Nitric oxide is negatively correlated to pain during acute inflammation

Molecular Pain

Volumn 6, Issue , 2010, Pages

  Hamza, May ^a,e   Wang, Xiao Min ^a   Wu, Tongtong ^b   Brahim, Jaime S ^c   Rowan, Janet S ^d   Dionne, Raymond A ^a  

^a NATIONAL INSTITUTE OF NURSING RESEARCH   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e African Union Organization St Abbassia   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCEROL NITRATE; INDUCIBLE NITRIC OXIDE SYNTHASE; KETOROLAC; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PLACEBO; GLYCERYL TRINITRATE; ISOENZYME; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE;

ADOLESCENT; ADULT; ANALGESIC ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE CALCULATION; DOSE RESPONSE; DRUG DOSE COMPARISON; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICRODIALYSIS; PAIN PARAMETERS; PILOT STUDY; POSTOPERATIVE INFLAMMATION; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; TISSUE INJURY; TISSUE LEVEL; TOOTH DISEASE; TOOTH EXTRACTION; VISUAL ANALOG SCALE; ACUTE DISEASE; BIOLOGICAL MODEL; CLINICAL TRIAL; DRUG EFFECT; GENETICS; INFLAMMATION; METABOLISM; PAIN; STATISTICAL MODEL;

ACUTE DISEASE; ADOLESCENT; ADULT; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INFLAMMATION; ISOENZYMES; KETOROLAC; LINEAR MODELS; MALE; MICRODIALYSIS; MODELS, BIOLOGICAL; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITROGLYCERIN; PAIN; YOUNG ADULT;

EID: 77956506638     PISSN: 17448069     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-8069-6-55     Document Type: Article

References (49)

1. Schuman EM, Madison DV. Nitric oxide and synaptic function. Annual Review of Neuroscience 1994, 17:153-183. 10.1146/annurev.ne.17.030194.001101, 7516125.
2. Miclescu A, Gordh T. Nitric oxide and pain: 'Something old, something new'. Acta Anaesthesiologica Scandinavica 2009, 53:1107-1120. 10.1111/j.1399-6576.2009.02054.x, 19702699.
3. McMahon SB, Bennett DLH, Bevan S. Inflammatory mediators and modulators of pain. Wall and Melzack's Textbook of Pain 2006, 49-72. Edinburgh: Elsevier Churchill Livingstone, McMahon SB, Koltzenburg M.
4. Vetter G, Geisslinger G, Tegeder I. Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation. Pain 2001, 92:213-218. 10.1016/S0304-3959(01)00258-5, 11323142.
5. Gühring H, Hamza M, Sergejeva M, Ates M, Kotalla CE, Ledent C, Brune K. A role for endocannabinoids in indomethacin-induced spinal antinociception. Eur J Pharmacol 2002, 454:153-163. 10.1016/S0014-2999(02)02485-8, 12421642.
6. Osborne MG, Coderre TJ. Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan-induced thermal hyperalgesia. Br J Pharmacol 1999, 126:1840-1846. 10.1038/sj.bjp.0702508, 1565961, 10372828.
7. Schmidtko A, Tegeder I, Geisslinger G. No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing. Trends Neurosci 2009, 32:339-346. 10.1016/j.tins.2009.01.010, 19414201.
8. Durate ID, Lorenzetti BB, Ferreira SH. Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Eur J Pharmacol 1990, 186:289-293. 10.1016/0014-2999(90)90446-D, 1981187.
9. Aley KO, McCarter G, Levine JD. Nitric Oxide Signaling in Pain and Nociceptor Sensitization in the Rat. J Neurosci 1998, 18:7008-7014.
10. Holthusen H, Arndt JO. Nitric oxide evokes pain in humans on intracutaneous injection. Neurosci Lett 1994, 165:71-74. 10.1016/0304-3940(94)90712-9, 8015741.
11. Berrazueta JR, Losada A, Poveda J, Ochoteco A, Riestra A, Salas E, Amado JA. Successful treatment of shoulder pain syndrome due to supraspinatus tendinitis with transdermal nitroglycerin. A double blind study. Pain 1996, 66:63-67. 10.1016/0304-3959(96)03021-7, 8857632.
12. Brisby H, Ashley H, Diwan AD. In vivo measurement of facet joint nitric oxide in patients with chronic low back pain. Spine 2007, 32:1488-1492. 10.1097/BRS.0b013e318067dc97, 17572616.
13. Bica BE, Gomes NM, Fernandes PD, Luiz RR, Koatz VL. Nitric oxide levels and the severity of juvenile idiopathic arthritis. Rheumatol Int 2007, 27:819-825. 10.1007/s00296-007-0321-x, 17287934.
14. Gühring H, Tegeder I, Lötsch J, Pahl A, Werner U, Reeh PW, Rehse K, Brune K, Geisslinger G. Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia. Inflammation Research 2001, 50:83-88. 10.1007/s000110050728, 11289658.
15. Jorge De A, Nick MC, Sue DC, Philip C, Iain C, Richard GK. GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain. Pain 2006, 120:170-181. 10.1016/j.pain.2005.10.028, 16360270.
16. Boettger MK, Üceyler N, Zelenka M, Schmitt A, Reif A, Chen Y, Sommer C. Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice. European Journal of Pain 2007, 11:810-818. 10.1016/j.ejpain.2006.12.008, 17395508.
17. Doursout M-F, Liang Y, Chelly JE. NOS inhibitors exhibit antinociceptive properties in the rat formalin test. Can J Anesth 2003, 50:909-916. 10.1007/BF03018738, 14617588.
18. Gühring H, Gorig M, Ates M, Coste O, Zeilhofer HU, Pahl A, Rehse K, Brune K. Suppressed Injury-Induced Rise in Spinal Prostaglandin E2 Production and Reduced Early Thermal Hyperalgesia in iNOS-Deficient Mice. J Neurosci 2000, 20:6714-6720.
19. Vandivier RW, Eidsath A, Banks SM, Preas HL, Leighton SB, Godin PJ, Suffredini AF, Danner RL. Down-regulation of nitric oxide production by ibuprofen in human volunteers. J Pharmacol Exp Ther 1999, 289:1398-1403.
20. Ryu YS, Lee JH, Seok JH, Hong JH, Lee YS, Lim JH, Kim YM, Hur GM. Acetaminophen inhibits iNOS gene expression in RAW 264.7 macrophages: differential regulation of NF-kappaB by acetaminophen and salicylates. Biochem Biophys Res Commun 2000, 272:758-764. 10.1006/bbrc.2000.2863, 10860828.
21. Granados-Soto V, Flores-Murrieta FJ, Castaneda-Hernandez G, Lopez-Munoz FJ. Evidence for the involvement of nitric oxide in the antinociceptive effect of ketorolac. Eur J Pharmacol 1995, 277:281-284. 10.1016/0014-2999(95)00123-3, 7493621.
22. Ventura-Martinez R, Deciga-Campos M, Diaz-Reval MI, Gonzalez-Trujano ME, Lopez-Munoz FJ. Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat. Eur J Pharmacol 2004, 503:43-48. 10.1016/j.ejphar.2004.09.018, 15496294.
23. Prado WA, Schiavon VF, Cunha FQ. Dual effect of local application of nitric oxide donors in a model of incision pain in rats. Eur J Pharmacol 2002, 441:57-65. 10.1016/S0014-2999(02)01413-9, 12007920.
24. Kawabata A, Manabe S, Manabe Y, Takagi H. Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation. Br J Pharmacol 1994, 112:547-550. 1910365, 7521259.
25. Levy D, Strassman AM. Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade. J Neurophysiol 2004, 92:766-772. 10.1152/jn.00058.2004, 15056690.
26. Vivancos GG, Parada CA, Ferreira SH. Opposite nociceptive effects of the arginine/NO/cGMP pathway stimulation in dermal and subcutaneous tissues. British Journal of Pharmacology 2003, 138:1351-1357. 10.1038/sj.bjp.0705181, 1573782, 12711636.
27. Tanabe M, Nagatani Y, Saitoh K, Takasu K, Ono H. Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice. Neuropharmacology 2009, 56:702-708. 10.1016/j.neuropharm.2008.12.003, 19111753.
28. Celerier E, Gonzalez JR, Maldonado R, Cabanero D, Puig MM. Opioid-induced hyperalgesia in a murine model of postoperative pain: role of nitric oxide generated from the inducible nitric oxide synthase. Anesthesiology 2006, 104:546-555. 10.1097/00000542-200603000-00023, 16508403.
29. Tao F, Tao YX, Mao P, Zhao C, Li D, Liaw WJ, Raja SN, Johns RA. Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase. Neuroscience 2003, 120:847-854. 10.1016/S0306-4522(03)00362-2, 12895524.
30. Tao F, Tao YX, Zhao C, Dore S, Liaw WJ, Raja SN, Johns RA. Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia. Neuroscience 2004, 128:421-430. 10.1016/j.neuroscience.2004.06.038, 15350652.
31. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proceedings of the National Academy of Sciences of the United States of America 1991, 88:4651-4655. 10.1073/pnas.88.11.4651, 51723, 1675786.
32. Cunha TM, Verri WA, Schivo IR, Napimoga MH, Parada CA, Poole S, Teixeira MM, Ferreira SH, Cunha FQ. Crucial role of neutrophils in the development of mechanical inflammatory hypernociception. J Leukoc Biol 2008, 83:824-832. 10.1189/jlb.0907654, 18203872.
33. Paoloni JA, Appleyard RC, Nelson J, Murrell GA. Topical nitric oxide application in the treatment of chronic extensor tendinosis at the elbow: a randomized, double-blinded, placebo-controlled clinical trial. Am J Sports Med 2003, 31:915-920.
34. Hamza M, Wang X-M, Adam A, Brahim J, Rowan J, Carmona G, Dionne R. Kinin B1 receptors contributes to acute pain following minor surgery in humans. Molecular Pain 2010, 6:12. 10.1186/1744-8069-6-12, 2834653, 20152050.
35. Leeb-Lundberg LMF, Marceau F, Muller-Esterl W, Pettibone DJ, Zuraw BL. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev 2005, 57:27-77. 10.1124/pr.57.1.2, 15734727.
36. Joussen AM, Poulaki V, Mitsiades N, Kirchhof B, Koizumi K, Dohmen S, Adamis AP. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-α suppression. FASEB J 2002, 01-0707fje.
37. Paoloni JA, Appleyard RC, Nelson J, Murrell GA. Topical glyceryl trinitrate treatment of chronic noninsertional achilles tendinopathy. A randomized, double-blind, placebo-controlled trial. J Bone Joint Surg Am 2004, 86-A:916-922.
38. Paoloni JA, Appleyard RC, Nelson J, Murrell GA. Topical glyceryl trinitrate application in the treatment of chronic supraspinatus tendinopathy: a randomized, double-blinded, placebo-controlled clinical trial. Am J Sports Med 2005, 33:806-813. 10.1177/0363546504270998, 15827365.
39. Hrabak A, Vercruysse V, Kahan IL, Vray B. Indomethacin prevents the induction of inducible nitric oxide synthase in murine peritoneal macrophages and decreases their nitric oxide production. Life Sci 2001, 68:1923-1930. 10.1016/S0024-3205(01)00978-X, 11292070.
40. Matsuda KK, Nakamura SS, Matsushita TT. Celecoxib inhibits nitric oxide production in chondrocytes of ligament-damaged osteoarthritic rat joints. Rheumatol Int 2006, 26:991-995. 10.1007/s00296-006-0107-6, 16437200.
41. Sprott H, Gay RE, Michel BA, Gay S. Influence of ibuprofen-arginine on serum levels of nitric oxide metabolites in patients with chronic low back pain--a single-blind, placebo controlled pilot trial (ISRCTN18723747). J Rheumatol 2006, 33:2515-2518.
42. Paul-Clark MJ, van Cao T, Moradi-Bidhendi N, Cooper D, Gilroy DW. 15-epi-lipoxin A4-mediated Induction of Nitric Oxide Explains How Aspirin Inhibits Acute Inflammation. J Exp Med 2004, 200:69-78. 10.1084/jem.20040566, 2213311, 15238606.
43. Shimpo M, Ikeda U, Maeda Y, Ohya K, Murakami Y, Shimada K. Effects of Aspirin-Like Drugs on Nitric Oxide Synthesis in Rat Vascular Smooth Muscle Cells. Hypertension 2000, 35:1085-1091.
44. Amin AAR, Vyas PP, Attur MM, Leszczynska-Piziak JJ, Patel IIR, Weissmann GG, Abramson SSB. The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase. Proc Natl Acad Sci USA 1995, 92:7926-7930. 10.1073/pnas.92.17.7926, 41259, 7544010.
45. Gordon SM, Chuang BP, Wang XM, Hamza MA, Rowan JS, Brahim JS, Dionne RA. The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. Anesth Analg 2008, 106:321-327. 10.1213/01.ane.0000296474.79437.23, 18165598.
46. Lee Y-S, Kim H, Brahim JS, Rowan J, Lee G, Dionne RA. Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. Pain 2007, 129:279-286. 10.1016/j.pain.2006.10.020, 17175104.
47. Wang X-M, Wu T-X, Hamza M, Ramsay ES, Wahl SM, Dionne RA. Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain 2007, 128:136-147. 10.1016/j.pain.2006.09.011, 1894940, 17070997.
48. Wang XM, Hamza M, Gordon SM, Wahl SM, Dionne RA. COX Inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain. Clin Pharmacol Ther 2008, 84:39-42. 10.1038/sj.clpt.6100501, 18288087.
49. Flam BR, Eichler DC, Solomonson LP. Endothelial nitric oxide production is tightly coupled to the citrulline-NO cycle. Nitric Oxide 2007, 17:115-121. 10.1016/j.niox.2007.07.001, 17869551.