Molecular mechanisms of Id2 down-regulation in rat liver after acetaminophen overdose. Protection by N-acetyl-L-cysteine

Free Radical Research

Volumn 44, Issue 9, 2010, Pages 1044-1053

  Penella, Estela ^a   Sandoval, Juan ^a   Zaragozá, Rosa ^a   García, Concha ^a   Viña, Juan R ^a   Torres, Luis ^a   García Trevijano, Elena R ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

c Myc; ChIP assay!; GSH; histone acetylation; Id2; N acetyl L cysteine

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE; HISTONE H3; INHIBITOR OF DIFFERENTIATION 2; MESSENGER RNA; MYC PROTEIN; PARACETAMOL; RNA POLYMERASE II;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG INTOXICATION; ENZYME RELEASE; MALE; NONHUMAN; OXIDATIVE STRESS; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RAT;

ACETAMINOPHEN; ACETYLCYSTEINE; ANALGESICS, NON-NARCOTIC; ANIMALS; CYTOPROTECTION; DOWN-REGULATION; GENE EXPRESSION REGULATION; GENES, MYC; GLUTATHIONE; INHIBITOR OF DIFFERENTIATION PROTEIN 2; LIVER; MALE; OVERDOSE; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

RATTUS;

EID: 77956368251     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2010.498825     Document Type: Article

References (35)

1. Yokota Y, Mori S, Narumi O, Kitajima K. In vivo function of a differentiation inhibitor, Id2. IUBMB Life 2001;51: 207-214.
2. Hasskarl J, Münger K. Id proteins-tumor markers or oncogenes? Cancer Biol Ther 2002;1:91-96.
3. Rothschild G, Zhao X, Iavarone A, Lasorella A. Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells. Mol Cell Biol 2006;26:4351-4361.
4. Lasorella A, Iavarone A. The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system. Proc Natl Acad Sci USA. 2006;103: 4976-4981.
5. Newton TR, Parsons PG, Lincoln DJ, Cummings MC, Wyld DK, Webb PM, Green, AC, Boyle GM. Expression profiling correlates with treatment response in women with advanced serous epithelial ovarian cancer. Int J Cancer 2006;119:875-883.
6. Hua H, Zhang YQ, Dabernat S, Kritzik M, Dietz D, Sterling L, Sarvetnick N. BMP4 regulates pancreatic progenitor cell expansion through Id2. J Biol Chem 2006;281: 13574-13580.
7. Asirvatham AJ, Carey JP, Chaudhary J. ID1-, ID2-, and ID3-regulated gene expression in E2A positive or negative prostate cancer cells. Prostate 2007;67:1411-1420.
8. Cao Y, Liu X, Zhang W, Deng X, Zhang H, Liu Y, Chen L, Thompson EA, Townsend CM, Jr, Ko TC. TGF-beta repression of Id2 induces apoptosis in gut epithelial cells. Oncogene 2009;28:1089-1098.
9. Torres L, Sandoval J, Penella E, Zaragoz á R, Garc í a C, Rodr í guez JL, Vi ñ a JR, Garc í a-Trevijano ER. In vivo GSH depletion induces c-myc expression by modulation of chro-matin protein complexes. Free Radic Biol Med 2009;46: 1534-1542
10. Rodríguez JL, Sandoval J, Serviddio G, Sastre J, Morante M, Perrelli MG, Mart í nez-Chantar ML, Viña J, Viña JR, Mato JM, Avila MA, Franco L, L ó pez-Rodas G, Torres L. Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration. Biochem J 2006;398:431-437.
11. Siegel PM, Shu W, Massagu é J. Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression. J Biol Chem 2003;278:35444-35450.
12. Lasorella A, Noseda M, Beyna M, Yokota Y, Iavarone A. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. Nature 2000;407:592-598.
13. Liu RM, Gaston Pravia KA. Oxidative stress and glutathione in TGF-β-mediated fi brogenesis. Free Radic Biol Med 2010;48:1-15.
14. James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 2003;31:1499-1506.
15. Liu L, Klaassen CD. Different mechanism of saturation of acetaminophen sulfate conjugation in mice and rats. Toxicol Appl Pharm 1996;139:128-134.
16. Henderson NC, Pollock KJ, Frew J, Mackinnon AC, Flavell RA, Davis RJ, Sethi T, Simpson KJ. Critical role of c-jun (NH2) terminal kinase in paracetamol-induced acute liver failure. Gut 2007;56:982-990.
17. Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Effi cacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multi-center study (1976 to 1985) N Engl J Med. 1988;319(24): 1557-1562
18. Brigelius R, Muckel C, Akerboom TPM, Sies M. Identifi-cation and quantitation of glutathione in hepatic protein mixed disulfi des and its relationship to glutathione disulfi de. Biochem. Pharmacol. 1983;32:2529-2534
19. García-Trevijano ER, Martínez-Chantar ML, Latasa MU, Mato JM, Avila MA. NO sensitizes rat hepatocytes to proliferation by modifying S-adenosylmethionine levels. Gastroen-terology 2002;122:1355-1363.
20. Jaeschke H. Glutathione disulfi de formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol. J. Pharmacol. Exp. Ther. 1990;255;935-941.
21. Sandoval J, Rodríguez JL, Tur G, Serviddio G, Pereda J, Boukaba A, Sastre J, Torres L, Franco L, López-Rodas G. RNAPol-ChIP: a novel application of chromatin immunopre-cipitation to the analysis of real-time gene transcription. Nucleic Acids Res. 2004;32:e88.
22. Bertola LD, Ott EB, Griepsma S, Vonk FJ, Bagowski CP. Developmental expression of the alpha-skeletal actin gene. BMC. Evol. Biol. 2008;8:166.
23. James LP, McCullough SS, Lamps LW, Hinson JA. Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. Toxicol. Sci. 2003;75:458-467.
24. Kurland JF, Tansey W P. Myc-mediated transcriptional repression by recruitment of histone deacetylase. Cancer Res. 2008;68:3624-3629.
25. Liang G, Lin JC, Wei V, Yoo C, Cheng JC, Nguyen CT, Weisenberger DJ, Egger G, Takai D, Gonzales FA, Jones PA. Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. Proc. Natl. Acad. Sci. USA. 2004;101:7357-7362.
26. rd, Gingeras TR, Schreiber SL, Lander ES. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell 2005;120:169-181.
27. Junttila MR, Westermarck J Mechanisms of MYC Stabilization in Human Malignancies Cell Cycle 2008;7:592-596.
28. Lee Y-S, Wan J, Kim BJ, Bae M-A, Song BJ. Ubiquitin-dependent degradation of p53 protein despite phosphoryla-tion at its N terminus by acetaminophen. J. Pharm. Exp. Ther. 2006;317:202-208.
29. Abdelmegeed MA, Moon K-H, Chen C, Gonzalez FJ, Song B-J. Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity. Biochem. Pharmacol. 2010;79:57-66.
30. Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, et al. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci 2007;99:326-349.
31. Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU, Cranson AB, Cunningham ML, Fannin RD, Higgins GM, Hurban P, Kayton RJ, Kerr KF, Kosyk O, Lobenhofer EK, Sieber SO, Vliet PA, Weis BK, Wolfi nger R, Woods CG, Freedman JH, Linney E, Kaufmann WK, Kavanagh TJ, Paules RS, Rusyn I, Samson LD, Spencer PS, Suk W, Tennant RJ, Zarbl H; Members of the Toxicogenomics Research Consortium. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol. Sci. 2007;99:326-337.
32. Morello D, Fitzgerald MJ, Babinet C, Fausto N. c-myc, c-fos, and c-jun regulation in the regenerating livers of normal and H-2K/c-myc transgenic mice. Mol Cell Biol. 1990;10:3185-3193.
33. Pajonk F, Riess K, Sommer A, McBride WH. N-acetyl-L-cysteine inhibits 26S proteasome function, implications for effects on NF-kappaB activation. Free Rad. Biol. Med. 2002; 32:536-543.
34. Biroccio A, Benassi B, Fiorentino F, Zupi G. Glutathione depletion induced by c-Myc downregulation triggers apoptosis on treatment with alkylating agents. Neoplasia 2004;6:195-206.
35. Saito, C.; Zwingmann, C.; Jaeschke, H. Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. Hepatology. 51:246-254, 2010.