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Volumn 2, Issue 4, 2008, Pages 645-653

Denosumab: An investigational drug for the management of postmenopausal osteoporosis

Author keywords

AMG 162; Denosumab; OPG; Osteoporosis; RANKL; Treatment

Indexed keywords


EID: 77956361572     PISSN: 11775475     EISSN: 11775491     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (29)

References (69)
  • 1
    • 33749328352 scopus 로고    scopus 로고
    • Denosumab (AMG 162), a fully human RANKL antibody, increases bone mass and bone strength in cynomolgus monkeys
    • Atkinson JE, Cranmer P, Saunders T, et al. 2005. Denosumab (AMG 162), a fully human RANKL antibody, increases bone mass and bone strength in cynomolgus monkeys. J Bone Miner Res, 20(Suppl 1):S294.
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Atkinson, J.E.1    Cranmer, P.2    Saunders, T.3
  • 2
    • 0033938154 scopus 로고    scopus 로고
    • Costs induced by hip fractures: A prospective controlled study in Belgium. Belgian Hip Fracture Study Group
    • Autier P, Haentjens P, Bentin J, et al. 2000. Costs induced by hip fractures: a prospective controlled study in Belgium. Belgian Hip Fracture Study Group. Osteoporos Int, 11:373-80.
    • (2000) Osteoporos Int , vol.11 , pp. 373-380
    • Autier, P.1    Haentjens, P.2    Bentin, J.3
  • 3
    • 0035139584 scopus 로고    scopus 로고
    • The effect of a single dose of osteoprotegerin in postmenopausal women
    • Bekker, PJ, Holloway, D, Nakanishi, A, et al. 2001. The effect of a single dose of osteoprotegerin in postmenopausal women. J Bone Miner Res, 16:348-60.
    • (2001) J Bone Miner Res , vol.16 , pp. 348-360
    • Bekker, P.J.1    Holloway, D.2    Nakanishi, A.3
  • 4
    • 3342982829 scopus 로고    scopus 로고
    • A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women
    • Bekker PJ, Holloway DL, Rasmussen AS, et al. 2004. A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res, 19:1059-66.
    • (2004) J Bone Miner Res , vol.19 , pp. 1059-1066
    • Bekker, P.J.1    Holloway, D.L.2    Rasmussen, A.S.3
  • 5
    • 0346837985 scopus 로고    scopus 로고
    • A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
    • Body JJ, Greipp P, Coleman RE, et al. 2003. A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer, 97(3 Suppl):887-92.
    • (2003) Cancer , vol.97 , Issue.3 SUPPL. , pp. 887-892
    • Body, J.J.1    Greipp, P.2    Coleman, R.E.3
  • 6
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle WJ, Simonet WS, Lacey DL. 2003. Osteoclast differentiation and activation. Nature, 423:337-42.
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 7
    • 0032079445 scopus 로고    scopus 로고
    • Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    • Bucay N, Sarosi I, Dunstan CR, et al. 1998. osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev, 12:1260-8.
    • (1998) Genes Dev , vol.12 , pp. 1260-1268
    • Bucay, N.1    Sarosi, I.2    Dunstan, C.R.3
  • 8
    • 34247194211 scopus 로고    scopus 로고
    • Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025
    • Burge R, Dawson-Hughes B, Solomon DH, et al. 2007. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. Journal of Bone and Mineral Research, 22:465-75.
    • (2007) Journal of Bone and Mineral Research , vol.22 , pp. 465-475
    • Burge, R.1    Dawson-Hughes, B.2    Solomon, D.H.3
  • 9
    • 0033519221 scopus 로고    scopus 로고
    • The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
    • Burgess TL, Qian Y, Kaufman S, et al. 1999. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J Cell Biol, 145:527-38.
    • (1999) J Cell Biol , vol.145 , pp. 527-538
    • Burgess, T.L.1    Qian, Y.2    Kaufman, S.3
  • 10
    • 3242667700 scopus 로고    scopus 로고
    • Changes in serum receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and interleukin-6 levels in patients with glucocorticoid-induced osteoporosis treated with human parathyroid hormone (1-34)
    • Buxton EC, Yao W, Lane NE. 2004. Changes in serum receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and interleukin-6 levels in patients with glucocorticoid-induced osteoporosis treated with human parathyroid hormone (1-34). J Clin Endocrinol Metab, 89:3332-6.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3332-3336
    • Buxton, E.C.1    Yao, W.2    Lane, N.E.3
  • 11
    • 10844254896 scopus 로고    scopus 로고
    • CD4BCD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin
    • Byrne FR, Morony S, Warmington K, et al. 2005. CD4BCD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin. Gut, 54:78-86.
    • (2005) Gut , vol.54 , pp. 78-86
    • Byrne, F.R.1    Morony, S.2    Warmington, K.3
  • 12
    • 0142122879 scopus 로고    scopus 로고
    • Sustained antiresorptive effects after a single treatment with human recombinant osteoprotegerin (OPG): A pharmacodynamic and pharmacokinetic analysis in rats
    • Capparelli C, Morony S, Warmington K, et al. 2003. Sustained antiresorptive effects after a single treatment with human recombinant osteoprotegerin (OPG): a pharmacodynamic and pharmacokinetic analysis in rats. J Bone Miner Res, 18:852-8.
    • (2003) J Bone Miner Res , vol.18 , pp. 852-858
    • Capparelli, C.1    Morony, S.2    Warmington, K.3
  • 13
    • 11244292048 scopus 로고    scopus 로고
    • The impact of compliance with osteoporosis therapy on fracture rates in actual practice
    • Caro JJ, Ishak KJ, Huybrechts KF, et al. 2004. The impact of compliance with osteoporosis therapy on fracture rates in actual practice. Osteoporos Int, 15:1003-8.
    • (2004) Osteoporos Int , vol.15 , pp. 1003-1008
    • Caro, J.J.1    Ishak, K.J.2    Huybrechts, K.F.3
  • 14
    • 0033550968 scopus 로고    scopus 로고
    • Mortality after all major types of osteoporotic fracture in men and women: An observational study
    • Center JR, Nguyen TV, Schneider D, et al. 1999. Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet, 353:878-82.
    • (1999) Lancet , vol.353 , pp. 878-882
    • Center, J.R.1    Nguyen, T.V.2    Schneider, D.3
  • 15
    • 28544439444 scopus 로고    scopus 로고
    • The role of the immune system in the pathophysiology of osteoporosis
    • Clowes JA, Riggs BL, Khosla S. 2005. The role of the immune system in the pathophysiology of osteoporosis. Immunol Rev, 208:207-27.
    • (2005) Immunol Rev , vol.208 , pp. 207-227
    • Clowes, J.A.1    Riggs, B.L.2    Khosla, S.3
  • 16
    • 33646374730 scopus 로고    scopus 로고
    • Phase 2 study of denosumab (AMG 162) in postmenopausal women: Subanalyses and supplemental safety
    • Cohen SB, Lewiecki EM, Liu Y, et al. 2005. Phase 2 study of denosumab (AMG 162) in postmenopausal women: subanalyses and supplemental safety. J Bone Miner Res, 20(Suppl 1):S295.
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Cohen, S.B.1    Lewiecki, E.M.2    Liu, Y.3
  • 17
    • 9344246863 scopus 로고    scopus 로고
    • Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin
    • Collin-Osdoby P. 2004. Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res, 95:1046-57.
    • (2004) Circ Res , vol.95 , pp. 1046-1057
    • Collin-Osdoby, P.1
  • 18
    • 0030930232 scopus 로고    scopus 로고
    • The crippling consequences of fractures and their impact on quality of life
    • Cooper C. 1997. The crippling consequences of fractures and their impact on quality of life. Am J Med, 103:12S-9S.
    • (1997) Am J Med , vol.103
    • Cooper, C.1
  • 19
    • 34347406006 scopus 로고    scopus 로고
    • A systematic review of persistence and compliance with bisphosphonates for osteoporosis
    • Cramer JA, Gold DT, Silverman SL, et al. 2007. A systematic review of persistence and compliance with bisphosphonates for osteoporosis. Osteoporos Int, 18:1023-31.
    • (2007) Osteoporos Int , vol.18 , pp. 1023-1031
    • Cramer, J.A.1    Gold, D.T.2    Silverman, S.L.3
  • 20
    • 0033568341 scopus 로고    scopus 로고
    • RANK is essential for osteoclast and lymph node development
    • Dougall WC, Glaccum M, Charrier K, et al. 1999. RANK is essential for osteoclast and lymph node development. Genes Dev, 13(18):2412-24.
    • (1999) Genes Dev , vol.13 , Issue.18 , pp. 2412-2424
    • Dougall, W.C.1    Glaccum, M.2    Charrier, K.3
  • 21
    • 0037398261 scopus 로고    scopus 로고
    • Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
    • Eghbali-Fatourechi G, Khosla S, Sanyal A, et al. 2003. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest, 111:1221-30.
    • (2003) J Clin Invest , vol.111 , pp. 1221-1230
    • Eghbali-Fatourechi, G.1    Khosla, S.2    Sanyal, A.3
  • 22
    • 0141993640 scopus 로고    scopus 로고
    • Bone mineral density measurement and treatment for osteoporosis in older individuals with fractures-A gap in evidence-based practice guideline implementation
    • Feldstein A, Elmer PJ, Orwoll E, et al. 2003. Bone mineral density measurement and treatment for osteoporosis in older individuals with fractures-A gap in evidence-based practice guideline implementation. Arch Intern Med, 163:2165-72.
    • (2003) Arch Intern Med , vol.163 , pp. 2165-2172
    • Feldstein, A.1    Elmer, P.J.2    Orwoll, E.3
  • 23
    • 58649121926 scopus 로고    scopus 로고
    • A comparison of denosumab and alendronate in combination with PTH in ovariectomized knockin mice expressing humanized RANKL
    • Ferrari SL, Pierroz D, Bonnet N, et al. 2007. A comparison of denosumab and alendronate in combination with PTH in ovariectomized knockin mice expressing humanized RANKL. J Bone Miner Res, 22(Suppl 1):S37.
    • (2007) J Bone Miner Res , vol.22 , Issue.SUPPL. 1
    • Ferrari, S.L.1    Pierroz, D.2    Bonnet, N.3
  • 24
    • 0033304632 scopus 로고    scopus 로고
    • Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells
    • Hofbauer LC, Khosla S, Dunstan CR, et al. 1999. Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. Endocrinology, 140:4367-70.
    • (1999) Endocrinology , vol.140 , pp. 4367-4370
    • Hofbauer, L.C.1    Khosla, S.2    Dunstan, C.R.3
  • 25
    • 3242781731 scopus 로고    scopus 로고
    • Clinical implications of the osteoprotegerin/ RANKL/RANK system for bone and vascular diseases
    • Hofbauer LC, Schoppet, M. 2004. Clinical implications of the osteoprotegerin/ RANKL/RANK system for bone and vascular diseases. JAMA, 292:490-5.
    • (2004) JAMA , vol.292 , pp. 490-495
    • Hofbauer, L.C.1    Schoppet, M.2
  • 26
    • 58649121657 scopus 로고    scopus 로고
    • RANK Ligand inhibition by denosumab prevents cortical bone loss in a murine model of glucocorticoid-induced osteoporosis
    • Hofbauer LC, Zeitz U, Schoppet M, et al. 2007. RANK Ligand inhibition by denosumab prevents cortical bone loss in a murine model of glucocorticoid-induced osteoporosis. J Bone Miner Res, 22(Suppl 1):S4.
    • (2007) J Bone Miner Res , vol.22 , Issue.SUPPL. 1
    • Hofbauer, L.C.1    Zeitz, U.2    Schoppet, M.3
  • 27
    • 13044316551 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    • Hsu H, Lacey DL, Dunstan CR, et al. 1999. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci U S A, 96:3540-5.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3540-3545
    • Hsu, H.1    Lacey, D.L.2    Dunstan, C.R.3
  • 28
    • 1642301168 scopus 로고    scopus 로고
    • Fracture risk following an osteoporotic fracture
    • Johnell O, Kanis JA, Oden A, et al. 2004. Fracture risk following an osteoporotic fracture. Osteoporos Int, 15:175-9.
    • (2004) Osteoporos Int , vol.15 , pp. 175-179
    • Johnell, O.1    Kanis, J.A.2    Oden, A.3
  • 29
    • 0033104614 scopus 로고    scopus 로고
    • TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells
    • Josien R, Wong BR, Li HL, et al. 1999. TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells. J Immunol, 162:2562-8.
    • (1999) J Immunol , vol.162 , pp. 2562-2568
    • Josien, R.1    Wong, B.R.2    Li, H.L.3
  • 31
    • 0035857351 scopus 로고    scopus 로고
    • Osteoporosis prevention, diagnosis, and therapy
    • Klibanski A, Adams-Campbell L, Bassford T, et al. 2001. Osteoporosis prevention, diagnosis, and therapy. JAMA, 285:785-95.
    • (2001) JAMA , vol.285 , pp. 785-795
    • Klibanski, A.1    Adams-Campbell, L.2    Bassford, T.3
  • 32
    • 0033581952 scopus 로고    scopus 로고
    • Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    • Kong YY, Feige U, Sarosi I, et al. 1999a. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature, 402:304-9.
    • (1999) Nature , vol.402 , pp. 304-309
    • Kong, Y.Y.1    Feige, U.2    Sarosi, I.3
  • 33
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong YY, Yoshida H, Sarosi I, et al. 1999b. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature, 397:315-23.
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3
  • 34
    • 1642289532 scopus 로고    scopus 로고
    • Gene therapy with human recombinant osteoprotegerin reverses established osteopenia in ovariectomized mice
    • Kostenuik PJ, Bolon B, Morony S, et al. 2004. Gene therapy with human recombinant osteoprotegerin reverses established osteopenia in ovariectomized mice. Bone, 34:656-64.
    • (2004) Bone , vol.34 , pp. 656-664
    • Kostenuik, P.J.1    Bolon, B.2    Morony, S.3
  • 35
    • 0034816809 scopus 로고    scopus 로고
    • OPG and PTH-(1-34) have additive effects on bone density and mechanical strength in osteopenic ovariectomized rats
    • Kostenuik PJ, Capparelli C, Morony S, et al. 2001. OPG and PTH-(1-34) have additive effects on bone density and mechanical strength in osteopenic ovariectomized rats. Endocrinology, 142:4295-304.
    • (2001) Endocrinology , vol.142 , pp. 4295-4304
    • Kostenuik, P.J.1    Capparelli, C.2    Morony, S.3
  • 36
    • 83255178026 scopus 로고    scopus 로고
    • RANKL inhibition with (denosumab) AMG 162, a fully human MAb, causes sustaned suppression of bone resorption and increased BMD in knockin mice expressing humanized RANKL
    • Kostenuik PJ, Warmington K, Grisanti M, et al. 2005. RANKL inhibition with (denosumab) AMG 162, a fully human MAb, causes sustaned suppression of bone resorption and increased BMD in knockin mice expressing humanized RANKL. J Bone Miner Res, 20(Suppl 1):S261.
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Kostenuik, P.J.1    Warmington, K.2    Grisanti, M.3
  • 37
    • 0033888977 scopus 로고    scopus 로고
    • Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo
    • Lacey DL, Tan HL, Lu J, et al. 2000. Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am J Pathol, 157:435-48.
    • (2000) Am J Pathol , vol.157 , pp. 435-448
    • Lacey, D.L.1    Tan, H.L.2    Lu, J.3
  • 38
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey DL, Timms E, Tan HL, et al. 1998. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell, 93:165-76.
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3
  • 39
    • 38749105490 scopus 로고    scopus 로고
    • Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD
    • Lewiecki EM, Miller PD, McClung MR, et al. 2007. Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD. J Bone Miner Res, 22:1832-41.
    • (2007) J Bone Miner Res , vol.22 , pp. 1832-1841
    • Lewiecki, E.M.1    Miller, P.D.2    McClung, M.R.3
  • 40
    • 12944262423 scopus 로고    scopus 로고
    • RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
    • Li J, Sarosi I, Yan XQ, et al. 2000. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A, 97:1566-71.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1566-1571
    • Li, J.1    Sarosi, I.2    Yan, X.Q.3
  • 41
    • 35348897212 scopus 로고    scopus 로고
    • Randomized active-controlled phase ii study of denosumab efficacy and safety in patients with breast cancer-related bone metastases
    • Lipton A, Steger GG, Figueroa J, et al. 2007. Randomized active-controlled phase ii study of denosumab efficacy and safety in patients with breast cancer-related bone metastases. J Clin Oncol, 25:4431-7.
    • (2007) J Clin Oncol , vol.25 , pp. 4431-4437
    • Lipton, A.1    Steger, G.G.2    Figueroa, J.3
  • 42
    • 8644234910 scopus 로고    scopus 로고
    • Antibody pharmacokinetics and pharmacodynamics
    • Lobo, ED, Hansen, RJ, and Balthasar, JP. 2004. Antibody pharmacokinetics and pharmacodynamics. J Pharm Sci, 93(11):2645-68.
    • (2004) J Pharm Sci , vol.93 , Issue.11 , pp. 2645-2668
    • Lobo, E.D.1    Hansen, R.J.2    Balthasar, J.P.3
  • 43
    • 0032495975 scopus 로고    scopus 로고
    • Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures
    • Matsuzaki K, Udagawa N, Takahashi N, et al. 1998. Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures. Biochem Biophys Res Commun, 246:199-204.
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 199-204
    • Matsuzaki, K.1    Udagawa, N.2    Takahashi, N.3
  • 44
    • 33344469853 scopus 로고    scopus 로고
    • Denosumab in postmenopausal women with low bone mineral density
    • McClung MR, Lewiecki EM, Cohen SB, et al. 2006. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med, 354:821-31.
    • (2006) N Engl J Med , vol.354 , pp. 821-831
    • McClung, M.R.1    Lewiecki, E.M.2    Cohen, S.B.3
  • 45
    • 2942672302 scopus 로고    scopus 로고
    • Compliance with drug therapies for the treatment and prevention of osteoporosis
    • McCombs JS, Thiebaud P, Laughlin-Miley C, et al. 2004. Compliance with drug therapies for the treatment and prevention of osteoporosis. Maturitas, 48:271-87.
    • (2004) Maturitas , vol.48 , pp. 271-287
    • McCombs, J.S.1    Thiebaud, P.2    Laughlin-Miley, C.3
  • 46
    • 0029243810 scopus 로고
    • How many women have osteoporosis now?
    • Melton LJ III. 1995. How many women have osteoporosis now? J Bone Miner Res, 10:175-7.
    • (1995) J Bone Miner Res , vol.10 , pp. 175-177
    • Melton III, L.J.1
  • 48
    • 52449112052 scopus 로고    scopus 로고
    • Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: A randomized blinded phase 2 clinical trial
    • Miller PD, Bolognese MA, Lewiecki EM, et al. 2008. Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: A randomized blinded phase 2 clinical trial. Bone, 43:222-9.
    • (2008) Bone , vol.43 , pp. 222-229
    • Miller, P.D.1    Bolognese, M.A.2    Lewiecki, E.M.3
  • 49
    • 0025896380 scopus 로고
    • The anabolic effects of human parathyroid hormone (hPTH) on rat vertebral body mass are also reflected in the quality of bone, assessed by biomechanical testing: A comparison study between hPTH-(1-34) and hPTH-(1-84)
    • Mosekilde L, Sogaard CH, Danielsen CC, et al. 1991. The anabolic effects of human parathyroid hormone (hPTH) on rat vertebral body mass are also reflected in the quality of bone, assessed by biomechanical testing: a comparison study between hPTH-(1-34) and hPTH-(1-84). Endocrinology, 129:421-8.
    • (1991) Endocrinology , vol.129 , pp. 421-428
    • Mosekilde, L.1    Sogaard, C.H.2    Danielsen, C.C.3
  • 50
    • 26844544038 scopus 로고    scopus 로고
    • The RANK/RANKL/ osteoprotegerin system in rheumatoid arthritis: New insights from animal models
    • Neumann E, Gay S, Muller-Ladner U. 2005. The RANK/RANKL/ osteoprotegerin system in rheumatoid arthritis: new insights from animal models. Arthritis Rheum, 52:2960-7.
    • (2005) Arthritis Rheum , vol.52 , pp. 2960-2967
    • Neumann, E.1    Gay, S.2    Muller-Ladner, U.3
  • 51
    • 0034596229 scopus 로고    scopus 로고
    • Osteoprotegerin ligand regulates osteoclast adherence to the bone surface in mouse calvaria
    • O'Brien EA, Williams JH, Marshall, MJ. 2000. Osteoprotegerin ligand regulates osteoclast adherence to the bone surface in mouse calvaria. Biochem Biophys Res Commun, 274:281-90.
    • (2000) Biochem Biophys Res Commun , vol.274 , pp. 281-290
    • O'Brien, E.A.1    Williams, J.H.2    Marshall, M.J.3
  • 52
    • 0035137818 scopus 로고    scopus 로고
    • Osteoprotegerin is produced when prostaglandin synthesis is inhibited causing osteoclasts to detach from the surface of mouse parietal bone and attach to the endocranial membrane
    • O'Brien EA, Williams JH, Marshall, MJ. 2001. Osteoprotegerin is produced when prostaglandin synthesis is inhibited causing osteoclasts to detach from the surface of mouse parietal bone and attach to the endocranial membrane. Bone, 28:208-14.
    • (2001) Bone , vol.28 , pp. 208-214
    • O'Brien, E.A.1    Williams, J.H.2    Marshall, M.J.3
  • 53
    • 33745627615 scopus 로고    scopus 로고
    • The pharmacokinetics of denosumab (AMG 162) following various multiple subcutaneous dosing regimens in postmenopausal women with low bone mass
    • Peterson MC, Stouch BJ, Martin SW, et al. 2005. The pharmacokinetics of denosumab (AMG 162) following various multiple subcutaneous dosing regimens in postmenopausal women with low bone mass. J Bone Miner Res, 20(Suppl 1):S293.
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Peterson, M.C.1    Stouch, B.J.2    Martin, S.W.3
  • 54
    • 0036185343 scopus 로고    scopus 로고
    • Tumor necrosis factor alphamediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin
    • Redlich K, Hayer S, Maier A, et al. 2002. Tumor necrosis factor alphamediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin. Arthritis Rheum, 46:785-92.
    • (2002) Arthritis Rheum , vol.46 , pp. 785-792
    • Redlich, K.1    Hayer, S.2    Maier, A.3
  • 55
    • 12544251402 scopus 로고    scopus 로고
    • Drugs used to treat osteoporosis: The critical need for a uniform nomenclature based on their action on bone remodeling
    • Riggs BL, Parfitt, AM. 2005. Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling. J Bone Miner Res, 20:177-84.
    • (2005) J Bone Miner Res , vol.20 , pp. 177-184
    • Riggs, B.L.1    Parfitt, A.M.2
  • 56
    • 0034915025 scopus 로고    scopus 로고
    • The effects of osteoprotegerin on the mechanical properties of rat bone
    • Ross AB, Bateman TA, Kostenuik PJ, et al. 2001. The effects of osteoprotegerin on the mechanical properties of rat bone. J Mater Sci Mater Med, 12:583-8.
    • (2001) J Mater Sci Mater Med , vol.12 , pp. 583-588
    • Ross, A.B.1    Bateman, T.A.2    Kostenuik, P.J.3
  • 57
    • 0038342686 scopus 로고    scopus 로고
    • Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice
    • Schett G, Redlich K, Hayer S, et al. 2003. Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice. Arthritis Rheum, 48:2042-51.
    • (2003) Arthritis Rheum , vol.48 , pp. 2042-2051
    • Schett, G.1    Redlich, K.2    Hayer, S.3
  • 58
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet WS, Lacey DL, Dunstan CR, et al. 1997. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell, 89:309-19.
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3
  • 59
    • 13244279380 scopus 로고    scopus 로고
    • Medication use patterns for osteoporosis: An assessment of guidelines, treatment rates, and quality improvement interventions
    • Solomon DH, Morris C, Cheng H, et al. 2005. Medication use patterns for osteoporosis: an assessment of guidelines, treatment rates, and quality improvement interventions. Mayo Clin Proc, 80:194-202.
    • (2005) Mayo Clin Proc , vol.80 , pp. 194-202
    • Solomon, D.H.1    Morris, C.2    Cheng, H.3
  • 60
    • 2942715123 scopus 로고    scopus 로고
    • Skeletal changes in osteoprotegerin and receptor activator of nuclear factor-kappab ligand mRNA levels in primary hyperparathyroidism: Effect of parathyroidectomy and association with bone metabolism
    • Stilgren LS, Rettmer E, Eriksen EF, et al. 2004. Skeletal changes in osteoprotegerin and receptor activator of nuclear factor-kappab ligand mRNA levels in primary hyperparathyroidism: effect of parathyroidectomy and association with bone metabolism. Bone, 35:256-65.
    • (2004) Bone , vol.35 , pp. 256-265
    • Stilgren, L.S.1    Rettmer, E.2    Eriksen, E.F.3
  • 61
    • 33745630786 scopus 로고    scopus 로고
    • Rats and mice overexpressing soluble OPG have high bone mass but no alteration in immunological parameters or lymphocyte function
    • Stolina M, Dwyer D, Morony S, et al. 2005. Rats and mice overexpressing soluble OPG have high bone mass but no alteration in immunological parameters or lymphocyte function. Arthritis Rheum, (52):S708.
    • (2005) Arthritis Rheum , Issue.52
    • Stolina, M.1    Dwyer, D.2    Morony, S.3
  • 62
    • 38849169884 scopus 로고    scopus 로고
    • Continuous RANKL inhibition in osteoprotegerin transgenic mice and rats suppresses bone resorption without impairing lymphorganogenesis or functional immune responses
    • Stolina M, Dwyer D, Ominsky MS, et al. 2007. Continuous RANKL inhibition in osteoprotegerin transgenic mice and rats suppresses bone resorption without impairing lymphorganogenesis or functional immune responses. J Immunol, 179:7497-505.
    • (2007) J Immunol , vol.179 , pp. 7497-7505
    • Stolina, M.1    Dwyer, D.2    Ominsky, M.S.3
  • 63
    • 4344634877 scopus 로고    scopus 로고
    • Pharmacokinetic aspects of biotechnology products
    • Tang L, Persky AM, Hochhaus G, et al. 2004. Pharmacokinetic aspects of biotechnology products. J Pharm Sci, 93:2184-204.
    • (2004) J Pharm Sci , vol.93 , pp. 2184-2204
    • Tang, L.1    Persky, A.M.2    Hochhaus, G.3
  • 64
    • 11844251380 scopus 로고    scopus 로고
    • US Department of Health and Human Services, Rockville, MD, US Department of Health and Human Services, Office of the Surgeon General
    • US Department of Health and Human Services. 2004. Bone Health and Osteoporosis: A Report of the Surgeon General. Rockville, MD, US Department of Health and Human Services, Office of the Surgeon General.
    • (2004) Bone Health and Osteoporosis: A Report of the Surgeon General
  • 65
    • 0037439916 scopus 로고    scopus 로고
    • Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma
    • Vanderkerken K, De LE, Shipman C, et al. 2003. Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma. Cancer Res, 63:287-9.
    • (2003) Cancer Res , vol.63 , pp. 287-289
    • Vanderkerken, K.1    De, L.E.2    Shipman, C.3
  • 66
    • 33344468025 scopus 로고    scopus 로고
    • The long and the short of bone therapy
    • Whyte MP. 2006. The long and the short of bone therapy. N Engl J Med, 354:860-3.
    • (2006) N Engl J Med , vol.354 , pp. 860-863
    • Whyte, M.P.1
  • 67
    • 0031439265 scopus 로고    scopus 로고
    • TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
    • Wong BR, Josien R, Lee SY, et al. 1997. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med, 186:2075-80.
    • (1997) J Exp Med , vol.186 , pp. 2075-2080
    • Wong, B.R.1    Josien, R.2    Lee, S.Y.3
  • 68
    • 28544433422 scopus 로고    scopus 로고
    • Osteoclast precursors, RANKL/ RANK, and immunology
    • Xing L, Schwarz EM, Boyce, BF. 2005. Osteoclast precursors, RANKL/ RANK, and immunology. Immunol Rev, 208:19-29.
    • (2005) Immunol Rev , vol.208 , pp. 19-29
    • Xing, L.1    Schwarz, E.M.2    Boyce, B.F.3
  • 69
    • 10644236522 scopus 로고    scopus 로고
    • Compliance with pharmacologic therapy for osteoporosis
    • Yood RA, Emani S, Reed JI, et al. 2003. Compliance with pharmacologic therapy for osteoporosis. Osteoporos Int, 14:965-8.
    • (2003) Osteoporos Int , vol.14 , pp. 965-968
    • Yood, R.A.1    Emani, S.2    Reed, J.I.3


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