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Volumn 23, Issue 6, 2008, Pages 949-960

Diosmetin induces human osteoblastic differentiation through the protein kinase C/p38 and extracellular signal-regulated kinase 1/2 pathway

Author keywords

Differentiation; Diosmetin; Mitogen activated protein kinase; Osteoblast; Protein kinase C

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; DIOSMETIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCALCIN; OSTEOPONTIN; PROTEIN KINASE C; PROTEIN KINASE C DELTA; RAC1 PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RUNX2;

EID: 44449100174     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.080219     Document Type: Article
Times cited : (47)

References (51)
  • 1
    • 0028925088 scopus 로고
    • Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
    • Manolagas SC, Jilka RL 1995 Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332:305-311.
    • (1995) N Engl J Med , vol.332 , pp. 305-311
    • Manolagas, S.C.1    Jilka, R.L.2
  • 2
    • 0034285013 scopus 로고    scopus 로고
    • The osteoblast: A sophisticated fibroblast under central surveillance
    • Ducy P, Schinke T, Karsenty G 2000 The osteoblast: A sophisticated fibroblast under central surveillance. Science 289:1501-1504.
    • (2000) Science , vol.289 , pp. 1501-1504
    • Ducy, P.1    Schinke, T.2    Karsenty, G.3
  • 3
    • 0033768860 scopus 로고    scopus 로고
    • Osteoclasts, integrins, and osteoporosis
    • Teitelbaum SL 2000 Osteoclasts, integrins, and osteoporosis. J Bone Miner Metab 18:344-349.
    • (2000) J Bone Miner Metab , vol.18 , pp. 344-349
    • Teitelbaum, S.L.1
  • 4
    • 33947427924 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase regulates osteoblast differentiation through osterix
    • Wang X, Goh CH, Li B 2007 p38 mitogen-activated protein kinase regulates osteoblast differentiation through osterix. Endocrinology 148:1629-1637.
    • (2007) Endocrinology , vol.148 , pp. 1629-1637
    • Wang, X.1    Goh, C.H.2    Li, B.3
  • 5
    • 0034284550 scopus 로고    scopus 로고
    • Therapeutic approaches to bone diseases
    • Rodan GA, Martin TJ 2000 Therapeutic approaches to bone diseases. Science 289:1508-1514.
    • (2000) Science , vol.289 , pp. 1508-1514
    • Rodan, G.A.1    Martin, T.J.2
  • 7
    • 0141857862 scopus 로고    scopus 로고
    • A review of anabolic therapies for osteoporosis
    • Lane NE, Kelman A 2003 A review of anabolic therapies for osteoporosis. Arthritis Res Ther 5:214-222.
    • (2003) Arthritis Res Ther , vol.5 , pp. 214-222
    • Lane, N.E.1    Kelman, A.2
  • 8
    • 34248597065 scopus 로고    scopus 로고
    • Differential regulation and properties of MAPKs
    • Raman M, Chen W, Cobb MH 2007 Differential regulation and properties of MAPKs. Oncogene 26:3100-3112.
    • (2007) Oncogene , vol.26 , pp. 3100-3112
    • Raman, M.1    Chen, W.2    Cobb, M.H.3
  • 10
    • 33646867022 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells
    • Li CF, Hughes-Fulford M 2006 Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells. J Bone Miner Res 21:946-955.
    • (2006) J Bone Miner Res , vol.21 , pp. 946-955
    • Li, C.F.1    Hughes-Fulford, M.2
  • 11
    • 27844487984 scopus 로고    scopus 로고
    • ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells
    • Miguel SM, Namdar-Attar M, Noh T, Frenkel B, Bab I 2005 ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells. J Biol Chem 280:37495-37502.
    • (2005) J Biol Chem , vol.280 , pp. 37495-37502
    • Miguel, S.M.1    Namdar-Attar, M.2    Noh, T.3    Frenkel, B.4    Bab, I.5
  • 12
    • 33947508765 scopus 로고    scopus 로고
    • Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation
    • Ghosh-Choudhury N, Mandal CC, Choudhury GG 2007 Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation. J Biol Chem 282:4983-4993.
    • (2007) J Biol Chem , vol.282 , pp. 4983-4993
    • Ghosh-Choudhury, N.1    Mandal, C.C.2    Choudhury, G.G.3
  • 13
    • 33847375078 scopus 로고    scopus 로고
    • Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development
    • Ge C, Xiao G, Jiang D, Franceschi RT 2007 Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol 176:709-718.
    • (2007) J Cell Biol , vol.176 , pp. 709-718
    • Ge, C.1    Xiao, G.2    Jiang, D.3    Franceschi, R.T.4
  • 14
    • 34547906444 scopus 로고    scopus 로고
    • Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts
    • Kanno T, Takahashi T, Tsujisawa T, Ariyoshi W, Nishihara T 2007 Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts. J Cell Biochem 101:1266-1277.
    • (2007) J Cell Biochem , vol.101 , pp. 1266-1277
    • Kanno, T.1    Takahashi, T.2    Tsujisawa, T.3    Ariyoshi, W.4    Nishihara, T.5
  • 15
    • 34247594219 scopus 로고    scopus 로고
    • Osterix is a key target for mechanical signals in human thoracic ligament flavum cells
    • Fan D, Chen Z, Wang D, Guo Z, Qiang Q, Shang Y 2007 Osterix is a key target for mechanical signals in human thoracic ligament flavum cells. J Cell Physiol 211:577-584.
    • (2007) J Cell Physiol , vol.211 , pp. 577-584
    • Fan, D.1    Chen, Z.2    Wang, D.3    Guo, Z.4    Qiang, Q.5    Shang, Y.6
  • 16
    • 33845924373 scopus 로고    scopus 로고
    • Myricetin induces human osteoblast differentiation through bone morphogenetic protein-2/p38 mitogen-activated protein kinase pathway
    • Hsu YL, Chang JK, Tsai CH, Chien TT, Kuo PL 2007 Myricetin induces human osteoblast differentiation through bone morphogenetic protein-2/p38 mitogen-activated protein kinase pathway. Biochem Pharmacol 73:504-514.
    • (2007) Biochem Pharmacol , vol.73 , pp. 504-514
    • Hsu, Y.L.1    Chang, J.K.2    Tsai, C.H.3    Chien, T.T.4    Kuo, P.L.5
  • 17
    • 0032077004 scopus 로고    scopus 로고
    • Protein kinase C modulates estrogen receptors in differentiated osteoblastic cells in vitro
    • Migliaccio S, Bernardini S, Wetsel WC, Korach KS, Faraggiana T, Teti A 1998 Protein kinase C modulates estrogen receptors in differentiated osteoblastic cells in vitro. Steroids 63:352-354.
    • (1998) Steroids , vol.63 , pp. 352-354
    • Migliaccio, S.1    Bernardini, S.2    Wetsel, W.C.3    Korach, K.S.4    Faraggiana, T.5    Teti, A.6
  • 18
    • 33947603008 scopus 로고    scopus 로고
    • Protein kinase C and other diacylglycerol effectors in cancer
    • Griner EM, Kazanietz MG 2007 Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 7:281-294.
    • (2007) Nat Rev Cancer , vol.7 , pp. 281-294
    • Griner, E.M.1    Kazanietz, M.G.2
  • 20
    • 0037414760 scopus 로고    scopus 로고
    • The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2
    • Kim HJ, Kim JH, Bae SC, Choi JY, Kim HJ, Ryoo HM 2003 The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. J Biol Chem 278:319-326.
    • (2003) J Biol Chem , vol.278 , pp. 319-326
    • Kim, H.J.1    Kim, J.H.2    Bae, S.C.3    Choi, J.Y.4    Kim, H.J.5    Ryoo, H.M.6
  • 21
    • 33644986596 scopus 로고    scopus 로고
    • Parathyroid hormone activates PKC-delta and regulates osteoblastic differentiation via a PLC-independent pathway
    • Yang D, Guo J, Divieti P, Bringhurst FR 2006 Parathyroid hormone activates PKC-delta and regulates osteoblastic differentiation via a PLC-independent pathway. Bone 38:485-496.
    • (2006) Bone , vol.38 , pp. 485-496
    • Yang, D.1    Guo, J.2    Divieti, P.3    Bringhurst, F.R.4
  • 22
    • 34548757300 scopus 로고    scopus 로고
    • Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr(311) and Tyr(565) and phospholipase C signalling
    • Hall KJ, Jones ML, Poole AW 2007 Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr(311) and Tyr(565) and phospholipase C signalling. Biochem J 406:501-509.
    • (2007) Biochem J , vol.406 , pp. 501-509
    • Hall, K.J.1    Jones, M.L.2    Poole, A.W.3
  • 23
    • 23344444562 scopus 로고    scopus 로고
    • Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells
    • Kaul S, Anantharam V, Yang Y, Choi CJ, Kanthasamy A, Kanthasamy AG 2005 Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells. J Biol Chem 280:28721-28730.
    • (2005) J Biol Chem , vol.280 , pp. 28721-28730
    • Kaul, S.1    Anantharam, V.2    Yang, Y.3    Choi, C.J.4    Kanthasamy, A.5    Kanthasamy, A.G.6
  • 24
    • 33947417220 scopus 로고    scopus 로고
    • Apigenin increases osteoblastic differentiation and inhibits tumor necrosis factor-alpha-induced production of interleukin-6 and nitric oxide in osteoblastic MC3T3-E1 cells
    • Choi EM 2007 Apigenin increases osteoblastic differentiation and inhibits tumor necrosis factor-alpha-induced production of interleukin-6 and nitric oxide in osteoblastic MC3T3-E1 cells. Pharmazie 62:216-220.
    • (2007) Pharmazie , vol.62 , pp. 216-220
    • Choi, E.M.1
  • 25
    • 33646435803 scopus 로고    scopus 로고
    • The soybean isoflavone genistein induces differentiation of MG63 human osteosarcoma osteoblasts
    • Morris C, Thorpe J, Ambrosio L, Santin M 2006 The soybean isoflavone genistein induces differentiation of MG63 human osteosarcoma osteoblasts. J Nutr 136:1166-1170.
    • (2006) J Nutr , vol.136 , pp. 1166-1170
    • Morris, C.1    Thorpe, J.2    Ambrosio, L.3    Santin, M.4
  • 26
    • 0034599543 scopus 로고    scopus 로고
    • Bioflavonoids: Selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1
    • Doostdar H, Burke MD, Mayer RT 2000 Bioflavonoids: Selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1. Toxicology 144:31-38.
    • (2000) Toxicology , vol.144 , pp. 31-38
    • Doostdar, H.1    Burke, M.D.2    Mayer, R.T.3
  • 27
    • 0033034804 scopus 로고    scopus 로고
    • In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites
    • Bae EA, Han MJ, Kim DH 1999 In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites. Planta Med 65:442-443.
    • (1999) Planta Med , vol.65 , pp. 442-443
    • Bae, E.A.1    Han, M.J.2    Kim, D.H.3
  • 28
    • 0032126507 scopus 로고    scopus 로고
    • Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity
    • Ciolino HP, Wang TT, Yeh GC 1998 Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity. Cancer Res 58:2754-2760.
    • (1998) Cancer Res , vol.58 , pp. 2754-2760
    • Ciolino, H.P.1    Wang, T.T.2    Yeh, G.C.3
  • 30
    • 33745189426 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding protein delta activates the Runx2-mediated transcription of mouse osteocalcin II promoter
    • Shin CS, Jeon MJ, Yang JY, Her SJ, Kim D, Kim SW, Kim SY 2006 CCAAT/enhancer-binding protein delta activates the Runx2-mediated transcription of mouse osteocalcin II promoter. J Mol Endocrinol 36:531-546.
    • (2006) J Mol Endocrinol , vol.36 , pp. 531-546
    • Shin, C.S.1    Jeon, M.J.2    Yang, J.Y.3    Her, S.J.4    Kim, D.5    Kim, S.W.6    Kim, S.Y.7
  • 35
    • 1542345740 scopus 로고    scopus 로고
    • Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway
    • Prouillet C, Mazière JC, Mazière C, Wattel A, Brazier M, Kamel S 2004 Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Biochem Pharmacol 67:1307-1313.
    • (2004) Biochem Pharmacol , vol.67 , pp. 1307-1313
    • Prouillet, C.1    Mazière, J.C.2    Mazière, C.3    Wattel, A.4    Brazier, M.5    Kamel, S.6
  • 36
    • 24744462930 scopus 로고    scopus 로고
    • BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways
    • Celil AB, Campbell PG 2005 BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways. J Biol Chem 280:31353-31359.
    • (2005) J Biol Chem , vol.280 , pp. 31353-31359
    • Celil, A.B.1    Campbell, P.G.2
  • 37
    • 23944463238 scopus 로고    scopus 로고
    • Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells
    • Kuo PL, Hsu YL, Chang CH, Chang JK 2005 Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells. J Pharmacol Exp Ther 314:1290-1299.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 1290-1299
    • Kuo, P.L.1    Hsu, Y.L.2    Chang, C.H.3    Chang, J.K.4
  • 39
    • 0038185348 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation
    • Hu Y, Chan E, Wang SX, Li B 2003 Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation. Endocrinology 144:2068-2074.
    • (2003) Endocrinology , vol.144 , pp. 2068-2074
    • Hu, Y.1    Chan, E.2    Wang, S.X.3    Li, B.4
  • 41
    • 33644966988 scopus 로고    scopus 로고
    • Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation
    • Phillips JE, Gersbach CA, Wojtowicz AM, García AJ 2006 Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation. J Cell Sci 119:581-591.
    • (2006) J Cell Sci , vol.119 , pp. 581-591
    • Phillips, J.E.1    Gersbach, C.A.2    Wojtowicz, A.M.3    García, A.J.4
  • 42
    • 0037441529 scopus 로고    scopus 로고
    • Regulation of the osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways
    • Franceschi RT, Xiao G 2003 Regulation of the osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways. J Cell Biochem 88:446-454.
    • (2003) J Cell Biochem , vol.88 , pp. 446-454
    • Franceschi, R.T.1    Xiao, G.2
  • 43
    • 33845975665 scopus 로고    scopus 로고
    • Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311
    • Balasubramanian S, Zhu L, Eckert RL 2006 Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311. J Biol Chem 281:36162-36172.
    • (2006) J Biol Chem , vol.281 , pp. 36162-36172
    • Balasubramanian, S.1    Zhu, L.2    Eckert, R.L.3
  • 44
    • 33744904691 scopus 로고    scopus 로고
    • Insulin-like growth factor-I-coupled mitogenic signaling in primary cultured human skeletal muscle cells and in C2C12 myoblasts. A central role of protein kinase Cdelta
    • Czifra G, Tóth IB, Marincsák R, Juhász I, Kovács I, Acs P, Kovács L, Blumberg PM, Bíró T 2006 Insulin-like growth factor-I-coupled mitogenic signaling in primary cultured human skeletal muscle cells and in C2C12 myoblasts. A central role of protein kinase Cdelta. Cell Signal 18:1461-1472.
    • (2006) Cell Signal , vol.18 , pp. 1461-1472
    • Czifra, G.1    Tóth, I.B.2    Marincsák, R.3    Juhász, I.4    Kovács, I.5    Acs, P.6    Kovács, L.7    Blumberg, P.M.8    Bíró, T.9
  • 45
    • 9444260940 scopus 로고    scopus 로고
    • Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: Its role in leukemic cell differentiation
    • Zhao KW, Li X, Zhao Q, Huang Y, Li D, Peng ZG, Shen WZ, Zhao J, Zhou Q, Chen Z, Sims PJ, Wiedmer T, Chen GQ 2004 Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: Its role in leukemic cell differentiation. Blood 104:3731-3738.
    • (2004) Blood , vol.104 , pp. 3731-3738
    • Zhao, K.W.1    Li, X.2    Zhao, Q.3    Huang, Y.4    Li, D.5    Peng, Z.G.6    Shen, W.Z.7    Zhao, J.8    Zhou, Q.9    Chen, Z.10    Sims, P.J.11    Wiedmer, T.12    Chen, G.Q.13
  • 47
    • 33947517322 scopus 로고    scopus 로고
    • Central role of protein kinase Cepsilon in constitutive activation of ERK1/2 and Rac1 in the malignant cells of hairy cell leukemia
    • Slupsky JR, Kamiguti AS, Harris RJ, Cawley JC, Zuzel M 2007 Central role of protein kinase Cepsilon in constitutive activation of ERK1/2 and Rac1 in the malignant cells of hairy cell leukemia. Am J Pathol 170:745-754.
    • (2007) Am J Pathol , vol.170 , pp. 745-754
    • Slupsky, J.R.1    Kamiguti, A.S.2    Harris, R.J.3    Cawley, J.C.4    Zuzel, M.5
  • 48
    • 1342326676 scopus 로고    scopus 로고
    • ERK activation by mechanical strain is regulated by the small G proteins rac-1 and rhoA
    • Laboureau J, Dubertret L, Lebreton-De Coster C, Coulomb B 2004 ERK activation by mechanical strain is regulated by the small G proteins rac-1 and rhoA. Exp Dermatol 13:70-77.
    • (2004) Exp Dermatol , vol.13 , pp. 70-77
    • Laboureau, J.1    Dubertret, L.2    Lebreton-De Coster, C.3    Coulomb, B.4
  • 49
    • 17644367566 scopus 로고    scopus 로고
    • H-Ras-specific activation of Rac-MKK3/6-p38 pathway: Its critical role in invasion and migration of breast epithelial cells
    • Shin I, Kim S, Song H, Kim HR, Moon A 2005 H-Ras-specific activation of Rac-MKK3/6-p38 pathway: Its critical role in invasion and migration of breast epithelial cells. J Biol Chem 280:14675-14683.
    • (2005) J Biol Chem , vol.280 , pp. 14675-14683
    • Shin, I.1    Kim, S.2    Song, H.3    Kim, H.R.4    Moon, A.5
  • 50
    • 26844471162 scopus 로고    scopus 로고
    • Angiotensin II-induced activation of p21-activated kinase 1 requires Ca2+ and protein kinase C{delta} in vascular smooth muscle cells
    • Woolfolk EA, Eguchi S, Ohtsu H, Nakashima H, Ueno H, Gerthoffer WT, Motley ED 2005 Angiotensin II-induced activation of p21-activated kinase 1 requires Ca2+ and protein kinase C{delta} in vascular smooth muscle cells. Am J Physiol Cell Physiol 289:C1286-C1294.
    • (2005) Am J Physiol Cell Physiol , vol.289
    • Woolfolk, E.A.1    Eguchi, S.2    Ohtsu, H.3    Nakashima, H.4    Ueno, H.5    Gerthoffer, W.T.6    Motley, E.D.7
  • 51
    • 0035920174 scopus 로고    scopus 로고
    • Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta isrequired for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation
    • Schuringa JJ, Dekker LV, Vellenga E, Kruijer W 2001 Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta isrequired for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation. J Biol Chem 276:27709-27715.
    • (2001) J Biol Chem , vol.276 , pp. 27709-27715
    • Schuringa, J.J.1    Dekker, L.V.2    Vellenga, E.3    Kruijer, W.4


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