Antitumour activity of S-p-bromobenzylglutathione cyclopentyl diester in vitro and in vivo. Inhibition of glyoxalase I and induction of apoptosis

Biochemical Pharmacology

Volumn 51, Issue 10, 1996, Pages 1365-1372

  Thornalley, Paul J ^a   Edwards, Linda G ^a   Kang, Yubin ^a   Wyatt, Catherine ^a   Davies, Nathan ^a   Ladan, Muhatri J ^a   Double, John ^b  

^a UNIVERSITY OF ESSEX   (United Kingdom)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

apoptosis; glyoxalase I; human leukaemia 60; methylglyoxal

Indexed keywords

3 AMINOBENZAMIDE; ANTINEOPLASTIC AGENT; DRUG METABOLITE; GLYOXALASE I INHIBITOR; LACTOYLGLUTATHIONE LYASE; METHYLGLYOXAL; PONALRESTAT; S (4 BROMOBENZYL)GLUTATHIONE; S (4 BROMOBENZYL)GLUTATHIONE CYCLOPENTYL DIESTER; SORBINIL; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GRAFT; CANCER INHIBITION; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG METABOLISM; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA CELL; MOUSE; PRIORITY JOURNAL;

EID: 0029878798     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00059-7     Document Type: Article

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