Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 7, 2009, Pages 1908-1912

  Tsai, Ting Yueh ^a   Hsu, Tsu ^a   Chen, Chiung Tong ^a   Cheng, Jai Hong ^a   Chiou, Mei Chun ^a   Huang, Chih Hsiang ^a   Tseng, Ya Ju ^a   Yeh, Teng Kuang ^a   Huang, Chung Yu ^a   Yeh, Kai Chia ^a   Huang, Yu Wen ^a   Wu, Ssu Hui ^a   Wang, Min Hsien ^a   Chen, Xin ^a   Chao, Yu Sheng ^a   Jiaang, Weir Torn ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

DPP IV; Glutamic acid; Inhibitor

Indexed keywords

CYANOPYRROLIDINE DERIVATIVE; DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE 8; DIPEPTIDYL PEPTIDASE II; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCOSE; GLUTAMIC ACID DERIVATIVE; SEPRASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; GLUCOSE METABOLISM; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD26; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DRUG DESIGN; GLUCOSE; GLUTAMIC ACID; MICE; MICE, INBRED C57BL; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62149152364     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.061     Document Type: Article

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