Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 4, 2008, Pages 1764-1774

  Bi, Lanrong ^a   Zhao, Ming ^a   Gu, Keli ^a   Wang, Chao ^b   Ju, Jingfang ^c   Peng, Shiqi ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c USA   (United States)

Author keywords

5 Glycylamino 2 substituted phenyl 1,3 dioxacycloalkanes; Anti inflammatory activity; Chemoprevention; Structure activity relationship

Indexed keywords

(2 PHENYL 1,3 DIOXAN 5 YL)AMINE; (2 PHENYL 4 METHYL 1,3 DIOXAN 5 YL)AMINE; 2 (3' NITROPHENYL) 4 METHYL 5 GLYCYLAMINO 1,3 DIOXANE; 2 (3' NITROPHENYL) 5 GLYCYLAMINO 1,3 DIOXA HEPTANE DERIVATIVE; 2 (3' NITROPHENYL) 5 GLYCYLAMINO 1,3 DIOXANE; 2 (4' CHLOROPHENYL 1,3 DIOXAHEPTAN 5 YL)AMINE; 2 (4' CHLOROPHENYL) 4 METHYL 5 GLYCYLAMINO 1,3 DIOXANE; 2 (4' CHLOROPHENYL) 5 GLYCYLAMINO 1,3 DIOXAHEPTANE DERIVATIVE; 2 (4' CHLOROPHENYL) 5 GLYCYLAMINO 1,3 DIOXANE; 2 (4' METHYLPHENYL) 4 METHYL 5 GLYCYLAMINO 1,3 DIOXANE; 2 (4' METHYLPHENYL) 5 GLYCYLAMINO 1,3 DIOXANE; 2 (4' NITROPHENYL 1,3 DIOXAHEPTAN 5 YL)AMINE; 2 (4' NITROPHENYL) 4 METHYL 5 GLYCYLAMINO 1,3 DIOXANE; 2 (4' NITROPHENYL) 5 GLYCYLAMINO 1,3 DIOXAHEPTANE DERIVATIVE; 2 (4' NITROPHENYL) 5 GLYCYLAMINO 1,3 DIOXANE; 2 [(4' CHLOROPHENYL) 4 METHYL 1,3 DIOXAN 5 YL]AMINE; 2 [(4' METHYLPHENYL) 4 METHYL 1,3 DIOXAN 5 YL]AMINE; 2 [(4' NITROPHENYL) 4 METHYL 1,3 DIOXAN 5 YL]AMINE; 2 [3' NITROPHENYL] 1,3 DIOXAN 5 YL]AMINE; 2 [4' NITROPHENYL] 1,3 DIOXAN 5 YL]AMINE; 2 PHENYL 4 METHYL 5 GLYCYLAMINO 1,3 DIOXANE; 2 PHENYL 5 GLYCYLAMINO 1,3 DIOXANE; [2 (3' NITROPHENYL) 1,3 DIOXAHEPTAN 5 YL]AMINE; [2 (4' CHLOROPHENYL) 1,3 DIOXAN 5 YL]AMINE; [2 (4' METHYLPHENYL) 1,3 DIOXAN 5 YL]AMINE; ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG; XYLENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG SYNTHESIS; EAR DISEASE; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZENE DERIVATIVES; CHEMOPREVENTION; INFLAMMATION; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; TREATMENT OUTCOME;

MUS;

EID: 38949191611     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.017     Document Type: Article

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