Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist

Journal of Medicinal Chemistry

Volumn 49, Issue 11, 2006, Pages 3362-3367

  Li, Haitao ^a   Anderes, Kenna L ^a   Kraynov, Eugenia A ^a   Luthin, David R ^a   Do, Quyen Quyen ^a   Hong, Yufeng ^a   Tompkins, Eileen ^a   Sun, Eric T ^a   Rajapakse, Ranjan ^a   Pathak, Ved P ^a   Christie, Lance C ^a   Vazir, Haresh ^a   Castillo, Rosemary ^a   Gregory, Margaret L ^a   Castro, Mary ^a   Nared Hood, Karen ^a   Paderes, Genevive ^a   Anderson, Mark B ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; N [4,6 DIMETHOXY 2 [(3 MORPHOLIN 4 YLPROPYL)AMINO]PYRIMIDIN 5 YL] 5 [(3,3,6 TRIMETHYL 2,3 DIHYDRO 1H INDEN 5 YL)OXY] 2 FURAMIDE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG INDICATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HORMONE ACTION; IN VITRO STUDY; MALE; NONHUMAN; OVARY CANCER; PHARMACODYNAMICS; PROSTATE CANCER; RAT; REPRODUCTION; TESTOSTERONE BLOOD LEVEL;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; HUMANS; INDENES; INOSITOL PHOSPHATES; MALE; MORPHOLINES; ORCHIECTOMY; PITUITARY GLAND; PYRIMIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LHRH; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TESTIS; TESTOSTERONE;

EID: 33744832168     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060012g     Document Type: Article

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