Characterizing single-channel behavior of GluA3 receptors

Biophysical Journal

Volumn 99, Issue 5, 2010, Pages 1437-1446

  Poon, Kinning ^a   Nowak, Linda M ^a   Oswald, Robert E ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956608909     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2010.06.058     Document Type: Article

References (50)

1. Dingledine, R., K. Borges, S. F. Traynelis. 1999. The glutamate receptor ion channels. Pharmacol. Rev. 51:7-61.
2. Hollmann, M., and S. Heinemann. 1994. Cloned glutamate receptors. Annu. Rev. Neurosci. 17:31-108.
3. Nakanishi, S., and M. Masu. 1994. Molecular diversity and functions of glutamate receptors. Annu. Rev. Biophys. Biomol. Struct. 23:319-348.
4. Sommer, B., and P. H. Seeburg. 1992. Glutamate receptor channels: novel properties and new clones. Trends Pharmacol. Sci. 13:291-296.
5. Weaver, C. D., T. L. Yao, T. A. Verdoorn. 1996. Differential expression of glutamate receptor subtypes in rat pancreatic islets. J. Biol. Chem. 271:12977-12984.
6. Gill, S. S., O. M. Pulido, P. F. McGuire. 1998. Molecular and immunochemical characterization of the ionotropic glutamate receptors in the rat heart. Brain Res. Bull. 46:429-434.
7. Kwak, S., and J. H. Weiss. 2006. Calcium-permeable AMPA channels in neurodegenerative disease and ischemia. Curr. Opin. Neurobiol. 16:281-287.
8. Chen, P. E., and D. J. Wyllie. 2006. Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors. Br. J. Pharmacol. 147:839-853.
9. Black, M. D. 2005. Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data. Psychopharmacology (Berl.). 179:154-163.
10. Madden, D. R. 2002. The structure and function of glutamate receptor ion channels. Nat. Rev. Neurosci. 3:91-101.
11. Rosenmund, C., Y. Stern-Bach, and C. F. Stevens. 1998. The tetrameric structure of a glutamate receptor channel. Science. 280:1596-1599.
12. Schmauss, C., and J. R. Howe. 2002. RNA editing of neurotransmitter receptors in the mammalian brain. Sci. STKE. 2002: pe26.
13. Sun, Y., R. Olson, E. Gouaux. 2002. Mechanism of glutamate receptor desensitization. Nature. 417:245-253.
14. Stern-Bach, Y., S. Russo, C. Rosenmund. 1998. A point mutation in the glutamate binding site blocks desensitization of AMPA receptors. Neuron. 21:907-918.
15. Paas, Y. 1998. The macro-and microarchitectures of the ligand-binding domain of glutamate receptors. Trends Neurosci. 21:117-125.
16. Sommer, B., K. Keinanen, P. H. Seeburg. 1990. Flip and flop: a cellspecific functional switch in glutamate-operated channels of the CNS. Science. 249:1580-1585.
17. Pei, W., Z. Huang, and L. Niu. 2007. GluR3 flip and flop: differences in channel opening kinetics. Biochemistry. 46:2027-2036.
18. Pei, W., Z. Huang, L. Niu. 2009. Flip and flop: a molecular determinant for AMPA receptor channel opening. Biochemistry. 48:3767-3777.
19. Armstrong, N., Y. Sun, E. Gouaux. 1998. Structure of a glutamatereceptor ligand-binding core in complex with kainate. Nature. 395:913-917.
20. Sobolevsky, A. I., M. P. Rosconi, and E. Gouaux. 2009. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature. 462:745-756.
21. Armstrong, N., and E. Gouaux. 2000. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron. 28:165-181.
22. Gouaux, E. 2004. Structure and function of AMPA receptors. J. Physiol. 554:249-253.
23. Jin, R., T. G. Banke, E. Gouaux. 2003. Structural basis for partial agonist action at ionotropic glutamate receptors. Nat. Neurosci. 6:803-810.
24. Jin, R., and E. Gouaux. 2003. Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal. Biochemistry. 42:5201-5213.
25. Zhang, W., A. Robert, J. R. Howe. 2006. The relationship between agonist potency and AMPA receptor kinetics. Biophys. J. 91:1336-1346.
26. Smith, T. C., L. Y. Wang, and J. R. Howe. 2000. Heterogeneous conductance levels of native AMPA receptors. J. Neurosci. 20:2073-2085.
27. Smith, T. C., and J. R. Howe. 2000. Concentration-dependent substate behavior of native AMPA receptors. Nat. Neurosci. 3:992-997.
28. Swanson, G. T., R. W. Gereau, 4th, S. F. Heinemann. 1997. Identification of amino acid residues that control functional behavior in GluR5 and GluR6 kainate receptors. Neuron. 19:913-926.
29. Zhang, W., Y. Cho, J. R. Howe. 2008. Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J. Neurosci. 28:932-943.
30. Popescu, G., and A. Auerbach. 2003. Modal gating of NMDA receptors and the shape of their synaptic response. Nat. Neurosci. 6:476-483.
31. Lema, G. M., and A. Auerbach. 2006. Modes and models of GABA (A) receptor gating. J. Physiol. 572:183-200.
32. Maltsev, A. S., A. H. Ahmed, R. E. Oswald. 2008. Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution. Biochemistry. 47:10600-10610.
33. Fenwick, M. K., and R. E. Oswald. 2008. NMR spectroscopy of the ligand-binding core of ionotropic glutamate receptor 2 bound to 5-substituted willardiine partial agonists. J. Mol. Biol. 378:673-685.
34. Baum, L. E., T. Petrie, N. Weiss. 1970. A maximization technique occurring in the statistical analysis of probabilistic functions of Markov chains. Ann. Math. Stat. 41:164-171.
35. Qin, F., and L. Li. 2004. Model-based fitting of single-channel dwelltime distributions. Biophys. J. 87:1657-1671.
36. Qin, F., A. Auerbach, and F. Sachs. 1996. Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events. Biophys. J. 70:264-280.
37. Magleby, K. L., and B. S. Pallotta. 1983. Burst kinetics of single calcium-activated potassium channels in cultured rat muscle. J. Physiol. 344:605-623.
38. Pelleg, D., and A. W. Moore. 2000. X-means: extending K-means with efficient estimation of the number of clusters. Morgan Kaufmann Publishers, San Francisco, CA.
39. Reference deleted in proof.
40. Prieto, M. L., and L. P. Wollmuth. 2010. Gating modes in AMPA receptors. J. Neurosci. 30:4449-4459.
41. Patneau, D. K., M. L. Mayer, J. C. Watkins. 1992. Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J. Neurosci. 12:595-606.
42. Swanson, G. T., S. K. Kamboj, and S. G. Cull-Candy. 1997. Singlechannel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition. J. Neurosci. 17:58-69.
43. Kubo, M., and E. Ito. 2004. Structural dynamics of an ionotropic glutamate receptor. Proteins. 56:411-419.
44. Ahmed, A. H., Q. Wang, R. E. Oswald. 2009. Structure of the S1S2 glutamate binding domain of GLuR3. Proteins. 75:628-637.
45. Fenwick, M. K., and R. E. Oswald. 2010. On the mechanisms of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor binding to glutamate and kainate. J. Biol. Chem. 285:12334-12343.
46. Gonzalez, J., M. Du, V. Jayaraman. 2010. Role of dimer interface in activation and desensitization in AMPA receptors. Proc. Natl. Acad. Sci. USA. 107:9891-9896.
47. Johnson, J. W., and P. Ascher. 1987. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature. 325:529-531.
48. Auerbach, A., and Y. Zhou. 2005. Gating reaction mechanisms for NMDA receptor channels. J. Neurosci. 25:7914-7923.
49. Kussius, C. L., A. M. Popescu, and G. K. Popescu. 2010. Agonistspecific gating of NMDA receptors. Channels (Austin). 4:78-82.
50. Robert, A., and J. R. Howe. 2003. How AMPA receptor desensitization depends on receptor occupancy. J. Neurosci. 23:847-858.