메뉴 건너뛰기




Volumn 6, Issue 6, 2010, Pages 1895-1903

Biomolecular surface engineering of pancreatic islets with Thrombomodulin

Author keywords

Cell surface engineering; Islet transplantation; Staudinger ligation; Thrombomodulin

Indexed keywords

CATALYST ACTIVITY; CELL MEMBRANES; COENZYMES; GLYCOPROTEINS;

EID: 77956623971     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.01.027     Document Type: Article
Times cited : (37)

References (62)
  • 1
    • 1442265579 scopus 로고    scopus 로고
    • Islet transplantation as a treatment for diabetes - A work in progress
    • Robertson RP. Islet transplantation as a treatment for diabetes - a work in progress. N Engl J Med 2004;350:694-705.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 694-705
    • Robertson, R.P.1
  • 2
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • Shapiro AM et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000;343:230-8.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 230-238
    • Shapiro, A.M.1
  • 3
    • 0038353787 scopus 로고    scopus 로고
    • Islet transplantation: A brave new world
    • Ricordi C. Islet transplantation: a brave new world. Diabetes 2003;52:1595-603.
    • (2003) Diabetes , vol.52 , pp. 1595-1603
    • Ricordi, C.1
  • 4
    • 1842527591 scopus 로고    scopus 로고
    • Evidence of functional impairment of syngeneically transplanted mouse pancreatic islets retrieved from the liver
    • Mattsson G, Jansson L, Nordin A, Andersson A, Carlsson PO. Evidence of functional impairment of syngeneically transplanted mouse pancreatic islets retrieved from the liver. Diabetes 2004;53:948-54.
    • (2004) Diabetes , vol.53 , pp. 948-954
    • Mattsson, G.1    Jansson, L.2    Nordin, A.3    Andersson, A.4    Carlsson, P.O.5
  • 5
    • 0035085643 scopus 로고    scopus 로고
    • Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol
    • Ryan EA et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001;50:710-9.
    • (2001) Diabetes , vol.50 , pp. 710-719
    • Ryan, E.A.1
  • 6
    • 0036097472 scopus 로고    scopus 로고
    • Beta-cell death and mass in syngeneically transplanted islets exposed to short-and long-term hyperglycemia
    • Biarnes M, Montolio M, Nacher V, Raurell M, Soler J, Montanya E. Beta-cell death and mass in syngeneically transplanted islets exposed to short-and long-term hyperglycemia. Diabetes 2002;51:66-72.
    • (2002) Diabetes , vol.51 , pp. 66-72
    • Biarnes, M.1    Montolio, M.2    Nacher, V.3    Raurell, M.4    Soler, J.5    Montanya, E.6
  • 7
    • 22844450663 scopus 로고    scopus 로고
    • Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience
    • Froud T et al. Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. Am J Transplant 2005;5:2037-46.
    • (2005) Am. J. Transplant , vol.5 , pp. 2037-2046
    • Froud, T.1
  • 8
    • 21144439148 scopus 로고    scopus 로고
    • Current status of clinical islet transplantation
    • Korsgren O et al. Current status of clinical islet transplantation. Transplantation 2005;79:1289-93.
    • (2005) Transplantation , vol.79 , pp. 1289-1293
    • Korsgren, O.1
  • 9
    • 0344984343 scopus 로고    scopus 로고
    • Clinical islet transplant: Current and future directions towards tolerance
    • Shapiro AMJ, Nanji SA, Lakey JRT. Clinical islet transplant: current and future directions towards tolerance. Immunol Rev 2003;196:219-36.
    • (2003) Immunol. Rev. , vol.196 , pp. 219-236
    • Shapiro, A.M.J.1    Nanji, S.A.2    Lakey, J.R.T.3
  • 10
    • 4644328997 scopus 로고    scopus 로고
    • Transplantation for type 1 diabetes - Comparison of vascularized whole-organ pancreas with isolated pancreatic islets
    • Frank A et al. Transplantation for type 1 diabetes - comparison of vascularized whole-organ pancreas with isolated pancreatic islets. Ann Surg 2004;240:631-40.
    • (2004) Ann. Surg. , vol.240 , pp. 631-640
    • Frank, A.1
  • 11
    • 7044229738 scopus 로고    scopus 로고
    • Activated protein C preserves functional islet mass after intraportal transplantation: A novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death
    • Contreras JL et al. Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. Diabetes 2004;53:2804-14.
    • (2004) Diabetes , vol.53 , pp. 2804-2814
    • Contreras, J.L.1
  • 12
    • 25844462860 scopus 로고    scopus 로고
    • Valpha14 NK T cell-triggered IFN-gamma production by Gr-1+CD11b+ cells mediates early graft loss of syngeneic transplanted islets
    • Yasunami Y et al. Valpha14 NK T cell-triggered IFN-gamma production by Gr-1+CD11b+ cells mediates early graft loss of syngeneic transplanted islets. J Exp Med 2005;202:913-8.
    • (2005) J. Exp. Med. , vol.202 , pp. 913-918
    • Yasunami, Y.1
  • 13
    • 34548448849 scopus 로고    scopus 로고
    • Montanya E. Role of blood glucose in cytokine gene expression in early syngeneic islet transplantation
    • Montolio M, Tellez N, Soler J, Montanya E. Role of blood glucose in cytokine gene expression in early syngeneic islet transplantation. Cell Transplant 2007;16:517-25.
    • (2007) Cell. Transplant , vol.16 , pp. 517-525
    • Montolio, M.1    Tellez, N.2    Soler, J.3
  • 14
    • 0031890972 scopus 로고    scopus 로고
    • Transplantation of allogeneic islets of Langerhans in the rat liver: Effects of macrophage depletion on graft survival and microenvironment activation
    • Bottino R, Fernandez LA, Ricordi C, Lehmann R, Tsan MF, Oliver R, et al. Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation. Diabetes 1998;47:316-23.
    • (1998) Diabetes , vol.47 , pp. 316-323
    • Bottino, R.1    Fernandez, L.A.2    Ricordi, C.3    Lehmann, R.4    Tsan, M.F.5    Oliver, R.6
  • 15
    • 34247476877 scopus 로고    scopus 로고
    • Successful islet transplantation to two recipients from a single donor by targeting proinflammatory cytokines in mice
    • Satoh M et al. Successful islet transplantation to two recipients from a single donor by targeting proinflammatory cytokines in mice. Transplantation 2007;83:1085-92.
    • (2007) Transplantation , vol.83 , pp. 1085-1092
    • Satoh, M.1
  • 16
    • 0032523104 scopus 로고    scopus 로고
    • Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus
    • Rabinovitch A, Suarez-Pinzon WL. Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochem Pharmacol 1998;55:1139-49.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 1139-1149
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2
  • 17
    • 18244364592 scopus 로고    scopus 로고
    • Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: Implications for intrahepatic grafts
    • Barshes NR, Wyllie S, Goss JA. Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts. J Leukoc Biol 2005;77:587-97.
    • (2005) J. Leukoc Biol. , vol.77 , pp. 587-597
    • Barshes, N.R.1    Wyllie, S.2    Goss, J.A.3
  • 18
    • 0023848647 scopus 로고
    • In vitro and in vivo interactions of cells with biomaterials
    • Ziats NP, Miller KM, Anderson JM. In vitro and in vivo interactions of cells with biomaterials. Biomaterials 1988;9:5-13.
    • (1988) Biomaterials , vol.9 , pp. 5-13
    • Ziats, N.P.1    Miller, K.M.2    Anderson, J.M.3
  • 19
    • 0032883638 scopus 로고    scopus 로고
    • Incompatibility between human blood and isolated islets of Langerhans: A finding with implications for clinical intraportal islet transplantation?
    • Bennet W et al. Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation? Diabetes 1999;48:1907-14.
    • (1999) Diabetes , vol.48 , pp. 1907-1914
    • Bennet, W.1
  • 20
    • 0037153731 scopus 로고    scopus 로고
    • Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation
    • Moberg L et al. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 2002;360:2039-45.
    • (2002) Lancet , vol.360 , pp. 2039-2045
    • Moberg, L.1
  • 21
    • 20044371024 scopus 로고    scopus 로고
    • Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation
    • Johansson H et al. Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes 2005;54:1755-62.
    • (2005) Diabetes , vol.54 , pp. 1755-1762
    • Johansson, H.1
  • 23
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and protease-activated receptors
    • Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 2000;407:258-64.
    • (2000) Nature , vol.407 , pp. 258-264
    • Coughlin, S.R.1
  • 24
    • 19344377535 scopus 로고    scopus 로고
    • Interactions between the innate immune and blood coagulation systems
    • Esmon CT. Interactions between the innate immune and blood coagulation systems. Trends Immunol 2004;25:536-42.
    • (2004) Trends Immunol. , vol.25 , pp. 536-542
    • Esmon, C.T.1
  • 25
    • 33947282669 scopus 로고    scopus 로고
    • Platelet-neutrophilinteractions: Linking hemostasis and inflammation
    • Zarbock A, Polanowska-Grabowska RK, Ley K. Platelet- neutrophilinteractions: linking hemostasis and inflammation. Blood Rev 2007;21:99-111.
    • (2007) Blood Rev. , vol.21 , pp. 99-111
    • Zarbock, A.1    Polanowska-Grabowska, R.K.2    Ley, K.3
  • 26
    • 31044436262 scopus 로고    scopus 로고
    • Platelets in inflammation and atherogenesis
    • Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005;115:3378-84.
    • (2005) J. Clin. Invest. , vol.115 , pp. 3378-3384
    • Gawaz, M.1    Langer, H.2    May, A.E.3
  • 28
    • 0028851203 scopus 로고
    • Ultrastructural evidence for blood microvessels devoid of an endothelial cell lining in transplanted pancreatic islets
    • Lukinius A, Jansson L, Korsgren O. Ultrastructural evidence for blood microvessels devoid of an endothelial cell lining in transplanted pancreatic islets. Am J Pathol 1995;146:429-35.
    • (1995) Am. J. Pathol. , vol.146 , pp. 429-435
    • Lukinius, A.1    Jansson, L.2    Korsgren, O.3
  • 29
    • 1942439753 scopus 로고    scopus 로고
    • Crosstalk between inflammation and thrombosis
    • Esmon CT. Crosstalk between inflammation and thrombosis. Maturitas 2004;47:305-14.
    • (2004) Maturitas , vol.47 , pp. 305-314
    • Esmon, C.T.1
  • 30
    • 3943060904 scopus 로고    scopus 로고
    • Thrombomodulin-protein C-EPCR system-integrated to regulate coagulation and inflammation
    • Van de Wouwer M, Collen D, Conway EM. Thrombomodulin-protein C-EPCR system-integrated to regulate coagulation and inflammation. Arterioscler Thromb Vasc Biol 2004;24:1374-83.
    • (2004) Arterioscler Thromb. Vasc. Biol. , vol.24 , pp. 1374-1383
    • Van De Wouwer, M.1    Collen, D.2    Conway, E.M.3
  • 31
    • 0027998013 scopus 로고
    • Selective inhibitory effects of the anticoagulant activated protein-C on the responses of human mononuclear phagocytes to Lps, Ifn-gamma, or phorbol ester
    • Grey ST, Tsuchida A, Hau H, Orthner CL, Salem HH, Hancock WW. Selective inhibitory effects of the anticoagulant activated protein-C on the responses of human mononuclear phagocytes to Lps, Ifn-gamma, or phorbol ester. J Immunol 1994;153:3664-72.
    • (1994) J. Immunol. , vol.153 , pp. 3664-3672
    • Grey, S.T.1    Tsuchida, A.2    Hau, H.3    Orthner, C.L.4    Salem, H.H.5    Hancock, W.W.6
  • 32
    • 0030034186 scopus 로고    scopus 로고
    • Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats
    • Murakami K, Okajima K, Uchiba M, Johno M, Nakagaki T, Okabe H, et al. Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood 1996;87:642-7.
    • (1996) Blood , vol.87 , pp. 642-647
    • Murakami, K.1    Okajima, K.2    Uchiba, M.3    Johno, M.4    Nakagaki, T.5    Okabe, H.6
  • 33
    • 0030755533 scopus 로고    scopus 로고
    • Immunobiology and therapeutic applications of protein C protein S thrombomodulin in human and experimental allotransplantation and xenotransplantation
    • Hancock WW, Bach FH. Immunobiology and therapeutic applications of protein C protein S thrombomodulin in human and experimental allotransplantation and xenotransplantation. Trends Cardiovasc Med 1997;7:174-83.
    • (1997) Trends Cardiovasc. Med. , vol.7 , pp. 174-183
    • Hancock, W.W.1    Bach, F.H.2
  • 34
    • 0035815747 scopus 로고    scopus 로고
    • Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
    • Joyce DE, Gelbert L, Ciaccia A, DeHoff B, Grinnell BW. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 2001;276:11199-203.
    • (2001) J. Biol. Chem. , vol.276 , pp. 11199-11203
    • Joyce, D.E.1    Gelbert, L.2    Ciaccia, A.3    DeHoff, B.4    Grinnell, B.W.5
  • 35
    • 0028299926 scopus 로고
    • Human protein C inhibits selectinmediated cell adhesion: Role of unique fucosylated oligosaccharide
    • Grinnell BW, Hermann RB, Yan SB. Human protein C inhibits selectinmediated cell adhesion: role of unique fucosylated oligosaccharide. Glycobiology 1994;4:221-5.
    • (1994) Glycobiology , vol.4 , pp. 221-225
    • Grinnell, B.W.1    Hermann, R.B.2    Yan, S.B.3
  • 36
    • 66249133355 scopus 로고    scopus 로고
    • Thrombomodulin improves early outcomes after intraportal islet transplantation
    • Cui W, Wilson JT, Wen J, Angsana J, Qu Z, Haller CA, et al. Thrombomodulin improves early outcomes after intraportal islet transplantation. Am J Transplant 2009;9:1308-16.
    • (2009) Am. J. Transplant , vol.9 , pp. 1308-1316
    • Cui, W.1    Wilson, J.T.2    Wen, J.3    Angsana, J.4    Qu, Z.5    Haller, C.A.6
  • 37
    • 0037447246 scopus 로고    scopus 로고
    • Engineering the proteolytic specificity of activated protein C improves its pharmacological properties
    • Berg DT et al. Engineering the proteolytic specificity of activated protein C improves its pharmacological properties. Proc Natl Acad Sci USA 2003;100:4423-8.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4423-4428
    • Berg, D.T.1
  • 38
    • 31044444925 scopus 로고    scopus 로고
    • Catalytic efficiency of a thrombomodulin-functionalized membrane-mimetic film in a flow model
    • Tseng PY, Jordan SW, Sun XL, Chaikof EL. Catalytic efficiency of a thrombomodulin-functionalized membrane-mimetic film in a flow model. Biomaterials 2006;27:2768-75.
    • (2006) Biomaterials , vol.27 , pp. 2768-2775
    • Tseng, P.Y.1    Jordan, S.W.2    Sun, X.L.3    Chaikof, E.L.4
  • 39
    • 1942454381 scopus 로고    scopus 로고
    • Covalently immobilized thrombomodulin inhibits coagulation and complement activation of artificial surfaces in vitro
    • Sperling C, Salchert K, Streller U, Werner C. Covalently immobilized thrombomodulin inhibits coagulation and complement activation of artificial surfaces in vitro. Biomaterials 2004;25:5101-13.
    • (2004) Biomaterials , vol.25 , pp. 5101-5113
    • Sperling, C.1    Salchert, K.2    Streller, U.3    Werner, C.4
  • 40
    • 0035660385 scopus 로고    scopus 로고
    • Transplantation of mouse pancreatic islets into primates - In vivo and in vitro evaluation
    • Badet L, Titus TT, McShane P, Chang LW, Song ZS, Ferguson DJP, et al. Transplantation of mouse pancreatic islets into primates - in vivo and in vitro evaluation. Transplantation 2001;72:1867-74.
    • (2001) Transplantation , vol.72 , pp. 1867-1874
    • Badet, L.1    Titus, T.T.2    McShane, P.3    Chang, L.W.4    Song, Z.S.5    Ferguson, D.J.P.6
  • 41
    • 4644256655 scopus 로고    scopus 로고
    • C-terminal site specific PEGylation of a truncated thrombomodulin mutant with retention of full bioactivity
    • Cazalis CS, Haller CA, Sease-Cargo L, Chaikof EL. C-terminal site specific PEGylation of a truncated thrombomodulin mutant with retention of full bioactivity. Bioconjug Chem 2004;15:1005-9.
    • (2004) Bioconjug Chem. , vol.15 , pp. 1005-1009
    • Cazalis, C.S.1    Haller, C.A.2    Sease-Cargo, L.3    Chaikof, E.L.4
  • 43
    • 0034643993 scopus 로고    scopus 로고
    • A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds
    • Saxon E, Armstrong JI, Bertozzi CR. A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds. Org Lett 2000;2:2141-3.
    • (2000) Org. Lett. , vol.2 , pp. 2141-2143
    • Saxon, E.1    Armstrong, J.I.2    Bertozzi, C.R.3
  • 44
    • 53149100989 scopus 로고    scopus 로고
    • Layer-by-layer assembly of a conformal nanothin PEG coating for intraportal islet transplantation
    • Wilson JT, Cui W, Chaikof EL. Layer-by-layer assembly of a conformal nanothin PEG coating for intraportal islet transplantation. Nano Lett 2008;8:1940-8.
    • (2008) Nano. Lett. , vol.8 , pp. 1940-1948
    • Wilson, J.T.1    Cui, W.2    Chaikof, E.L.3
  • 47
    • 0037039298 scopus 로고    scopus 로고
    • Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation
    • Kiick KL, Saxon E, Tirrell DA, Bertozzi CR. Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation. Proc Natl Acad Sci USA 2002;99:19-24.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 19-24
    • Kiick, K.L.1    Saxon, E.2    Tirrell, D.A.3    Bertozzi, C.R.4
  • 48
    • 0034677879 scopus 로고    scopus 로고
    • Cell surface engineering by a modified Staudinger reaction
    • Saxon E, Bertozzi CR. Cell surface engineering by a modified Staudinger reaction. Science 2000;287:2007-10.
    • (2000) Science , vol.287 , pp. 2007-2010
    • Saxon, E.1    Bertozzi, C.R.2
  • 49
    • 34547610974 scopus 로고    scopus 로고
    • Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation
    • Cabric S et al. Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation. Diabetes 2007;56:2008-15.
    • (2007) Diabetes , vol.56 , pp. 2008-2015
    • Cabric, S.1
  • 50
    • 18744416830 scopus 로고    scopus 로고
    • Cell membrane modification for rapid display of proteins as a novel means of immunomodulation: FasL-decorated cells prevent islet graft rejection
    • Yolcu ES, Askenasy N, Singh NP, Cherradi SE, Shirwan H. Cell membrane modification for rapid display of proteins as a novel means of immunomodulation: FasL-decorated cells prevent islet graft rejection. Immunity 2002;17:795-808.
    • (2002) Immunity , vol.17 , pp. 795-808
    • Yolcu, E.S.1    Askenasy, N.2    Singh, N.P.3    Cherradi, S.E.4    Shirwan, H.5
  • 51
    • 4444319296 scopus 로고    scopus 로고
    • A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets
    • Contreras JL et al. A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets. Surgery 2004;136:537-47.
    • (2004) Surgery , vol.136 , pp. 537-547
    • Contreras, J.L.1
  • 52
    • 34548100653 scopus 로고    scopus 로고
    • Highly poly (ethylene) glycolylated islets improve long-term islet allograft survival without immunosuppressive medication
    • Lee DY, Park SJ, Lee S, Nam JH, Byun Y. Highly poly (ethylene) glycolylated islets improve long-term islet allograft survival without immunosuppressive medication. Tissue Eng 2007;13:2133-41.
    • (2007) Tissue Eng. , vol.13 , pp. 2133-2141
    • Lee, D.Y.1    Park, S.J.2    Lee, S.3    Nam, J.H.4    Byun, Y.5
  • 54
    • 0032401970 scopus 로고    scopus 로고
    • Chemoselective ligation reactions with proteins, oligosaccharides and cells
    • Lemieux GA, Bertozzi CR. Chemoselective ligation reactions with proteins, oligosaccharides and cells. Trends Biotechnol 1998;16:506-13.
    • (1998) Trends Biotechnol. , vol.16 , pp. 506-513
    • Lemieux, G.A.1    Bertozzi, C.R.2
  • 55
    • 28744443105 scopus 로고    scopus 로고
    • Rapid localized cell trapping on biodegradable polymers using cell surface derivatization and microfluidic networking
    • Sinclair J, Salem AK. Rapid localized cell trapping on biodegradable polymers using cell surface derivatization and microfluidic networking. Biomaterials 2006;27:2090-4.
    • (2006) Biomaterials , vol.27 , pp. 2090-2094
    • Sinclair, J.1    Salem, A.K.2
  • 56
    • 20144365779 scopus 로고    scopus 로고
    • Grafting of branched polymers onto nano-sized silica surface. postgrafting of polymers with pendant isocyanate groups of polymer chain grafted onto nano-sized silica surface
    • Nishizawa N, Nishimura J, Saitoh H, Fujiki K, Tsubokawa N. Grafting of branched polymers onto nano-sized silica surface. postgrafting of polymers with pendant isocyanate groups of polymer chain grafted onto nano-sized silica surface. Prog Org Coat 2005;53:306-11.
    • (2005) Prog. Org. Coat , vol.53 , pp. 306-311
    • Nishizawa, N.1    Nishimura, J.2    Saitoh, H.3    Fujiki, K.4    Tsubokawa, N.5
  • 57
    • 13244253945 scopus 로고    scopus 로고
    • Thrombomodulin expression on Langerhans' islet: Can endogenous 'anticoagulant on demand' overcome detrimental thrombotic complications in clinical islet transplantation?
    • Iino S, Abeyama K, Kawahara KI, Aikou T, Maruyama I. Thrombomodulin expression on Langerhans' islet: can endogenous 'anticoagulant on demand' overcome detrimental thrombotic complications in clinical islet transplantation? J Thromb Haemost 2004;2:833-4.
    • (2004) J. Thromb. Haemost. , vol.2 , pp. 833-834
    • Iino, S.1    Abeyama, K.2    Kawahara, K.I.3    Aikou, T.4    Maruyama, I.5
  • 59
    • 0037235585 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide decreases thrombomodulin expression in the sinusoidal endothelial cells of rats - A possible mechanism of intrasinusoidal microthrombus formation and liver dysfunction
    • Kume M et al. Bacterial lipopolysaccharide decreases thrombomodulin expression in the sinusoidal endothelial cells of rats - a possible mechanism of intrasinusoidal microthrombus formation and liver dysfunction. J Hepatol 2003;38:9-17.
    • (2003) J. Hepatol. , vol.38 , pp. 9-17
    • Kume, M.1
  • 60
    • 0028806399 scopus 로고
    • Blood coagulation equilibrium in rat liver microcirculation as evaluated by endothelial cell thrombomodulin and macrophage tissue factor
    • Arai M, Mochida S, Ohno A, Ogata I, Obama H, Maruyama I, et al. Blood coagulation equilibrium in rat liver microcirculation as evaluated by endothelial cell thrombomodulin and macrophage tissue factor. Thromb Res 1995;80:113-23.
    • (1995) Thromb. Res. , vol.80 , pp. 113-123
    • Arai, M.1    Mochida, S.2    Ohno, A.3    Ogata, I.4    Obama, H.5    Maruyama, I.6
  • 61
    • 0026495339 scopus 로고
    • Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor
    • Ishii H, Horie S, Kizaki K, Kazama M. Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor. Blood 1992;80:2556-62.
    • (1992) Blood , vol.80 , pp. 2556-2562
    • Ishii, H.1    Horie, S.2    Kizaki, K.3    Kazama, M.4
  • 62
    • 10244250329 scopus 로고    scopus 로고
    • Patients with severe sepsis vary markedly in their ability to generate activated protein C
    • Liaw PC et al. Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood 2004;104:3958-64.
    • (2004) Blood , vol.104 , pp. 3958-3964
    • Liaw, P.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.