Down-regulation of nitric oxide production by ibuprofen in human volunteers

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 3, 1999, Pages 1398-1403

  Vandivier, R William ^a   Eidsath, Alec ^a   Banks, Steven M ^a   Preas II, Hugh L ^a   Leighton, Stephen B ^a   Godin, Paul J ^a   Suffredini, Anthony F ^a   Danner, Robert L ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; ENDOTOXIN; IBUPROFEN; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; NITROPRUSSIDE SODIUM; PLACEBO; PROSTACYCLIN DERIVATIVE; PROSTAGLANDIN SYNTHASE; THROMBOXANE DERIVATIVE;

ADULT; ARTICLE; BED REST; BLOOD VESSEL TONE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SIMULATION; ENDOTOXEMIA; ENZYME INHIBITION; FEMALE; HUMAN; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROSTAGLANDIN URINE LEVEL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY AIRFLOW; SINGLE BLIND PROCEDURE; URINARY EXCRETION;

ADULT; BLOOD PRESSURE; CARBON DIOXIDE; CROSS-OVER STUDIES; CYCLIC GMP; ENDOTOXINS; FEMALE; HEART RATE; HUMANS; IBUPROFEN; INFUSIONS, INTRAVENOUS; MALE; NITRATES; NITRIC OXIDE; NITROPRUSSIDE; PULMONARY ALVEOLI; REPRODUCIBILITY OF RESULTS; SINGLE-BLIND METHOD;

EID: 0033060908     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Aeberhard EE, Henderson SA, Arabolos NS, Griscavage JM, Castro FE, Barrett CT and Ignarro LJ (1995) Nonsteroidal anti-inflammatory drugs inhibit expression of the inducible nitric oxide synthase gene. Biochem Biophys Res Commun 208:1053-1059.
2. Amin, AR, Vyas P, Attur M, Leszczynska-Piziak J, Patel IR, Weissmann G and Abramson SB (1995) The mode of action of aspirin-like drugs: Effect on inducible nitric oxide synthase. Proc Natl Acad Sci USA 92:7926-7930.
3. Bernard GR, Wheeler AP, Russell JA, Schein R, Summer WR, Steinberg KP, Fulkerson WJ, Wright PE, Christman BW, Dupont WD, Higgins SB and Swindell BB (1997) The effects of ibuprofen on the physiology and survival of patients with sepsis. N Engl J Med 336:912-918.
4. Bornstein SR, Preas HL, Chrousos GP and Suffredini AF (1998) Circulating leptin levels during acute experimental endotoxemia and anti-inflammatory therapy in humans. J Infect Dis 178:887-90.
5. Boujoukos AJ, Martich GD, Supinski E and Suffredini AF (1993) Compartmentalization of the acute cytokine response in humans after intravenous endotoxin administration. J Appl Physiol 74:3027-3033.
6. Cobb JP, Natanson C, Quezado ZMN, Hoffman WD, Koev CA, Banks S, Correa R, Levi R, Elin RJ, Hosseini JM and Danner RL (1995) Differential hemodynamic effects of L-NMMA in endotoxemic and normal dogs. Am J Physiol 268: H1634-H1642.
7. Dahm P, Thörne J, Zoucas E, Mårtensson L, Myhre E and Blomquist S (1997) Differential effects of nitric oxide synthase modulation on porcine systemic and pulmonary circulation in vivo. Crit Care Med 26:280-285.
8. Dixon WJ (1951) Ratios involving extreme values. Ann Math Stat 22:68-78.
9. Evans T, Carpenter A, Kinderman H and Cohen J (1993) Evidence of increased nitric oxide production in patients with the sepsis syndrome. Circ Shock 41:77-81.
10. Farivar RS, Chobanian AV and Brecher P (1996) Salicylate or aspirin inhibits the induction of the inducible nitric oxide synthase in rat cardiac fibroblasts. Cir Res 78:759-768.
11. Fletcher JR, Ramwell PW and Herman CM (1976) Prostaglandins and the hemodynamic course of endotoxin shock. J Surg Res 20:589-594.
12. Gaboury J, Woodman RC, Granger DN, Reinhardt P and Kubes P (1993) Nitric oxide prevents leukocyte adherence: Role of superoxide. Am J Physiol 265:H862-H867.
13. Gardiner SM, Kemp PA, March JE and Bennett T (1995) Cardiac and regional haemodynamics, inducible nitric oxide synthase (NOS) activity, and the effects of NOS inhibitors in conscious, endotoxemic rats. Br J Pharmacol 116:2005-2016.
14. Godin PJ, Fleisher LA, Eidsath A, Vandivier RW, Preas HL, Banks SM, Buchman TG and Suffredini AF (1996) Experimental human endotoxemia increases cardiac regularity: Results from a prospective, randomized crossover trial. Crit Care Med 24:1117-1124.
15. Husain M, Adrie C, Ichinose F, Kavosi M and Zapol WM (1994) Exhaled nitric oxide as a marker for organic nitrate tolerance. Circulation 89:2498-2502.
16. Jacob TD, Ochoa JB, Udekwu AO, Wilkinson J, Murray T, Billiar TR, Simmons R L, Marion DW and Peitzman AB (1993) Nitric oxide production is inhibited in trauma patients. J Trauma 35:590-596.
17. Jacobs ER, Soulsby ME, Bone RC, Wilson FJ Jr. and Hiller FC (1982) Ibuprofen in canine endotoxin shock. J Clin Invest 70:536-541.
18. Kepka-Lenhart D, Chen L and Morris SM Jr. (1996) Novel actions of aspirin and sodium salicylate: Discordant effects on nitric oxide synthesis and induction of nitric oxide synthase mRNA in a murine macrophage cell line. J Leukocyte Biol 59:840-846.
19. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA and Barnes PJ (1994) Increased nitric oxide in exhaled air of asthmatic patients. Lancet 343:133-135.
20. Macmicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Xie QW, Sokol K and Hutchinson N (1995) Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81:641-650.
21. Martich GD, Danner RL, Ceska M and Suffredini AF (1991) Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: The effect of anti-inflammatory agents. J Exp Med 173:1021-1024.
22. Martich GD, Parker MM, Cunnion RE and Suffredini AF (1992) Effects of ibuprofen and pentoxifylline on the cardiovascular response of normal humans to endotoxin. J Appl Physiol 73:925-931.
23. Menzel JE and Kolarz G (1997) Modulation of nitric oxide synthase activity by ibuprofen. Inflammation 21:451-461.
24. O'Grady NP, Tropea M, Preas HL II, Reda D, Vandivier RW, Banks SM and Suffredini AF (1999) Detection of macrophage inflammatory protein (MIP-α) and MIP-1β during experimental endotoxemia and human sepsis. J Infect Dis 179: 136-141.
25. Persson MG, Agvald P and Gustafsson LE (1994) Detection of nitric oxide in exhaled air during administration of nitroglycerin. Br J Pharmacol 111:825-828.
26. Petros A, Lamb G, Leone A, Moncada S, Bennett D and Vallance P (1994) Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc Res 28:34-39.
27. Radomski MW, Palmer RMJ and Moncada S (1990) Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 87:10043-10047.
28. Revhaug A, Michie HR, Manson JM, Watters JM, Dinarello CA, Wolff SM and Wilmore DW (1988) Inhibition of cyclooxygenase attenuates the metabolic response to endotoxin in humans. Arch Surg 123:162-170.
29. Sakurai H, Kohsaka H, Liu MF, Higashiyama H, Hirata Y, Kanno K, Saito I and Miyasaka N (1995) Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides. J Clin Invest 96:2357-2363.
30. Smith MA, Richey Harris PL, Sayre LM, Beckman JS and Perry G (1997) Widespread peroxynitrite-mediated damage in Alzheimer's disease. J Neurosci 17: 2653-2657.
31. Stamler JS, Simon DI, Osborne JA, MuUins ME, Jaraki O, Michel T, Singel DJ and Loscalzo J (1992) S-Nitrosylation of proteins with nitric oxide: Synthesis and characterization of biologically active compounds. Proc Natl Acad Sci USA 89: 444-448.
32. Stitt JT, Dubois AB, Douglas JS and Shimada SG (1997) Exhalation of gaseous nitric oxide by rats in response to endotoxin and its absorption by the lungs. J Appl Physiol 82:305-316.
33. Suffredini AF, Fromm RE, Parker MM, Brenner M, Kovacs JA, Wesley RA and Parrillo JE (1989) The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 321:280-287.
34. Szabo C, Mitchell JA, Thiemermann C and Vane JR (1993) Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 108:786-792.
35. Tetsuka T, Daphna-Iken D, Srivastava SK, Baier LD, DuMaine J and Morrison AR (1994) Cross-talk between cyclooxygenase and nitric oxide pathways: Prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1. Proc Natl Acad Sci USA 91:12168-12172.
36. Vallance P, Collier J and Moncada S (1989) Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 2:997-1000.
37. van den Berg C, van Amsterdam JGC, Bisschop A, Piet JJ, Wemer J and de Wildt DJ (1994) Septic shock: No correlation between plasma levels of nitric oxide metabolites and hypotension or lethality. Bur J Pharmacol 270:379-382.
38. Weitzberg E, Lundberg JM and Rudehill A (1995) Inhibitory effects of diclofenac on the endotoxin shock response in relation to endothelin turnover in the pig. Acta Anaesthesiol Scand 39:50-59.
39. Wever RM, Luscher TF, Cosentino F and Rabelink TJ (1998) Atherosclerosis and the two faces of endothelial nitric oxide synthase. Circulation 97:108-112.
40. Wolin MS (1996) Reactive oxygen species and vascular signal transduction mechanisms. Microcirculation 3:1-17.
41. Xu XP, Tanner MA and Meyers PR (1995) Prostaglandin-mediated inhibition of nitric oxide production by bovine aortic endothelium during hypoxia. Cardiovascular Res 30:345-350.
42. Yan L, Vandivier RW, Suffredini AF and Danner RL (1994) Human polymorphonuclear leukocytes lack detectable nitric oxide synthase activity. J Immunol 153: 1825-1834.