HIF-2α-a mediator of osteoarthritis?

Cell Research

Volumn 20, Issue 9, 2010, Pages 977-979

  Murphy, Christopher L ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYOESTRADIOL; 2-METHOXYOESTRADIOL; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; COL2A1 PROTEIN, MOUSE; COLLAGEN TYPE 2; DRUG DERIVATIVE; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; ESTRADIOL; PHD1 PROTEIN, MOUSE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE;

ANIMAL; ARTICLE; CARTILAGE CELL; GENETICS; HUMAN; METABOLISM; MOUSE; OSTEOARTHRITIS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CHONDROCYTES; COLLAGEN TYPE II; ESTRADIOL; HUMANS; MICE; OSTEOARTHRITIS; PROCOLLAGEN-PROLINE DIOXYGENASE;

EID: 77956343781     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2010.99     Document Type: Article

References (15)

1. Yang S, Kim J, Ryu JH, et al. Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med 2010; 16:687-693.
2. Saito T, Fukai A, Mabuchi A, et al. Transcriptional regulation of endo-chondral ossifcation by HIF-2alpha during skeletal growth and osteoar-thritis development. Nat Med 2010; 16:678-686.
3. Schofeld CJ, Ratcliffe PJ. Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 2004; 5:343-354.
4. Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev 2001; 15:2865-2876.
5. Pfander D, Kobayashi T, Knight MC, et al. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development 2004; 131:2497-2508.
6. Rankin EB, Biju MP, Liu Q, et al. Hy-poxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest 2007; 117:1068-1077.
7. Coimbra IB, Jimenez SA, Hawkins DF, Piera-Velazquez S, Stokes DG. Hypox-ia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes. Osteoarthritis Cartilage 2004; 12:336-345.
8. Bohensky J, Terkhorn SP, Freeman TA, et al. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondro-cyte autophagy. Arthritis Rheum 2009; 60:1406-1415.
9. Thoms BL, Murphy CL. Inhibition of hypoxia-inducible factor- targetingprolyl hydroxylase domain-containing protein 2 (PHD2) enhances matrix synthesis by human chondrocytes. J Biol Chem 2010; doi/10.1074/jbc. M110.115238
10. Gelse K, Pfander D, Obier S, et al. Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints. Arthritis Res Ther 2008; 10:R111.
11. Adams MA. The mechanical environment of chondrocytes in articular cartilage. Biorheology 2006; 43:537-545.
12. Murphy CL, Sambanis A. Effect of oxygen tension and alginate encapsulation on restoration of the differentiated phenotype of passaged chondrocytes. Tissue Eng 2001; 7:791-803.
13. Lafont JE, Talma S, Murphy CL. Hy-poxia-inducible factor 2alpha is essential for hypoxic induction of the human articular chondrocyte phenotype. Arthritis Rheum 2007; 56:3297-3306.
14. Lafont JE, Talma S, Hopfgarten C, Murphy CL. Hypoxia promotes the differentiated human articular chondro-cyte phenotype through SOX9-depen-dent and-independent pathways. J Biol Chem 2008; 283:4778-4786.
15. Yudoh K, Nakamura H, Masuko-Hon-go K, Kato T, Nishioka K. Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritis. Arthritis Res Ther 2005; 7:R904-R914.