Large-scale synthesis of 1,1,3,3,6-pentamethyl-1,3-disilaindan-5-ol via a CoBr2/Zn-catalyzed [2+2+2] cycloaddition reaction

Tetrahedron

Volumn 66, Issue 39, 2010, Pages 7738-7742

  Mizojiri, Ryo ^a   Conroy, Richard ^c   Daiss, Jürgen ^b   Kotani, Etsuo ^a   Tacke, Reinhold ^b   Miller, David ^c   Walsh, Louise ^c   Kawamoto, Tetsuji ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c Takeda Cambridge Ltd   (United Kingdom)

Author keywords

1,1,3,3,6 Pentamethyl 1,3 disilaindan 5 ol; Cobalt(II) bromide; Cobalt catalyzed 2+2+2 cycloaddition reaction; Gonadotropin releasing hormone receptor antagonist; Sila substituted drug

Indexed keywords

(1,1,3,3,6 PENTAMETHYL 1,3 DISILAINDAN 5 YL)METHANAL; 1,1,3,3,6 PENTAMETHYL 1,3 DISILAINDAN 5 OL; 5 (DIETHOXYMETHYL) 1,1,3,3,6 PENTAMETHYL 1,3 DISILAINDANE; COBALT BROMIDE; COBALT DERIVATIVE; INDAN DERIVATIVE; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BAEYER VILLIGER REACTION; CATALYSIS; CHEMICAL ANALYSIS; CYCLOADDITION; DRUG SYNTHESIS; ONE POT SYNTHESIS; PRIORITY JOURNAL;

EID: 77956393021     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.07.068     Document Type: Article

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