메뉴 건너뛰기




Volumn 14, Issue 12, 1999, Pages 2067-2078

Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALKALINE PHOSPHATASE; CIGLITAZONE; COLLAGEN TYPE 1; MITOGEN ACTIVATED PROTEIN KINASE; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; ROSIGLITAZONE;

EID: 0033398460     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1999.14.12.2067     Document Type: Article
Times cited : (239)

References (56)
  • 3
    • 0026758216 scopus 로고
    • The number of fibroblastic colonies formed from bone marrow is decreased and the in vitro proliferation rate of trabecular bone cells increased in aged rats
    • Egrise D, Martin D, Vienne A, Neve P, Schoutens A 1992 The number of fibroblastic colonies formed from bone marrow is decreased and the in vitro proliferation rate of trabecular bone cells increased in aged rats. Bone 13:355-361.
    • (1992) Bone , vol.13 , pp. 355-361
    • Egrise, D.1    Martin, D.2    Vienne, A.3    Neve, P.4    Schoutens, A.5
  • 4
    • 0031194017 scopus 로고    scopus 로고
    • Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation
    • Majors AK, Boehm CA, Nitto H, Midura RJ, Muschler GF 1997 Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation. J Orthop Res 15:546-557.
    • (1997) J Orthop Res , vol.15 , pp. 546-557
    • Majors, A.K.1    Boehm, C.A.2    Nitto, H.3    Midura, R.J.4    Muschler, G.F.5
  • 5
    • 0015137446 scopus 로고
    • Osteoporosis and the replacement of cell populations of the marrow by adipose tissue: A quantitative study of 84 iliac bone biopsies
    • Meunier P, Aaron J, Edouard C, Vignon G 1971 Osteoporosis and the replacement of cell populations of the marrow by adipose tissue: A quantitative study of 84 iliac bone biopsies. Clin Orthop 80:147-154.
    • (1971) Clin Orthop , vol.80 , pp. 147-154
    • Meunier, P.1    Aaron, J.2    Edouard, C.3    Vignon, G.4
  • 6
    • 0023276009 scopus 로고
    • Changes in trabecular bone, hematopoeisis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: A comparative histomorphometric study
    • Burkhardt R, Kettner G, Bohm W, Schmidmeir M, Schlag R, Frisch B, Mallmann B, Eisenmenger W, Gilg T 1987 Changes in trabecular bone, hematopoeisis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: A comparative histomorphometric study. Bone 8:157-164.
    • (1987) Bone , vol.8 , pp. 157-164
    • Burkhardt, R.1    Kettner, G.2    Bohm, W.3    Schmidmeir, M.4    Schlag, R.5    Frisch, B.6    Mallmann, B.7    Eisenmenger, W.8    Gilg, T.9
  • 7
    • 0027973996 scopus 로고
    • Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy
    • Bruder SP, Fink DJ, Caplan AI 1994 Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 56:283-294.
    • (1994) J Cell Biochem , vol.56 , pp. 283-294
    • Bruder, S.P.1    Fink, D.J.2    Caplan, A.I.3
  • 8
    • 0028903468 scopus 로고
    • Bone morphogenetic proteins, bone marrow stromal cells, and mesenchymal stem cells: Maureen Owen revisited
    • Reddi AH 1995 Bone morphogenetic proteins, bone marrow stromal cells, and mesenchymal stem cells: Maureen Owen revisited. Clin Orthop 313:115-119.
    • (1995) Clin Orthop , vol.313 , pp. 115-119
    • Reddi, A.H.1
  • 9
    • 0030093454 scopus 로고    scopus 로고
    • The in vivo role of bone marrow fibroblast-like stromal cells
    • Simmons DJ 1996 The in vivo role of bone marrow fibroblast-like stromal cells [editorial]. Calcif Tissue Int 58:129-132.
    • (1996) Calcif Tissue Int , vol.58 , pp. 129-132
    • Simmons, D.J.1
  • 11
    • 0031953736 scopus 로고    scopus 로고
    • Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: Implications for osteopenic disorders
    • Nuttal ME, Patton AJ, Olivera DL, Nadeau DP, Gowen M 1998 Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: Implications for osteopenic disorders. J Bone Miner Res 13:371-382.
    • (1998) J Bone Miner Res , vol.13 , pp. 371-382
    • Nuttal, M.E.1    Patton, A.J.2    Olivera, D.L.3    Nadeau, D.P.4    Gowen, M.5
  • 12
    • 0027321842 scopus 로고
    • Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype
    • Stein G, Lian J 1993 Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr Rev 14:424-442.
    • (1993) Endocr Rev , vol.14 , pp. 424-442
    • Stein, G.1    Lian, J.2
  • 13
    • 0026635508 scopus 로고
    • Cellular and molecular aspects of adipose tissue development
    • Ailhaud G, Grimaldi P, Negrel R 1992 Cellular and molecular aspects of adipose tissue development. Annu Rev Nutr 12:207-233.
    • (1992) Annu Rev Nutr , vol.12 , pp. 207-233
    • Ailhaud, G.1    Grimaldi, P.2    Negrel, R.3
  • 14
    • 0023811651 scopus 로고
    • Regulation of gene expression in the adipocyte: Implications for the obesity and proto-oncogene function
    • Spiegelman B 1988 Regulation of gene expression in the adipocyte: Implications for the obesity and proto-oncogene function. Trends Genet 4:203-207.
    • (1988) Trends Genet , vol.4 , pp. 203-207
    • Spiegelman, B.1
  • 15
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • published erratum appears in Cell 1995 80: following 957
    • Tontonoz P, Hu E, Spiegelman BM 1994 Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor [published erratum appears in Cell 1995 80: following 957]. Cell 79:1147-1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 18
    • 0030929793 scopus 로고    scopus 로고
    • Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation: A possible explanation for the paradox of arterial calcification in osteoporotic patients
    • Parhami F, Morrow AD, Balucan J, Leitinger N, Watson AD, Tintut Y, Berliner JA, Demer LL 1997 Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation: A possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler Thromb Vasc Biol 17:680-687.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 680-687
    • Parhami, F.1    Morrow, A.D.2    Balucan, J.3    Leitinger, N.4    Watson, A.D.5    Tintut, Y.6    Berliner, J.A.7    Demer, L.L.8
  • 19
    • 0030832843 scopus 로고    scopus 로고
    • Arterial calcification in face of osteoporosis in ageing: Can we blame oxidized lipids?
    • Parhami F, Demer LL 1997 Arterial calcification in face of osteoporosis in ageing: Can we blame oxidized lipids? Curr Opin Lipidol 8:312-314.
    • (1997) Curr Opin Lipidol , vol.8 , pp. 312-314
    • Parhami, F.1    Demer, L.L.2
  • 20
    • 0027165150 scopus 로고
    • The mitogen-activated protein kinase signal transduction pathways
    • Davis R 1993 The mitogen-activated protein kinase signal transduction pathways. J Biol Chem 268:14553-14556.
    • (1993) J Biol Chem , vol.268 , pp. 14553-14556
    • Davis, R.1
  • 21
    • 0030898417 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways
    • Robinson MJ, Cobb MH 1997 Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 9:180-186.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 180-186
    • Robinson, M.J.1    Cobb, M.H.2
  • 22
    • 0023729166 scopus 로고
    • Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats
    • Maniotopoulos C, Sodek J, Melcher A 1988 Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res 254:317-330.
    • (1988) Cell Tissue Res , vol.254 , pp. 317-330
    • Maniotopoulos, C.1    Sodek, J.2    Melcher, A.3
  • 23
    • 0028346280 scopus 로고
    • Cellular expression of bone-related proteins during in vitro osteogenesis in rat bone marrow stromal cell cultures
    • Malaval L, Modrowski D, Gupta AK, Aubin JE 1994 Cellular expression of bone-related proteins during in vitro osteogenesis in rat bone marrow stromal cell cultures. J Cell Physiol 158:555-572.
    • (1994) J Cell Physiol , vol.158 , pp. 555-572
    • Malaval, L.1    Modrowski, D.2    Gupta, A.K.3    Aubin, J.E.4
  • 24
    • 0032571363 scopus 로고    scopus 로고
    • cAMP stimulates osteoblast-like differentiation of calcifying vascular cells: Potential signaling pathway for vascular calcification
    • Tintut Y, Parhami F, Bostrom K, Jackson SM, Demer LL 1998 cAMP stimulates osteoblast-like differentiation of calcifying vascular cells: Potential signaling pathway for vascular calcification. J Biol Chem 273:7547-7553.
    • (1998) J Biol Chem , vol.273 , pp. 7547-7553
    • Tintut, Y.1    Parhami, F.2    Bostrom, K.3    Jackson, S.M.4    Demer, L.L.5
  • 25
    • 0026541591 scopus 로고
    • The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene
    • Tugwood J, Isabelle I, Anderson R, Bundell K, McPheat W, Green S 1992 The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J 11:433-439.
    • (1992) EMBO J , vol.11 , pp. 433-439
    • Tugwood, J.1    Isabelle, I.2    Anderson, R.3    Bundell, K.4    McPheat, W.5    Green, S.6
  • 26
    • 0030590074 scopus 로고    scopus 로고
    • Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2
    • Elbrecht A, Chen Y, Cullinan CA, Hayes N, Leibowitz M, Moller DE, Berger J 1996 Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2. Biochem Biophys Res Commun 224:431-437.
    • (1996) Biochem Biophys Res Commun , vol.224 , pp. 431-437
    • Elbrecht, A.1    Chen, Y.2    Cullinan, C.A.3    Hayes, N.4    Leibowitz, M.5    Moller, D.E.6    Berger, J.7
  • 27
    • 0028149049 scopus 로고
    • Identification of a 6-base pair element involved in the sterol-mediated transcriptional regulation of farnesyl diphosphate synthase
    • Spear DH, Ericsson J, Jackson SM, Edwards PA 1994 Identification of a 6-base pair element involved in the sterol-mediated transcriptional regulation of farnesyl diphosphate synthase. J Biol Chem 269:25212-25218.
    • (1994) J Biol Chem , vol.269 , pp. 25212-25218
    • Spear, D.H.1    Ericsson, J.2    Jackson, S.M.3    Edwards, P.A.4
  • 28
    • 0029847076 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activation by thiazolidine-diones induces adipogenesis in bone marrow stromal cells
    • Gimble JM, Robinson CE, Wu X, Kelly KA, Rodriguez BR, Kliewer SA, Lehmann JM, Morris DC 1996 Peroxisome proliferator-activated receptor gamma activation by thiazolidine-diones induces adipogenesis in bone marrow stromal cells. Mol Pharmacol 50:1087-1094.
    • (1996) Mol Pharmacol , vol.50 , pp. 1087-1094
    • Gimble, J.M.1    Robinson, C.E.2    Wu, X.3    Kelly, K.A.4    Rodriguez, B.R.5    Kliewer, S.A.6    Lehmann, J.M.7    Morris, D.C.8
  • 29
    • 0027982166 scopus 로고
    • L-ascorbic acid 2-phosphate promotes osteoblastic differentiation of MC3T3-E1 mediated by accumulation of type I collagen
    • Torri Y, Hitomi K, Tsukagoshi N 1994 L-ascorbic acid 2-phosphate promotes osteoblastic differentiation of MC3T3-E1 mediated by accumulation of type I collagen. J Nutr Sci Vitaminol 40:229-238.
    • (1994) J Nutr Sci Vitaminol , vol.40 , pp. 229-238
    • Torri, Y.1    Hitomi, K.2    Tsukagoshi, N.3
  • 30
    • 0028942119 scopus 로고
    • The influence of type I collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: Modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization
    • Lynch MP, Stein JL, Stein GS, Lian JB 1995 The influence of type I collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: Modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization. Exp Cell Res 216:35-45.
    • (1995) Exp Cell Res , vol.216 , pp. 35-45
    • Lynch, M.P.1    Stein, J.L.2    Stein, G.S.3    Lian, J.B.4
  • 31
    • 0032032089 scopus 로고    scopus 로고
    • Collagen cross-links in mineralizing tissues: A review of their chemistry, function, and clinical relevance
    • Knott L, Bailey AJ 1998 Collagen cross-links in mineralizing tissues: A review of their chemistry, function, and clinical relevance. Bone 22:181-187.
    • (1998) Bone , vol.22 , pp. 181-187
    • Knott, L.1    Bailey, A.J.2
  • 32
    • 0030018849 scopus 로고    scopus 로고
    • Inhibition of growth factor-induced protein synthesis by a selective MEK inhibitor in aortic smooth muscle cells
    • Servant MJ, Giasson E, Meloche S 1996 Inhibition of growth factor-induced protein synthesis by a selective MEK inhibitor in aortic smooth muscle cells. J Biol Chem 271:16047-16052.
    • (1996) J Biol Chem , vol.271 , pp. 16047-16052
    • Servant, M.J.1    Giasson, E.2    Meloche, S.3
  • 33
    • 0031028381 scopus 로고    scopus 로고
    • Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway
    • Pumiglia KM, Decker SJ 1997 Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA 94:448-452.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 448-452
    • Pumiglia, K.M.1    Decker, S.J.2
  • 34
    • 0028176297 scopus 로고
    • cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells
    • Faure M, Voyno-Yasenetskaya TA, Bourne HR 1994 cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J Biol Chem 269:7851-7854.
    • (1994) J Biol Chem , vol.269 , pp. 7851-7854
    • Faure, M.1    Voyno-Yasenetskaya, T.A.2    Bourne, H.R.3
  • 36
    • 0029061758 scopus 로고
    • Molecular biology of matrix vesicles
    • Anderson HC 1995 Molecular biology of matrix vesicles. Clin Orthop 314:266-280.
    • (1995) Clin Orthop , vol.314 , pp. 266-280
    • Anderson, H.C.1
  • 37
    • 0027368064 scopus 로고
    • Studies of the levamisole inhibitory effect on rat stromal-cell commitment to mineralization
    • Klein B, Gal I, Segal S 1993 Studies of the levamisole inhibitory effect on rat stromal-cell commitment to mineralization. J Cell Biochem 53:114-121.
    • (1993) J Cell Biochem , vol.53 , pp. 114-121
    • Klein, B.1    Gal, I.2    Segal, S.3
  • 38
    • 0027930471 scopus 로고
    • Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization
    • Whyte MP 1994 Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization. Endocr Rev 15:439-461.
    • (1994) Endocr Rev , vol.15 , pp. 439-461
    • Whyte, M.P.1
  • 39
    • 0030889354 scopus 로고    scopus 로고
    • Marrow stromal cells as stem cells for non-hematopoietic tissues
    • Prockop DJ 1997 Marrow stromal cells as stem cells for non-hematopoietic tissues. Science 276:71-74.
    • (1997) Science , vol.276 , pp. 71-74
    • Prockop, D.J.1
  • 40
    • 0030705161 scopus 로고    scopus 로고
    • Modulation of osteogenesis and adipogenesis by human serum in human bone marrow cultures
    • Oreffo RO, Virdi AS, Triffitt JT 1997 Modulation of osteogenesis and adipogenesis by human serum in human bone marrow cultures. Eur J Cell Biol 74:251-261.
    • (1997) Eur J Cell Biol , vol.74 , pp. 251-261
    • Oreffo, R.O.1    Virdi, A.S.2    Triffitt, J.T.3
  • 41
    • 0032540012 scopus 로고    scopus 로고
    • PPAR gamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM 1998 PPAR gamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93:241-252.
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.3    Thomazy, V.A.4    Evans, R.M.5
  • 42
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR gamma
    • Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM 1998 Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR gamma. Cell 93:229-240.
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.3    Chen, H.4    Evans, R.M.5
  • 43
    • 0031912445 scopus 로고    scopus 로고
    • Atherogenic lipoproteins stimulate mesangial cell p42 mitogen-activated protein kinase
    • Bassa BV, Roh DD, Kirschenbaum MA, Kamanna VS 1998 Atherogenic lipoproteins stimulate mesangial cell p42 mitogen-activated protein kinase. J Am Soc Nephrol 9:488-496.
    • (1998) J Am Soc Nephrol , vol.9 , pp. 488-496
    • Bassa, B.V.1    Roh, D.D.2    Kirschenbaum, M.A.3    Kamanna, V.S.4
  • 44
    • 0031015765 scopus 로고    scopus 로고
    • Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages
    • Kusuhara M, Chait A, Cader A, Berk BC 1997 Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages. Arterioscler Thromb Vasc Biol 17:141-148.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 141-148
    • Kusuhara, M.1    Chait, A.2    Cader, A.3    Berk, B.C.4
  • 47
    • 0028031534 scopus 로고
    • Regulation of heparin binding- epidermal growth factor like growth factor gene expression by LDL and oxidized LDL in rat mesangial cells
    • Tan MS, Lee YJ, Shin SJ, Tsai JH 1994 Regulation of heparin binding- epidermal growth factor like growth factor gene expression by LDL and oxidized LDL in rat mesangial cells. Biochem Biophys Res Commun 202:1001-1008.
    • (1994) Biochem Biophys Res Commun , vol.202 , pp. 1001-1008
    • Tan, M.S.1    Lee, Y.J.2    Shin, S.J.3    Tsai, J.H.4
  • 48
    • 0028349237 scopus 로고
    • Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells
    • Kume N, Gimbrone MA Jr 1994 Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells. J Clin Invest 93:907-911.
    • (1994) J Clin Invest , vol.93 , pp. 907-911
    • Kume, N.1    Gimbrone M.A., Jr.2
  • 51
    • 0030896949 scopus 로고    scopus 로고
    • Incorporation of long-chain n-3 fatty acids in tissues and enhanced bone marrow cellularity with docosahexaenoic acid feeding in post-weanling Fischer 344 rats
    • Atkinson TG, Barker HJ, Meckling-Gill KA 1997 Incorporation of long-chain n-3 fatty acids in tissues and enhanced bone marrow cellularity with docosahexaenoic acid feeding in post-weanling Fischer 344 rats. Lipids 32:293-302.
    • (1997) Lipids , vol.32 , pp. 293-302
    • Atkinson, T.G.1    Barker, H.J.2    Meckling-Gill, K.A.3
  • 52
    • 0031976761 scopus 로고    scopus 로고
    • Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n-6 or n-3 fatty acids
    • Li Y, Watkins BA 1998 Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n-6 or n-3 fatty acids. Lipids 33:417-425.
    • (1998) Lipids , vol.33 , pp. 417-425
    • Li, Y.1    Watkins, B.A.2
  • 53
    • 0031839737 scopus 로고    scopus 로고
    • Effects of high-fat diet on mature bone mineral content, structure, and mechanical properties
    • Wohl G, Loehrke L, Watkins B, Zernicke R 1998 Effects of high-fat diet on mature bone mineral content, structure, and mechanical properties. Calcif Tissue Int 63:74-79.
    • (1998) Calcif Tissue Int , vol.63 , pp. 74-79
    • Wohl, G.1    Loehrke, L.2    Watkins, B.3    Zernicke, R.4
  • 54
    • 0028051762 scopus 로고
    • Effect of degenerative spinal and aortic calcification on bone density measurements in post-menopausal women: Links between osteoporosis and cardiovascular disease?
    • Banks LM, Lees B, MacSweeney JE, Stevenson JC 1994 Effect of degenerative spinal and aortic calcification on bone density measurements in post-menopausal women: Links between osteoporosis and cardiovascular disease? Eur J Clin Invest 24:813-817.
    • (1994) Eur J Clin Invest , vol.24 , pp. 813-817
    • Banks, L.M.1    Lees, B.2    MacSweeney, J.E.3    Stevenson, J.C.4
  • 56
    • 0026333959 scopus 로고
    • Role of oxidized low density lipoprotein in atherogenesis
    • Witztum J, Steinberg D 1991 Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest 88:1785-1792.
    • (1991) J Clin Invest , vol.88 , pp. 1785-1792
    • Witztum, J.1    Steinberg, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.