-
1
-
-
0028931102
-
CpG motifs in bacterial DNA trigger direct Bcell activation
-
Krieg AM, Yi AK, Matson S et al. CpG motifs in bacterial DNA trigger direct Bcell activation. Nature 1995, 374(6522): 546-9.
-
(1995)
Nature
, vol.374
, Issue.6522
, pp. 546-549
-
-
Krieg, A.M.1
Yi, A.K.2
Matson, S.3
-
2
-
-
4043170040
-
Inhibition of experimental asthma by indoleamine 2,3-dioxygenase
-
Hayashi T, Beck L, Rossetto C et al. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest 2004, 114(2): 270-9.
-
(2004)
J Clin Invest
, vol.114
, Issue.2
, pp. 270-279
-
-
Hayashi, T.1
Beck, L.2
Rossetto, C.3
-
3
-
-
28444437011
-
Perspectives in asthma: Molecular use of microbial products in asthma prevention and treatment
-
Racila DM, Kline JN. Perspectives in asthma: molecular use of microbial products in asthma prevention and treatment. J Allergy Clin Immunol 2005, 116(6): 1202-5.
-
(2005)
J Allergy Clin Immunol
, vol.116
, Issue.6
, pp. 1202-1205
-
-
Racila, D.M.1
Kline, J.N.2
-
4
-
-
0032521274
-
Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
-
Kline JN, Waldschmidt TJ, Businga TR et al. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol 1998, 160(6): 2555-9.
-
(1998)
J Immunol
, vol.160
, Issue.6
, pp. 2555-2559
-
-
Kline, J.N.1
Waldschmidt, T.J.2
Businga, T.R.3
-
5
-
-
0033429176
-
CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma
-
Kline JN, Krieg AM, Waldschmidt TJ, Ballas ZK, Jain V, Businga TR. CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma. J Allergy Clin Immunol 1999, 104(6): 1258-64.
-
(1999)
J Allergy Clin Immunol
, vol.104
, Issue.6
, pp. 1258-1264
-
-
Kline, J.N.1
Krieg, A.M.2
Waldschmidt, T.J.3
Ballas, Z.K.4
Jain, V.5
Businga, T.R.6
-
6
-
-
0036844343
-
Immunomodulatory effects of CpG oligodeoxynucleotides on established Th2 responses
-
Kitagaki K, Jain VV, Businga TR, Hussain I, Kline JN. Immunomodulatory effects of CpG oligodeoxynucleotides on established Th2 responses. Clin Diagn Lab Immunol 2002; 9(6): 1260-9.
-
(2002)
Clin Diagn Lab Immunol
, vol.9
, Issue.6
, pp. 1260-1269
-
-
Kitagaki, K.1
Jain, V.V.2
Businga, T.R.3
Hussain, I.4
Kline, J.N.5
-
7
-
-
0036912223
-
CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma
-
Jain VV, Kitagaki K, Businga T et al. CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma. J Allergy Clin Immunol 2002, 110(6): 867-72.
-
(2002)
J Allergy Clin Immunol
, vol.110
, Issue.6
, pp. 867-872
-
-
Jain, V.V.1
Kitagaki, K.2
Businga, T.3
-
8
-
-
0036789431
-
Kline JN Modulation of murine allergic rhinosinusitis by CpG oligodeoxynucleotides
-
Hussain I, Jain VV, Kitagaki K, Businga TR, OShaughnessy P, Kline JN Modulation of murine allergic rhinosinusitis by CpG oligodeoxynucleotides. Laryngoscope 2002, 112(10): 1819-26.
-
(2002)
Laryngoscope
, vol.112
, Issue.10
, pp. 1819-1826
-
-
Hussain, I.1
Jain, V.V.2
Kitagaki, K.3
Businga, T.R.4
Oshaughnessy, P.5
-
9
-
-
0036315258
-
Treatment of established asthma in a murine model using CpG oligodeoxynucleotides
-
Kline JN, Kitagaki K, Businga TR, Jain VV. Treatment of established asthma in a murine model using CpG oligodeoxynucleotides. Am J Physiol Lung Cell Mol Physiol 2002, 283(1): L170-9.
-
(2002)
Am J Physiol Lung Cell Mol Physiol
, vol.283
, Issue.1
-
-
Kline, J.N.1
Kitagaki, K.2
Businga, T.R.3
Jain, V.V.4
-
10
-
-
0142150951
-
Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure
-
Jain VV, Businga TR, Kitagaki K, George CL, OShaughnessy PT, Kline JN. Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure. Am J Physiol Lung Cell Mol Physiol 2003, 285(5): L1137-46.
-
(2003)
Am J Physiol Lung Cell Mol Physiol
, vol.285
, Issue.5
-
-
Jain, V.V.1
Businga, T.R.2
Kitagaki, K.3
George, C.L.4
Oshaughnessy, P.T.5
Kline, J.N.6
-
11
-
-
33644778501
-
Immunostimulatory DNA inhibits allergen-induced peribronchial angiogenesis in mice
-
Lee SY, Cho JY, Miller M et al. Immunostimulatory DNA inhibits allergen-induced peribronchial angiogenesis in mice. J Allergy Clin Immunol 2006, 117(3): 597-603.
-
(2006)
J Allergy Clin Immunol
, vol.117
, Issue.3
, pp. 597-603
-
-
Lee, S.Y.1
Cho, J.Y.2
Miller, M.3
-
12
-
-
10344222650
-
Immunostimulatory DNA reverses established allergen-induced airway remodeling
-
Youn CJ, Miller M, Baek KJ et al. Immunostimulatory DNA reverses established allergen-induced airway remodeling. J Immunol 2004, 173(12): 7556-64.
-
(2004)
J Immunol
, vol.173
, Issue.12
, pp. 7556-7564
-
-
Youn, C.J.1
Miller, M.2
Baek, K.J.3
-
13
-
-
0035038915
-
Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma
-
Broide DH, Stachnick G, Castaneda D et al. Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma. J Clin Immunol 2001, 21(3): 175-82.
-
(2001)
J Clin Immunol
, vol.21
, Issue.3
, pp. 175-182
-
-
Broide, D.H.1
Stachnick, G.2
Castaneda, D.3
-
14
-
-
0033563211
-
Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides
-
Sur S, Wild JS, Choudhury BK, Sur N, Alam R, Klinman DM. Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. J Immunol 1999, 162(10): 6284-93.
-
(1999)
J Immunol
, vol.162
, Issue.10
, pp. 6284-6293
-
-
Sur, S.1
Wild, J.S.2
Choudhury, B.K.3
Sur, N.4
Alam, R.5
Klinman, D.M.6
-
15
-
-
0032534602
-
Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice
-
Broide D, Schwarze J, Tighe H et al. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J Immunol 1998, 161(12): 7054-62.
-
(1998)
J Immunol
, vol.161
, Issue.12
, pp. 7054-7062
-
-
Broide, D.1
Schwarze, J.2
Tighe, H.3
-
16
-
-
0034090116
-
Regulation of murine airway eosinophilia and Th2 cells by antigen- conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator
-
Shirota H, Sano K, Kikuchi T, Tamura G, Shirato K. Regulation of murine airway eosinophilia and Th2 cells by antigen- conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator. J Immunol 2000, 164(11): 5575-82.
-
(2000)
J Immunol
, vol.164
, Issue.11
, pp. 5575-5582
-
-
Shirota, H.1
Sano, K.2
Kikuchi, T.3
Tamura, G.4
Shirato, K.5
-
17
-
-
0036126748
-
Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma
-
Santeliz JV, Nest GV, Traquina P, Larsen E, Wills-Karp M. Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J Allergy Clin Immunol 2002, 109(3): 455-62.
-
(2002)
J Allergy Clin Immunol
, vol.109
, Issue.3
, pp. 455-462
-
-
Santeliz, J.V.1
Nest, G.V.2
Traquina, P.3
Larsen, E.4
Wills-Karp, M.5
-
18
-
-
0037379515
-
Intranasal immunotherapy is more effective than intradermal immunotherapy for the induction of airway allergen tolerance in Th2-sensitized mice
-
Takabayashi K, Libet L, Chisholm D, Zubeldia J, Horner AA. Intranasal immunotherapy is more effective than intradermal immunotherapy for the induction of airway allergen tolerance in Th2-sensitized mice. J Immunol 2003, 170(7): 3898-905.
-
(2003)
J Immunol
, vol.170
, Issue.7
, pp. 3898-905
-
-
Takabayashi, K.1
Libet, L.2
Chisholm, D.3
Zubeldia, J.4
Horner, A.A.5
-
19
-
-
0343953087
-
Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity
-
Tighe H, Takabayashi K, Schwartz D et al. Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity. J Allergy Clin Immunol 2000, 106(1 Pt. 1): 124-34.
-
(2000)
J Allergy Clin Immunol
, vol.106
, Issue.1 PART 1
, pp. 124-134
-
-
Tighe, H.1
Takabayashi, K.2
Schwartz, D.3
-
20
-
-
33646251833
-
Suppression of allergic response by CpG motif oligodeoxynucleotide-house- dust mite conjugate in animal model of allergic rhinitis
-
Mo JH, Park SW, Rhee CS et al. Suppression of allergic response by CpG motif oligodeoxynucleotide-house-dust mite conjugate in animal model of allergic rhinitis. Am J Rhinol 2006, 20(2): 212-8.
-
(2006)
Am J Rhinol
, vol.20
, Issue.2
, pp. 212-218
-
-
Mo, J.H.1
Park, S.W.2
Rhee, C.S.3
-
21
-
-
0142210354
-
Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: Modulation by immunostimulatory DNA sequences
-
Ikeda RK, Miller M, Nayar J et al. Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences. J Immunol 2003, 171(9): 4860-7.
-
(2003)
J Immunol
, vol.171
, Issue.9
, pp. 4860-4867
-
-
Ikeda, R.K.1
Miller, M.2
Nayar, J.3
-
22
-
-
34447128388
-
Antiinfective applications of toll-like receptor 9 agonists
-
Krieg AM. Antiinfective applications of toll-like receptor 9 agonists. Proc Am Thorac Soc 2007, 4(3): 289-94.
-
(2007)
Proc Am Thorac Soc
, vol.4
, Issue.3
, pp. 289-294
-
-
Krieg, A.M.1
-
23
-
-
34248169629
-
Development of TLR9 agonists for cancer therapy
-
Krieg AM. Development of TLR9 agonists for cancer therapy. J Clin Invest 2007, 117(5): 1184-94.
-
(2007)
J Clin Invest
, vol.117
, Issue.5
, pp. 1184-1194
-
-
Krieg, A.M.1
-
24
-
-
3843052308
-
Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine
-
Cooper CL, Davis HL, Morris ML et al. Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine. Vaccine 2004, 22(23-24): 3136-43.
-
(2004)
Vaccine
, vol.22
, Issue.23-24
, pp. 3136-3143
-
-
Cooper, C.L.1
Davis, H.L.2
Morris, M.L.3
-
25
-
-
33745946911
-
Therapeutic potential of Toll-like receptor 9 activation
-
Krieg AM. Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 2006, 5(6): 471-84.
-
(2006)
Nat Rev Drug Discov
, vol.5
, Issue.6
, pp. 471-484
-
-
Krieg, A.M.1
-
26
-
-
33748683549
-
Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma
-
Link BK, Ballas ZK, Weisdorf D et al. Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma. J Immunother 2006, 29(5): 558-68.
-
(2006)
J Immunother
, vol.29
, Issue.5
, pp. 558-568
-
-
Link, B.K.1
Ballas, Z.K.2
Weisdorf, D.3
-
27
-
-
33746214819
-
New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site
-
Appay V, Jandus C, Voelter V et al. New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site. J Immunol 2006, 177(3): 1670-8.
-
(2006)
J Immunol
, vol.177
, Issue.3
, pp. 1670-1678
-
-
Appay, V.1
Jandus, C.2
Voelter, V.3
-
28
-
-
0036467426
-
CpG are efficient adjuvants for specific CTL induction against tumor antigen-derived peptide
-
Miconnet I, Koenig S, Speiser D et al. CpG are efficient adjuvants for specific CTL induction against tumor antigen-derived peptide. J Immunol 2002, 168(3): 1212-8.
-
(2002)
J Immunol
, vol.168
, Issue.3
, pp. 1212-1218
-
-
Miconnet, I.1
Koenig, S.2
Speiser, D.3
-
29
-
-
14644390867
-
Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909
-
Speiser DE, Lienard D, Rufer N et al. Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J Clin Invest 2005, 115(3): 739-46.
-
(2005)
J Clin Invest
, vol.115
, Issue.3
, pp. 739-746
-
-
Speiser, D.E.1
Lienard, D.2
Rufer, N.3
-
30
-
-
34247389227
-
Phase II trial of a toll-like receptor 9- activating oligonucleotide in patients with metastatic melanoma
-
Pashenkov M, Goes, G, Wagner C et al. Phase II trial of a toll-like receptor 9- activating oligonucleotide in patients with metastatic melanoma. J Clin Oncol 2006, 24(36): 5716-24.
-
(2006)
J Clin Oncol
, vol.24
, Issue.36
, pp. 5716-5724
-
-
Pashenkov, M.1
Goes, G.2
Wagner, C.3
-
31
-
-
33749436870
-
Immunotherapy with a ragweedtoll- like receptor 9 agonist vaccine for allergic rhinitis
-
Creticos PS, Schroeder JT, Hamilton RG et al. Immunotherapy with a ragweedtoll- like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med 2006, 355(14): 1445-55.
-
(2006)
N Engl J Med
, vol.355
, Issue.14
, pp. 1445-1455
-
-
Creticos, P.S.1
Schroeder, J.T.2
Hamilton, R.G.3
-
33
-
-
33745471091
-
Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses
-
Gauvreau GM, Hessel EM, Boulet LP, Coffman RL, OByrne .M. Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses. Am J Respir Crit Care Med 2006, 174(1): 15-20.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, Issue.1
, pp. 15-20
-
-
Gauvreau, G.M.1
Hessel, E.M.2
Boulet, L.P.3
Coffman, R.L.4
Obyrne ., M.5
-
34
-
-
0032697942
-
A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides
-
Levin AA. A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides. Biochim Biophys Acta 1999, 1489(1): 69-84.
-
(1999)
Biochim Biophys Acta
, vol.1489
, Issue.1
, pp. 69-84
-
-
Levin, A.A.1
-
35
-
-
0036844423
-
Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide
-
Henry SP, Beattie G, Yeh G et al. Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide. Int Immunopharmacol 2002, 2(12): 1657-66.
-
(2002)
Int Immunopharmacol
, vol.2
, Issue.12
, pp. 1657-1666
-
-
Henry, S.P.1
Beattie, G.2
Yeh, G.3
-
36
-
-
0032430114
-
Preclinical evaluation of the effects of a novel antisense compound targeting C-raf kinase in mice and monkeys
-
Monteith DK, Geary RS, Leeds JM, Johnston J, Monia BP, Levin AA. Preclinical evaluation of the effects of a novel antisense compound targeting C-raf kinase in mice and monkeys. Toxicol Sci 1998, 46(2): 365-75.
-
(1998)
Toxicol Sci
, vol.46
, Issue.2
, pp. 365-375
-
-
Monteith, D.K.1
Geary, R.S.2
Leeds, J.M.3
Johnston, J.4
Monia, B.P.5
Levin, A.A.6
|