MZ3 can induce G2/M-phase arrest and apoptosis in human leukemia cells

Journal of Cancer Research and Clinical Oncology

Volumn 134, Issue 12, 2008, Pages 1337-1345

  Fang, Liang ^a   Shen, Li ^b   Fang, Yanfen ^a   Hu, Yongzhou ^b   He, Qiaojun ^a   Yang, Bo ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; G2 M phase arrest; Leukemia; Microtubule

Indexed keywords

4 (4 BROMOPHENY1) 2,3 DIHYDRO N,3 BIS(3,4,5 TRIMETHOXYPHENYL) 2 OXOIDMIDAZOLE 1 CARBOXAMIDE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CDC25C PROTEIN; CELL CYCLE PROTEIN; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; DAUNORUBICIN; DOXORUBICIN; EPITOPE; IMIDAZOLE DERIVATIVE; MZ 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; TUBULIN; UNCLASSIFIED DRUG; WEE1 PROTEIN; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN K 562; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DNA STRUCTURE; ENZYME ACTIVATION; ENZYME DEGRADATION; HUMAN; HUMAN CELL; LEUKEMIA; MICROTUBULE ASSEMBLY; MITOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASE 3; CASPASE 9; CDC25 PHOSPHATASES; CELL CYCLE PROTEINS; CELL DIVISION; COLLAGEN TYPE XI; CYCLIN B; DRUG RESISTANCE, NEOPLASM; FLUORESCENT ANTIBODY TECHNIQUE; FORKHEAD TRANSCRIPTION FACTORS; G2 PHASE; HUMANS; IMIDAZOLES; K562 CELLS; LEUKEMIA; MITOSIS; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; TUBULIN; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 54949157985     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-008-0416-0     Document Type: Article

References (29)

1. A Amantana CA London PL Iversen GR Devi 2004 X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells Mol Cancer Ther 3 699 707
2. YF Cheng YZ Hu QJ He 2005 Synthesis and antitumor activity of arylsubstituted imidazolin-2-one derivatives Yao Xue Xue Bao 40 711 716
3. HC Dan M Sun S Kaneko 2004 Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP) J Biol Chem 279 5405 5412
4. FM Davis TY Tsao SK Fowler PN Rao 1983 Monoclonal antibodies to mitotic cells Proc Natl Acad Sci USA 80 2926 2930
5. A Dowlati K Robertson M Cooney 2002 A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer Cancer Res 62 3408 3416
6. L Fang Q He Y Hu B Yang 2007 MZ3 induces apoptosis in human leukemia cells Cancer Chemother Pharmacol 59 397 405
7. SL Gwaltney II HM Imade KJ Barr 2001 Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents Bioorg Med Chem Lett 11 871 874
8. S Haldar A Basu CM Croce 1997 Bcl2 is the guardian of microtubule integrity Cancer Res 57 229 233
9. P Hu Z Han AD Couvillon JH Exton 2004 Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death J Biol Chem 279 49420 49429
10. T Kawabe 2004 G2 checkpoint abrogators as anticancer drugs Mol Cancer Ther 3 513 519
11. KL King JA Cidlowski 1995 Cell cycle and apoptosis: common pathways to life and death J Cell Biochem 58 175 180
12. RM Kluck E Bossy-Wetzel DR Green DD Newmeyer 1997 The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis Science 275 1132 1136
13. S Krajewski S Tanaka S Takayama MJ Schibler W Fenton JC Reed 1993 Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes Cancer Res 53 4701 4714
14. A Kumagai WG Dunphy 1991 The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system Cell 64 903 914
15. RL Margolis L Wilson 1998 Microtubule treadmilling: what goes around comes around Bioessays 20 830 836
16. P Marchetti M Castedo SA Susin 1996 Mitochondrial permeability transition is a central coordinating event of apoptosis J Exp Med 184 1155 1160
17. L Naumovski J Ramos M Sirisawad 2005 Sapphyrins induce apoptosis in hematopoietic tumor-derived cell lines and show in vivo antitumor activity Mol Cancer Ther 4 968 976
18. CD Scatena ZA Stewart D Mays 1998 Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest J Biol Chem 273 30777 30784
19. G Song G Ouyang S Bao 2005 The activation of Akt/PKB signaling pathway and cell survival J Cell Mol Med 9 59 71
20. RK Srivastava AR Srivastava SJ Korsmeyer M Nesterova YS Cho-Chung DL Longo 1998 Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase Mol Cell Biol 18 3509 3517
21. U Strausfeld JC Labbe D Fesquet 1991 Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein Nature 351 242 245
22. SA Susin HK Lorenzo N Zamzami 1999 Mitochondrial release of caspase-2 and -9 during the apoptotic process J Exp Med 189 381 394
23. SA Susin N Zamzami M Castedo 1997 The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis J Exp Med 186 25 37
24. SK Tahir EK Han B Credo 2001 A-204197, a new tubulin-binding agent with antimitotic activity in tumor cell lines resistant to known microtubule inhibitors Cancer Res 61 5480 5485
25. MD Vos A Martinez C Elam 2004 A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability Cancer Res 64 4244 4250
26. LG Wang XM Liu W Kreis DR Budman 1999 The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review Cancer Chemother Pharmacol 44 355 361
27. B Yang CP Reynolds 2005 Tirapazamine cytotoxicity for neuroblastoma is p53 dependent Clin Cancer Res 11 2774 2780
28. C Yu M Rahmani Y Dai 2003 The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process Cancer Res 63 1822 1833
29. LJ Zhou XZ Zhu 2000 Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide J Pharmacol Exp Ther 293 982 988