Toward the development of chemoprevention agents. Part II: Chemo-enzymatic synthesis and anti-inflammatory activities of a new class of 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 18, 2007, Pages 6273-6290

  Gu, Keli ^a   Bi, Lanrong ^a   Zhao, Ming ^a   Wang, Chao ^b   Ju, Jingfang ^c   Peng, Shiqi ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c USA   (United States)

Author keywords

2,5 Disubstituted dioxacycloalkanes; Anti inflammatory activity; Chemo enzymatic synthesis; Chemoprevention; Structure activity relationship study

Indexed keywords

1,3 DIOXANE DERIVATIVE; ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; CYCLOALKANE DERIVATIVE; XYLENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLEEDING TIME; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG PENETRATION; DRUG STRUCTURE; DRUG SYNTHESIS; EDEMA; EXTERNAL EAR; HUMAN; HUMAN CELL; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASPIRIN; BLEEDING TIME; CELL MEMBRANE PERMEABILITY; CHEMOPREVENTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DESIGN; EDEMA; HYDROCARBONS, CYCLIC; MALE; MICE; MOLECULAR STRUCTURE; OXYGEN; PROTEIN KINASE C; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XYLENES;

RATTUS;

EID: 34447637130     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.018     Document Type: Article

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