Novel 2-substituted nitronyl nitroxides as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5711-5720

  Wu, Yihui ^a,b   Bi, Lanrong ^a,b   Bi, Wei ^b,c   Li, Zeng ^a,b   Zhao, Ming ^a,b   Wang, Chao ^a,b   Ju, Jingfang ^b,d   Peng, Shiqi ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c HEBEI MEDICAL UNIVERSITY   (China)

^d USA   (United States)

Author keywords

Free radical scavenger; Nitronyl nitroxide derivatives; Structure activity relationship

Indexed keywords

2 (2' FLUOROPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (2' HYDROXYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (2' NITROPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (2' OXYMETHYLCARBOXYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (2',4' DICHLOROPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (2',4' DIMETHOXYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (3' HYDROXYL 4' METHOXYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (3' HYDROXYPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (3' METHOXYL 4' HYDROXYPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (3' NITROPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (3',4' DIMETHOXYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (3',4' METHYLENEDIOXYPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (4' BROMOETHOXYPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (4' CHLOROPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (4' METHOXYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (4' METHYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (4' N,N DIMETHYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 (PHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; 2 PHENYL 4,4,5,5 TETRAMETHYLIMIDAZOLINE 3 OXIDE 1 OXYL; NITROXIDE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON TRANSPORT; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; VASODILATATION;

ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; CYCLIC N-OXIDES; ELECTRONS; FREE RADICAL SCAVENGERS; HYDROCARBONS, AROMATIC; HYDROGEN PEROXIDE; IMIDAZOLES; NITROGEN OXIDES; OXIDATION-REDUCTION; PC12 CELLS; RATS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33745594611     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.016     Document Type: Article

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