A viral PAMP double-stranded RNA induces allergen-specific Th17 cell response in the airways which is dependent on VEGF and IL-6

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 65, Issue 10, 2010, Pages 1322-1330

  Choi, J P ^a   Kim, Y S ^a   Tae, Y M ^a   Choi, E J ^a   Hong, B S ^a   Jeon, S G ^a   Gho, Y S ^a   Zhu, Z ^b   Kim, Y K ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

IL 6; noneosinophilic asthma; Th17; vascular endothelial growth factor; virus associated asthma

Indexed keywords

DOUBLE STRANDED RNA; INTERLEUKIN 17; INTERLEUKIN 6; OVALBUMIN; POLYINOSINIC POLYCYTIDYLIC ACID; SEMAXANIB; VASCULOTROPIN;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE RESPONSE; INNATE IMMUNITY; LUNG LAVAGE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; TH17 CELL; TH2 CELL;

ADAPTIVE IMMUNITY; ALLERGENS; ANIMALS; ASTHMA; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNITY, INNATE; INTERLEUKIN-6; MICE; MICE, TRANSGENIC; OVALBUMIN; POLY I-C; RESPIRATORY SYSTEM; RNA, DOUBLE-STRANDED; RNA, VIRAL; T-CELL ANTIGEN RECEPTOR SPECIFICITY; TH17 CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77956443815     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2010.02369.x     Document Type: Article

References (32)

1. Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006 368 : 733 743.
2. Martinez FD. Development of wheezing disorders and asthma in preschool children. Pediatrics 2002 109 : 362 367.
3. Kotaniemi-Syrjanen A, Vainionpaa R, Reijonen TM, Waris M, Korhonen K, Korppi M. Rhinovirus-induced wheezing in infancy - the first sign of childhood asthma? J Allergy Clin Immunol 2003 111 : 66 71.
4. Gern JE, Busse WW. Relationship of viral infections to wheezing illnesses and asthma. Nat Rev Immunol 2002 2 : 132 138.
5. Yang YL, Reis LF, Pavlovic J, Aguzzi A, Schafer R, Kumar A et al. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J 1995 14 : 6095 6106.
6. Guillot L, Le Goffic R, Bloch S, Escriou N, Akira S, Chignard M et al. Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem 2005 280 : 5571 5580.
7. Loo YM, Fornek J, Crochet N, Bajwa G, Perwitasari O, Martinez-Sobrido L et al. Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol 2008 82 : 335 345.
8. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappa B by Toll-like receptor 3. Nature 2001 413 : 732 738.
9. Kulka M, Alexopoulou L, Flavell RA, Metcalfe DD. Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3. J Allergy Clin Immunol 2004 114 : 174 182.
10. Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006 441 : 101 105.
11. Jeon SG, Oh SY, Park HK, Kim YS, Shim EJ, Lee HS et al. TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA. J Allergy Clin Immunol 2007 120 : 803 812.
12. Holtzman MJ, Sampath D, Castro M, Look DC, Jayaraman S. The one-two of T helper cells: does interferon-gamma knock out the Th2 hypothesis for asthma? Am J Respir Cell Mol Biol 1996 14 : 316 318.
13. Stevenson EC, Turner G, Heaney LG, Schock BC, Taylor R, Gallagher T et al. Bronchoalveolar lavage findings suggest two different forms of childhood asthma. Clin Exp Allergy 1997 27 : 1027 1035.
14. Simpson JL, Grissell TV, Douwes J, Scott RJ, Boyle MJ, Gibson PG. Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax 2007 62 : 211 218.
15. Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005 201 : 233 240.
16. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005 6 : 1133 1141.
17. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005 6 : 1123 1132.
18. McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A et al. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol 2008 181 : 4089 4097.
19. Fossiez F, Djossou O, Chomarat P, Flores-Romo L, Ait-Yahia S, Maat C et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 1996 183 : 2593 2603.
20. Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007 25 : 821 852.
21. Linden A, Hoshino H, Laan M. Airway neutrophils and interleukin-17. Eur Respir J 2000 15 : 973 977.
22. Oboki K, Ohno T, Saito H, Nakae S. Th17 and allergy. Allergol Int 2008 57 : 121 134.
23. Langrish CL, McKenzie BS, Wilson NJ, de Waal Malefyt R, Kastelein RA, Cua DJ. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev 2004 202 : 96 105.
24. Schmidt-Weber CB, Akdis M, Akdis CA. TH17 cells in the big picture of immunology. J Allergy Clin Immunol 2007 120 : 247 254.
25. Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007 8 : 967 974.
26. Kim YS, Hong SW, Choi JP, Shin TS, Moon HG, Choi EJ et al. Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. J Immunol 2009 183 : 5113 5120.
27. Douwes J, Gibson P, Pekkanen J, Pearce N. Non-eosinophilic asthma: importance and possible mechanisms. Thorax 2002 57 : 643 648.
28. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986 136 : 2348 2357.
29. Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med 2004 10 : 1095 1103.
30. Psarras S, Volonaki E, Skevaki CL, Xatzipsalti M, Bossios A, Pratsinis H et al. Vascular endothelial growth factor-mediated induction of angiogenesis by human rhinoviruses. J Allergy Clin Immunol 2006 117 : 291 297.
31. De Silva D, Dagher H, Ghildyal R, Lindsay M, Li X, Freezer NJ et al. Vascular endothelial growth factor induction by rhinovirus infection. J Med Virol 2006 78 : 666 672.
32. Shannon J, Ernst P, Yamauchi Y, Olivenstein R, Lemiere C, Foley S et al. Differences in airway cytokine profile in severe asthma compared to moderate asthma. Chest 2008 133 : 420 426.