooxygenase-2 deficiency enhances Th2 immune responses and impairs neutrophil recruitment in hepatic ischemia/reperfusion injury. J Immunol. 2008;180(3):1843-1853.
130. Pulitanò C, Sitia G, Aldrighetti L, et al. Reduced severity of liver ischemia/reperfusion injury following hepatic resection in humans is associated with enhanced intrahepatic expression of Th2 cytokines. Hepatol Res. 2006;36(1):20-26. (Pubitemid 44309283)
131. Moore C, Shen XD, Fondevila C, Gao F, Coito AJ. Blockade of fibronectin-alpha4beta1 adhesive interactions down-regulates cyclooxygenase-2 inducible nitric oxide synthase and prolongs recipient survival in a 24-hour model of cold hepatic ischemia-reperfusion injury. Transplant Proc. 2005;37(4):1682-1683. (Pubitemid 40790794)
132. Amersi F, Shen XD, Moore C, et al. Fibronectin-alpha 4 beta 1 integrin-mediated blockade protects genetically fat Zucker rat livers from ischemia/reperfusion injury. Am J Pathol. 2003;162(4):1229-1239. (Pubitemid 36350667)
133. Xue H, Guo H, Li YC, Hao ZM. Heme oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats. World J Gastroenterol. 2007;13(40):5384-5390. (Pubitemid 47559473)
134. Tsuchihashi S, Zhai Y, Fondevila C, Busuttil RW, Kupiec-Weglinski JW. HO-1 upregulation suppresses type 1 IFN pathway in hepatic ischemia/reperfusion injury. Transplant Proc. 2005;37(4):1677-1678. (Pubitemid 40790792)
135. Kato H, Amersi F, Buelow R, et al. Heme oxygenase-1 overexpression protects rat livers from ischemia/reperfusion injury with extended cold preservation. Am J Transplant. 2001;1(2):121-128. (Pubitemid 33674151)
136. Ke QH, Zheng SS, Liang TB, Xie HY, Xia WL. [Effects of hypertonic saline on expression of heme oxygenase enzyme-1 in hepatic ischemia/reperfusion injury rats] Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006;18(1):5-8. Chinese.
137. Lai IR, Chang KJ, Tsai HW, Chen CF. Pharmacological preconditioning with simvastatin protects liver from ischemia-reperfusion injury by heme oxygenase-1 induction. Transplantation. 2008;85(5):732-738.
138. Coito AJ, Buelow R, Shen XD, et al. Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury. Transplantation. 2002;74(1):96-102. (Pubitemid 34779218)
139. Ke B, Buelow R, Shen XD, et al. Heme oxygenase 1 gene transfer prevents CD95/Fas ligand-mediated apoptosis and improves liver allograft survival via
140. Tsuchihashi S, Zhai Y, Bo Q, Busuttil RW, Kupiec-Weglinski JW. Heme oxygenase-1 mediated cytoprotection against liver ischemia and reperfusion injury: inhibition of type-1 interferon signaling. Transplantation. 2007;83(12):1628-1634. (Pubitemid 46987916)
141. Nakahira K, Takahashi T, Shimizu H, et al. Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity. Biochem Pharmacol. 2003;66(6):1091-1105. (Pubitemid 37083606)
142. Wen T, Guan L, Zhang YL, Zhao JY. Dynamic changes of heme oxygenase-1 and carbon monoxide production in acute liver injury induced by carbon tetrachloride in rats. Toxicology. 2006;228(1):51-57. (Pubitemid 44548102)
143. Lee CH, Park SW, Kim YS, et al. Protectivemechanismof glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice. Biol Pharm Bull. 2007;30(10):1898-1904. (Pubitemid 47607779)
144. Eipel C, Eisold M, Schuett H, Vollmar B. Inhibition of heme oxygenase-1 protects against tissue injury in carbon tetrachloride exposed livers. J Surg Res. 2007;139(1):113-120. (Pubitemid 46482571)
145. Wang XH, Wang K, Zhang F, et al. Heme oxygenase-1 alleviates ischemia/reperfusion injury in aged liver. World J Gastroenterol. 2005;11(5):690-694. (Pubitemid 40220759)
146. Fondevila C, Shen XD, Tsuchiyashi S, et al. Biliverdin therapy protects rat livers from ischemia and reperfusion injury. Hepatology. 2004;40(6):1333-1341. (Pubitemid 39657007)
147. Kato Y, Shimazu M, Kondo M, et al. Bilirubin rinse: A simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning. Hepatology. 2003;38(2):364-373. (Pubitemid 36919857)
148. Kaizu T, Ikeda A, Nakao A, et al. Protection of transplant-induced hepatic ischemia/reperfusion injury with carbon monoxide via MEK/ERK1/2 pathway downregulation. Am J Physiol Gastrointest Liver Physiol. 2008;294(1):G236-G244.
149. Kaizu T, Nakao A, Tsung A, et al. Carbon monoxide inhalation ameliorates cold ischemia/reperfusion injury after rat liver transplantation. Surgery. 2005;138(2):229-235. (Pubitemid 41253805)
150. Wen T, Zhao JY, Mei S, Guan L, Zhang YL. [Protective effect of heme oxygenase-1 and its reaction product, carbon monoxide on acute liver injury induced by carbon tetrachloride in rats] Beijing Da Xue Xue Bao. 2006;38(6):618-622. Chinese.
151. Amersi F, Shen XD, Anselmo D, et al. Ex vivo exposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway. Hepatology. 2002;35(4):815-823. (Pubitemid 34258375)
152. Yamagami K, Enders G, Schauer RJ, et al. Heat-shock preconditioning protects fatty livers in genetically obese Zucker rats from microvascular perfusion failure after ischemia reperfusion. Transpl Int. 2003;16(8):456-463. (Pubitemid 37193303)
153. Yamagami K, Yamamoto Y, Toyokuni S, Hata K, Yamaoka Y. Heat shock preconditioning reduces the formation of 8-hydroxy-2′-deoxyguanosine and 4-hydroxy-2-nonenal modified proteins in ischemia-reperfused liver of rats. Free Radic Res. 2002;36(2):169-176.
154. Matsuo K, Togo S, Sekido H, et al. Pharmacologic preconditioning effects: prostaglandin E1 induces heat-shock proteins immediately after ischemia/reperfusion of the mouse liver. J Gastrointest Surg. 2005;9(6):758-768. (Pubitemid 40883970)
155. Shen SQ, Zhang Y, Xiang JJ, Xiong CL. Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes. World J Gastroenterol. 2007;13(13):1953-1961. (Pubitemid 46758857)
156. Bedirli A, Sakrak O, Muhtaroglu S, et al. Ergothioneine pretreatment protects the liver from ischemia-reperfusion injury caused by increasing hepatic heat shock protein 70. J Surg Res. 2004;122(1):96-102. (Pubitemid 39441239)
157. Shen SQ, Zhang Y, Xiong CL. The protective effects of 17beta-estradiol on hepatic ischemia-reperfusion injury in rat model, associated with regulation of heat-shock protein expression. J Surg Res. 2007;140(1):67-76. (Pubitemid 46669544)
158. Ikeyama S, Kusumoto K, Miyake H, Rokutan K, Tashiro S. A non-toxic heat shock protein 70 inducer, geranylgeranylacetone, suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol. J Hepatol. 2001;35(1):53-61. (Pubitemid 32646224)
159. Shi Q, Dong Z, Wei H. The involvement of heat shock proteins in murine liver regeneration. Cell Mol Immunol. 2007;4(1):53-57.
160. Noh J, Behrends M, Choi S, et al. Glutamine does not protect against hepatic warm ischemia/reperfusion injury in rats. J Gastrointest Surg. 2006;10(2):234-239. (Pubitemid 43187186)
161. Sakai T, Takaya S, Fukuda A, Harada O, Kobayashi M. Evaluation of warm ischemia-reperfusion injury using heat shock protein in the rat liver. Transpl Int. 2003;16(2):88-99. (Pubitemid 36682204)
162. Chen H, Yu YY, Zhang MJ, et al. Protective effect of doxorubicin induced heat shock protein 72 on cold preservation injury of rat livers. World J Gastroenterol. 2004;10(9):1375-1378. (Pubitemid 39162453)
163. Cheng Y, Liu YF, Liang J. Protective effect of zinc: a potent heat shock protein inducer in cold preservation of rat liver. Hepatobiliary Pancreat Dis Int. 2002;1(2):258-261. (Pubitemid 36748214)
164. Boeri D, Dondero F, Storace D, Maiello M, Pasqualini M, Pellicci R. Heat-shock protein 70 favours human liver recovery from ischaemia-reperfusion. Eur J Clin Invest. 2003;33(6):500-504. (Pubitemid 36754215)
165. Uchinami H, Yamamoto Y, Kume M, et al. Effect of heat shock preconditioning on NF-kappaB/I-kappaB pathway during I/R injury of the rat liver. Am J Physiol Gastrointest Liver Physiol. 2002;282(6):G962-G971. (Pubitemid 34651602)
166. Chen H, Peng CH, Deng XX, et al. [The protective effect of heat shock protein 72 by Doxorubicin in cold ischemia-reperfusion injury of the rat liver] Zhonghua Wai Ke Za Zhi. 2006;44(5):310-313. Chinese.
167. Doi Y, Hamazaki K, Yabuki M, Tanaka N, Utsumi K. Effect of HSP70 induced by warm ischemia to the liver on liver function after partial hepatectomy. Hepatogastroenterology. 2001;48(38):533-540. (Pubitemid 32391606)
168. Kuboki S, Schuster R, Blanchard J, Pritts TA, Wong HR, Lentsch AB. Role of heat shock protein 70 in hepatic ischemia-reperfusion injury in mice. Am J Physiol Gastrointest Liver Physiol. 2007;292(4):G1141-G1149. (Pubitemid 46557791)
169. Galloway E, Shin T, Huber N, et al. Activation of hepatocytes by extracellular heat shock protein 72. Am J Physiol Cell Physiol. 2008;295(2):C514-C520. (Pubitemid 352755777)
170. Li F, Chong ZZ, Maiese K. Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways. Neurosignals. 2004;13(6):265-289. (Pubitemid 40073625)
171. Maiese K, Chong ZZ, Li F, Shang YC. Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies. Prog Neurobiol. 2008;85(2):194-213.
172. Yilmaz S, Ates E, Tokyol C, Pehlivan T, Erkasap S, Koken T. The protective effect of erythropoietin on ischaemia/reperfusion injury of liver. HPB (Oxford). 2004;6(3):169-173. (Pubitemid 39248177)
173. Hochhauser E, Pappo O, Ribakovsky E, et al. Recombinant human erythropoietin attenuates hepatic injury induced by ischemia/reperfusion in an isolated mouse liver model. Apoptosis. 2008;13(1):77-86.
174. Sepodes B, Maio R, Pinto R, et al. Recombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat. Transpl Int. 2006;19(11):919-926. (Pubitemid 44511117)
175. Schmeding M, Neumann UP, Boas-Knoop S, Spinelli A, Neuhaus P. Erythropoietin reduces ischemia-reperfusion injury in the rat liver. Eur Surg Res. 2007;39(3):189-197. (Pubitemid 46633182)
176. Solaroglu A, Dede FS, Okutan E, Bayrak A, Haberal A, Kilinc K. A single dose of erythropoietin attenuates lipid peroxidation in experimental liver ischemia-reperfusion injury in the rat fetus. J Matern Fetal Neonatal Med. 2004;16(4):231-234. (Pubitemid 39657819)
177. Schmeding M, Boas-Knoop S, Lippert S, et al. Erythropoietin promotes hepatic regeneration after extended liver resection in rats. J Gastroenterol Hepatol. 2008;23(7 Pt 1):1125-1131. (Pubitemid 352019375)
178. Yazihan N, Ataoǧlu H, Yener B, Aydin C. Erythropoietin attenuates hydrogen peroxide-induced damage of hepatocytes. Turk J Gastroenterol. 2007;18(4):239-244. (Pubitemid 351676977)
179. Ates E, Yilmaz S, Ihtiyar E, Yasar B, Karahuseyinoglu E. Preconditioning- like amelioration of erythropoietin against laparoscopy-induced oxidative injury. Surg Endosc. 2006;20(5):815-819. (Pubitemid 43978787)
180. Calvey CR, Toledo-Pereyra LH. Selectin inhibitors and their proposed role in ischemia and reperfusion. J Invest Surg. 2007;20(2):71-85.
181. Kubes P, Payne D, Woodman RC. Molecular mechanisms of leukocyte recruitment in postischemic liver microcirculation. Am J Physiol Gastrointest Liver Physiol. 2002;283(1):G139-G147. (Pubitemid 34666172)
182. Khandoga A, Biberthaler P, Enders G, et al. P-selectin mediates platelet-endothelial cell interactions and reperfusion injury in the mouse liver in vivo. Shock. 2002;18(6):529-535.
183. Tsuchihashi S, Fondevila C, Shaw GD, et al. Molecular characterization of rat leukocyte P-selectin glycoprotein ligand-1 and effect of its blockade: protection from ischemia-reperfusion injury in liver transplantation. J Immunol. 2006;176(1):616-624. (Pubitemid 43023310)
184. Amersi F, Farmer DG, Shaw GD, et al. P-selectin glycoprotein ligand-1 (rPSGL-Ig)-mediated blockade of CD62 selectinmolecules protects rat steatotic liver grafts from ischemia/reperfusion injury. Am J Transplant. 2002;2(7):600-608. (Pubitemid 36306851)
185. Amersi F, Dulkanchainun T, Nelson SK, et al. A novel iron chelator in combination with a P-selectin antagonist prevents ischemia/reperfusion injury in a rat liver model. Transplantation. 2001;71(1):112-118. (Pubitemid 32105787)
186. Zhou T, Sun GZ, Zhang MJ, et al. Role of adhesion molecules and dendritic cells in rat hepatic/renal ischemia-reperfusion injury and anti-adhesive intervention with anti-P-selectin lectin-EGF domain monoclonal antibody. World J Gastroenterol. 2005;11(7):1005-1010. (Pubitemid 40347753)
187. Rivera-Chavez FA, Toledo-Pereyra LH, Martinez-Mier G, et al. L-selectin blockade and liver function in rats after uncontrolled hemorrhagic shock. J Invest Surg. 2001;14(1):7-12. (Pubitemid 32208459)
188. Taut FJ, Schmidt H, Zapletal CM, et al. N-acetylcysteine induces shedding of selectins from liver and intestine during orthotopic liver transplantation. Clin Exp Immunol. 2001;124(2):337-341. (Pubitemid 32587620)
189. Young CS, Palma JM, Mosher BD, et al. Hepatic ischemia/reperfusion injury in P-selectin and intercellular adhesion molecule-1 double-mutant mice. Am Surg. 2001;67(8):737-744. (Pubitemid 33738878)
190. López-Neblina F, Toledo-Pereyra LH. Anti-ischemic effect of selectin blocker through modulation of tumor necrosis factor-alpha and interleukin-10. J Surg Res. 2007;138(2):275-283. (Pubitemid 46365717)
191. Toledo-Pereyra LH, Lopez-Neblina F, Reuben JS, Toledo AH, Ward PA. Selectin inhibition modulates Akt/MAPK signaling and chemokine expression after liver ischemia-reperfusion. J Invest Surg. 2004;17(6):303-313. (Pubitemid 40109632)
192. Toledo-Pereyra LH, Lopez-Neblina F, Lentsch AB, Anaya-Prado R, Romano SJ, Ward PA. Selectin inhibition modulates NF-kappa B and AP-1 signaling after liver ischemia/reperfusion. J Invest Surg. 2006;19(5):313-322. (Pubitemid 44377552)
193. Shinoda M, Shimazu M, Matsuda S, et al. c-Jun N-terminal kinase activation during warm hepatic ischemia/reperfusion injuries in a rat model. Wound Repair Regen. 2002;10(5):314-319. (Pubitemid 35315680)
194. Mollen KP, McCloskey CA, Tanaka H, et al. Hypoxia activates c-Jun N-terminal kinase via Rac1-dependent reactive oxygen species production in hepatocytes. Shock. 2007;28(3):270-277. (Pubitemid 47282017)
195. Uehara T, Xi Peng X, Bennett B, et al. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 2004;78(3):324-332. (Pubitemid 39095396)
196. Uehara T, Bennett B, Sakata ST, et al. JNK mediates hepatic ischemia reperfusion injury. J Hepatol. 2005;42(6):850-859. (Pubitemid 40693202)
197. Crenesse D, Laurens M, Heurteaux C, et al. Rat liver ischemia- reperfusion-induced apoptosis and necrosis are decreased by FK506 pretreatment. Eur J Pharmacol. 2003;473(2-3):177-184. (Pubitemid 36929882)
198. Lee KH, Kim SE, Lee YS. SP600125, a selective JNK inhibitor, aggravates hepatic ischemia-reperfusion injury. Exp Mol Med. 2006;38(4):408-416. (Pubitemid 44351436)
199. Zhao Y, Man K, Lo CM, et al. Attenuation of small-for-size liver graft injury by FTY720: significance of cell-survival Akt signaling pathway. Am J Transplant. 2004;4(9):1399-1407. (Pubitemid 39159054)
200. Man K, Ng KT, Lee TK, et al. FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers. Am J Transplant. 2005;5(1):40-49. (Pubitemid 40095126)
201. Kobayashi M, Takeyoshi I, Yoshinari D, Matsumoto K, Morishita Y. P38 mitogen-activated protein kinase inhibition attenuates ischemia-reperfusion injury of the rat liver. Surgery. 2002;131(3):344-349. (Pubitemid 34229789)
202. Kobayashi K, Oshima K, Muraoka M, et al. Effect of atrial natriuretic peptide on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model. World J Gastroenterol. 2007;13(25):3487-3492. (Pubitemid 47162022)
203. Shiotani S, Shimada M, Suehiro T, et al. Involvement of Rho-kinase in cold ischemia-reperfusion injury after liver transplantation in rats. Transplantation. 2004;78(3):375-382. (Pubitemid 39095403)
204. Ikeda F, Terajima H, Shimahara Y, Kondo T, Yamaoka Y. Reduction of hepatic ischemia/reperfusion-induced injury by a specific ROCK/Rho kinase inhibitor Y-27632. J Surg Res. 2003;109(2):155-160. (Pubitemid 36315743)
205. Kawaguchi A, Ohmori M, Fujimura A. Partial protective effect of Y-27632, a Rho kinase inhibitor, against hepatic ischemia-reperfusion injury in rats. Eur J Pharmacol. 2004;493(1-3):167-171. (Pubitemid 38746946)
206. Takeda K, Jin MB, Fujita M, et al. A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats. Surgery. 2003;133(2):197-206. (Pubitemid 36407984)
207. Mizunuma K, Ohdan H, Tashiro H, Fudaba Y, Ito H, Asahara T. Prevention of ischemia-reperfusion-induced hepatic microcirculatory disruption by inhibiting stellate cell contraction using rock inhibitor. Transplantation. 2003;75(5):579-586. (Pubitemid 36337352)
208. Ikeda H, Kume Y, Tejima K, et al. Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats. Am J Physiol Gastrointest Liver Physiol. 2007;293(4):G911-G917. (Pubitemid 47605940)
209. Shiotani S, Shimada M, Taketomi A, et al. Rho-kinase as a novel gene therapeutic target in treatment of cold ischemia/reperfusion-induced acute lethal liver injury: effect on hepatocellular NADPH oxidase system. Gene Ther. 2007;14(19):1425-1433. (Pubitemid 47423742)
210. Lee MH, Murphy G. Matrix metalloproteinases at a glance. J Cell Sci. 2004;117(Pt 18):4015-4016.
211. Fowell AJ, Benyon RC. Can matrix metalloproteinases be targeted in hepatic ischemia/reperfusion injury? Hepatology. 2008;47(1):14-16.
212. Defamie V, Laurens M, Patrono D, et al. Matrix metalloproteinase inhibition protects rat livers from prolonged cold ischemia-warm reperfusion injury. Hepatology. 2008;47(1):177-185. (Pubitemid 351171055)
213. Cursio R, Mari B, Louis K, et al. Rat liver injury after normothermic ischemia is prevented by a phosphinic matrix metalloproteinase inhibitor. FASEB J. 2002;16(1):93-95.
214. Shirahane K, Yamaguchi K, Koga K, Watanabe M, Kuroki S, Tanaka M. Hepatic ischemia/reperfusion injury is prevented by a novel matrix metalloproteinase inhibitor, ONO-4817. Surgery. 2006;139(5):653-664.
215. Chen CF, Leu FJ, Chen HI, Wang D. Oxygen radicals and matrix metalloproteinases mediate reperfusion liver injury. Transplant Proc. 2005;37(10):4547-4549. (Pubitemid 43016077)
216. Kuyvenhoven JP, Molenaar IQ, Verspaget HW, et al. Plasma MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 during human orthotopic liver transplantation. The effect of aprotinin and the relation to ischemia/reperfusion injury. Thromb Haemost. 2004;91(3):506-513.
217. Kuyvenhoven JP, Ringers J, Verspaget HW, Lamers CB, van Hoek B. Serum matrix metalloproteinase MMP-2 and MMP-9 in the late phase of ischemia and reperfusion injury in human orthotopic liver transplantation. Transplant Proc. 2003;35(8):2967-2969. (Pubitemid 38102103)
218. Moore C, Shen XD, Gao F, Busuttil RW, Coito AJ. Fibronectin-alpha4beta1 integrin interactions regulate metalloproteinase-9 expression in steatotic liver ischemia and reperfusion injury. Am J Pathol. 2007;170(2):567-577. (Pubitemid 47339394)
219. Hamada T, Fondevila C, Busuttil RW, Coito AJ. Metalloproteinase-9 deficiency protects against hepatic ischemia/reperfusion injury. Hepatology. 2008;47(1):186-198. (Pubitemid 351171056)
220. Khandoga A, Kessler JS, Hanschen M, et al. Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver. J Leukoc Biol. 2006;79(6):1295-1305. (Pubitemid 44835565)
221. Frangogiannis NG. Chemokines in ischemia and reperfusion. Thromb Haemost. 2007;97(5):738-747.
222. Harada H, Wakabayashi G, Takayanagi A, et al. Transfer of the interleukin-1 receptor antagonist gene into rat liver abrogates hepatic ischemia-reperfusion injury. Transplantation. 2002;74(10):1434-1441. (Pubitemid 35379551)
223. Zhai Y, Qiao B, Gao F, et al. Type I, but not type II, interferon is critical in liver injury induced after ischemia and reperfusion. Hepatology. 2008;47(1):199-206. (Pubitemid 351171057)
224. Motoki A, Adachi N, Liu K, et al. Suppression of ischaemia-induced cytokine release by dimaprit and amelioration of liver injury in rats. Basic Clin Pharmacol Toxicol. 2008;102(4):394-398.
225. Kato A, Graul-Layman A, Edwards MJ, Lentsch AB. Promotion of hepatic ischemia/reperfusion injury by IL-12 is independent of STAT4. Transplantation. 2002;73(7):1142-1145. (Pubitemid 34415450)
226. Takiguchi M, Totsuka E, Umehara M, et al. Attenuation of microcirculatory disturbance after liver ischemia by newly synthesized inflammatory cytokine suppressor, FR167653. Hepatogastroenterology. 2003;50(51):789-793.
227. Ben-Ari Z, Hochhauser E, Burstein I, et al. Role of anti-tumor necrosis factor-alpha in ischemia/reperfusion injury in isolated rat liver in a blood-free environment. Transplantation. 2002;73(12):1875-1880. (Pubitemid 34700992)
228. Takeuchi D, Yoshidome H, Kato A, et al. Interleukin 18 causes hepatic ischemia/reperfusion injury by suppressing antiinflammatory cytokine expression in mice. Hepatology. 2004;39(3):699-710. (Pubitemid 38337649)
229. Conzelmann LO, Lehnert M, Kremer M, Zhong Z, Wheeler MD, Lemasters JJ. Graft tumor necrosis factor receptor-1 protects after mouse liver transplantation whereas host tumor necrosis factor receptor-1 promotes injury. Transplantation. 2006;82(9):1214-1220. (Pubitemid 44748025)
230. Guidi L, Tricerri A, Costanzo M, et al. Interleukin-6 release in the hepatic blood outflow during normothermic liver ischaemia in humans. Dig Liver Dis. 2003;35(6):409-415. (Pubitemid 41070455)
231. Ke B, Shen XD, Tsuchihashi S, et al. Viral interleukin-10 gene transfer prevents liver ischemia-reperfusion injury: Toll-like receptor-4 and heme oxygenase-1 signaling in innate and adaptive immunity. Hum Gene Ther. 2007;18(4):355-366. (Pubitemid 46709347)
232. Ke QH, Zheng SS, Liang TB, Xie HY, Xia WL. Pretreatment of hypertonic saline can increase endogenous interleukin 10 release to attenuate hepatic ischemia reperfusion injury. Dig Dis Sci. 2006;51(12):2257-2263.
233. Oreopoulos GD, Wu H, Szaszi K, et al. Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion in mice: a role for interleukin 10. Hepatology. 2004;40(1):211-220. (Pubitemid 38868940)
234. Kawakami T, Takahashi T, Shimizu H, et al. Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity. Int J Mol Med. 2006;18(4):537-546.
235. Kato A, Okaya T, Lentsch AB. Endogenous IL-13 protects hepatocytes and vascular endothelial cells during ischemia/reperfusion injury. Hepatology. 2003;37(2):304-312. (Pubitemid 36152529)