BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 299, Issue 3, 2010, Pages

  Lang, Charles H ^a   Lynch, Christopher J ^a   Vary, Thomas C ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Branched chain amino acids; eIF3; mTOR; Raptor; Skeletal muscle

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BRANCHED CHAIN AMINO ACID; BRANCHED CHAIN AMINO ACID AMINOTRANSFERASE; CYTOKINE; ENDOTOXIN; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; INITIATION FACTOR 4G; MAMMALIAN TARGET OF RAPAMYCIN; MUSCLE PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); AMINOTRANSFERASE; BCAT1 PROTEIN, MOUSE; LIPOPOLYSACCHARIDE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; COMPLEX FORMATION; CONTROLLED STUDY; ESCHERICHIA COLI; KNOCKOUT MOUSE; MALE; MOUSE; MUSCLE MASS; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SEPSIS; SKELETAL MUSCLE; SURVIVAL; WILD TYPE; ANIMAL; C57BL MOUSE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOCHONDRION; MORTALITY; PHYSIOLOGY; TOXICITY;

AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MUSCLE PROTEINS; SEPSIS; TRANSAMINASES;

EID: 77956679005     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00297.2010     Document Type: Article

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