Role of pneumococcal pneumolysin in the induction of an inflammatory response in human epithelial cells

FEMS Immunology and Medical Microbiology

Volumn 60, Issue 1, 2010, Pages 28-35

  Yoo, In Hwa ^a   Shin, Hee Sung ^a   Kim, Yong Jae ^a   Kim, Hyong Bai ^a   Jin, Shouguang ^b   Ha, Un Hwan ^a  

^a Korea University   (South Korea)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

epithelial cell; inflammatory response; pneumolysin; Streptococcus pneumoniae

Indexed keywords

INTERLEUKIN 1BETA; PNEUMOLYSIN; TUMOR NECROSIS FACTOR ALPHA; VIRULENCE FACTOR;

ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPITHELIUM CELL; HAEMOPHILUS INFLUENZAE; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

BACTERIAL PROTEINS; CELL LINE; CYTOKINES; EPITHELIAL CELLS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HAEMOPHILUS INFLUENZAE; HUMANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STREPTOCOCCUS PNEUMONIAE; STREPTOLYSINS;

EID: 77956504023     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2010.00699.x     Document Type: Article

References (53)

1. Avery OT, MacLeod CM McCarty M (1979) Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Inductions of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III. J Exp Med 149 : 297 326.
2. Baldassare JJ, Bi Y Bellone CJ (1999) The role of p38 mitogen-activated protein kinase in IL-1 beta transcription. J Immunol 162 : 5367 5373.
3. Berry AM, Yother J, Briles DE, Hansman D Paton JC (1989) Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infect Immun 57 : 2037 2042.
4. Black S, Shinefield H, Fireman B et al 2000) Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group. Pediatr Infect Dis J 19 : 187 195.
5. Bluestone CD, Stephenson JS Martin LM (1992) Ten-year review of otitis media pathogens. Pediatr Infect Dis J 11 : S7 11.
6. Braun JS, Novak R, Gao G, Murray PJ Shenep JL (1999) Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages. Infect Immun 67 : 3750 3756.
7. Briles DE, Crain MJ, Gray BM, Forman C Yother J (1992) Strong association between capsular type and virulence for mice among human isolates of Streptococcus pneumoniae. Infect Immun 60 : 111 116.
8. Bruyn GA van Furth R (1991) Pneumococcal polysaccharide vaccines: indications, efficacy and recommendations. Eur J Clin Microbiol Infec Dis 10 : 897 910.
9. Canvin JR, Marvin AP, Sivakumaran M, Paton JC, Boulnois GJ, Andrew PW Mitchell TJ (1995) The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus. J Infect Dis 172 : 119 123.
10. Chun KS Surh YJ (2004) Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. Biochem Pharmacol 68 : 1089 1100.
11. Clemans DL, Bauer RJ, Hanson JA, Hobbs MV, St Geme JW III., Marrs CF Gilsdorf JR (2000) Induction of proinflammatory cytokines from human respiratory epithelial cells after stimulation by nontypeable Haemophilus influenzae. Infect Immun 68 : 4430 4440.
12. Cockeran R, Steel HC, Mitchell TJ, Feldman C Anderson R (2001) Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils. Infect Immun 69 : 3494 3496.
13. Cockeran R, Durandt C, Feldman C, Mitchell TJ Anderson R (2002) Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro. J Infect Dis 186 : 562 565.
14. Cundell DR, Gerard NP, Gerard C, Idanpaan-Heikkila I Tuomanen EI (1995) Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature 377 : 435 438.
15. Dave S, Brooks-Walter A, Pangburn MK McDaniel LS (2001) PspC, a pneumococcal surface protein, binds human factor H. Infect Immun 69 : 3435 3437.
16. Dinarello CA (2000) Proinflammatory cytokines. Chest 118 : 503 508.
17. Faden H, Stanievich J, Brodsky L, Bernstein J Ogra PL (1990) Changes in nasopharyngeal flora during otitis media of childhood. Pediatr Infect Dis J 9 : 623 626.
18. Ferrante A, Rowan-Kelly B Paton JC (1984) Inhibition of in vitro human lymphocyte response by the pneumococcal toxin pneumolysin. Infect Immun 46 : 585 589. (Pubitemid 15204639)
19. Givon-Lavi N, Fraser D, Porat N Dagan R (2002) Spread of Streptococcus pneumoniae and antibiotic-resistant S. pneumoniae from day-care center attendees to their younger siblings. J Infect Dis 186 : 1608 1614.
20. Gok U, Bulut Y, Keles E, Yalcin S Doymaz MZ (2001) Bacteriological and PCR analysis of clinical material aspirated from otitis media with effusions. Int J Pediatr Otorhi 60 : 49 54.
21. Ha U, Lim JH, Jono H et al 2007) A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. J Immunol 178 : 1736 1747.
22. Ha UH, Lim JH, Kim HJ, Wu W, Jin S, Xu H Li JD (2008) MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem 283 : 30624 30631.
23. Hausdorff WP, Bryant J, Kloek C, Paradiso PR Siber GR (2000a) The contribution of specific pneumococcal serogroups to different disease manifestations: implications for conjugate vaccine formulation and use, part II. Clin Infect Dis 30 : 122 140. (Pubitemid 30067070)
24. Hausdorff WP, Bryant J, Paradiso PR Siber GR (2000b) Which pneumococcal serogroups cause the most invasive disease: implications for conjugate vaccine formulation and use, part I. Clin Infect Dis 30 : 100 121. (Pubitemid 30067069)
25. Henderson B, Poole S Wilson M (1996) Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis. Microbiol Rev 60 : 316 341.
26. Hersh D, Weiss J Zychlinsky A (1998) How bacteria initiate inflammation: aspects of the emerging story. Curr Opin Microbiol 1 : 43 48.
27. Houldsworth S, Andrew PW Mitchell TJ (1994) Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes. Infect Immun 62 : 1501 1503.
28. Jedrzejas MJ (2001) Pneumococcal virulence factors: structure and function. Microbiol Mol Biol R 65 : 187 207.
29. Jono H, Shuto T, Xu H et al 2002) Transforming growth factor-beta-Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription. J Biol Chem 277 : 45547 45557.
30. Kalin M (1998) Pneumococcal serotypes and their clinical relevance. Thorax 53 : 159 162.
31. Kweon SM, Wang B, Rixter D et al 2006) Synergistic activation of NF-kappaB by nontypeable H. influenzae and S. pneumoniae is mediated by CK2, IKKbeta-IkappaBalpha, and p38 MAPK. Biochem Bioph Res Co 351 : 368 375.
32. Lagoa CE, Vodovotz Y, Stolz DB et al 2005) The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock. Hepatology 42 : 390 399.
33. Lim JH, Jono H, Koga T et al 2007a) Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice. PLoS One 2 : e1032.
34. Lim JH, Stirling B, Derry J et al 2007b) Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity 27 : 349 360.
35. Madsen M, Lebenthal Y, Cheng Q, Smith BL Hostetter MK (2000) A pneumococcal protein that elicits interleukin-8 from pulmonary epithelial cells. J Infect Dis 181 : 1330 1336.
36. Mitchell TJ (2006) Streptococcus pneumoniae: infection, inflammation and disease. Adv Exp Med Biol 582 : 111 124.
37. Mitchell TJ Andrew PW (1997) Biological properties of pneumolysin. Microb Drug Resist 3 : 19 26.
38. Murphy TF (2006) The role of bacteria in airway inflammation in exacerbations of chronic obstructive pulmonary disease. Curr Opin Infect Dis 19 : 225 230.
39. Obaro SK (2002) The new pneumococcal vaccine. Clin Microbiol Infec 8 : 623 633.
40. Ozyilmaz E, Akan OA, Gulhan M, Ahmed K Nagatake T (2005) Major bacteria of community-acquired respiratory tract infections in Turkey. Jpn J Infect Dis 58 : 50 52.
41. Paton JC Ferrante A (1983) Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin. Infect Immun 41 : 1212 1216.
42. Paton JC, Rowan-Kelly B Ferrante A (1984) Activation of human complement by the pneumococcal toxin pneumolysin. Infect Immun 43 : 1085 1087.
43. Paton JC, Berry AM Lock RA (1997) Molecular analysis of putative pneumococcal virulence proteins. Microb Drug Resist 3 : 1 10.
44. Price KE Camilli A (2009) Pneumolysin localizes to the cell wall of Streptococcus pneumoniae. J Bacteriol 191 : 2163 2168.
45. Rijneveld AW, van den Dobbelsteen GP, Florquin S, Standiford TJ, Speelman P, van Alphen L van der Poll T (2002) Roles of interleukin-6 and macrophage inflammatory protein-2 in pneumolysin-induced lung inflammation in mice. J Infect Dis 185 : 123 126.
46. Rosenow C, Ryan P, Weiser JN, Johnson S, Fontan P, Ortqvist A Masure HR (1997) Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae. Mol Microbiol 25 : 819 829.
47. Shuto T, Xu H, Wang B et al 2001) Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha/beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. P Natl Acad Sci USA 98 : 8774 8779.
48. Spratt BG Greenwood BM (2000) Prevention of pneumococcal disease by vaccination: does serotype replacement matter? Lancet 356 : 1210 1211.
49. Srivastava A, Henneke P, Visintin A et al 2005) The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease. Infect Immun 73 : 6479 6487.
50. Tuomanen E, Liu H, Hengstler B, Zak O Tomasz A (1985) The induction of meningeal inflammation by components of the pneumococcal cell wall. J Infect Dis 151 : 859 868.
51. Ware LB, Bastarache JA Wang L (2005) Coagulation and fibrinolysis in human acute lung injury - new therapeutic targets? Keio J Med 54 : 142 149.
52. Wheeler J, Freeman R, Steward M et al 1999) Detection of pneumolysin in sputum. J Med Microbiol 48 : 863 866.
53. Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R Golenbock D (1999) Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 163 : 1 5.