Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation

Pain

Volumn 92, Issue 1-2, 2001, Pages 213-218

  Vetter, Gregor ^a   Geisslinger, Gerd ^a   Tegeder, Irmgard ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Formalin; Glycerol; Lactate; Microdialysis; Nociception; Zymosan

Indexed keywords

FORMALDEHYDE; GLUCOSE; GLUTAMIC ACID; GLYCEROL; LACTIC ACID; NITRIC OXIDE; PROSTAGLANDIN E2; ZYMOSAN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INFLAMMATION; MALE; METABOLIC DISORDER; METABOLISM; MICRODIALYSIS; NEUROTRANSMITTER RELEASE; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; TISSUE INJURY;

ANIMALS; DINOPROSTONE; GLUTAMIC ACID; GLYCEROL; LACTIC ACID; MALE; MICRODIALYSIS; NITRATES; NITRIC OXIDE; NITRITES; NOCICEPTORS; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; ZYMOSAN;

EID: 0035056034     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(01)00258-5     Document Type: Article

References (42)

1. Spinal cord metabolic response to noxious radiant heat stimulation of the cat hind footpad
2. Changes in formalin-evoked spinal Fos expression and nociceptive behaviour after oral administration of Bufferin A (aspirin) and L- 5409709 (ibuprofen+caffeine+paracetamol)
3. Pharmacological modulation of secondary mediator systems - cyclic AMP and cyclic GMP - on inflammatory hyperalgesia
4. Peripheral glutamate release in the hindpaw following low and high intensity sciatic stimulation
5. A cure for wind up: NMDA receptor antagonists as potential analgesics
6. The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
7. Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat
8. Changes of extracellular levels of amino acids after graded compression trauma to the spinal cord: An experimental study in the rat using microdialysis
9. Intrathecal administration of prostaglandin E2 causes sensitization of the primary afferent neuron via the spinal release of glutamate
10. Spinal actions of cyclooxygenase isozyme inhibitors
11. Inhibition of noxious stimulus-induced spinal prostaglandin E2 release by flurbiprofen enantiomers: A microdialysis study
12. Interstitial glycerol as a marker for membrane phospholipid degradation in the acutely injured human brain
13. Activation of spinal N-methyl-D-aspartate receptors stimulates a nitric oxide/cyclic guanosine 3,5-monophosphate/glutamate release cascade in nociceptive signaling
14. Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse
15. Amino acid release into the knee joint: Key role in nociception and inflammation
16. Involvement of reactive oxygen species in membrane phospholipid breakdown and energy perturbation after traumatic brain injury in the rat
17. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat
18. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats
19. Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: A microdialysis study in unanesthetized rats
20. Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase
21. Post-injury treatment with GM1 ganglioside reduces nociceptive behaviors and spinal cord metabolic activity in rats with experimental peripheral mononeuropathy
22. Spatial patterns of spinal cord [14C]-2-deoxyglucose metabolic activity in a rat model of painful peripheral mononeuropathy
23. Spatial patterns of increased spinal cord membrane-bound protein kinase C and their relation to increases in 14C-2-deoxyglucose metabolic activity in rats with painful peripheral mononeuropathy
24. Nitric oxide (NO) and nociceptive processing in the spinal cord
25. Intraplantar zymosan as a reliable, quantifiable model of thermal and mechanical hyperalgesia in the rat
26. Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex
27. Involvement of glutamate receptors in allodynia induced by prostaglandins E2 and F2 alpha injected into conscious mice
28. L-NAME, an inhibitor of nitric oxide synthase, blocks the established allodynia induced by intrathecal administration of prostaglandin E2
29. L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse
30. Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation
31. Functional activity mapping of the rat spinal cord during formalin-induced noxious stimulation
32. Regional changes in spinal cord glucose metabolism in a rat model of painful neuropathy
33. A nitric oxide synthesis inhibitor (L-NAME) reduces licking behavior and Fos-labeling in the spinal cord of rats during formalin-induced inflammation
34. Region-specific increase in glutamate release from dorsal horn of rats with adjuvant inflammation
35. Afferent and spinal mechanisms of joint pain
36. Peripheral noxious stimulation releases spinal PGE2 during the first phase in the formalin assay of the rat
37. Increased spinal release of excitatory amino acids following intradermal injection of capsaicin is reduced by a protein kinase G inhibitor
38. NMDA evokes an L-NAME sensitive spinal release of glutamate and citrulline
39. Activation of cGMP-dependent protein kinase 1α is required for N-methyl-d-aspartate- or nitric oxide-produced spinal thermal hyperalgesia
40. Intrathecally administered cGMP-dependent protein kinase Ialpha inhibitor significantly reduced the threshold for isoflurane anesthesia: Implication for a novel role of cGMP-dependent protein kinase Ialpha
41. Nitric oxide contributes to central sensitization following intradermal injection of capsaicin
42. Time course of energy perturbation after compression trauma to the spinal cord: An experimental study in the rat using microdialysis