Identifying targets for autoantibodies in CNS inflammation: Strategies and achievements

Clinical and Experimental Neuroimmunology

Volumn 1, Issue 2, 2010, Pages 47-60

  Meinl, Edgar ^a,b   Derfuss, Tobias ^c   Linington, Chris ^d  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Acute disseminated encephalomyelitis; Multiple sclerosis; Nodes of Ranvier; Paraneoplastic diseases; Proteomics

Indexed keywords

4 AMINOBUTYRIC ACID; AMPHIPHYSIN; AQUAPORIN; AQUAPORIN 4; AUTOANTIBODY; BETA TUBULIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CONTACTIN; FASCIN; FRUCTOSE BISPHOSPHATE ALDOLASE; GALACTOSYLCERAMIDE; GANGLIOSIDE ANTIBODY; GANGLIOSIDE GM1; GANGLIOSIDE GQ 1B; GANGLIOTETRAOSYLCERAMIDE; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 65; GLYCOLIPID; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; MYELIN; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEURON SPECIFIC ENOLASE; PYRUVATE KINASE; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNINDEXED DRUG;

ACUTE DISSEMINATED ENCEPHALOMYELITIS; ALLERGIC ENCEPHALOMYELITIS; B LYMPHOCYTE; BLOOD BRAIN BARRIER; BRAIN TISSUE; CELL IMMORTALIZATION; CELL LINE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CHANNELOPATHY; CHOREA MINOR; DEMYELINATION; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDEMIC ENCEPHALITIS; EPSTEIN BARR VIRUS; EXTRACELLULAR MATRIX; GUILLAIN BARRE SYNDROME; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MASS SPECTROMETRY; MEASLES VIRUS; MULTIPLE SCLEROSIS; MUSCLE STIFFNESS; MYELIN SHEATH; MYELOOPTIC NEUROPATHY; NERVOUS SYSTEM INFLAMMATION; NEUROBLASTOMA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARANEOPLASTIC NEUROPATHY; PATHOGENICITY; PLASMAPHERESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SPINAL CORD DISEASE; STIFF MAN SYNDROME; SUBACUTE SCLEROSING PANENCEPHALITIS; TROPICAL SPASTIC PARAPARESIS; WESTERN BLOTTING;

EID: 77956490398     PISSN: None     EISSN: 17591961     Source Type: Journal    
DOI: 10.1111/j.1759-1961.2009.00006.x     Document Type: Review

References (118)

1. Bornstein MB, Appel SH. Tissue culture studies of demyelination. Ann N Y Acad Sci. 1965; 122: 280-6.
2. Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol. 2000; 47: 707-17. (Pubitemid 30390191)
3. Keegan M, Konig F, McClelland R, Brück W, Morales Y, Bitsch A, et al. Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange. Lancet. 2005; 366: 579-82. (Pubitemid 41140333)
4. Linington C, Bradl M, Lassmann H, Brunner C, Vass K. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Am J Pathol. 1988; 130: 443-54. (Pubitemid 18091372)
5. Litzenburger T, Fässler R, Bauer J, Lassmann H, Linington C, Wekerle H, et al. B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice. J Exp Med. 1998; 188: 169-80. (Pubitemid 28328615)
6. Brehm U, Piddlesden SJ, Gardinier MV, Linington C. Epitope specificity of demyelinating monoclonal autoantibodies directed against the human myelin oligodendrocyte glycoprotein (MOG). J Neuroimmunol. 1999; 97: 9-15. (Pubitemid 29301408)
7. Breithaupt C, Schafer B, Pellkofer H, Huber R, Linington C, Jacob U. Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents. J Immunol. 2008; 181: 1255-63.
8. von Budingen HC, Hauser SL, Fuhrmann A, Nabavi CB, Lee JI, Genain CP. Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination. Proc Natl Acad Sci USA. 2002; 99: 8207-12. (Pubitemid 34651031)
9. Marta CB, Oliver AR, Sweet RA, Pfeiffer SE, Ruddle NH. Pathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiology. Proc Natl Acad Sci USA. 2005; 102: 13992-7. (Pubitemid 41377691)
10. Lalive PH, Menge T, Delarasse C, Della GB, Pham-Dinh D, Villoslada P, et al. Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis. Proc Natl Acad Sci USA. 2006; 103: 2280-5. (Pubitemid 43271661)
11. Mathey EK, Derfuss T, Storch MK, Williams KR, Hales K, Woolley DR, et al. Neurofascin as a novel target for autoantibody-mediated axonal injury. J Exp Med. 2007; 204: 2363-72. (Pubitemid 47529322)
12. Berger T, Rubner P, Schautzer F, Egg R, Ulmer H, Mayringer I, et al. Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. N Engl J Med. 2003; 349: 139-45. (Pubitemid 36818783)
13. Kuhle J, Pohl C, Mehling M, Edan G, Freedman MS, Hartung HP, et al. Lack of association between antimyelin antibodies and progression to multiple sclerosis. N Engl J Med. 2007; 356: 371-8. (Pubitemid 46148779)
14. O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, et al. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med. 2007; 13: 211-7.
15. Haase CG, Guggenmos J, Brehm U, Andersson M, Olsson T, Reindl M, et al. The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls. J Neuroimmunol. 2001; 114: 220-5. (Pubitemid 32184745)
16. Zhou D, Srivastava R, Nessler S, Grummel V, Sommer N, Bruck W, et al. Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis. Proc Natl Acad Sci USA. 2006; 103: 19057-62. (Pubitemid 350002827)
17. McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, et al. Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol. 2009; 183: 4067-76.
18. Derfuss T, Parikh K, Velhin S, Braun M, Mathey E, Krumbholz M, et al. Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proc Natl Acad Sci USA. 2009; 106: 8302-7.
19. Poliak S, Peles E. The local differentiation of myelinated axons at nodes of Ranvier. Nat Rev Neurosci. 2003; 4: 968-80. (Pubitemid 37486673)
20. Kusunoki S, Iwamori M, Chiba A, Hitoshi S, Arita M, Kanazawa I. GM1b is a new member of antigen for serum antibody in Guillain-Barre syndrome. Neurology. 1996; 47: 237-42. (Pubitemid 26243890)
21. Kaida K, Ariga T, Yu RK. Antiganglioside antibodies and their pathophysiological effects on Guillain-Barre syndrome and related disorders - a review. Glycobiology. 2009; 19: 676-92.
22. Podbielska M, Hogan E. Molecular and immunogenic features of myelin lipids: incitants or modulators of multiple sclerosis? Mult Scler. 2009; 15: 1011-29.
23. Kusunoki S, Shimizu J, Chiba A, Ugawa Y, Hitoshi S, Kanazawa I. Experimental sensory neuropathy induced by sensitization with ganglioside GD1b. Ann Neurol. 1996; 39: 424-31. (Pubitemid 26117997)
24. Plomp JJ, Molenaar PC, O'Hanlon GM, Jacobs BC, Veitch J, Daha MR, et al. Miller Fisher anti-GQ1b antibodies: alpha-latrotoxin-like effects on motor end plates. Ann Neurol. 1999; 45: 189-99. (Pubitemid 29072365)
25. Yuki N, Susuki K, Koga M, Nishimoto Y, Odaka M, Hirata K, et al. Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni lipooligosaccharide causes Guillain-Barre syndrome. Proc Natl Acad Sci USA. 2004; 101: 11404-9. (Pubitemid 39038359)
26. Susuki K, Rasband MN, Tohyama K, Koibuchi K, Okamoto S, Funakoshi K, et al. Anti-GM1 antibodies cause complement-mediated disruption of sodium channel clusters in peripheral motor nerve fibers. J Neurosci. 2007; 27: 3956-67. (Pubitemid 46597169)
27. Kanter JL, Narayana S, Ho PP, Catz I, Warren KG, Sobel RA, et al. Lipid microarrays identify key mediators of autoimmune brain inflammation. Nat Med. 2006; 12: 138-43. (Pubitemid 43050089)
28. Menge T, Lalive PH, von Budingen HC, Cree B, Hauser SL, Genain CP. Antibody responses against galactocerebroside are potential stage-specific biomarkers in multiple sclerosis. J Allergy Clin Immunol. 2005; 116: 453-9. (Pubitemid 41096558)
29. Ilyas AA, Chen ZW, Cook SD. Antibodies to sulfatide in cerebrospinal fluid of patients with multiple sclerosis. J Neuroimmunol. 2003; 139: 76-80. (Pubitemid 36700418)
30. Rosenbluth J, Schiff R, Liang WL, Dou W. Antibody-mediated CNS demyelination II. Focal spinal cord lesions induced by implantation of an IgM antisulfatide-secreting hybridoma. J Neurocytol. 2003; 32: 265-76. (Pubitemid 38197826)
31. Nishimura M, Saida T, Kuroki S, Kawabata T, Obayashi H, Saida K, et al. Post-infectious encephalitis with antigalactocerebroside antibody subsequent to Mycoplasma pneumoniae infection. J Neurol Sci. 1996; 140: 91-5. (Pubitemid 26273624)
32. Kumada S, Kusaka H, Okaniwa M, Kobayashi O, Kusunoki S. Encephalomyelitis subsequent to mycoplasma infection with elevated serum anti-Gal C antibody. Pediatr Neurol. 1997; 16: 241-4. (Pubitemid 27225434)
33. Villar LM, Sadaba MC, Roldan E, Masjuan J, Gonzalez-Porque P, Villarrubia N, et al. Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS. J Clin Invest. 2005; 115: 187-94. (Pubitemid 40385520)
34. Rodriguez M, Warrington AE, Pease LR. Invited Article: Human natural autoantibodies in the treatment of neurologic disease. Neurology. 2009; 72: 1269-76.
35. Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. Lancet Neurol. 2007; 6: 805-15. (Pubitemid 47238676)
36. Jarius S, Paul F, Franciotta D, Waters P, Zipp F, Hohlfeld R, et al. Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica. Nat Clin Pract Neurol. 2008; 4: 202-14. (Pubitemid 351516748)
37. Lennon VA, Wingerchuk DM, Kryzer TJ, Pittock SJ, Lucchinetti CF, Fujihara K, et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 2004; 364: 2106-12. (Pubitemid 39626806)
38. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med. 2005; 202: 473-7. (Pubitemid 41186945)
39. Matiello M, Lennon VA, Jacob A, Pittock SJ, Lucchinetti CF, Wingerchuk DM, et al. NMO-IgG predicts the outcome of recurrent optic neuritis. Neurology. 2008; 70: 2197-200.
40. McKeon A, Lennon VA, Lotze T, Tenenbaum S, Ness JM, Rensel M, et al. CNS aquaporin-4 autoimmunity in children. Neurology. 2008; 71: 93-100.
41. Hinson SR, Roemer SF, Lucchinetti CF, Fryer JP, Kryzer TJ, Chamberlain JL, et al. Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2. J Exp Med. 2008; 205: 2473-81.
42. Kinoshita M, Nakatsuji Y, Moriya M, Okuno T, Kumanogoh A, Nakano M, et al. Astrocytic necrosis is induced by anti-aquaporin-4 antibody-positive serum. Neuroreport. 2009; 20: 508-12.
43. Vincent T, Saikali P, Cayrol R, Roth AD, Bar-Or A, Prat A, et al. Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment. J Immunol. 2008; 181: 5730-7.
44. Kinoshita M, Nakatsuji Y, Kimura T, Moriya M, Takata K, Okuno T, et al. Neuromyelitis optica: passive transfer to rats by human immunoglobulin. Biochem Biophys Res Commun. 2009; 386: 637-7.
45. Bradl M, Misu T, Takahashi T, Watanabe M, Mader S, Reindl M, et al. Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo. Ann Neurol 2009; 66: 630-43.
46. Lucchinetti CF, Mandler RN, McGavern D, Brück W, Gleich G, Ransohoff RM, et al. A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica. Brain. 2002; 125: 1450-61. (Pubitemid 34755161)
47. Roemer SF, Parisi JE, Lennon VA, Benarroch EE, Lassmann H, Bruck W, et al. Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis. Brain. 2007; 130: 1194-205. (Pubitemid 47355941)
48. Misu T, Fujihara K, Kakita A, Konno H, Nakamura M, Watanabe S, et al. Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis. Brain. 2007; 130: 1224-34. (Pubitemid 47355951)
49. Bennett JL, Lam C, Kalluri SR, Saikali P, Bautista K, Dupree C, et al. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol. 2009; 66: 617-29.
50. Nishiyama S, Ito T, Misu T, Takahashi T, Kikuchi A, Suzuki N, et al. A case of NMO seropositive for aquaporin-4 antibody more than 10 years before onset. Neurology. 2009; 72: 1960-1.
51. Takahashi T, Fujihara K, Nakashima I, Misu T, Miyazawa I, Nakamura M, et al. Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. Brain. 2007; 130: 1235-43. (Pubitemid 47355956)
52. Jarius S, Aboul-Enein F, Waters P, Kuenz B, Hauser A, Berger T, et al. Antibody to aquaporin-4 in the long-term course of neuromyelitis optica. Brain. 2008; 131: 3072-80.
53. Krumbholz M, Faber H, Steinmeyer F, Hoffmann LA, Kumpfel T, Pellkofer H, et al. Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Brain. 2008; 131: 1455-63. (Pubitemid 351806460)
54. Dale RC, Brilot F, Banwell B. Pediatric central nervous system inflammatory demyelination: acute disseminated encephalomyelitis, clinically isolated syndromes, neuromyelitis optica, and multiple sclerosis. Curr Opin Neurol. 2009; 22: 233-40.
55. Dale RC, Church AJ, Cardoso F, Goddard E, Cox TC, Chong WK, et al. Poststreptococcal acute disseminated encephalomyelitis with basal ganglia involvement and auto-reactive antibasal ganglia antibodies. Ann Neurol. 2001; 50: 588-95. (Pubitemid 33021916)
56. Menge T, Kieseier BC, Nessler S, Hemmer B, Hartung HP, Stuve O. Acute disseminated encephalomyelitis: an acute hit against the brain. Curr Opin Neurol. 2007; 20: 247-54. (Pubitemid 46743104)
57. Kirvan CA, Swedo SE, Heuser JS, Cunningham MW. Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea. Nat Med. 2003; 9: 914-20. (Pubitemid 36889935)
58. Kirvan CA, Cox CJ, Swedo SE, Cunningham MW. Tubulin is a neuronal target of autoantibodies in Sydenham's chorea. J Immunol. 2007; 178: 7412-21. (Pubitemid 46847469)
59. Church AJ, Cardoso F, Dale RC, Lees AJ, Thompson EJ, Giovannoni G. Anti-basal ganglia antibodies in acute and persistent Sydenham's chorea. Neurology. 2002; 59: 227-31. (Pubitemid 34779182)
60. Voltz R. Paraneoplastic neurological syndromes: an update on diagnosis, pathogenesis and therapy. Lancet Neurol. 2002; 1: 294-305. (Pubitemid 37159173)
61. Wilkinson PC, Zeromski J. Immunofluorescent detection of antibodies against neurones in sensory carcinomatous neuropathy. Brain. 1965; 88: 529-83.
62. Graus F, Cordon-Cardo C, Posner JB. Neuronal antinuclear antibody in sensory neuronopathy from lung cancer. Neurology. 1985; 35: 538-43. (Pubitemid 15085073)
63. Szabo A, Dalmau J, Manley G, Rosenfeld M, Wong E, Henson J, et al. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. Cell. 1991; 67: 325-33. (Pubitemid 121001448)
64. Graus F, Dalmau J. Paraneoplastic neurological syndromes: diagnosis and treatment. Curr Opin Neurol. 2007; 20: 732-7. (Pubitemid 350085019)
65. Pellkofer HL, Voltz R, Goebels N, Hohlfeld R, Dornmair K. Cross-reactive T-cell receptors in tumor and paraneoplastic target tissue. Arch Neurol. 2009; 66: 655-8.
66. Sommer C, Weishaupt A, Brinkhoff J, Biko L, Wessig C, Gold R, et al. Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin. Lancet. 2005; 365: 1406-11. (Pubitemid 40523735)
67. Ohguro H, Ogawa K, Maeda T, Maeda A, Maruyama I. Cancer-associated retinopathy induced by both antirecoverin and anti-hsc70 antibodies in vivo. Invest Ophthalmol Vis Sci. 1999; 40: 3160-7.
68. Pittock SJ, Kryzer TJ, Lennon VA. Paraneoplastic antibodies coexist and predict cancer, not neurological syndrome. Ann Neurol. 2004; 56: 715-9. (Pubitemid 39540753)
69. Sillevis SP, Kinoshita A, De Leeuw B, Moll W, Coesmans M, Jaarsma D, et al. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. N Engl J Med. 2000; 342: 21-7. (Pubitemid 30020656)
70. DeGiorgio LA, Konstantinov KN, Lee SC, Hardin JA, Volpe BT, Diamond B. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med. 2001; 7: 1189-93. (Pubitemid 33063773)
71. Kowal C, DeGiorgio LA, Nakaoka T, Hetherington H, Huerta PT, Diamond B, et al. Cognition and immunity; antibody impairs memory. Immunity. 2004; 21: 179-88. (Pubitemid 39094048)
72. Kowal C, DeGiorgio LA, Lee JY, Edgar MA, Huerta PT, Volpe BT, et al. Human lupus autoantibodies against NMDA receptors mediate cognitive impairment. Proc Natl Acad Sci USA. 2006; 103: 19854-9. (Pubitemid 46037520)
73. Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008; 7: 1091-8.
74. Dale RC, Irani SR, Brilot F, Pillai S, Webster R, Gill D, et al. NMDA receptor antibodies in pediatric dyskinetic encephalitis lethargica. Ann Neurol. 2009; 66: 704-9.
75. Solimena M, Folli F, Denis-Donini S, Comi GC, Pozza G, De Camilli P, et al. Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus. N Engl J Med. 1988; 318: 1012-20. (Pubitemid 18095005)
76. Dalakas MC, Li M, Fujii M, Jacobowitz DM. Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodies. Neurology. 2001; 57: 780-4. (Pubitemid 32845494)
77. Dinkel K, Meinck HM, Jury KM, Karges W, Richter W. Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiffman syndrome. Ann Neurol. 1998; 44: 194-201. (Pubitemid 28374107)
78. Levy LM, Levy-Reis I, Fujii M, Dalakas MC. Brain gamma-aminobutyric acid changes in stiff-person syndrome. Arch Neurol. 2005; 62: 970-4. (Pubitemid 40973459)
79. Raju R, Hampe CS. Immunobiology of stiff-person syndrome. Int Rev Immunol. 2008; 27: 79-92. (Pubitemid 351321674)
80. Murinson BB, Vincent A. Stiff-person syndrome: autoimmunity and the central nervous system. CNS Spectr. 2001; 6: 427-33. (Pubitemid 32634168)
81. Gilden DH. Infectious causes of multiple sclerosis. Lancet Neurol. 2005; 4: 195-202. (Pubitemid 40269150)
82. Meinl E, Krumbholz M, Hohlfeld R. B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation. Ann Neurol. 2006; 59: 880-92. (Pubitemid 43830920)
83. Obermeier B, Mentele R, Malotka J, Kellermann J, Kümpfel T, Wekerle H, et al. Matching of oligoclonal Ig transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nat Med. 2008; 14: 688-93. (Pubitemid 351809541)
84. Dörries R, ter Meulen V. Detection and identification of virus-specific, oligoclonal IgG in unconcentrated cerebrospinal fluid by immunoblot technique. J Neuroimmunol. 1984; 7: 77-89. (Pubitemid 15199786)
85. Derfuss T, Guerkov R, Then Bergh F, Goebels N, Hartmann M, Barz C, et al. Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response. Brain. 2001; 124: 1325-35. (Pubitemid 32606094)
86. Burgoon MP, Owens GP, Carlson S, Maybach AL, Gilden DH. Antigen discovery in chronic human inflammatory central nervous system disease: panning phage-displayed antigen libraries identifies the targets of central nervous system-derived IgG in subacute sclerosing panencephalitis. J Immunol. 2001; 167: 6009-14. (Pubitemid 33062799)
87. Burgoon MP, Williamson RA, Owens GP, Ghausi O, Bastidas RB, Burton DR, et al. Cloning the antibody response in humans with inflammatory CNS disease: isolation of measles virus-specific antibodies from phage display libraries of a subacute sclerosing panencephalitis brain. J Neuroimmunol. 1999; 94: 204-11. (Pubitemid 29071261)
88. Burgoon MP, Keays KM, Owens GP, Ritchie AM, Rai PR, Cool CD, et al. Laser-capture microdissection of plasma cells from subacute sclerosing panencephalitis brain reveals intrathecal disease-relevant antibodies. Proc Natl Acad Sci USA. 2005; 102: 7245-50. (Pubitemid 40696364)
89. Owens GP, Ritchie AM, Gilden DH, Burgoon MP, Becker D, Bennett JL. Measles virus-specific plasma cells are prominent in subacute sclerosing panencephalitis CSF. Neurology. 2007; 68: 1815-9. (Pubitemid 46791394)
90. Kuenzle S, von Budingen HC, Meier M, Harrer MD, Urich E, Becher B, et al. Pathogen specificity and autoimmunity are distinct features of antigen-driven immune responses in neuroborreliosis. Infect Immun. 2007; 75: 3842-7. (Pubitemid 47206281)
91. Owens GP, Bennett JL, Lassmann H, O'Connor KC, Ritchie AM, Shearer A, et al. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Ann Neurol. 2009; 65: 639-49.
92. Lambracht-Washington D, O'Connor KC, Cameron EM, Jowdry A, Ward ES, Frohman E, et al. Antigen specificity of clonally expanded and receptor edited cerebrospinal fluid B cells from patients with relapsing remitting MS. J Neuroimmunol. 2007; 186: 164-76. (Pubitemid 46770863)
93. von Budingen HC, Harrer MD, Kuenzle S, Meier M, Goebels N. Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin-specific antibodies. Eur J Immunol. 2008; 38: 2014-23.
94. Yu X, Gilden DH, Ritchie AM, Burgoon MP, Keays KM, Owens GP. Specificity of recombinant antibodies generated from multiple sclerosis cerebrospinal fluid probed with a random peptide library. J Neuroimmunol. 2006; 172: 121-31. (Pubitemid 43277497)
95. Levin MC, Lee SM, Kalume F, Morcos Y, Dohan FC Jr, Hasty KA, et al. Autoimmunity due to molecular mimicry as a cause of neurological disease. Nat Med. 2002; 8: 509-13. (Pubitemid 34546754)
96. Bechmann I, Galea I, Perry VH. What is the blood-brain barrier (not)? Trends Immunol. 2007; 28: 5-11.
97. Hochmeister S, Grundtner R, Bauer J, Engelhardt B, Lyck R, Gordon G, et al. Dysferlin is a new marker for leaky brain blood vessels in multiple sclerosis. J Neuropathol Exp Neurol. 2006; 65: 855-65. (Pubitemid 44371231)
98. Anthony IC, Crawford DH, Bell JE. B lymphocytes in the normal brain: contrasts with HIV-associated lymphoid infiltrates and lymphomas. Brain. 2003; 126: 1058-67. (Pubitemid 36522949)
99. Roopenian DC, Akilesh S. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol. 2007; 7: 715-25. (Pubitemid 47327396)
100. Schlachetzki F, Zhu C, Pardridge WM. Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier. J Neurochem. 2002; 81: 203-6. (Pubitemid 34808868)
101. Lovato L, Cianti R, Gini B, Marconi S, Bianchi L, Armini A, et al. Transketolase and 2′,3′-cyclic-nucleotide 3′-phosphodiesterase type I isoforms are specifically recognized by IgG autoantibodies in multiple sclerosis patients. Mol Cell Proteomics. 2008; 7: 2337-49.
102. Wenthold RJ, Skaggs KK, Reale RR. Characterization of retrograde axonal transport of antibodies in central and peripheral neurons. J Histochem Cytochem. 1986; 34: 373-80. (Pubitemid 16158345)
103. Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, et al. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005; 25: 11495-503. (Pubitemid 43102486)
104. Zhang Y, Pardridge WM. Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier. J Neuroimmunol. 2001; 114: 168-72. (Pubitemid 32184738)
105. Kolln J, Ren HM, Da RR, Zhang Y, Spillner E, Olek M, et al. Triosephosphate isomerase- and glyceraldehyde-3-phosphate dehydrogenase-reactive autoantibodies in the cerebrospinal fluid of patients with multiple sclerosis. J Immunol. 2006; 177: 5652-8. (Pubitemid 44527641)
106. Dale RC, Candler PM, Church AJ, Wait R, Pocock JM, Giovannoni G. Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS disease. J Neuroimmunol. 2006; 172: 187-97. (Pubitemid 43277505)
107. Rosenbluth J, Schiff R, Liang WL, Dou WK, Moon D. Antibody-mediated CNS demyelination: focal spinal cord lesions induced by implantation of an IgM antigalactocerebroside-secreting hybridoma. J Neurocytol. 1999; 28: 397-416. (Pubitemid 30321018)
108. Vincent A, Lang B, Kleopa KA. Autoimmune channelopathies and related neurological disorders. Neuron. 2006; 52: 123-38. (Pubitemid 44466364)
109. Almeras L, Lefranc D, Drobecq H, de Seze J, Dubucquoi S, Vermersch P, et al. New antigenic candidates in multiple sclerosis: identification by serological proteome analysis. Proteomics. 2004; 4: 2184-94. (Pubitemid 38880382)
110. Somers K, Govarts C, Stinissen P, Somers V. Multiplexing approaches for autoantibody profiling in multiple sclerosis. Autoimmun Rev. 2009; 8: 573-9.
111. Robinson WH, DiGennaro C, Hueber W, Haab BB, Kamachi M, Dean EJ, et al. Autoantigen microarrays for multiplex characterization of autoantibody responses. Nat Med. 2002; 8: 295-301. (Pubitemid 34250109)
112. Quintana FJ, Farez MF, Viglietta V, Iglesias AH, Merbl Y, Izquierdo G, et al. Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis. Proc Natl Acad Sci USA. 2008; 105: 18889-94.
113. Somers V, Govarts C, Somers K, Hupperts R, Medaer R, Stinissen P. Autoantibody profiling in multiple sclerosis reveals novel antigenic candidates. J Immunol. 2008; 180: 3957-63.
114. Cepok S, Zhou D, Srivastava R, Nessler S, Stei S, Bussow K, et al. Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis. J Clin Invest. 2005; 115: 1352-60. (Pubitemid 40629055)
115. Archelos JJ, Trotter J, Previtali S, Weissbrich B, Toyka KV, Hartung HP. Isolation and characterization of an oligodendrocyte precursor-derived B-cell epitope in multiple sclerosis. Ann Neurol. 1998; 43: 15-24. (Pubitemid 28124644)
116. Owens GP, Shearer AJ, Yu X, Ritchie AM, Keays KM, Bennett JL, et al. Screening random peptide libraries with subacute sclerosing panencephalitis brain-derived recombinant antibodies identifies multiple epitopes in the C-terminal region of the measles virus nucleocapsid protein. J Virol. 2006; 80: 12121-30.
117. Burgoon MP, Caldas YA, Keays KM, Yu X, Gilden DH, Owens GP. Recombinant antibodies generated from both clonal and less abundant plasma cell immunoglobulin G sequences in subacute sclerosing panencephalitis brain are directed against measles virus. J Neurovirol. 2006; 12: 398-402. (Pubitemid 44650053)
118. Fraussen J, Vrolix K, Martinez-Martinez P, Losen M, De Baets MH, Stinissen P, et al. B cell characterization and reactivity analysis in multiple sclerosis. Autoimmun Rev. 2009; 8: 654-8.