Oxidized low density lipoprotein inhibits phosphate signaling and phosphate-induced mineralization in osteoblasts. Involvement of oxidative stress

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1802, Issue 11, 2010, Pages 1013-1019

  Mazière, Cécile ^a,b,c   Savitsky, Valéry ^a,b,c   Galmiche, Antoine ^a,b,c   Gomila, Cathy ^a,b,c   Massy, Ziad ^a,c   Mazière, Jean Claude ^a,b,c  

^a INSERM   (France)

^b North Hospital   (France)

^c UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

Author keywords

Differentiation; Osteoblasts; Oxidative stress; OxLDL; Signaling

Indexed keywords

ALPHA TOCOPHEROL; BIOLOGICAL MARKER; CALCIUM; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPONTIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PHOSPHATE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RUNX2;

ANIMAL CELL; ARTICLE; BONE REMODELING; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CONTROLLED STUDY; MINERALIZATION; NONHUMAN; OSTEOBLAST; OSTEOPOROSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; CALCIFICATION, PHYSIOLOGIC; CALCIUM; CELL LINE, TUMOR; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOBLOTTING; LIPOPROTEINS, LDL; MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOBLASTS; OSTEOPONTIN; OXIDATIVE STRESS; PHOSPHATES; RANK LIGAND; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; VITAMIN E;

RATTUS;

EID: 77956651388     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2010.07.010     Document Type: Article

References (50)

1. Beck G.R., Sullivan E.C., Moran E., Zerler B. Relationship between alkaline phosphatase levels, osteopontin expression, and mineralization in differentiating MC3T3-E1 osteoblasts. J. Cell. Biochem. 1998, 68:269-280.
2. Hsu Y.L., Kuo P.L. Diosmetin induces human osteoblastic differentiation through the protein kinase C/p38 and extracellular signal-regulated kinase 1/2 pathway. J. Bone Miner. Res. 2008, 23:949-960.
3. Zirngibl R.A., Chan J.S., Aubin J.E. Estrogen receptor-related receptor alpha (ERRalpha) regulates osteopontin expression through a non-canonical ERRalpha response element in a cell context-dependent manner. J. Mol. Endocrinol. 2008, 40:61-73.
4. Giner M., Montoya M.J., Vázquez M.A., Rios M.J., Moruno R., Miranda M.J., Pérez-Cano Modifying R. RANKL/OPG mRNA expression in differentiating and growing human primary osteoblasts. Horm. Metab. Res. 2008, 40:869-874.
5. Beck G.R., Moran E., Knecht N. Inorganic phosphate regulates multiple genes during osteoblast differentiation, including Nrf2. Exp. Cell Res. 2003, 288:288-300.
6. Beck G.R., Knecht N. Osteopontin regulation by inorganic phosphate is ERK1/2, protein kinase C-, and proteasome-dependent. J. Biol. Chem. 2003, 278:41921-41929.
7. Celil A.B., Campbell P.G. BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways. J. Biol. Chem. 2005, 280:31353-31359.
8. T. Matsuguchi, N. Chiba, K. Bandow, K. Kakimoto, A. Masuda, T. Ohnishi. JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation, J. Bone Miner. Res. 24 (2009) 398-410.
9. Ducy P., Zhang R., Geoffroy V., Ridall A.L., Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 1997, 89:747-754.
10. Chen N.X., Duan D., O'Neill K.D., Moe S.M. High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells. Nephrol. Dial. Transplant. 2006, 21:3435-3442.
11. Lee K.S., Hong S.H., Bae S.C. Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein. Oncogene 2002, 21:7156-7163.
12. Kanno T., Takahashi T., Tsujisawa T., Ariyoshi W., Nishihara T. Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts. J. Cell. Biochem. 2007, 101:1266-1277.
13. Lai C.F., Cheng S.L. Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells. J. Biol. Chem. 2002, 277:15514-15522.
14. Wu J.B., Fong Y.C., Tsai H.Y., Chen Y.F., Tsuzuki M., Tang C.H. Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts. Eur. J. Pharmacol. 2008, 588:333-341.
15. Tintut Y., Patel J., Parhami F., Demer L.L. Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation 2000, 102:2636-2642.
16. Franceschi R.T., Xiao G., Jiang D., Gopalakrishnan R., Yang S., Reith E. Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation. Connect. Tissue Res. 2003, 44(Suppl 1):109-116.
17. Steinberg D. Hypercholesterolemia and inflammation in atherogenesis: two sides of the same coin. Mol. Nutr. Food Res. 2005, 49:995-998.
18. Hofbauer L.C., Brueck C.C., Shanahan C.M., Schoppet M., Dobnig H. Vascular calcification and osteoporosis-from clinical observation towards molecular understanding. Osteoporos. Int. 2007, 18:251-259.
19. Mazière C., Louvet L., Gomila C., Kamel S., Massy Z., Mazière J.C. Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signalling. J. Cell. Physiol. 2009, 9999:1-7.
20. Parhami F., Morrow A.D., Balucan J., Leitinger N., Watson A.D., Tintut Y., Berliner J.A., Demer L.L. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler. Thromb. Vasc. Biol. 1997, 17:680-687.
21. Mody N., Parhami F., Sarafian T.A., Demer L.L. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic. Biol. Med. 2001, 31:509-519.
22. Mazière C., Morlière P., Santus R., Marcheux V., Louandre C., Conte M.A., Mazière J.C. Inhibition of insulin signaling by oxidized low density lipoprotein. Protective effect of the antioxidant Vitamin E. Atherosclerosis 2004, 175:23-30.
23. Fatokun A.A., Stone T.W., Smith R.A. Responses of differentiated MC3T3-E1 osteoblast-like cells to reactive oxygen species. Eur. J. Pharmacol. 2008, 587:35-41.
24. Lee K.H., Choi E.M. Myricetin, a naturally occurring flavonoid, prevents 2-deoxy-d-ribose induced dysfunction and oxidative damage in osteoblastic MC3T3-E1 cells. Eur. J. Pharmacol. 2008, 591:1-6.
25. M. Almeida, L. Han, M. Martin-Millan, C.A. O'Brien, S.C. Manolagas. Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor to forkhead box O-mediated transcription, J. Biol. Chem. 282 (2007) 27298-27305.
26. Towler D.A., Bidder M., Latifi T., Coleman T., Semenkovich C.F. Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. J. Biol. Chem. 1988, 273:30427-30434.
27. Ray Sarkar B.C., Chauhan U.P.S. A new method for determining microquantities of calcium in biological materials. Anal. Biochem. 1967, 20:155-166.
28. Havel R.J., Eden M.A., Bragdon J.H. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 1955, 34:1345-1353.
29. Yagi K. Lipid peroxide and human diseases. Chem. Phys. Lipids 1987, 45:337-351.
30. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 1959, 37:911-917.
31. Scott J.A., Homcy C.J., Khaw B.A., Rabito C.A. Quantitation of intracellular oxidation in a renal epithelial cell line. Free Radic. Biol. Med. 1988, 4:79-83.
32. Parhami F., Jackson S.M., Tintut Y., Le V., Balucan J.P., Territo M., Demer L.L. Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J. Bone Miner. Res. 1999, 14:2067-2078.
33. Camalier C.E., Young M.R., Bobe G., Perella C.M., Colburn N.H., Beck G.R. Elevated phosphate activates N-ras and promotes cell transformation and skin tumorigenesis. Cancer Prev. Res. (Phila Pa) 2010, 3:359-370.
34. Augé N., Escargueil-Blanc I., Lajoie-Mazenc I., Suc I., Andrieu-Abadie N., Pieraggi M.T., Chatelut M., Thiers J.C., Jaffrézou J.P., Laurent G., Levade T., Nègre-Salvayre A., Salvayre R. Potential role for ceramide in mitogen-activated protein kinase activation and proliferation of vascular smooth muscle cells induced by oxidized low density lipoprotein. J. Biol. Chem. 1998, 273:12893-12900.
35. Schroeter Test H. Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3. Biochem. J. 2001, 358:547-557.
36. Mazière Test C. Copper and cell-oxidized low-density lipoprotein induces activator protein 1 in fibroblasts, endothelial and smooth muscle cells. FEBS Lett. 1997, 409:351-356.
37. Benkoussa M., Brand C., Delmotte M.H., Formstecher P., Lefebvre P. Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. Mol. Cell. Biol. 2002, 22:4522-4534.
38. Bokui N., Otani T., Igarashi K., Kaku J., Oda M., Nagaoka T., Seno M., Tatematsu K., Okajima T., Matsuzaki T., Ting K., Tanizawa K., Kuroda S. Involvement of MAPK signaling molecules and Runx2 in the NELL1-induced osteoblastic differentiation. FEBS Lett. 2008, 582:365-371.
39. Moses S., Franzén A., Lövdahl C., Hultgårdh-Nilsson A. Injury-induced osteopontin gene expression in rat arterial smooth muscle cells is dependent on mitogen-activated protein kinases ERK1/ERK2. Arch. Biochem. Biophys. 2001, 396:133-137.
40. Xie Z., Singh M., Singh K. ERK1/2 and JNKs, but not p38 kinase, are involved in reactive oxygen species-mediated induction of osteopontin gene expression by angiotensin II and interleukin-1beta in adult rat cardiac fibroblasts. J. Cell. Physiol. 2004, 198:399-407.
41. Bidder M., Shao J.S., Charlton-Kachigian N., Loewy A.P., Semenkovich C.F., Towler D.A. Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities. J. Biol. Chem. 2002, 277:44485-44496.
42. Jalvy S., Renault M.A., Leen L.L., Belloc I., Bonnet J., Gadeau A.P., Desgranges C. Autocrine expression of osteopontin contributes to PDGF-mediated arterial smooth muscle cell migration. Cardiovasc. Res. 2007, 75:738-747.
43. Mak K.K., Bi Y., Wan C., Chuang P.T., Clemens T., Young M., Yang Y. Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev. Cell 2008, 14:674-688.
44. Brodeur M.R., Brissette L., Falstrault L., Ouellet P., Moreau R. Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells. Free Radic. Biol. Med. 2008, 44:506-517.
45. Shuto E., Taketani Y., Tanaka R., Harada N., Isshiki M., Sato M., Nashiki K., Amo K., Yamamoto H., Higashi Y., Nakaya Y., Takeda E. Dietary phosphorus acutely impairs endothelial function. J. Am. Soc. Nephrol. 2009, 20:1504-1512.
46. Huang M.S., Morony S., Lu J., Zhang Z., Bezouglaia O., Tseng W., Tetradis S., Demer L.L., Tintut Y. Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts. J. Biol. Chem. 2007, 282:21237-21243.
47. Park Y.M., Febbraio M., Silverstein R.L. CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. J. Clin. Invest. 2009, 119:136-145.
48. Hsieh C.C., Yen M.H., Yen C.H., Lau Y.T. Oxidized low density lipoprotein induces apoptosis via generation of reactive oxygen species in vascular smooth muscle cells. Cardiovasc. Res. 2001, 49:135-145.
49. Hamel P., Abed E., Brissette L., Moreau R. Characterization of oxidized low-density lipoprotein-induced hormesis-like effects in osteoblastic cells. Am. J. Physiol. Cell Physiol. 2008, 294:C1021-C1033.
50. Vindis C., Escargueil-Blanc I., Elbaz M., Marcheix B., Grazide M.H., Uchida K., Salvayre R., Nègre-Salvayre A. Desensitization of platelet-derived growth factor receptor-beta by oxidized lipids in vascular cells and atherosclerotic lesions: prevention by aldehyde scavengers. Circ. Res. 2006, 98:785-792.