Placental FTO expression relates to fetal growth

International Journal of Obesity

Volumn 34, Issue 9, 2010, Pages 1365-1370

  Bassols, J ^a,b   Prats Puig, A ^a,b   Vazquez Ruiz M ^c   Garcia Gonzalez M M ^c   Martinez Pascual M ^c   Avelli P ^c   Martinez Martinez R ^c   Fbrega, R ^c   Colomer Virosta, C ^c   Soriano Rodriguez P ^c   Diaz M ^d,e   De Zegher, F ^f   Ibanez L ^d,e   Lopez Bermejo A ^a,b  

^a HOSPITAL JOSEP TRUETA   (Spain)

^b GIRONA BIOMEDICAL RESEARCH INSTITUTE IDIBGI   (Spain)

^c Salut Emporda Foundation   (Spain)

^d HOSPITAL SANT JOAN DE DÉU   (Spain)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

^f UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

birth weight; FTO; gene expression; placenta; polymorphism

Indexed keywords

INSULIN; SOMATOMEDIN C; SUCCINATE DEHYDROGENASE; TATA BINDING PROTEIN;

ADULT; ARTICLE; BIRTH WEIGHT; BODY HEIGHT; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FETUS GROWTH; FETUS WEIGHT; GENE; GENE EXPRESSION; GENOTYPE; HUMAN; OBESITY ASSOCIATED GENE; PLACENTA; PLACENTA WEIGHT; PREGNANCY; PRIMIPARA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; UMBILICAL CORD BLOOD; WEIGHT GAIN;

ADULT; BODY WEIGHT; FEMALE; FETAL BLOOD; FETAL DEVELOPMENT; GENOTYPE; HUMANS; PLACENTA; PREGNANCY; PROTEINS; WEIGHT GAIN;

EID: 77956682284     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2010.62     Document Type: Article

References (31)

1. Hales CN, Barker DJ. The thrifty phenotype hypothesis. Br Med Bull 2001; 60: 5-20.
2. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894.
3. Dina C, Meyre D, Gallina S, Durand E, Korner A, Jacobson P et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007; 39: 724-726.
4. Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007; 3: e115.
5. Peeters A, Beckers S, Verrijken A, Roevens P, Peeters P, Van Gaal L et al. Variants in the FTO gene are associated with common obesity in the Belgian population. Mol Genet Metab 2008; 93: 481-484.
6. Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, Andersen G et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008; 57: 95-101.
7. Zabena C, Gonzalez-Sanchez JL, Martinez-Larrad MT, Torres-Garcia A, Alvarez-Fernandez-Represa J, Corbaton-Anchuelo A et al. The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients. Obes Surg 2009; 19: 87-95.
8. Stratigopoulos G, Padilla SL, LeDuc CA, Watson E, Hattersley AT, McCarthy MI et al. Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol 2008; 294: R1185-R1196.
9. Wahlen K, Sjolin E, Hoffstedt J. The common rs9939609 gene variant of the fat mass-and obesity-associated gene FTO is related to fat cell lipolysis. J Lipid Res 2008; 49: 607-611.
10. Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007; 318: 1469-1472.
11. Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, Gerken T et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet 2009; 5: e1000599.
12. Fredriksson R, Hagglund M, Olszewski PK, Stephansson O, Jacobsson JA, Olszewska AM et al. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 2008; 149: 2062-2071.
13. Speakman JR, Rance KA, Johnstone AM. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) 2008; 16: 1961-1965.
14. Timpson NJ, Emmett PM, Frayling TM, Rogers I, Hattersley AT, McCarthy MI et al. The fat mass-and obesity-associated locus and dietary intake in children. Am J Clin Nutr 2008; 88: 971-978.
15. Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly S, Plomin R. Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 2008; 93: 3640-3643.
16. Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 2008; 359: 2558-2566.
17. den Hoed M, Westerterp-Plantenga MS, Bouwman FG, Mariman EC, Westerterp KR. Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO. Am J Clin Nutr 2009; 90: 1426-1432.
18. Olszewski PK, Fredriksson R, Olszewska AM, Stephansson O, Alsio J, Radomska KJ et al. Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. BMC Neurosci 2009; 10: 129.
19. Tanofsky-Kraff M, Han JC, Anandalingam K, Shomaker LB, Columbo KM, Wolkoff LE et al. The FTO gene rs9939609 obesity-risk allele and loss of control over eating. Am J Clin Nutr 2009; 90: 1483-1488.
20. Tews D, Fischer-Posovszky P, Wabitsch M. FTOFfriend or foe? Horm Metab Res 2010; 42: 75-80.
21. Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll AP et al. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One 2010; 5: e8771.
22. Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Bruning JC et al. Inactivation of the Fto gene protects from obesity. Nature 2009; 458: 894-898.
23. Hakanen M, Raitakari OT, Lehtimaki T, Peltonen N, Pahkala K, Sillanmaki L et al. FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. J Clin Endocrinol Metab 2009; 94: 1281-1287.
24. Jacobsson JA, Danielsson P, Svensson V, Klovins J, Gyllensten U, Marcus C et al. Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. Biochem Biophys Res Commun 2008; 368: 476-482.
25. Lopez-Bermejo A, Petry CJ, Diaz M, Sebastiani G, de Zegher F, Dunger DB et al. The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks. J Clin Endocrinol Metab 2008; 93: 1501-1505.
26. Randhawa R, Cohen P. The role of the insulin-like growth factor system in prenatal growth. Mol Genet Metab 2005; 86: 84-90.
27. Lezcano-Carrascosa A, Fernández-García JM, Ferrández-Longás A, López-Siguero JP, Sánchez- González E (eds). Cross-Sectional Study of Growth and Development, 1st edn. Pfizer, S.A: Barcelona, Spain, 2008.
28. Ong KK, Preece MA, Emmett PM, Ahmed ML, Dunger DB. Size at birth and early childhood growth in relation to maternal smoking, parity and infant breast-feeding: longitudinal birth cohort study and analysis. Pediatr Res 2002; 52: 863-867.
29. Grunnet LG, Nilsson E, Ling C, Hansen T, Pedersen O, Groop L et al. Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue. Diabetes 2009; 58: 2402-2408.
30. Clifton IJ, McDonough MA, Ehrismann D, Kershaw NJ, Grana-tino N, Schofield CJ. Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. J Inorg Biochem 2006; 100: 644-669.
31. Sebert SP, Hyatt MA, Chan LL, Yiallourides M, Fainberg HP, Patel N et al. Influence of prenatal nutrition and obesity on tissue specific fat mass and obesity-associated (FTO) gene expression. Reproduction 2010; 139: 265-274.